公开(公告)号：US09216193B2

公开(公告)日：2015-12-22

申请号：US13818848

申请日：2011-08-23

申请人： Masamichi Hashimoto ,  Tadashi Morikawa ,  Yoshiaki Miyata ,  Akio Ohno ,  Kei Takahashi ,  Daisuke Ogasawara ,  Kenji Fujii ,  Teruaki Kakema ,  Mariko Takeda

发明人： Masamichi Hashimoto ,  Tadashi Morikawa ,  Yoshiaki Miyata ,  Akio Ohno ,  Kei Takahashi ,  Daisuke Ogasawara ,  Kenji Fujii ,  Teruaki Kakema ,  Mariko Takeda

IPC分类号： A61K31/727 ,  A61K31/728 ,  C08B37/08 ,  C08L5/08 ,  A61K8/73 ,  A61K9/00

CPC分类号： A61K31/728 ,  A61K8/735 ,  A61K9/0019 ,  A61K9/0024 ,  A61K2800/87 ,  A61K2800/91 ,  A61Q19/08 ,  C08B37/0072 ,  C08L5/08 ,  Y10T428/2982

摘要： The present invention provides a crosslinked hyaluronic acid composition including self-crosslinking hyaluronic acid particles having an equilibrium swelling capacity of 3-fold to 10-fold, and an aqueous solvent, wherein a dry weight of the self-crosslinking hyaluronic acid particles based on the total volume of the crosslinked hyaluronic acid composition is 3 w/v % to 8 w/v %.The crosslinked hyaluronic acid composition of the invention uses self-crosslinking hyaluronic acid particles of which the equilibrium swelling capacity is within the above predetermined range. Accordingly, the viscosity does not sharply increase even if the concentration thereof is increased. Therefore, if the crosslinked hyaluronic acid composition is applied to an injection, it is possible to obtain a sufficient curative effect on knee osteoarthritis even with a small frequency of administration.

摘要翻译： 本发明提供一种交联透明质酸组合物，其包含平衡溶胀能力为3倍至10倍的自交联透明质酸颗粒和水性溶剂，其中基于所述自交联透明质酸颗粒的干重 交联透明质酸组合物的总体积为3w / v％至8w / v％。 本发明的交联透明质酸组合物使用自交联透明质酸颗粒，其平衡溶胀能力在上述预定范围内。 因此，即使其浓度增加，粘度也不会急剧增加。 因此，如果将交联透明质酸组合物应用于注射剂，则即使施用次数较少，也可以获得对膝关节骨性关节炎的充分治疗效果。

公开(公告)号：US08946303B2

公开(公告)日：2015-02-03

申请号：US10541020

申请日：2004-01-19

申请人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

发明人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

IPC分类号： A61K31/122 ,  A61K38/43 ,  A61K38/44 ,  A61K31/09

CPC分类号： A61K31/09 ,  A61K31/122

摘要： To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.

摘要翻译： 为了保持生活在老龄化社会门槛的中老年人的身体健康和健康，本发明提供了一种对预防和减轻疲劳高度有效的疲劳减轻剂，其中药剂由物质组成 这是非常安全的，以便长期管理是可能的。 发现含有还原型辅酶Q的组合物可有效预防和减少疲劳，包括肌肉疲劳。 由于本发明的组合物的疲劳降低效果不仅在年轻大鼠中被观察到，而且在老年大鼠中也更加显着，本发明可以提供非常有用的疲劳减轻剂，特别是对于中老年人 以及年轻人。

公开(公告)号：US08904639B2

公开(公告)日：2014-12-09

申请号：US13223066

申请日：2011-08-31

申请人： Keiji Matsumoto ,  Shuji Koyama ,  Sakai Yokoyama ,  Kenji Fujii ,  Jun Yamamuro

发明人： Keiji Matsumoto ,  Shuji Koyama ,  Sakai Yokoyama ,  Kenji Fujii ,  Jun Yamamuro

IPC分类号： B21D53/76 ,  B23P17/00 ,  B41J2/135 ,  B41J2/16

CPC分类号： B41J2/1603 ,  B41J2/1606 ,  B41J2/1628 ,  B41J2/1629 ,  B41J2/1632 ,  B41J2/1634 ,  Y10T29/49401

摘要： Disclosed is a method of including the steps of preparing a substrate having a flow-path-wall member; bonding the flow-path-wall member to a resin layer that is composed of a photo-curing resin and serves as the ejection port member such that spaces serving as the flow paths are provided between the substrate and the photo-curing resin; providing through-holes in the resin layer such that the spaces communicate with the outside air; exposing part of the resin layer to light to form an exposed portion and an unexposed portion; heating the exposed portion of the resin layer; and removing the unexposed portion from the heated resin layer to form the ejection ports, removing the unexposed portion from the heated resin layer to form the ejection ports, thereby forming the ejection port member.

摘要翻译： 公开了一种包括制备具有流路壁构件的基板的步骤的方法， 将流路壁构件结合到由光固化树脂构成的树脂层，并且用作喷射口构件，使得在基板和光固化树脂之间设置用作流路的空间; 在树脂层中设置通孔，使得空间与外部空气连通; 将树脂层的一部分暴露于光以形成暴露部分和未曝光部分; 加热树脂层的暴露部分; 从被加热的树脂层去除未曝光部分以形成喷射口，从被加热的树脂层去除未曝光部分以形成喷射口，从而形成喷射口部件。

公开(公告)号：US08715197B2

公开(公告)日：2014-05-06

申请号：US13033746

申请日：2011-02-24

申请人： Yukiya Sawanoi ,  Kenji Fujii ,  Naomi Matsumura ,  Reiji Fujita

发明人： Yukiya Sawanoi ,  Kenji Fujii ,  Naomi Matsumura ,  Reiji Fujita

IPC分类号： A61B5/02

CPC分类号： A61B5/0225 ,  A61B5/02255 ,  A61B5/7239 ,  G06F19/00

摘要： A blood pressure information measurement device instantaneously changes cuff pressure in a specified pressure section in order to detect a control target value in artery volume constant control. An artery volume signal is detected in that period, and an inflection point of the detected artery volume signal is detected by performing differentiation processing or the like. The inflection point of the detected artery volume signal is fixed as the control target value.

摘要翻译： 血压信息测量装置瞬时改变指定压力部分中的袖带压力，以检测动脉体积恒定控制中的控制目标值。 在该期间检测到动脉体积信号，通过进行微分处理等来检测检测到的动脉体积信号的拐点。 检测到的动脉体积信号的拐点被固定为控制目标值。

公开(公告)号：US08429820B2

公开(公告)日：2013-04-30

申请号：US13219502

申请日：2011-08-26

申请人： Shuji Koyama ,  Sakai Yokoyama ,  Kenji Fujii ,  Jun Yamamuro ,  Keiji Matsumoto ,  Tetsuro Honda ,  Kouji Sasaki ,  Kenta Furusawa ,  Keisuke Kishimoto

发明人： Shuji Koyama ,  Sakai Yokoyama ,  Kenji Fujii ,  Jun Yamamuro ,  Keiji Matsumoto ,  Tetsuro Honda ,  Kouji Sasaki ,  Kenta Furusawa ,  Keisuke Kishimoto

IPC分类号： B21D53/76 ,  B23P17/00

CPC分类号： B41J2/1604 ,  B41J2/1628 ,  B41J2/1629 ,  B41J2/1631 ,  B41J2/1632 ,  B41J2/1634 ,  B41J2/1635 ,  B41J2/1639 ,  B41J2/1643 ,  B41J2/1645 ,  B41J2/1646 ,  Y10T29/49401

摘要： The present invention is a method of manufacturing a liquid discharge head, which includes providing a substrate on which a solid member is disposed to surround a region that becomes the flow path, and a metal layer made of a metal or a metal compound is disposed inside of the region, forming a mold made of a metal or a metal compound inside of the region, disposing a cover layer made of a resin to cover the solid member and the mold in contact with the solid member and the mold wherein the solid member and the metal are formed with a distance therebetween, and removing the mold to form the flow path.

摘要翻译： 本发明是一种液体排出头的制造方法，其特征在于，具备：设置固体部件的基板，围绕成为流路的区域，金属或金属化合物构成的金属层配置在内部 在该区域内形成由金属或金属化合物制成的模具，设置由树脂制成的覆盖层以覆盖固体构件和与实心构件和模具接触的模具，其中固体构件和 金属形成在它们之间的距离，并且移除模具以形成流动路径。

公开(公告)号：US08408678B2

公开(公告)日：2013-04-02

申请号：US13188211

申请日：2011-07-21

申请人： Mitsuru Chida ,  Jun Yamamuro ,  Kenji Fujii ,  Tetsuro Honda

发明人： Mitsuru Chida ,  Jun Yamamuro ,  Kenji Fujii ,  Tetsuro Honda

IPC分类号： B41J2/135

CPC分类号： B41J2/14024 ,  B41J2/1603 ,  B41J2/1626 ,  B41J2/1631 ,  B41J2/1645 ,  B41J2002/14387

摘要： A liquid ejection head includes a substrate having an energy-generating device configured to generate energy used for ejecting a liquid from an orifice; a transparent channel wall member forming an inner wall of a channel leading to the orifice; and an intermediate layer disposed between and in contact with a surface of the substrate and the channel wall member and having a refractive index different from a refractive index of the channel wall member. The intermediate layer has a first outer end surface forming contours of a symbol as viewed in a direction from the orifice toward the substrate and making a first angle with the surface of the substrate and a second outer end surface facing the channel and making a second angle with the surface of the substrate. The first angle is an obtuse angle. The second angle is smaller than the first angle.

摘要翻译： 液体喷射头包括具有能量产生装置的基板，该能量产生装置被配置为产生用于从孔口喷射液体的能量; 形成通向所述孔口的通道的内壁的透明通道壁构件; 以及中间层，其设置在所述基板和所述通道壁构件的表面之间并且与所述通道壁构件的表面接触并且具有与所述通道壁构件的折射率不同的折射率。 所述中间层具有第一外端表面，其形成从沿着所述孔朝向所述基板的方向观察的符号轮廓，并且与所述基板的表面形成第一角度，以及与所述通道相对的第二外端表面，并形成第二角度 与基板的表面。 第一个角度是钝角。 第二角度小于第一角度。

公开(公告)号：US20130008551A1

公开(公告)日：2013-01-10

申请号：US13535906

申请日：2012-06-28

申请人： Koji KANETA ,  Kenji Fujii ,  Hiroyoshi Kaneta

发明人： Koji KANETA ,  Kenji Fujii ,  Hiroyoshi Kaneta

IPC分类号： F16L9/14 ,  B32B37/14

CPC分类号： B29C63/36 ,  B29C63/0086 ,  B29L2023/006 ,  F16L55/1651 ,  F16L55/179

摘要： A resin sheet that is comprised of a thermoplastic resin capable of being thermally welded to a lining material of a main pipe is attached to a flange of a lateral pipe liming material via a resin-absorbing material. The resin sheet and the resin-absorbing material are thermally welded. The flange and the resin-absorbing material are respectively impregnated with a thermoplastic resin, which is cured to bond the flange and the resin-absorbing material. A similar configuration is provided to the bottom side of the flange as well. The resin sheet of the thermoplastic resin is integrally bonded to the flange, so that the flange of the lateral pipe lining material and the main pipe lining material can be reliably bonded by a simple method through thermally welding of the lining material of the main pipe and the resin sheet, even in a case in which the flange is hard.

摘要翻译： 由热塑性树脂组成的树脂片通过树脂吸收材料附着在侧管板材的凸缘上。 树脂片和树脂吸收材料被热焊接。 凸缘和树脂吸收材料分别浸渍有热塑性树脂，其被固化以将凸缘和树脂吸收材料结合。 类似的结构也提供到凸缘的底侧。 热塑性树脂的树脂片与凸缘一体地接合，从而可以通过简单的方法可靠地将侧管衬里材料和主管衬里材料的凸缘接合，通过主管的衬里材料的热焊接和 树脂片，即使在法兰硬的情况下也是如此。

公开(公告)号：US08329047B2

公开(公告)日：2012-12-11

申请号：US12635083

申请日：2009-12-10

申请人： Tadanobu Nagami ,  Junichi Kobayashi ,  Takeshi Terada ,  Makoto Watanabe ,  Hiroyuki Abo ,  Mitsunori Toshishige ,  Yoshinori Tagawa ,  Shuji Koyama ,  Kenji Fujii ,  Masaki Ohsumi ,  Jun Yamamuro ,  Hiroyuki Murayama ,  Yoshinobu Urayama ,  Taichi Yonemoto

发明人： Tadanobu Nagami ,  Junichi Kobayashi ,  Takeshi Terada ,  Makoto Watanabe ,  Hiroyuki Abo ,  Mitsunori Toshishige ,  Yoshinori Tagawa ,  Shuji Koyama ,  Kenji Fujii ,  Masaki Ohsumi ,  Jun Yamamuro ,  Hiroyuki Murayama ,  Yoshinobu Urayama ,  Taichi Yonemoto

IPC分类号： G01D15/00

CPC分类号： B41J2/1603 ,  B41J2/1629 ,  B41J2/1631 ,  B41J2/1639 ,  Y10T29/49401

摘要： The present invention provides a method for producing a liquid discharge head including a silicon substrate having, on a first surface, energy generating elements, and a supply port penetrating the substrate from the first surface to a second surface, which is a rear surface of the first surface of the substrate. The method includes the steps of: preparing the silicon substrate having a sacrifice layer at a portion on the first surface where the ink supply port is to be formed and an etching mask layer having a plurality of openings on the second surface, the volume of a portion of the sacrifice layer at a position corresponding to a portion between two adjacent said openings being smaller than the volume of a portion of the sacrifice layer at a position corresponding to the opening; etching the silicon substrate from the plurality of openings and etching the sacrifice layer.

摘要翻译： 本发明提供了一种液体排出头的制造方法，该液体排出头包括硅基板，该第一表面在第一表面上具有能量产生元件和从第一表面穿过该基板的供给口， 基片的第一表面。 该方法包括以下步骤：在要形成供墨口的第一表面上的一部分制备具有牺牲层的硅衬底和在第二表面上具有多个开口的蚀刻掩模层， 牺牲层的与相邻的两个开口之间的部分相对应的位置处的部分比对应于开口的位置处的牺牲层的一部分的体积小; 从多个开口蚀刻硅衬底并蚀刻牺牲层。

公开(公告)号：US20120302901A1

公开(公告)日：2012-11-29

申请号：US13567525

申请日：2012-08-06

申请人： Tatsuya Kobayashi ,  Kenji Fujii ,  Hideaki Yoshida

发明人： Tatsuya Kobayashi ,  Kenji Fujii ,  Hideaki Yoshida

IPC分类号： A61B5/0235 ,  A61B5/025

CPC分类号： A61B5/02233 ,  A61B5/022 ,  A61B5/02225 ,  A61B5/0235 ,  A61B5/7203

摘要： A blood pressure information measurement device includes a main body, including an inflation pump and an exhaust valve, and a cuff, including an air bladder for pulse wave measurement and an air bladder for blood pressure value measurement. The air bladder for pulse wave measurement and the air bladder for blood pressure value measurement are wrapped around a proximal side and a distal side of the upper arm, respectively. A first piping portion connects the air bladder for blood pressure value measurement to the inflation pump and the exhaust valve. A second piping portion branching from the first piping portion connects the air bladder for pulse wave measurement to the first piping portion. The second piping portion includes a 2-port valve that switches between connecting and disconnecting the air bladder for pulse wave measurement and the first piping portion, and a pressure sensor for measuring a pulse wave.

摘要翻译： 血压信息测量装置包括包括充气泵和排气阀的主体和包括用于脉搏波测量的气囊和用于血压值测量的气囊的袖带。 用于脉搏波测量的气囊和用于血压值测量的气囊分别围绕上臂的近侧和远侧缠绕。 第一管道部分将用于血压值测量的气囊连接到充气泵和排气阀。 从第一管道部分分支的第二管道部分将用于脉搏波测量的气囊连接到第一管道部分。 第二管道部分包括在连接和断开用于脉搏波测量的气囊和第一管道部分之间切换的2通阀，以及用于测量脉搏波的压力传感器。

公开(公告)号：US20120172734A1

公开(公告)日：2012-07-05

申请号：US13314355

申请日：2011-12-08

申请人： Kenji Fujii ,  Tatsuya Kobayashi ,  Toshihiko Ogura

发明人： Kenji Fujii ,  Tatsuya Kobayashi ,  Toshihiko Ogura

IPC分类号： A61B5/0225

CPC分类号： A61B5/02007 ,  A61B5/02125 ,  A61B5/0225

摘要： A blood pressure measurement device accurately calculates an index useful in determining the degree of arteriosclerosis by accurately detecting a difference in time of appearance of a ejection wave and reflected wave in a blood pressure waveform. The device sets a threshold value based on an index that expresses a characteristic of the blood pressure waveform with respect to the point of appearance of the reflected wave in the blood pressure and estimates a rise point of the reflected wave by calculating an x-coordinate value of a point based on a maximum amplitude of the reflected wave and the threshold value. The device obtains the index of degree of arteriosclerosis by calculating a time difference in appearance between the ejection wave and the reflected wave based on the estimated rise point of the reflected wave.

摘要翻译： 血压测量装置通过精确地检测血压波形中的喷射波和反射波的出现时间的差异来精确地计算用于确定动脉硬化程度的指标。 该装置基于表示相对于血压中的反射波的出现点的血压波形的特性的指标来设定阈值，并且通过计算x坐标值来估计反射波的上升点 基于反射波的最大幅度和阈值的点。 该装置根据估计的反射波的上升点，计算出喷射波和反射波之间的时间差，得到动脉硬化程度的指标。