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公开(公告)号：US20160310540A1
公开(公告)日：2016-10-27
申请号：US15203684
申请日：2016-07-06
发明人： John K. Fraser , Marc H. Hedrick , Eric Daniels
IPC分类号： A61K35/35 , A61K9/00 , A61K45/06 , C12N5/0775 , A61L15/40 , A61L27/54 , A61L27/36 , A61K35/44 , A61L15/44
CPC分类号： A61K35/28 , A61K9/0014 , A61K35/12 , A61K35/35 , A61K35/36 , A61K35/44 , A61K38/1866 , A61K45/06 , A61L15/40 , A61L15/44 , A61L27/3604 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2300/64 , C12N5/0667 , C12N5/069 , C12N2506/1384 , A61K2300/00
摘要： Cells present in adipose tissue are used to promote wound healing in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the regenerative cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
摘要翻译： 存在于脂肪组织中的细胞用于促进患者的伤口愈合。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。 所述方法可以在封闭系统中实施，使得再生细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的细胞与促进，产生或支持治疗益处所必需的这种添加剂一起直接放置在受体中。
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2.发明申请SYSTEMS AND METHODS FOR MANIPULATION OF REGENERATIVE CELLS FROM ADIPOSE TISSUE 审中-公开用于从ADIPOSE组织中处理再生细胞的系统和方法公开(公告)号：US20130288290A1
公开(公告)日：2013-10-31
申请号：US13926854
申请日：2013-06-25
发明人： Marc H. Hedrick , John K. Fraser
IPC分类号： C12N5/071
CPC分类号： A61K35/28 , A61K9/0024 , A61K35/35 , C12N5/0653 , C12N5/0667 , C12N2509/00 , C12N2509/10
摘要： The invention provides methods for manipulating regenerative cells from adipose tissue. Specifically, it provides methods for enrichment of desired cells and enhancement of their therapeutic effects.
摘要翻译： 本发明提供了从脂肪组织操纵再生细胞的方法。 具体地，其提供了富集所需细胞的方法和增强其治疗效果。
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3.发明申请公开(公告)号：US20170296697A1
公开(公告)日：2017-10-19
申请号：US15515870
申请日：2015-10-02
发明人： John K. Fraser , Philippe Foubert , Zeni Alfonso
IPC分类号： A61L27/24 , C12N5/077 , A61L27/38 , A61L27/56 , C12N5/0775 , A61L27/60 , C12N5/00 , A61L27/00
CPC分类号： A61L27/24 , A61L27/00 , A61L27/3834 , A61L27/56 , A61L27/60 , C12N5/00 , C12N5/0653 , C12N5/0667
摘要： Described herein are compositions and methods for the mitigation of burn progression. In particular, the described herein are compositions including regenerative cells for use in preventing and reducing burn progression. Also described are compositions and methods for improving graft take and healing, and preventing and/or treating hypertrophic scars.
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公开(公告)号：US20160143952A1
公开(公告)日：2016-05-26
申请号：US14954584
申请日：2015-11-30
发明人： John K. Fraser , Marc H. Hedrick
CPC分类号： A61K35/28 , A61B10/0283 , A61K9/0019 , A61K35/35 , A61M1/0039 , A61M2202/08 , C12M47/04 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Compositions that are administered to a patient include a mixture of adipose tissue and stem cells so that the composition has a higher concentration of stem cells than when the adipose tissue was removed from the patient.
摘要翻译： 存在于加工的lipoaspirate组织中的细胞用于治疗患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的干细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 施用于患者的组合物包括脂肪组织和干细胞的混合物，使得组合物具有比从患者中除去脂肪组织时更高浓度的干细胞。
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公开(公告)号：US20140227341A1
公开(公告)日：2014-08-14
申请号：US14180589
申请日：2014-02-14
发明人： John K. Fraser , Marc H. Hedrick , Eric Daniels
CPC分类号： A61K35/28 , A61K9/0014 , A61K35/12 , A61K35/35 , A61K35/36 , A61K35/44 , A61K38/1866 , A61K45/06 , A61L15/40 , A61L15/44 , A61L27/3604 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2300/64 , C12N5/0667 , C12N5/069 , C12N2506/1384 , A61K2300/00
摘要： Cells present in adipose tissue are used to promote wound healing in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the regenerative cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
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公开(公告)号：US10119113B2
公开(公告)日：2018-11-06
申请号：US14880891
申请日：2015-10-12
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
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公开(公告)号：US09872877B2
公开(公告)日：2018-01-23
申请号：US15203684
申请日：2016-07-06
发明人： John K. Fraser , Marc H. Hedrick , Eric Daniels
IPC分类号： A61M1/00 , A61K35/28 , A61K35/12 , C12N5/0775 , C12N5/071 , A61K35/36 , A61K35/44 , A61K38/18 , A61K45/06 , A61K9/00 , A61K35/35 , A61L15/40 , A61L15/44 , A61L27/36 , A61L27/54 , A61L27/38 , A61L27/56
CPC分类号： A61K35/28 , A61K9/0014 , A61K35/12 , A61K35/35 , A61K35/36 , A61K35/44 , A61K38/1866 , A61K45/06 , A61L15/40 , A61L15/44 , A61L27/3604 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2300/64 , C12N5/0667 , C12N5/069 , C12N2506/1384 , A61K2300/00
摘要： Cells present in adipose tissue are used to promote wound healing in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the regenerative cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
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公开(公告)号：US20170136069A1
公开(公告)日：2017-05-18
申请号：US15366924
申请日：2016-12-01
CPC分类号： A61K35/32 , A61F2/442 , A61F2/4455 , A61F2/4465 , A61F2/447 , A61F2002/30062 , A61F2002/30075 , A61F2002/30133 , A61F2002/30448 , A61F2002/30604 , A61F2002/30841 , A61F2002/30879 , A61F2002/4445 , A61F2002/445 , A61F2002/4475 , A61F2210/0004 , A61F2210/0061 , A61F2220/005 , A61F2230/0015 , A61K9/0019 , A61K35/28 , B33Y80/00 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： The present invention relates to a device comprising a cell carrier portion containing regenerative cells, e.g., stem and progenitor cells, and a cell carrier containment portion. The device is useful for the treatment of bone related disorders, including spinal fusion related disorders and long bone or flat bone related defects. The device may be used in conjunction with disclosed automated systems and methods for separating and concentrating regenerative cells.
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公开(公告)号：US20170136067A1
公开(公告)日：2017-05-18
申请号：US15362713
申请日：2016-11-28
CPC分类号： A61K35/28 , A61L27/18 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3691 , A61L27/3834 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/40 , A61L2300/412 , A61L2300/64 , A61L2400/06 , A61L2430/02 , A61L2430/06 , A61L2430/40 , C12N5/0667
摘要： Regenerative cells present in adipose tissue are used to treat patients, including patients with musculoskeletal diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, regenerative cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic musculoskeletal benefit.
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10.发明授权Methods of using adipose derived regenerative cells in the treatment of renal diseases and disorders 有权使用脂肪来源的再生细胞治疗肾脏疾病和病症的方法公开(公告)号：US09504718B2
公开(公告)日：2016-11-29
申请号：US13849900
申请日：2013-03-25
发明人： John K. Fraser , Marc H. Hedrick , Eric Daniels
IPC分类号： C12N5/00 , A61K35/35 , A61L27/38 , A61L27/54 , A61M1/36 , C12N5/0775 , A61K35/22 , A61K35/28 , A61K35/44
CPC分类号： A61K35/28 , A61K35/22 , A61K35/35 , A61K35/44 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2430/26 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0437 , A61M2202/08 , C12N5/0667
摘要： Cells present in processed lipoaspirate tissue are used to treat patients, including patients with renal conditions, diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in processed lipoaspirate are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic renal benefit.
摘要翻译： 存在于加工的脂肪抽吸组织中的细胞用于治疗患者，包括患有肾脏疾病或疾病的患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的干细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于加工的lipoaspirate中的细胞与用于促进，产生或支持治疗性肾功能所必需的这些添加剂一起直接放置在受体中。
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