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1.发明申请公开(公告)号：US20170182486A1
公开(公告)日：2017-06-29
申请号：US15129853
申请日：2015-03-30
发明人： Wenbin Lin, Ph.D. , Kuntal Manna , Teng Zhang
IPC分类号： B01J31/16 , C07F5/02 , C07F7/18 , C07C5/03 , C07C41/20 , C07D207/04 , C07D207/06 , C07C209/02 , B01J31/18 , C07C37/07
CPC分类号： B01J31/1691 , B01J31/18 , B01J31/1815 , B01J2531/16 , B01J2531/48 , B01J2531/824 , B01J2531/827 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07C5/03 , C07C37/07 , C07C41/20 , C07C209/02 , C07D207/04 , C07D207/06 , C07F5/025 , C07F7/1876 , Y02P20/544
摘要： Metal-organic framework (MOFs) compositions based on nitrogen donor-based organic bridging ligands, including ligands based on 1,3-diketimine (NacNac), bipyridines and salicylaldimine, were synthesized and then post-synthetically metalated with metal precursors, such as complexes of first row transition metals. Metal complexes of the organic bridging ligands could also be directly incorporated into the MOFs. The MOFs provide a versatile family of recyclable and reusable single-site solid catalysts for catalyzing a variety of asymmetric organic transformations. The solid catalysts can also be integrated into a flow reactor or a supercritical fluid reactor.
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公开(公告)号：US20240150294A1
公开(公告)日：2024-05-09
申请号：US18546525
申请日：2022-02-17
IPC分类号： C07D221/20 , A61K45/06 , A61P35/00 , C07D401/12
CPC分类号： C07D221/20 , A61K45/06 , A61P35/00 , C07D401/12
摘要： Provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof, in which R1, R2, R3, R4, R5, X1, X2, and n are described herein. Also provided is a method of treating an estrogen-mediated disease requiring inhibition of estrogen receptor alpha (ER-alpha), such as cancer, in a subject or inhibiting ER-alpha in a cell with the compound of formula (I) or a pharmaceutically acceptable salt thereof.
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3.发明申请Phase-change particulate ice slurry coolant medical delivery tubing and insertion devices 审中-公开相变微粒冰浆冷却液医疗输送管和插入装置公开(公告)号：US20060161232A1
公开(公告)日：2006-07-20
申请号：US11038570
申请日：2005-01-18
申请人： Kenneth Kasza , John Oras , HyunJin Son , Lance Becker , Terrry Hoek
发明人： Kenneth Kasza , John Oras , HyunJin Son , Lance Becker , Terrry Hoek
CPC分类号： A61F7/0085 , A61F2007/0059
摘要： Various systems for delivering phase-change particulate ice slurries to targeted areas or organs of a patient are provided. Systems for delivering phase-change particulate ice slurries include a slurry reservoir and a conduit for delivering slurry from the reservoir to the patient. The conduit may include multiple components, including a section of medical tubing, an insertion tip for directing the out flow of slurry to the targeted area, and one or more transition fittings to adapt the tubing to the insertion tip. Interfaces between the various components that form the slurry flow path are configured so that there are no sudden reductions in the cross sectional area of the flow path. Any narrowing of the flow path occurs in a gradual tapered manner. The entire flow path remains substantially free of all obstacles that may tend to trap particles and lead to plugging of the flow path.
摘要翻译： 提供用于将相变颗粒状冰浆递送到患者的目标区域或器官的各种系统。 用于递送相变微粒冰浆的系统包括浆料储存器和用于将淤浆从储存器输送到患者的导管。 导管可以包括多个部件，包括一部分医用管道，用于引导浆液流出到目标区域的插入尖端，以及一个或多个过渡配件以使管道适应插入尖端。 形成浆料流动路径的各种部件之间的接口被构造成使得流动通道的横截面积没有突然减小。 流动路径的任何变窄以渐变的方式发生。 整个流动路径基本上没有可能倾向于捕获颗粒并导致流动路径堵塞的所有障碍物。
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公开(公告)号：US20240352439A1
公开(公告)日：2024-10-24
申请号：US18688268
申请日：2022-09-02
发明人： Weixin TANG , Yulan XIAO
CPC分类号： C12N9/78 , C12N9/22 , C12N15/1058 , C12Y305/04004
摘要： The inventors have made TadA variants with improved activities, such as improved based editing in certain genomic contexts and altered editing window. Aspects of the disclosure relate to a polypeptide comprising SEQ ID NO: 1, wherein the polypeptide comprises one or more amino acid substitutions relative to SEQ ID NO: 1, wherein the one or more amino acid substitutions comprise a substitution at amino acid (23, 27, 36, 47, 48, 51, 76, 82, 106, 108, 109,110, 111, 114, 119, 122, 123, 126, 127, 146, 147, 152, 154, 155, 156, 157, 161, 166, 167), and combinations thereof.
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公开(公告)号：US20240340329A1
公开(公告)日：2024-10-10
申请号：US18626716
申请日：2024-04-04
发明人： Junchen Jiang , Yihua Cheng , Ziyi Zhang , Hanchen Li
CPC分类号： H04L65/70 , H04L65/762
摘要： Systems, methods, and computer program products are provided for streaming video over a network. In various embodiments, a source video including at least a source frame is read. The source frame is encoded into a corresponding tensor representation by a machine learning model. The corresponding tensor representation is decomposed into a plurality of sub-tensors. Each of the plurality of sub-tensors is encoded into a corresponding packet and transmitted via a network from a source node to a receiver node.
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公开(公告)号：US12111619B2
公开(公告)日：2024-10-08
申请号：US17890907
申请日：2022-08-18
发明人： Henry Hoffmann , Lester Teichner , Benjamin Vear
IPC分类号： G05B13/02 , G05B13/04 , G06F16/23 , G06F16/901
CPC分类号： G05B13/0265 , G05B13/042 , G05B13/048 , G06F16/2358 , G06F16/9017
摘要： Example embodiments allow for networks of hybrid controllers that can be computed efficiently and that can adapt to changes in the system(s) under control. Such a network includes at least one hybrid controller that includes a dynamic sub-controller and a learned system sub-controller. Information about the ongoing performance of the system under control is provided to both the hybrid controller and to an over-controller, which provides one or more control inputs to the hybrid controller in order to modify the ongoing operation of the hybrid controller. These inputs can include the set-point of the hybrid controller, one or more parameters of the dynamic controller, and an update rate or other parameter of the learned system controller. The over-controller can control multiple hybrid controllers (e.g., controlling respective sub-systems of an overall system) and can, itself, be a hybrid controller.
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公开(公告)号：US20240327844A1
公开(公告)日：2024-10-03
申请号：US18746903
申请日：2024-06-18
发明人： Elizabeth McNally
IPC分类号： C12N15/113 , A61K47/60 , C12N15/11
CPC分类号： C12N15/113 , A61K47/60 , C12N15/1138 , C12N15/111 , C12N2310/11 , C12N2310/321 , C12N2310/3233 , C12N2310/351 , C12N2310/3535 , C12N2320/30 , C12N2320/33
摘要： Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided, along with methods of preventing or treating dystrophic diseases such as Limb-Girdle Muscular Dystrophy.
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8.发明公开公开(公告)号：US20240304622A1
公开(公告)日：2024-09-12
申请号：US18416403
申请日：2024-01-18
发明人： Minsu SEOL , Ce LIANG , Jiwoong PARK , Kyung-Eun BYUN , Changhyun KIM
IPC分类号： H01L27/092 , H01L21/02 , H01L21/8256 , H01L29/24 , H01L29/66 , H01L29/76
CPC分类号： H01L27/092 , H01L21/02568 , H01L21/8256 , H01L29/24 , H01L29/66969 , H01L29/7606
摘要： Provided are a semiconductor device including a two-dimensional material and a method of manufacturing the semiconductor device. The semiconductor device may include a substrate, first and second two-dimensional material layers on the substrate and junctioned to each other in a lateral direction to form a coherent interface, a first source electrode and a first drain electrode on the first two-dimensional material layer, a first gate electrode between the first source electrode and the first drain electrode, a second source electrode and a second drain electrode on the second two-dimensional material layer, and a second gate electrode between the second source electrode and the second drain electrode.
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公开(公告)号：US20240303520A1
公开(公告)日：2024-09-12
申请号：US18271370
申请日：2022-01-31
摘要： Cavity resonators are promising resources for quantum technology, while native nonlinear interactions for cavities are typically too weak to provide the level of quan-turn control required to deliver complex targeted operations. Here we investigate a scheme to engineer a target Hamiltonian for photonic cavities using ancilla qubits. By off-resonantly driving dispersively coupled ancilla qubits, we develop an optimized approach to engineering an arbitrary photon-number dependent (PND) Hamiltonian for the cavities while minimizing the operation errors. The engineered Hamiltonian admits various applications including canceling unwanted cavity self-Kerr interac-tions, creating higher-order nonlinearities for quantum simulations, and designing quantum gates resilient to noise. Our scheme can be implemented with coupled microwave cavities and transmon qubits in superconducting circuit systems.
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10.发明公开公开(公告)号：US20240301428A1
公开(公告)日：2024-09-12
申请号：US18659737
申请日：2024-05-09
发明人： Elizabeth McNally , Eugene Wyatt
IPC分类号： C12N15/113
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/11 , C12N2310/31 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3233 , C12N2310/346 , C12N2310/351 , C12N2310/3513 , C12N2310/3521 , C12N2320/33
摘要： The invention is directed to one or more antisense polynucleotides and their use in pharmaceutical compositions in a strategy to induce exon skipping in the γ-sarcoglycan gene in patients suffering from Limb-Girdle Muscular Dystrophy-20 (LGM-D)2C) or in patients at risk of such a disease. The invention also provides methods of preventing or treating muscular dystrophy, e.g., LGMD)2C, by exon skipping in the gamma sarcoglycan gene using antisense polynucleotides. Accordingly, in some aspects the in-vention provides an isolated antisense oligonucleotide, wherein the oligonucleotide specifically hybridizes to an exon target region of a γ-sarcoglycan RNA. In another aspect, the invention provides a method of inducing exon-skipping of a gamma sarcoglycan RNA, comprising delivering an antisense oligonucleotide or a composition to a cell.
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