-
81.发明授权
公开(公告)号：US5958940A
公开(公告)日：1999-09-28
申请号：US927728
申请日：1997-09-11
申请人： Dinanath F. Rane , Alan B. Cooper , Alan K. Mallams , Ronald J. Doll , F. George Njoroge , Arthur G. Taveras
发明人： Dinanath F. Rane , Alan B. Cooper , Alan K. Mallams , Ronald J. Doll , F. George Njoroge , Arthur G. Taveras
IPC分类号： C07D401/14 , A61K31/44
CPC分类号： C07D401/14
摘要： Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
摘要翻译： 公开了新的三环化合物和药物组合物，其是酶的抑制剂，法呢基蛋白转移酶。 还公开了抑制Ras功能并因此抑制细胞异常生长的方法。 该方法包括将新型三环化合物施用于生物系统。 特别地，该方法抑制哺乳动物如人的细胞的异常生长。
-
82.发明授权2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases 有权2'-叠氮基取代的核苷衍生物及其用于治疗病毒性疾病的方法公开(公告)号：US09156872B2
公开(公告)日：2015-10-13
申请号：US14111685
申请日：2012-04-11
申请人： Vinay Girijavallabhan , F. George Njoroge , Stephane Bogen , Frank Bennett , Vishal Verma , Ashok Arasappan , Kevin Chen , Ying Huang , Angela Kerekes , Latha Nair , Dmitri Pissarnitski , Qun Dang , Ian Davies , David B. Olsen , Andrew Stamford , Joseph P. Vacca
发明人： Vinay Girijavallabhan , F. George Njoroge , Stephane Bogen , Frank Bennett , Vishal Verma , Ashok Arasappan , Kevin Chen , Ying Huang , Angela Kerekes , Latha Nair , Dmitri Pissarnitski , Qun Dang , Ian Davies , David B. Olsen , Andrew Stamford , Joseph P. Vacca
IPC分类号： C07H19/06 , C07H19/10 , C07H19/12 , C07H19/16 , C07H19/04 , C07H19/20 , C07H19/207 , C07H19/11 , C07H19/213 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , A61P31/14 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213
摘要： The present invention relates to 2′-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Azido Substituted Nucleoside Derivative, and methods of using the 2′-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的2'-叠氮基取代的核苷衍生物及其药学上可接受的盐，其中B，X，R 1，R 2和R 3如本文所定义。 本发明还涉及包含至少一种2'-叠氮基取代的核苷衍生物的组合物，以及使用2'-叠氮基取代的核苷衍生物治疗或预防患者HCV感染的方法。
-
83.发明授权Acylsulfonamide compounds as inhibitors of hepatitis C virus NS3 serine protease 有权酰基磺酰胺化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US07550559B2
公开(公告)日：2009-06-23
申请号：US11211771
申请日：2005-08-25
IPC分类号： C07K5/08
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0217
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
-
84.发明授权Imidazolidinones as NS3-serine protease inhibitors of hepatitis C virus 失效咪唑啉酮作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂公开(公告)号：US06838475B2
公开(公告)日：2005-01-04
申请号：US09909077
申请日：2001-07-19
申请人： Ashok Arasappan , Tejal Parekh , F. George Njoroge , Viyyoor Moopil Girijavallabhan , Ashit K. Ganguly
发明人： Ashok Arasappan , Tejal Parekh , F. George Njoroge , Viyyoor Moopil Girijavallabhan , Ashit K. Ganguly
IPC分类号： C12N9/99 , A61K31/4166 , A61K31/7056 , A61K38/00 , A61K38/21 , A61K38/55 , A61K45/00 , A61P31/14 , A61P43/00 , C07D233/38 , C07K5/02 , C07K5/023 , C07K5/062 , C07K7/02 , A01N43/50
CPC分类号： C07K7/02 , A61K38/00 , C07D233/38 , C07K5/0202
摘要： The present invention discloses novel imidazolidinones which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such imidazolidinones as well as methods of using them to treat disorders associated with the HCV protease.
-
85.发明授权Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases 失效可用于抑制G蛋白功能和治疗增殖性疾病的三环酰胺和尿素化合物公开(公告)号：US06242458B1
公开(公告)日：2001-06-05
申请号：US09400714
申请日：1999-09-21
申请人： W. Robert Bishop , Ronald J. Doll , Alan K. Mallams , F. George Njoroge , Joanne M. Petrin , John J. Piwinski , Ronald L. Wolin , Arthur G. Taveras , Stacy W. Remiszewski
发明人： W. Robert Bishop , Ronald J. Doll , Alan K. Mallams , F. George Njoroge , Joanne M. Petrin , John J. Piwinski , Ronald L. Wolin , Arthur G. Taveras , Stacy W. Remiszewski
IPC分类号： A61K314545
CPC分类号： C07D231/12 , A61K31/444 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , C07D221/16 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of the formulas 5.1 and 5.2 are disclosed.
摘要翻译： 公开了抑制Ras功能并因此抑制细胞异常生长的方法。 该方法包括向生物系统施用式1.0化合物。 特别地，该方法抑制哺乳动物例如人的细胞的异常生长。 公开了式5.1和5.2的新型化合物。
-
86.发明授权Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases 失效可用于抑制G蛋白功能和治疗增殖性疾病的三环化合物
公开(公告)号：US5958890A
公开(公告)日：1999-09-28
申请号：US927727
申请日：1997-09-11
IPC分类号： C07D401/14 , C07D413/14 , A61K31/70 , A61K31/44 , C07D221/16 , C07M15/00
CPC分类号： C07D401/14 , C07D413/14
摘要： Compounds the formula ##STR1## their use as farnesyl transferase protein inhibitors and pharmaceutical compositions containing them are disclosed, especially compounds of the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are halo, A and B are each H.sub.2, and R is as defined in the specification.
摘要翻译： 公开了将其用作法呢基转移酶蛋白抑制剂和含有它们的药物组合物的化合物，特别是下式的化合物其中R 1，R 2和R 3是卤素，A和B各自为H 2，R如说明书中所定义。
-
87.发明授权Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease 失效用于抑制G蛋白功能和治疗增殖性疾病的三环酰胺
公开(公告)号：US5874442A
公开(公告)日：1999-02-23
申请号：US766601
申请日：1996-12-12
申请人： Ronald J. Doll , Joseph M. Kelly , Alan K. Mallams , F. George Njoroge , Stacy W. Remiszewski , Arthur G. Taveras
发明人： Ronald J. Doll , Joseph M. Kelly , Alan K. Mallams , F. George Njoroge , Stacy W. Remiszewski , Arthur G. Taveras
IPC分类号： A61P35/00 , C07D401/14 , A61K31/44 , C07D221/16
CPC分类号： C07D401/14
摘要： "Novel compounds, such as: ##STR1## are disclosed. Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds."
摘要翻译： （图）（IMAGE）（27.0）
（27.0） （32.0） （39.0） 用于抑制细胞的异常生长，用于抑制法呢基蛋白转移酶和使用新化合物治疗癌症。 -
公开(公告)号：US5861395A
公开(公告)日：1999-01-19
申请号：US927469
申请日：1997-09-11
申请人： Arthur G. Taveras , Alan K. Mallams , Adriano Afonso , Stacy W. Remiszewski , F. George Njoroge , Ronald Doll , Tarik Lalwani , Carmen Alvarez
发明人： Arthur G. Taveras , Alan K. Mallams , Adriano Afonso , Stacy W. Remiszewski , F. George Njoroge , Ronald Doll , Tarik Lalwani , Carmen Alvarez
IPC分类号： C07D221/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , A61K31/495 , A61K31/535
CPC分类号： C07D401/04 , C07D221/06 , C07D401/12 , C07D401/14
摘要： Novel compounds of the formula: ##STR1## are disclosed. Compounds of Formula 1.0 are represented by the compounds of formulas: ##STR2## wherein R.sup.1, R.sup.3 and R.sup.4 are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.
摘要翻译： 公开了下式的新型化合物：
（1.0）。 式1.0的化合物由下式的化合物表示：其中R 1，R 3和R 4各自独立地选自卤素。 还公开了抑制法呢基蛋白转移酶和异常细胞如肿瘤细胞生长的方法。 -
89.发明授权Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases 失效可用于抑制G蛋白功能和治疗增殖性疾病的三环化合物
公开(公告)号：US5712280A
公开(公告)日：1998-01-27
申请号：US418973
申请日：1995-04-07
申请人： Ronald J. Doll , Alan K. Mallams , Adriano Afonso , Dinanath F. Rane , Randall R. Rossman , F. George Njoroge
发明人： Ronald J. Doll , Alan K. Mallams , Adriano Afonso , Dinanath F. Rane , Randall R. Rossman , F. George Njoroge
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/47 , A61K31/473 , A61K31/495 , A61P35/00 , A61P43/00 , C07D211/32 , C07D213/28 , C07D221/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D491/04 , C07D491/044
CPC分类号： C07D401/12 , C07D211/32 , C07D221/16 , C07D401/14 , C07D409/12 , C07D491/04
摘要： Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the Formula 1.0 to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
摘要翻译： 公开了新颖的式（IMAGE）化合物。 还公开了抑制Ras功能并因此抑制细胞异常生长的方法。 该方法包括向生物系统施用式1.0的化合物。 特别地，该方法抑制哺乳动物例如人的细胞的异常生长。
-
90.发明授权Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases 失效可用于抑制G蛋白功能和治疗增殖性疾病的三环酰胺和尿素化合物
公开(公告)号：US5700806A
公开(公告)日：1997-12-23
申请号：US410443
申请日：1995-03-24
申请人： Ronald J. Doll , F. George Njoroge
发明人： Ronald J. Doll , F. George Njoroge
IPC分类号： A61K31/4427 , A61K31/444 , A61K31/445 , A61K31/4545 , A61K31/54 , A61K31/541 , A61P35/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D417/14 , C07D401/06
CPC分类号： C07D401/04 , C07D401/14 , C07D417/14
摘要： Novel compounds of Formula (7.0a), (7.0b) or (7.0c): ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the formula (7.0a), (7.0b) or (7.0c) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
摘要翻译： 公开了新的式（7.0a），（7.0b）或（7.0c）化合物：（7.0a）（7.0b）或（IMAGE）（7.0c）。 还公开了抑制Ras功能并因此抑制细胞异常生长的方法。 该方法包括向生物系统施用式（7.0a），（7.0b）或（7.0c）的化合物。 特别地，该方法抑制哺乳动物例如人的细胞的异常生长。
-
-
-
-
-
-
-
-
-
搜索结果
126 条记录 (耗时 0.081 秒)
