摘要:
The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
摘要:
Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要:
Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要:
A method and system is presented for path discovery and asynchronous message transfer in a partially connected middleware communication space comprising mobile ad hoc networks. Embodiments of the present invention use mobile devices to bridge separated islands of networks and store and propagate messages. The system and software architecture supports methods for routing, messaging caching, and transferring. More specifically, embodiments provide methods and systems that extend a communication space concept into a distributed environment and combine it with the standard Web Services technologies, i.e., SOAP, and WS series protocols. The communication space provides an extension of Web Services to mobile ad hoc networks and provides asynchronous message caching, transferring and routing.
摘要:
An Instant Messaging (IM) method and server are provided. The method includes: receiving instance login information sent by an IM client, wherein the instance login information at least includes login information of a user of the IM client and instance information of a terminal located by the IM client (101); authenticating identity of the user of the IM client, according to the login information in the instance login information (102); when the authenticating is passed, allocating an instance number for the IM client, according to the instance information in the instance login information, wherein the instance number is configured to uniquely identify the IM client (103). The server includes a receiving module (801), an authenticating module (802) and an allocating module (803). By adopting the method and server provided, multipoint login of one login account may be effectively achieved, and multiple aspects requirements of a user may be satisfied.
摘要:
Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
摘要:
Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents. The viruses also can be used in diagnostic methods.
摘要:
Systems and methods are described for using a mobile phone to control a computing device. In one implementation, a communication protocol stack is established that includes a wireless layer, such as a BLUETOOTH wireless protocol (IEEE Standard 802.15.1) stack, a communication layer that multiplexes the wireless layer into virtual channels, and an application adaptation layer by which the mobile phone controls and previews content from each of multiple applications on the computing device. The communication protocol stack dynamically maps mobile phone keys to computer keyboard messages for controlling the applications on the computing device. A data packet structure is established for communications between the mobile phone and the computing device via the communication protocol stack.
摘要:
Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要:
The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.