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公开(公告)号：US09834749B2
公开(公告)日：2017-12-05
申请号：US14720853
申请日：2015-05-25
IPC分类号： C12N5/071 , C12N5/0735 , C12N5/00
CPC分类号： C12N5/0606 , C12N5/0031 , C12N5/0037 , C12N5/0043 , C12N2501/115 , C12N2501/15 , C12N2501/2306 , C12N2501/235 , C12N2533/12 , C12N2533/90
摘要： A method of expanding and maintaining human embryonic stem cells (ESCs) in an undifferentiated state by culturing the ESCs in a suspension culture under culturing conditions devoid of substrate adherence is provided. Also provided are a method of deriving ESC lines in the suspension culture and methods of generating lineage-specific cells from ESCs which were expanded in the suspension culture of the present invention.
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公开(公告)号：US20170342384A1
公开(公告)日：2017-11-30
申请号：US15657328
申请日：2017-07-24
IPC分类号： C12N5/071
CPC分类号： C12N5/0692 , A61K35/44 , A61K35/545 , C12N5/0603 , C12N2506/02 , C12N2506/45
摘要： Provided are methods of isolating pericyte progenitor cells from pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells, by isolating CD105+, CD73+ and/or CD105+/CD73+ cells from embryoid bodies and optionally by enriching the cells with CD31− cells. Also provided are methods of isolating endothelial cells and co-derivation of pericyte and endothelial cells progenitor cells from embryoid bodies, and methods of differentiating same for various therapeutic applications. In addition, the invention provides an isolated pericyte progenitor cell having an expression marker signature of CD105+/CD73+CD31−/alpha SMA−/CD133−/Flk-1−.
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公开(公告)号：US20170224618A1
公开(公告)日：2017-08-10
申请号：US15498526
申请日：2017-04-27
发明人： Marcelle MACHLUF , Tomer BRONSHTEIN
IPC分类号： A61K9/127
CPC分类号： A61K9/1271 , A61K9/1277 , A61K9/5176 , A61K47/48776 , A61K47/48815 , A61K47/6901 , A61K47/6911 , C12N15/88
摘要： Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.
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公开(公告)号：US20170211076A1
公开(公告)日：2017-07-27
申请号：US15480462
申请日：2017-04-06
发明人： Yoram REITER , Roy NOY , Kfir OVED
CPC分类号： C12N15/62 , A61K2039/505 , C07K14/70539 , C07K16/30 , C07K2317/56 , C07K2317/622 , C07K2319/00 , C07K2319/33
摘要： This invention provides fusion proteins comprising consecutive amino acids which beginning at the amino terminus of the protein correspond to consecutive amino acids present in (i) a cytomegalovirus human MHC-restricted peptide, (ii) a first peptide linker, (iii) a human β-2 microglobulin, (iv) a second peptide linker, (v) a HLA-A2 chain of a human MHC class I molecule, (vi) a third peptide linker, (vii) a variable region from a heavy chain of a scFv fragment of an antibody, and (viii) a variable region from a light chain of such scFv fragment, wherein the consecutive amino acids which correspond to (vii) and (viii) are bound together directly by a peptide bond or by consecutive amino acids which correspond to a fourth peptide linker, wherein the antibody from which the scFv fragment is derived specifically binds to mesothelin.
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公开(公告)号：US09683989B2
公开(公告)日：2017-06-20
申请号：US14512557
申请日：2014-10-13
发明人： Shy Shoham , Anat Marom , Sanjeev Kumar Mahto
IPC分类号： C12M1/34 , G01N33/50 , A61N5/06 , A61K35/30 , C12M1/00 , C12N5/0793 , A61B17/11 , A61L27/38 , A61L27/52
CPC分类号： G01N33/5058 , A61B17/1128 , A61F2230/0063 , A61K35/30 , A61L27/383 , A61L27/52 , A61N5/0622 , C12M31/00 , C12N5/0619 , C12N5/062 , C12N2501/13 , C12N2501/33 , C12N2503/04 , C12N2510/00 , C12N2513/00 , C12N2533/90
摘要： A neural network is disclosed. The neural network comprises a plurality of optogenetically modified neural cells being three-dimensionally distributed in a hydrogel medium and being disconnected from any solid support having a shear modulus above 1 GPa.
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公开(公告)号：US20170130702A1
公开(公告)日：2017-05-11
申请号：US15414789
申请日：2017-01-25
发明人： Yehuda AGNON , Guy RAMON , Carlos DOSORETZ
IPC分类号： F03G7/00
摘要： According to an aspect of some embodiments of the present invention there is provided a method for converting energy. The method comprises receiving energy from an external source, using the received energy for inducing a mass exchange process to release thermodynamic energy, and converting the thermodynamic energy directly into electrical energy at sufficient amount for performing work therewith. In some embodiments of the present invention, a portion of the released energy is converted to a pressure wave, and the mechanical energy constituted by the pressure wave is converted to non-mechanical energy.
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公开(公告)号：US09642860B2
公开(公告)日：2017-05-09
申请号：US14238756
申请日：2012-08-14
申请人： Zeev Gross , Michael Aviram , Adi Haber
发明人： Zeev Gross , Michael Aviram , Adi Haber
IPC分类号： C07D487/22 , A61K31/555 , A61K45/06 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/4418 , A61K31/47 , A61K31/505 , A61K31/405
CPC分类号： A61K31/555 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/4418 , A61K31/47 , A61K31/505 , A61K45/06 , A61K2300/00
摘要： Embodiments of the invention relate to methods of treatment a cardiovascular disease in a patient comprising administering an effective amount of a statin or a pharmaceutically acceptable salt thereof in combination with an effective amount of a transition metal complex of a corrole, an optically active isomer thereof or a pharmaceutically acceptable salt thereof. Further embodiments refer to pharmaceutical compositions comprising a statin and a corrole. Optionally, the corrole has a structure: wherein; M is a transition metal selected from the group consisting of Mn, Fe, Ru, Co, V, Cr, and Cu and R1, R2, R3, X1, X2, X3X4; E2, E3, E17 and E18 are each defined as in the specification.
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公开(公告)号：US20170102372A1
公开(公告)日：2017-04-13
申请号：US15311889
申请日：2015-05-19
发明人： Eyal ZUSSMAN , Yuval ESHED , Reshef GAL-OZ
CPC分类号： G01N33/227 , C09K9/00 , D01D5/0007 , D01D5/34 , D01F1/10 , D01F8/04 , G01N21/78 , G01N33/22
摘要： Compositions comprising electrospun fibers and colorimetric detection encapsulated thereto are provided. Further, methods of use of said composition, including, but not limited to in-situ detection of molecules of interest, such as explosive compounds, are provided.
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公开(公告)号：US09544065B2
公开(公告)日：2017-01-10
申请号：US14327702
申请日：2014-07-10
发明人： Mordechai Segev , Oren Cohen , Liad Levi
CPC分类号： H04B10/80
摘要： A method of transmitting light is disclosed. The method comprises: transmitting a first light pulse into a medium to form in the medium a filamented region that is capable of guiding light, and transmitting a second light into the filamented region, wherein the second light is a pulsed light or continues wave light, and wherein the second light is transmitted at least 10 nanoseconds after the first light pulse.
摘要翻译： 公开了一种透光方法。 该方法包括：将第一光脉冲发射到介质中以在介质中形成能够引导光的细丝区域，并将第二光透射到细丝区域，其中第二光是脉冲光或继续波光， 并且其中所述第二光在所述第一光脉冲之后传输至少10纳秒。
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公开(公告)号：US09487856B2
公开(公告)日：2016-11-08
申请号：US14416388
申请日：2013-07-22
发明人： Alon Hoffman
CPC分类号： C23C14/025 , C23C8/24 , C23C14/0611 , C23C16/0272 , C23C16/271 , Y10T428/265
摘要： A composite structure, comprising a cemented carbide substrate (e.g., tungsten carbide substrate cemented with cobalt, such as WC—Co), a thin interlayer disposed over the substrate, and a contiguous diamond film disposed over the interlayer, as well as processes of preparing such a composite structure and uses thereof, are provided. The composite structure is characterized by at least one of a substrate binder concentration of at least 2 percents by weight, interlayer thickness less than 20 microns, a homogenous interlayer made substantially of crystalline chromium nitride, a low to null binder concentration in the interlayer, and a high co-adhesion of the diamond film to the interlayer and the interlayer to the substrate.
摘要翻译： 一种复合结构，包括硬质合金基底（例如，与钴结合的碳化钨基底，例如WC-Co），设置在基底上的薄层，以及设置在中间层上的连续的金刚石膜，以及制备 提供这种复合结构及其用途。 所述复合结构的特征在于至少一种底物粘合剂浓度为至少2重量％，中间层厚度小于20微米，基本上由结晶氮化铬制成的均匀夹层，中间层中的低至无效粘合剂浓度，以及 金刚石膜与中间层和中间层与基底的高共粘合。
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