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1.发明申请公开(公告)号：US20050176648A1
公开(公告)日：2005-08-11
申请号：US11089192
申请日：2005-03-24
申请人： Anil Saksena , Viyyoor Girijavallabhan , Stephane Bogen , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Yi-Tsung Liu , Tin-Yau Chan , Zhaoning Zhu , Ashok Arasappan , Kevin Chen , Srikanth Venkatraman , Tejal Parekh , Patrick Pinto , Bama Santhanam , F. Njoroge , Ashit Ganguly , Henry Vaccaro , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura
发明人： Anil Saksena , Viyyoor Girijavallabhan , Stephane Bogen , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Yi-Tsung Liu , Tin-Yau Chan , Zhaoning Zhu , Ashok Arasappan , Kevin Chen , Srikanth Venkatraman , Tejal Parekh , Patrick Pinto , Bama Santhanam , F. Njoroge , Ashit Ganguly , Henry Vaccaro , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura
IPC分类号： C12N9/99 , A61K31/16 , A61K31/195 , A61K31/27 , A61K31/357 , A61K31/385 , A61K31/403 , A61K31/4164 , A61K31/445 , A61K31/7052 , A61K38/00 , A61K38/05 , A61K38/21 , A61K38/55 , A61K45/00 , A61P1/16 , A61P31/12 , A61P31/14 , A61P43/00 , C07C205/51 , C07C229/00 , C07D209/02 , C07K5/02 , C07K5/103 , C07K7/02 , C07K7/04 , C07K7/06 , A61K38/06 , A61K31/165 , A61K38/08
CPC分类号： C07K7/06 , A61K31/16 , A61K31/195 , A61K31/27 , A61K31/357 , A61K31/385 , A61K31/403 , A61K31/4164 , A61K31/445 , A61K38/05 , C07C205/51 , C07K5/101 , C07K7/02 , A61K2300/00
摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型肽化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US20060205672A1
公开(公告)日：2006-09-14
申请号：US11241656
申请日：2005-09-30
申请人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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3.发明申请公开(公告)号：US20070032433A1
公开(公告)日：2007-02-08
申请号：US10052386
申请日：2002-01-18
申请人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping Mc Cormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse Wong , Latha Nair
发明人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping Mc Cormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse Wong , Latha Nair
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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4.发明申请Novel peptides as NS3-serine protease inhibitors of hepatitis C virus 审中-公开新型肽作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂公开(公告)号：US20050059606A1
公开(公告)日：2005-03-17
申请号：US10934141
申请日：2004-09-03
申请人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Ashok Arasappan , Tejal Parekh , Patrick Pinto , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Stephane Bogen , Yi-Tsung Liu , F. Njoroge , Ashit Ganguly , Terence Brunck , Scott Kemp , Odile Levy , Marguerita Lim-Wilby
发明人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Ashok Arasappan , Tejal Parekh , Patrick Pinto , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Stephane Bogen , Yi-Tsung Liu , F. Njoroge , Ashit Ganguly , Terence Brunck , Scott Kemp , Odile Levy , Marguerita Lim-Wilby
IPC分类号： C12N9/99 , A61K31/7052 , A61K38/00 , A61K38/21 , A61K38/55 , A61K45/00 , A61P1/16 , A61P31/12 , A61P31/14 , A61P35/00 , A61P43/00 , C07K7/00 , C07K7/02 , C07K7/06 , A61K38/08
摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such peptides as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型肽化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些肽的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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5.发明申请Sulfur compounds as inhibitors of Hepatitis C virus NS3 serine protease 有权硫化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20070042968A1
公开(公告)日：2007-02-22
申请号：US11064673
申请日：2005-02-24
申请人： Frank Bennett , Raymond Lovey , Yuhua Huang , Siska Hendrata , Anil Saksena , Stephane Bogen , Yi-Tsung Liu , F. Njoroge , Srikanth Venkatraman , Kevin Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor Girijavallabhan , Francisco Velazquez
发明人： Frank Bennett , Raymond Lovey , Yuhua Huang , Siska Hendrata , Anil Saksena , Stephane Bogen , Yi-Tsung Liu , F. Njoroge , Srikanth Venkatraman , Kevin Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor Girijavallabhan , Francisco Velazquez
IPC分类号： A61K38/04 , C07K7/04 , C07D417/02 , C07D49/02
CPC分类号： C07D209/52 , A61K38/00 , C07D207/16 , C07D209/56 , C07D405/12 , C07D409/12 , C07D411/12 , C07D491/04 , C07K5/0202
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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6.发明申请Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection 失效利巴韦林 - 干扰素α联合治疗用于根除慢性丙型肝炎感染患者可检测的HCV-RNA公开(公告)号：US20050004053A1
公开(公告)日：2005-01-06
申请号：US10885374
申请日：2004-07-06
申请人： Ashit Ganguly , Jinping McCormick , Raymond Lovey , Frank Bennett , Anil Saksena , Viyyoor Girijavallabhan
发明人： Ashit Ganguly , Jinping McCormick , Raymond Lovey , Frank Bennett , Anil Saksena , Viyyoor Girijavallabhan
IPC分类号： A61P31/12 , C07H19/056 , A61K31/7056
CPC分类号： C07H19/056 , Y10S514/894
摘要： Ribavirin derivatives represented by the formula V, pharmaceutical compositions containing them as well as the use of the ribavirin derivatives represented by the formula V for the preparation of a medicament for the treatment of susceptible viral infections, for example, chronic hepatitis C infections administrating, the ribavirin derivatives being represented by formula V are disclosed.
摘要翻译： 由式V表示的利巴韦林衍生物，含有它们的药物组合物以及由式V表示的利巴韦林衍生物用于制备用于治疗易感病毒感染的药物的用途，例如，施用的慢性丙型肝炎感染， 公开了由式V表示的利巴韦林衍生物。
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公开(公告)号：US5238926A
公开(公告)日：1993-08-24
申请号：US926017
申请日：1992-08-07
CPC分类号： C07H19/06 , C07K5/06017 , C07K5/06034 , C07K5/0606 , C07K5/06078 , A61K38/00
摘要： Compounds of the formula ##STR1## or pharmaceutically acceptable salts thereof wherein R.sub.3, R.sub.4, R.sub.7, J, K, Z and Het are as set forth herein are described.The compounds of formula I are useful as agents in the treatment of fungal infections.
摘要翻译： 其中R 3，R 4，R 7，J，K，Z和Het如本文所述，其中描述了式I的化合物或其药学上可接受的盐。 式I化合物可用作治疗真菌感染的药剂。
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公开(公告)号：US5346898A
公开(公告)日：1994-09-13
申请号：US900712
申请日：1992-06-18
IPC分类号： C07H19/04 , C07H19/06 , A61K31/495 , A61K31/505 , C07D239/10 , C07D405/04
摘要： Compounds of the formula ##STR1## wherein R.sub.3, R.sub.4, J, K, Z, and Het are as set forth herein are described.The compounds of formula I are useful as agents in the treatment of fungal infections.
摘要翻译： 描述了其中R3，R4，J，K，Z和Het如本文所述的式“IMAGE”I的化合物。 式I化合物可用作治疗真菌感染的药剂。
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公开(公告)号：US5618793A
公开(公告)日：1997-04-08
申请号：US509923
申请日：1995-08-01
IPC分类号： C07H19/04 , C07H19/06 , A61K31/70 , A61K38/00 , C07D239/10
摘要： Compounds of the formula ##STR1## wherein R.sub.3, R.sub.4, J, K, Z, and Het are as set forth herein are described.The compounds of formula I are useful as agents in the treatment of fungal infections.
摘要翻译： 描述了其中R3，R4，J，K，Z和Het如本文所述的式“IMAGE”I的化合物。 式I化合物可用作治疗真菌感染的药剂。
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公开(公告)号：US5461055A
公开(公告)日：1995-10-24
申请号：US253640
申请日：1994-06-03
IPC分类号： C07H19/04 , C07H19/06 , A61K31/505 , C07D215/00 , C07D239/10
摘要： Compounds of the formula ##STR1## wherein R.sub.3, R.sub.4, J, K, Z, and Het are as set forth herein are described.The compounds of formula I are useful as agents in the treatment of fungal infections.
摘要翻译： 描述了其中R3，R4，J，K，Z和Het如本文所述的式“IMAGE”I的化合物。 式I化合物可用作治疗真菌感染的药剂。
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