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195 条记录 (耗时 0.026 秒)

    Polyester/cyanoacrylate tissue adhesive compositions
    83.
    发明授权
    Polyester/cyanoacrylate tissue adhesive compositions 有权
    聚酯/氰基丙烯酸酯组织粘合剂组合物

    公开(公告)号：US07351426B2

    公开(公告)日：2008-04-01

    申请号：US10792537

    申请日：2004-03-03

    申请人： Shalaby W. Shalaby ,  M. Aaron Vaughn

    发明人： Shalaby W. Shalaby ,  M. Aaron Vaughn

    IPC分类号： A61F13/02 ,  A61L15/16

    CPC分类号： A61L24/043 ,  A61B17/00491 ,  A61B17/11 ,  C08L35/04 ,  C08L67/04

    摘要： This invention addresses absorbable cyanoacrylate-based tissue adhesive compositions based primarily on an alkoxy cyanoacrylate combined with one or more alkyl cyanoacrylate(s), a stabilizer against premature anionic polymerization, and/or an absorbable polymeric modifier with improved, and preferably, functional properties for use, primarily, for internal wound repair applications.

    摘要翻译： 本发明涉及可吸收的基于氰基丙烯酸酯的组织粘合剂组合物，其主要基于与一种或多种氰基丙烯酸烷基酯结合的烷氧基氰基丙烯酸酯，抗过敏阴离子聚合的稳定剂和/或可吸收的聚合物改性剂，其具有改进的，优选的功能性质， 主要用于内伤修复应用。

    Absorbable &egr;-caprolactone copolymers
    85.
    发明授权
    Absorbable &egr;-caprolactone copolymers 失效
    可吸收的ε-己内酯共聚物

    公开(公告)号：US06703035B2

    公开(公告)日：2004-03-09

    申请号：US10087512

    申请日：2002-03-01

    申请人： Shalaby W. Shalaby

    发明人： Shalaby W. Shalaby

    IPC分类号： A01N2534

    CPC分类号： A61L17/12 ,  A61L17/145 ,  A61L24/046 ,  A61L27/18 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  C08G63/912 ,  C08L67/04

    摘要： This invention deals with crystalline, nitrogen copolyester lubricant coating devices comprising sutures, wherein said lubricant comprises a triaxial copolyester chain with a central nitrogenous base or a copolyester with more than one carboxylic group ionically linked to a basic amino acid.

    摘要翻译： 本发明涉及包含缝合线的结晶，氮共聚酯润滑剂涂覆装置，其中所述润滑剂包括具有中心含氮碱的三轴共聚酯链或具有多于一个与碱性氨基酸离子连接的羧基的共聚酯。

    Modulated molecularly bonded inherently conductive polymers on substrates with conjugated multiple lamellae and shaped articles thereof
    86.
    发明授权
    Modulated molecularly bonded inherently conductive polymers on substrates with conjugated multiple lamellae and shaped articles thereof 失效
    在具有共轭多层片及其成型制品的基底上调制分子结合的固有导电聚合物

    公开(公告)号：US6117554A

    公开(公告)日：2000-09-12

    申请号：US862945

    申请日：1997-05-30

    申请人： Shalaby W. Shalaby ,  Jacqueline M. Allan

    发明人： Shalaby W. Shalaby ,  Jacqueline M. Allan

    IPC分类号： C08G61/12 ,  C08J7/12 ,  C08J7/16 ,  C23C28/00 ,  B32B31/06 ,  B05D3/00 ,  B05D3/04 ,  B32B15/04

    CPC分类号： C23C28/00 ,  C08G61/122 ,  C08G61/124 ,  C08J7/12 ,  C08J7/16

    摘要： Organic inherently conductive polymers, such as those based on polyaniline, polypyrrole and polythiophene, are sequentially formed in-situ onto polymeric surfaces that are chemically functionalized to molecularly bond the conductive polymers to the substrates. The polymeric substrate is preferably a preshaped or preformed thermoplastic film, fabric, or tube, although other forms of thermoplastic and thermoset polymers can be used as the substrates for functionalization using, most preferably, phosphonylation-based processes followed by exposure to an oxidatively polymerizable compound capable of forming an electrically conductive polymer. It has been found that the degree of electrical conductivity may be modulated by bonding further electrically conductive layers to the article. That is, each underlying conductive layer is functionalized prior to bonding of a subsequent conductive layer thereto until the degree of conductivity is achieved. In an alternative embodiment, metals such as gold or platinum may be bonded to one of the functionalized surfaces.

    摘要翻译： 有机固有导电聚合物，例如基于聚苯胺，聚吡咯和聚噻吩的固体导电聚合物，原位地依次形成在化学官能化以将导电聚合物分子结合到基底上的聚合物表面上。 聚合物基材优选为预成型或预成型的热塑性薄膜，织物或管，尽管其它形式的热塑性和热固性聚合物可用作官能化底物，最优选使用基于膦酰基化的方法，随后暴露于氧化可聚合化合物 能够形成导电聚合物。 已经发现，可以通过将另外的导电层粘合到制品上来调节导电性的程度。 也就是说，每个下面的导电层在其后面的导电层结合之前被功能化，直到达到导电度。 在替代实施例中，诸如金或铂的金属可以结合到功能化表面之一。

    Peracylated proteins and synthetic polypeptides and process for making the same
    87.
    发明授权
    Peracylated proteins and synthetic polypeptides and process for making the same 失效
    过酰化蛋白质和合成多肽及其制备方法

    公开(公告)号：US5986050A

    公开(公告)日：1999-11-16

    申请号：US996366

    申请日：1997-12-22

    申请人： Shalaby W. Shalaby ,  Jacqueline M. Allan ,  Joel T. Corbett

    发明人： Shalaby W. Shalaby ,  Jacqueline M. Allan ,  Joel T. Corbett

    IPC分类号： C07K1/113 ,  C07K14/415 ,  C07K1/00 ,  A61K35/78

    CPC分类号： C07K14/415 ,  C07K1/113 ,  Y10T428/29 ,  Y10T428/2913 ,  Y10T428/2915

    摘要： A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or polypeptide with a cyclic anhydride having a carbon chain substituent selected from the group consisting of alkyl and alkenyl groups. Most preferably, the cyclic anhydride is succinic anhydride, although glutaric anhydride may also be employed. Preferably, the step of peracylating the protein or polypeptide is performed in the presence of an acid catalyst, most preferably .rho.-toluene sulfonic acid. The resultant modified protein or polypeptide may be employed in numerous applications including drug delivery, absorbable sutures, and thermoplastic films and molded articles.

    摘要翻译： 公开了一种修饰蛋白质或多肽的方法，其包括以下步骤：将蛋白质或多肽分散在基本上非水性的培养基中，并将所述蛋白质或多肽与具有选自以下的碳链取代基的环酸酐进行过酰化：烷基和 烯基。 最优选地，环状酸酐是琥珀酸酐，尽管也可以使用戊二酸酐。 优选地，在酰基化蛋白质或多肽的步骤在酸催化剂，最优选Rho-甲苯磺酸的存在下进行。 所得到的修饰的蛋白质或多肽可用于许多应用，包括药物递送，可吸收缝合线，以及热塑性薄膜和模塑制品。

    Surface modified glasses and composites thereof
    89.
    发明授权
    Surface modified glasses and composites thereof 失效
    表面改性玻璃及其复合材料

    公开(公告)号：US5874509A

    公开(公告)日：1999-02-23

    申请号：US676004

    申请日：1996-07-05

    申请人： Shalaby W. Shalaby ,  Daniel C. Clupper ,  Theodore D. Taylor

    发明人： Shalaby W. Shalaby ,  Daniel C. Clupper ,  Theodore D. Taylor

    IPC分类号： C08G83/00 ,  C08K9/04 ,  C08K9/06 ,  C08L101/02

    CPC分类号： C08K9/06 ,  C08G83/001 ,  C08K9/04

    摘要： An inorganic glass having an aliphatic polymer covalently bonded to the surface thereof is disclosed for providing improved adhesion to a matrix polymer when the glass is employed as a composite filler, as well as for the formation of a composite absent a separate matrix polymer. The polymer is grafted onto the glass by a method which includes the steps of pretreating the surface of the glass with an activator which an activating moiety to the surface, functionalizing the pretreated surface by bonding functional moieties thereto, and polymerizing a cycloaliphatic monomer onto the functionalized surface in the presence of a ring opening polymerization catalyst. Also disclosed are novel inorganic glasses which contain both silicate and phosphate linkages.

    摘要翻译： 公开了一种具有与其表面共价键合的脂肪族聚合物的无机玻璃，用于当将玻璃用作复合填料时提供对基体聚合物的改善的粘附性，以及形成不含单独的基质聚合物的复合材料。 聚合物通过一种方法接枝到玻璃上，所述方法包括以下步骤：用活化剂预处理玻璃的表面，活化剂是表面的活化部分，通过键合官能部分官能化预处理的表面，并将脂环族单体聚合到官能化的 在开环聚合催化剂存在下进行表面处理。 还公开了含有硅酸盐和磷酸酯键的新型无机玻璃。