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    Neuroaneurysm occlusion and delivery device and method of using same
    3.
    发明申请
    Neuroaneurysm occlusion and delivery device and method of using same 有权
    神经内膜闭塞和输送装置及其使用方法

    公开(公告)号：US20010044629A1

    公开(公告)日：2001-11-22

    申请号：US09852541

    申请日：2001-05-10

    申请人： Schneider (USA), Inc.

    发明人： Jonathan S. Stinson

    IPC分类号： A61B017/00 ,  A61F002/06

    CPC分类号： A61B17/12113 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12172 ,  A61B17/12177 ,  A61B2017/00004 ,  A61B2017/12059

    摘要： A delivery device for delivering an implantable endoprosthesis with an occlusion region for occluding fluid flow to a desired location in a body lumen. The delivery device includes an outer sleeve and an inner tube terminating at a distal tip. The distal tip is made of one of a dissolvable, bioabsorbable, or deformable material. Upon deployment of the endoprosthesis at the desired location, the shape of the distal tip is altered to a different shape and withdrawn through the constricted region of the endoprosthesis.

    摘要翻译： 用于递送具有闭塞区域的可植入内用假体的输送装置，用于阻塞流体流到体腔内的期望位置。 输送装置包括外套筒和终管于远端的内管。 远侧末端由可溶解的，生物可吸收的或可变形材料中的一种制成。 在将假体放置在所需位置时，将远端尖端的形状改变为不同的形状并且通过内假体的收缩区域撤回。

    Fluid actuated stent delivery system
    6.
    发明授权
    Fluid actuated stent delivery system 失效
    流体驱动支架输送系统

    公开(公告)号：US6056759A

    公开(公告)日：2000-05-02

    申请号：US122343

    申请日：1998-07-24

    申请人： Gary R. Fiedler

    发明人： Gary R. Fiedler

    IPC分类号： A61F2/82 ,  A61F2/06 ,  A61F2/84 ,  A61F11/00

    CPC分类号： A61F2/966 ,  A61F2/95

    摘要： A delivery system for procuring implantation of an expandable stent in a bodily lumen of interest is disclosed including a fluid-operated moving cylinder sleeve for retaining the stent in place during delivery and retracting to release a stent at the implantation site.

    摘要翻译： 公开了一种用于采购植入感兴趣的体腔中的可扩张支架的输送系统，其包括流体操作的移动气缸套筒，用于在输送期间将支架保持在适当位置并回缩以在植入部位释放支架。

    Drug-releasing coatings for medical devices
    7.
    发明授权
    Drug-releasing coatings for medical devices 失效
    用于医疗器械的药物释放涂层

    公开(公告)号：US6042875A

    公开(公告)日：2000-03-28

    申请号：US260971

    申请日：1999-03-02

    申请人： Ni Ding ,  Jennifer E. Raeder-Devens ,  Tuyethoa Thi Trinh

    发明人： Ni Ding ,  Jennifer E. Raeder-Devens ,  Tuyethoa Thi Trinh

    IPC分类号： A61F2/82 ,  A61L27/34 ,  A61L27/50 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  B05D3/00 ,  B05D3/02 ,  B05D3/04

    CPC分类号： A61L27/50 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/258 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/42 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2300/802

    摘要： The invention is directed to medical devices having a drug-releasing coating and methods for making such coated devices. The coating permits timed or prolonged pharmacological activity on the surface of medical devices through a reservoir concept. Specifically, the coating comprises at least two layers: an outer layer containing at least one drug-ionic surfactant complex overlying a reservoir layer containing a polymer and the drug which is substantially free of an ionic surfactant. Upon exposure to body tissue of a medical device covered with such coating, the ionically bound drug in the outer layer is released into body fluid or tissue. Following release of such bound drug, the ionic surfactant binding sites in the outer layer are left vacant. To maintain the pharmacological activity after delivery of the ionically bound drug, additional amounts of the drug are embedded or incorporated in the reservoir layer in a manner which allows the drug, which is substantially free of ionic surfactants, to complex with the vacant binding sites of the ionic surfactant of the outer layer. As a result, the surface of the medical device is enriched with the drug to provide sustained pharmacological activity to prevent the adverse reaction due to the presence of the medical device. The invention is further directed to medical devices with stabilized drug-releasing coatings. The coatings are stabilized by exposure to a low energy, relatively non-penetrating energy source, e.g., gas plasma or an electron beam energy source.

    摘要翻译： 本发明涉及具有药物释放涂层的医疗装置及其制造方法。 涂层允许通过储存器概念在医疗装置的表面上定时或延长药理活性。 具体地说，该涂层包括至少两层：包含至少一种药物 - 离子表面活性剂复合物的外层，其中包含聚合物的储存层和基本上不含离子表面活性剂的药物。 在暴露于用这种涂层覆盖的医疗装置的身体组织上时，外层中的离子结合药物被释放到体液或组织中。 释放这种结合药物后，外层中的离子表面活性剂结合位点留空。 为了在输送离子结合的药物之后保持药理活性，将额外量的药物以允许基本上不含离子表面活性剂的药物与储存层中的空位结合位点复合的方式嵌入或并入储存层中 外层的离子表面活性剂。 结果，医疗装置的表面富含药物以提供持续的药理活性，以防止由于存在医疗装置而引起的不良反应。 本发明进一步涉及具有稳定的药物释放涂层的医疗装置。 通过暴露于低能量，相对非穿透能量源（例如气体等离子体或电子束能量源）来使涂层稳定。

    Radially expanded prostheses with axial diameter control
    9.
    发明授权
    Radially expanded prostheses with axial diameter control 失效
    径向扩张的假体具有轴向直径控制

    公开(公告)号：US5984957A

    公开(公告)日：1999-11-16

    申请号：US79806

    申请日：1998-05-15

    申请人： Joseph E. Laptewicz, Jr. ,  Thomas A. Silvestrini

    发明人： Joseph E. Laptewicz, Jr. ,  Thomas A. Silvestrini

    IPC分类号： A61F2/00 ,  A61F2/86 ,  A61F2/90 ,  A61F2/06 ,  A61F2/02 ,  A61F2/04 ,  A61M29/00

    CPC分类号： A61F2/86 ,  A61F2/88 ,  A61F2/90 ,  A61F2/95 ,  A61F2002/9511 ,  A61F2250/0018

    摘要： A tubular, radially self-expanding stent includes a latticework of interbraided, helically wound resilient structural strands. An axial control member is secured to the tubular latticework at axially spaced apart proximal and distal coupling locations. At the proximal location, the control member is coupled slidably, to permit an adjustment of the axial distance between the coupling locations, thus to selectively adjust the radius profile of the latticework between the two locations. To set a desired radius profile, the control member either is crimped near the proximal location or fixed within a self-locking connector. The control members, preferably monofilament strands, can be elastic or substantially inextensible. Two or more control members can be used if desired. In an alternative embodiment, recovery metal control members are fixed at their opposite ends to the latticework, then plastically deformed by elongation to axially elongate and radially reduce the latticework. Following deployment, the control members are heated sufficiently to cause the control members to return to their shorter, nominal shapes, to axially shorten and radially enlarge the stent. Both versions preferably feature selvaged ends.

    摘要翻译： 管状的径向自扩张支架包括插入的，螺旋缠绕的弹性结构股线的网格。 轴向控制构件在轴向间隔开的近端和远端联接位置处固定到管状网格。 在近侧位置处，控制构件可滑动地联接，以允许调整联接位置之间的轴向距离，从而选择性地调整两个位置之间的网格的半径分布。 为了设置所需的半径轮廓，控制构件或者在近端位置附近被压接或固定在自锁连接器内。 控制构件，优选单丝股线可以是弹性的或基本不可伸长的。 如果需要，可以使用两个或多个控制构件。 在替代实施例中，回收金属控制构件在其相对端固定在网格上，然后通过伸长而被塑性变形以轴向延伸并径向减小网格。 在展开之后，控制构件被充分加热以使控制构件返回到其更短的标称形状，从而轴向缩短和径向扩大支架。 两种版本优选地具有边缘化。

    Medical device having a constricted region for occluding fluid flow in a body lumen
    10.
    发明授权
    Medical device having a constricted region for occluding fluid flow in a body lumen 失效
    具有用于阻塞体腔内的流体流动的收缩区域的医疗装置

    公开(公告)号：US5919224A

    公开(公告)日：1999-07-06

    申请号：US797983

    申请日：1997-02-12

    申请人： Paul J. Thompson ,  Claude Clerc

    发明人： Paul J. Thompson ,  Claude Clerc

    IPC分类号： A61B17/00 ,  A61B17/12 ,  A61F2/82 ,  A61F2/06 ,  A61M29/00

    CPC分类号： A61B17/12109 ,  A61B17/12022 ,  A61B17/12172

    摘要： The present invention is an occlusion device adapted for implantation into a fluid flow-supporting body lumen. The occlusion device comprises a flexible support structure and a flexible fluid flow-occluding membrane that is positioned concentric with the flexible support structure. The support structure is formed from a plurality of interwoven filaments that form an axially flexible and radially compressible structure that, in its expanded state, engages the lumen. The membrane generally includes a constricted region and constriction means, such as a mechanical seal, for closing the membrane at one end. The membrane is formed from a plurality of filaments, and in one embodiment, the membrane filaments are tightly interbraided with the structure filaments to form the occlusion device. Alternatively, the membrane is separately fabricated of interwoven filaments, and is positioned either within the support structure or without the structure so as to surround the support structure.

    摘要翻译： 本发明是一种适于植入流体流动支撑体腔内的闭塞装置。 闭塞装置包括柔性支撑结构和与柔性支撑结构同心定位的柔性流体阻流膜。 支撑结构由多个交织的长丝形成，其形成轴向柔性且可径向压缩的结构，其在其膨胀状态下与内腔接合。 膜通常包括用于在一端封闭膜的收缩区域和收缩装置，例如机械密封。 膜由许多细丝形成，在一个实施方案中，膜丝与结构细丝紧密接触以形成遮挡装置。 或者，膜分开地由交织的长丝制成，并且被定位在支撑结构内或不包括结构以包围支撑结构。