公开(公告)号：US12132299B2

公开(公告)日：2024-10-29

申请号：US17665340

申请日：2022-02-04

申请人： Sungrow Power Supply Co., Ltd.

发明人： Hao Zheng ,  Qiyao Zhu ,  Longlin Sun

IPC分类号： H02B1/56 ,  H02B1/28 ,  H02B1/30 ,  H02S40/38

CPC分类号： H02B1/565 ,  H02B1/28 ,  H02B1/306 ,  H02S40/38

摘要： A power cabinet, which includes a cabinet body and an electric reactor, a power unit and a switch arranged in the interior of the cabinet body. In the interior of the cabinet body of the power cabinet, the electric reactor is arranged close to a first side in the interior of the cabinet body, and the power unit and the switch are arranged on a second side in the interior of the cabinet body, opposite to the first side. Moreover, these electric reactor, the power unit and the switch are all located in a lower space. In addition, in the power cabinet, the electric reactor and power unit dissipate heat in different chambers from the switch dissipates heat.

公开(公告)号：US12131802B2

公开(公告)日：2024-10-29

申请号：US15443102

申请日：2017-02-27

申请人： OPKO Diagnostics, LLC ,  Oy Arctic Partners Ab

发明人： Andrew J. Vickers ,  Peter T. Scardino ,  Hans Lilja ,  Vincent Linder ,  David Steinmiller

IPC分类号： G16B20/00 ,  B01L3/00 ,  C12Q1/6886 ,  G01N33/543 ,  G01N33/574 ,  G01N33/68 ,  G16B40/00 ,  G16H10/40 ,  G16H50/20 ,  G16H50/30

CPC分类号： G16B20/00 ,  B01L3/502 ,  B01L3/502715 ,  B01L3/502761 ,  C12Q1/6886 ,  G01N33/54366 ,  G01N33/57434 ,  G01N33/6893 ,  G16B40/00 ,  G16H10/40 ,  G16H50/20 ,  G16H50/30 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0487 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N2333/96455

摘要： Methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided. More particularly, this disclosure relates to methods and apparatuses for providing the models and employing the models for predicting risk of prostate cancer and/or predicting prostate gland volume. The methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided using, at least in part, information from a panel of kallikrein markers.

公开(公告)号：US12129227B2

公开(公告)日：2024-10-29

申请号：US18027897

申请日：2021-09-23

申请人： Tetra Bio-Pharma Inc.

发明人： Harpreet Kaur ,  Xuejun Liu ,  Prabin Nepal ,  Subakar Paramanantham ,  Monika Garg ,  Zemin Li ,  Andy Tjeng ,  Moises Rodriguez ,  Laura Jong ,  Azam Mirzahossein ,  Ofer Yifrach-Stav ,  Erin Bassett ,  Randy Ringuette ,  Charles Campbell ,  Melanie Kelly

IPC分类号： C07C41/26 ,  C07C29/48 ,  C07C67/08 ,  C07C67/29 ,  C07C67/293 ,  C07C269/06

CPC分类号： C07C41/26 ,  C07C29/48 ,  C07C67/08 ,  C07C67/29 ,  C07C67/293 ,  C07C269/06 ,  C07B2200/07 ,  C07C2602/42 ,  C07C41/26 ,  C07C43/23 ,  C07C269/06 ,  C07C271/22 ,  C07C29/48 ,  C07C33/14 ,  C07C67/08 ,  C07C69/24 ,  C07C67/29 ,  C07C69/24 ,  C07C67/293 ,  C07C69/24

摘要： Disclosed herein are methods, processes and compositions for preparing a compound of formula 8: (8), and formula 18: (18). The methods and processes comprise performing a first allylic oxidation, a protection reaction, a second allylic oxidation, a reduction reaction, performing an acid-catalyzed coupling reaction, a methylation reaction and a deprotection reaction. Disclosed herein are methods, processes and compositions for enantioselectively preparing compounds of formulae 8 and 18. Also disclosed herein are compositions comprising compounds of formulae 8, 18 and/or intermediates and/or starting material thereof.

公开(公告)号：US12129171B2

公开(公告)日：2024-10-29

申请号：US17558782

申请日：2021-12-22

申请人： Sion Power Corporation ,  BASF SE

发明人： Holger Schneider ,  Hui Du ,  Klaus Leitner ,  Johan ter Maat ,  Pascal Hartmann ,  Joern Kulisch ,  Marina Safont-Sempere ,  Tracy Earl Kelley ,  Chariclea Scordilis-Kelley

IPC分类号： C01B25/14 ,  H01M4/36 ,  H01M4/38 ,  H01M4/485 ,  H01M4/62 ,  H01M10/0525 ,  H01M10/0562 ,  H01M50/434

CPC分类号： C01B25/14 ,  H01M4/366 ,  H01M4/38 ,  H01M4/382 ,  H01M4/386 ,  H01M4/485 ,  H01M4/62 ,  H01M10/0525 ,  H01M10/0562 ,  H01M50/434 ,  C01P2002/30 ,  C01P2002/72 ,  C01P2002/80 ,  C01P2006/40

摘要： Articles, compositions, and methods involving ionically conductive compounds are provided. In some embodiments, the ionically conductive compounds are useful for electrochemical cells. The disclosed ionically conductive compounds may be incorporated into an electrochemical cell (e.g., a lithium-sulfur electrochemical cell, a lithium-ion electrochemical cell, an intercalated-cathode based electrochemical cell) as, for example, a protective layer for an electrode, a solid electrolyte layer, and/or any other appropriate component within the electrochemical cell. In certain embodiments, electrode structures and/or methods for making electrode structures including a layer comprising an ionically conductive compound described herein are provided.

公开(公告)号：US12128109B2

公开(公告)日：2024-10-29

申请号：US18455351

申请日：2023-08-24

申请人： Dyne Therapeutics, Inc.

发明人： Timothy Weeden ,  Scott Hilderbrand ,  Sean Spring ,  Peiyi Shen ,  Cody A. Desjardins ,  Romesh R. Subramanian ,  Mohammed T. Qatanani ,  Brendan Quinn ,  John Najim

IPC分类号： A61K39/00 ,  A61K47/54 ,  A61K47/65 ,  A61K47/68 ,  A61P21/00

CPC分类号： A61K47/6807 ,  A61K47/545 ,  A61K47/548 ,  A61K47/65 ,  A61K47/6849 ,  A61P21/00

摘要： Aspects of the disclosure relate to complexes and other aspects relate to formulations (e.g., aqueous, lyophilized forms) comprising such complexes (e.g., wherein each complex is of the exemplary formula shown below) comprising a phosphorodiamidate morpholino oligomer (e.g., useful for targeting DMD) covalently linked to an antibody (e.g., anti-TfR1 antibody). In some embodiments, the complexes are formulated with histidine (e.g., L-histidine) and sucrose at a specified pH (e.g., about 5.0 to 7.0). Also provided are uses of these formulations for treating a subject having a mutated DMD allele associated with Duchenne Muscular Dystrophy.

公开(公告)号：US12124081B2

公开(公告)日：2024-10-22

申请号：US18356680

申请日：2023-07-21

申请人： Lightmatter, Inc.

发明人： Nicholas C. Harris ,  Carl Ramey ,  Michael Gould ,  Thomas Graham ,  Darius Bunandar ,  Ryan Braid ,  Mykhailo Tymchenko

IPC分类号： G02B6/12 ,  G02B6/122 ,  G02B6/13 ,  G02B6/136 ,  H01L21/027 ,  H04J14/02

CPC分类号： G02B6/1225 ,  G02B6/12004 ,  G02B6/12007 ,  G02B6/13 ,  G02B6/136 ,  H01L21/0275 ,  H04J14/02

摘要： Described herein are photonic communication platforms that can overcome the memory bottleneck problem, thereby enabling scaling of memory capacity and bandwidth well beyond what is possible with conventional computing systems. Some embodiments provide photonic communication platforms that involve use of photonic modules. Each photonic module includes programmable photonic circuits for placing the module in optical communication with other modules based on the needs of a particular application. The architecture developed by the inventors relies on the use of common photomask sets (or at least one common photomask) to fabricate multiple photonic modules in a single wafer. Photonic modules in multiple wafers can be linked together into a communication platform using optical or electronic means.

公开(公告)号：US12123772B2

公开(公告)日：2024-10-22

申请号：US17839698

申请日：2022-06-14

申请人： Quantum-Si Incorporated

发明人： Thomas Raymond Thurston ,  Benjamin Cipriany ,  Joseph D. Clark ,  Todd Rearick ,  Keith G. Fife

IPC分类号： G01J1/44 ,  G01N21/64 ,  G06T7/00 ,  H04N25/76 ,  H04N25/77

CPC分类号： G01J1/44 ,  G01N21/6408 ,  G01N21/6458 ,  H04N25/77 ,  G01J2001/446 ,  G01J2001/448 ,  G01N21/6428 ,  G01N2021/6439 ,  G06T7/0012 ,  G06T2207/10028 ,  G06T2207/10064 ,  G06T2207/30204 ,  H04N25/76

摘要： An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit includes a charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers directly into the at least one charge carrier storage region based upon times at which the charge carriers are produced.

公开(公告)号：US12123131B2

公开(公告)日：2024-10-22

申请号：US18565869

申请日：2022-06-02

申请人： TAKEMOTO YUSHI KABUSHIKI KAISHA

发明人： Keiichiro Oshima ,  Satoru Hamajima ,  Jun Ito

IPC分类号： D06M13/328 ,  D06M13/11 ,  D06M13/165 ,  D06M15/643 ,  D06M101/40

CPC分类号： D06M13/328 ,  D06M13/11 ,  D06M13/165 ,  D06M15/643 ,  D06M15/6436 ,  D06M2101/40 ,  D06M2200/30

摘要： Disclosed is a synthetic fiber treatment agent containing a phenol amine compound and a nonionic surfactant. The phenol amine compound is at least one selected from the group consisting of a compound formed from a phenol derivative, formaldehyde, and a polyamine compound and a compound obtained by reacting a boron-containing compound with a compound formed from a phenol derivative, formaldehyde, and a polyamine compound. The phenol derivative is a phenol in which a hydrocarbon group with a number average molecular weight of not less than 100 and not more than 2000 is modified.

公开(公告)号：US12123021B2

公开(公告)日：2024-10-22

申请号：US17707725

申请日：2022-03-29

申请人： KSQ Therapeutics, Inc.

发明人： Micah Benson ,  Jason J. Merkin ,  Gregory V. Kryukov ,  Solomon Martin Shenker ,  Michael R. Schlabach ,  Noah Jacob Tubo ,  James Martin Kaberna, II

IPC分类号： C12N5/0783 ,  A61K35/17 ,  A61P35/00 ,  A61P35/04 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K16/32 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113 ,  A61K38/00 ,  A61K39/00

CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61P35/00 ,  A61P35/04 ,  C07K14/7051 ,  C07K14/70517 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/32 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113 ,  C12N15/1135 ,  A61K38/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2319/30 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/20 ,  C12N2310/531 ,  C12N2800/80

摘要： The present disclosure provides methods and compositions related to the modification of immune effector cells to increase therapeutic efficacy. In some embodiments, immune effector cells modified to reduce expression of one or more endogenous target genes, or to reduce one or more functions of an endogenous protein to enhance effector functions of the immune cells are provided. In some embodiments, immune effector cells further modified by introduction of transgenes conferring antigen specificity, such as exogenous T cell receptors (TCRs) or chimeric antigen receptors (CARs) are provided. Methods of treating a cell proliferative disorder, such as a cancer, using the modified immune effector cells described herein are also provided.

公开(公告)号：US12118368B2

公开(公告)日：2024-10-15

申请号：US18510539

申请日：2023-11-15

申请人： ASCon Systems Holding GmbH

发明人： Kilian Grefen

IPC分类号： G06F9/448

CPC分类号： G06F9/4498 ,  G06F9/4494

摘要： The present invention aims at providing an approach to digital twin-based process control for efficient and accurate achievement of process objectives. Heretofore, a controller service module (18) runs an event-driven control process in a digital twin domain for control of process entities operated in a process domain. The behavior of process entities is modeled through execution of state machine models. Event data is communicated asynchronously to the controller service module (18) for storage in a process cycle buffer (26). A model-based process controller (24) reads input information in processing cycles and controls process entities by operating state machine models to reflect the input of event data. It is checked whether the operation of state machine models triggers the generation of external control commands which are then output by an outbound interface (32) to process entities for control processing.