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公开(公告)号：US20230293452A1
公开(公告)日：2023-09-21
申请号：US18074611
申请日：2022-12-05
发明人： Martin D. Burke , Anthony S. Grillo
IPC分类号： A61K31/122 , G01N33/50 , A61P7/06 , A61P39/04 , A61K45/06 , A61K9/00 , A61K31/34 , A61K31/351 , A61K31/4184 , A61K31/4412 , A61K31/7048
CPC分类号： A61K31/122 , G01N33/5008 , A61P7/06 , A61P39/04 , A61K45/06 , A61K9/0019 , A61K9/0053 , A61K31/34 , A61K31/351 , A61K31/4184 , A61K31/4412 , A61K31/7048 , G01N2800/22
摘要： Provided are methods of treating a disease or condition characterized by a deficiency of or a defect in an iron transporter using a small molecule. For example, the method may increase transepithelial iron transport, or it may increase iron release. Additionally, the small molecule may be hinokitiol, or it may be selected from the group consisting of amphotericin B, calcimycin, nonactin, deferiprone, purpurogallin, and maltol. Also provided is a method of identifying a compound capable of treating a disease or condition characterized by a deficiency of or a defect in an iron transporter.
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公开(公告)号：US20180267057A1
公开(公告)日：2018-09-20
申请号：US15762900
申请日：2016-09-26
发明人： David R. Barnidge , David L. Murray
IPC分类号： G01N33/68
CPC分类号： G01N33/6857 , C07K16/00 , C07K2317/515 , G01N33/6848 , G01N2800/22 , G01N2800/50 , G01N2800/52 , G01N2800/7047
摘要： This document relates to methods for identifying one or more immunoglobulin free light chains in a sample using mass spectrometry. For example, this document relates to a method for identifying one or more immunoglobulin free light chains in a sample that includes (a) providing a sample; (b) subjecting the sample to a mass spectrometry technique to obtain a mass spectrum of the sample; and (c) identifying the presence of the one or more immunoglobulin free light chains.
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公开(公告)号：US20180258168A1
公开(公告)日：2018-09-13
申请号：US15920244
申请日：2018-03-13
发明人： Mark Westerman , Huiling Han , Vaughn Ostland
IPC分类号： C07K16/26 , G01N33/541
CPC分类号： C07K16/26 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/92 , C12Y111/01007 , G01N33/541 , G01N33/6893 , G01N33/74 , G01N33/746 , G01N2800/22
摘要： Disclosed herein are antibodies specific for erythroferrone and assays comprising the antibodies. Also disclosed are methods for using the assays for the diagnosis or monitoring of disease.
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公开(公告)号：US09977035B2
公开(公告)日：2018-05-22
申请号：US14961144
申请日：2015-12-07
申请人： Ann Smith
发明人： Ann Smith
CPC分类号： G01N33/6893 , G01N33/5308 , G01N2333/47 , G01N2800/22 , G01N2800/26 , G01N2800/2871
摘要： A method of detecting and measuring the level of total hemopexin and nitrated hemopexin in a sample of a patient in need thereof. The method uses an ELISA for total and nitrated hemopexin.
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公开(公告)号：US20180031579A1
公开(公告)日：2018-02-01
申请号：US15550394
申请日：2016-02-11
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ PARIS DESCARTES , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , FONDATION IMAGINE , ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) , UNIVERSITÉ DE NANTES , UNIVERSITÉ D'ANGERS , CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERS
发明人： Ivan CRUZ-MOURA , Valérie BARDET , Michaël DUSSIOT , Thiago TROVATI MACIEL , Jérôme TAMBURINI , Norbert IFRAH , Olivier HERMINE
IPC分类号： G01N33/74 , A61K39/395 , C07K16/22
CPC分类号： G01N33/74 , A61K39/3955 , C07K16/22 , C07K2317/76 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/57426 , G01N2333/475 , G01N2333/51 , G01N2800/22 , G01N2800/52
摘要： The present invention relates to antagonists of GDF11, for use in the treatment of malignant hematological disease, such as Acute Myeloid Leukemia (AML). The present invention also relates to a method for predicting the responsiveness of a patient affected with malignant haematological disease, such as Acute Myeloid Leukemia, to a chemotherapy treatment.
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86.发明授权公开(公告)号：US09872839B2
公开(公告)日：2018-01-23
申请号：US15425528
申请日：2017-02-06
发明人： Zhenjia Wang , Jaehyung Cho , Asrar Malik
IPC分类号： A61K31/05 , A61K9/16 , G01N33/543 , G01N33/50 , A61K9/51 , A61K31/573 , A61K9/00
CPC分类号： A61K31/05 , A61K9/0019 , A61K9/1658 , A61K9/5169 , A61K31/573 , G01N33/5005 , G01N2800/22
摘要： Disclosed are nanoparticle compositions comprising nanoparticles prepared from denatured, cross-linked albumin and a therapeutic agent for treating a neutrophil-mediated inflammation, and methods of treating neutrophil-mediated inflammation using the compositions.
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公开(公告)号：US20170334964A1
公开(公告)日：2017-11-23
申请号：US15606660
申请日：2017-05-26
申请人： UCL BUSINESS PLC
发明人： Martin Pulé , Kwee Yong , Lydia Lee , Neil Chaplin , Ben Draper
IPC分类号： C07K14/525 , G01N33/574 , C12N15/85 , C07K14/725 , A61K35/17
CPC分类号： C07K14/525 , A61K35/17 , C07K14/7051 , C07K2319/00 , C07K2319/03 , C07K2319/30 , C07K2319/70 , C12N15/85 , G01N33/57407 , G01N2333/70575 , G01N2800/22
摘要： The present invention provides a variant proliferation-inducing ligand (APRIL), which has a higher binding affinity to BCMA than wild-type APRIL; and/or altered binding kinetics compared with wild-type APRIL, and/or a higher BCMA:TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) binding ratio than wild-type APRIL and which comprises mutations at one or more of the following positions: A125, V174, T175, M200, P201, S202, H203, D205 and R206.
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公开(公告)号：US09678088B2
公开(公告)日：2017-06-13
申请号：US14785980
申请日：2014-04-28
申请人： President and Fellows of Harvard College , Children's Medical Center Corporation , The Brigham and Women's Hospital, Inc.
发明人： George M. Whitesides , Ashok A. Kumar , Jonathan W. Hennek , Caeul Lim , Yovany Moreno , Charles R. Mace , Manoj T. Duraisingh , Matthew R. Patton , Si-yi Ryan Lee , Gaetana D'Alesio-Spina , Carlo Brugnara , Thomas P. Stossel
CPC分类号： G01N33/80 , G01N15/05 , G01N33/491 , G01N2015/003 , G01N2015/0073 , G01N2015/0076 , G01N2800/22
摘要： An aqueous multi-phase system for diagnosis of sickle cell disease is described, including two or more phase-separated phases including: a first aqueous phase including a first phase component and having a first density between about 1.025 g/cm3 and about 1.095 g/cm3; and a second aqueous phase including a second phase component and having a second density between about 1.100 g/cm3 and about 1.140 g/cm3; wherein the first density is lower than the second density; and each of the first and second phase components include at least one polymer.
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公开(公告)号：US20170052202A1
公开(公告)日：2017-02-23
申请号：US15344197
申请日：2016-11-04
发明人： Marie-Paule Roth
CPC分类号： G01N33/74 , A61K31/7088 , A61K38/00 , A61K38/1875 , C07K14/51 , C07K16/22 , C12N15/1136 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6887 , G01N33/6893 , G01N2333/51 , G01N2800/04 , G01N2800/22
摘要： The present invention relates to methods for diagnosing and treating iron overload and iron deficiency.
摘要翻译： 本发明涉及铁超载和铁缺乏症的诊断和治疗方法。
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公开(公告)号：US20160368975A1
公开(公告)日：2016-12-22
申请号：US15161603
申请日：2016-05-23
申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Universite Paris Descartes - Paris V , Assistance Publique - Hopitaux de Paris , Fondation Imagine
CPC分类号： C07K16/18 , A61K31/70 , A61K31/7088 , A61K38/02 , G01N33/5094 , G01N33/6893 , G01N33/80 , G01N2333/805 , G01N2500/02 , G01N2800/22
摘要： Methods and compositions for the treatment of β-thalassemia are provided. Methods and compositions restore or increase erythrocyte maturation in individuals afflicted with β-TM by preventing proteolysis of GATA-1 protein. Screening methods for identifying agents which bind heat shock protein 70 (HSP-70) and inhibit HSP-70 α-globin binding, but which allow GATA-1 protein-HSP-1 binding in a manner that prevents GATA-1 proteolysis.
摘要翻译： 提供了治疗β-地中海贫血的方法和组合物。 方法和组合物通过预防GATA-1蛋白的蛋白水解来恢复或增加患有β-TM的个体的红细胞成熟。 用于鉴定结合热休克蛋白70（HSP-70）并抑制HSP-70α-珠蛋白结合但允许以防止GATA-1蛋白水解的方式进行GATA-1蛋白-HSP-1结合的试剂的筛选方法。
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