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    TETRAHYDROPYRAZOLO [1,5-A] PYRIMIDINE AS ANTI-TUBERCULOSIS COMPOUNDS
    4.
    发明申请
    TETRAHYDROPYRAZOLO [1,5-A] PYRIMIDINE AS ANTI-TUBERCULOSIS COMPOUNDS 审中-公开
    四氢吡咯并[1,5-A]吡嗪作为抗结核药物

    公开(公告)号：US20140038989A1

    公开(公告)日：2014-02-06

    申请号：US14112564

    申请日：2012-04-20

    申请人： Emilio Alvarez-Ruiz ,  Luis Ballell-Pages ,  Julia Castro Pichel ,  Lourdes Encinas ,  Jorge Esquivias ,  Franscisco Gamo-Benito ,  Maria Cruz Garcia-Palancar ,  Modesto Jesus Remuinan-Blanco

    发明人： Emilio Alvarez-Ruiz ,  Luis Ballell-Pages ,  Julia Castro Pichel ,  Lourdes Encinas ,  Jorge Esquivias ,  Franscisco Gamo-Benito ,  Maria Cruz Garcia-Palancar ,  Modesto Jesus Remuinan-Blanco

    IPC分类号： C07D487/04 ,  A61K45/06 ,  A61K31/519

    CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

    摘要： A compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein: R1 represents a group selected from: i) phenyl optionally substituted with one or two substituents independently selected from Me, OMe, CF3, F, Cl and NMe2; furanyl, thiophenyl, pyrrolyl, pyridyl, cyclohexyl or naphthyl, each of which is optionally substituted with one or two substituents independently selected from Me, OMe, CF3, F, Cl and NMe2; and iii) benzo[1,3]dioxo5-yl or 2,3-dihydrobenzo[1,4]dioxin-6-yl; R2 represents CF3, C1-4alkyl, or CHF2; when R1 represents optionally substituted furanyl, thiophenyl, pyrrolyl, pyridyl or naphthyl, R3 represents Et; when R1 represents optionally substituted cyclohexyl, R3 represents Et or Me; otherwise R3 represents Et, Me, Br or OMe, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided, together with certain novel compounds.

    摘要翻译： 式（I）化合物或其药学上可接受的盐：其中：R1表示选自以下的基团：i）任选被一个或两个独立地选自Me，OMe，CF 3，F，Cl和NMe 2的取代基取代的苯基; 呋喃基，噻吩基，吡咯基，吡啶基，环己基或萘基，其各自任选被一个或两个独立地选自Me，OMe，CF 3，F，Cl和NMe 2的取代基取代; 和iii）苯并[1,3]二氧代-5-基或2,3-二氢苯并[1,4]二恶英-6-基; R 2表示CF 3，C 1-4烷基或CHF 2; 当R 1表示任选取代的呋喃基，噻吩基，吡咯基，吡啶基或萘基时，R 3表示Et; 当R 1表示任选取代的环己基时，R 3表示Et或Me; 否则R3表示Et，Me，Br或OMe，含有它们的组合物，它们在治疗中的用途，例如治疗结核病以及制备这些化合物的方法，以及某些新型化合物。

    Method of Processing a Bituminous Feed Using an Emulsion
    5.
    发明申请
    Method of Processing a Bituminous Feed Using an Emulsion 审中-公开
    使用乳液处理沥青进料的方法

    公开(公告)号：US20140034553A1

    公开(公告)日：2014-02-06

    申请号：US14110570

    申请日：2012-03-09

    申请人： Thomas R. Palmer ,  Brian C. Speirs ,  Fritz Pierre, Jr. ,  Emilio Alvarez

    发明人： Thomas R. Palmer ,  Brian C. Speirs ,  Fritz Pierre, Jr. ,  Emilio Alvarez

    IPC分类号： C10G1/04

    CPC分类号： C10G1/045 ,  B01D3/009 ,  C10G1/04 ,  C10G2300/44 ,  C10G2300/80 ,  C10G2300/805

    摘要： The present disclosure relates to a method of processing a bituminous feed. The bituminous feed is contacted with a bridging liquid-in-extraction liquor emulsion to form a slurry. Solids in the slurry are agglomerated, using agitation, to form an agglomerated slurry comprising agglomerated solids and a low solids bitumen extract. The agglomerates are then separated from the low solids bitumen extract. Emulsifying the bridging liquid prior to contacting it with the oil sands may reduce the amount of energy required for the agglomeration process. Other potential benefits may include the production of smaller and more uniform agglomerates. The former may lead to higher bitumen recoveries and the latter may improve the solid-liquid separation rate.

    摘要翻译： 本公开涉及一种处理沥青进料的方法。 沥青进料与桥接液体萃取液体乳液接触以形成浆料。 浆料中的固体在搅拌下凝聚，形成包含附聚固体和低固体沥青提取物的附聚浆料。 然后将聚集体与低固体沥青提取物分离。 在与油砂接触之前将桥接液体乳化可能会减少聚集过程所需的能量。 其他潜在的好处可能包括生产较小和更均匀的附聚物。 前者可能导致更高的沥青回收率，后者可能提高固液分离速率。

    Systems and Methods For Hydrotreating A Shale Oil Stream Using Hydrogen Gas That Is Concentrated From The Shale Oil Stream
    6.
    发明申请
    Systems and Methods For Hydrotreating A Shale Oil Stream Using Hydrogen Gas That Is Concentrated From The Shale Oil Stream 审中-公开
    使用从页岩油流中浓缩的氢气加氢处理页岩油流的系统和方法

    公开(公告)号：US20130319662A1

    公开(公告)日：2013-12-05

    申请号：US13888704

    申请日：2013-05-07

    申请人： Emilio Alvarez ,  Harry W. Deckman ,  Frank Hershkowitz ,  William P. Meurer ,  Thomas R. Palmer

    发明人： Emilio Alvarez ,  Harry W. Deckman ,  Frank Hershkowitz ,  William P. Meurer ,  Thomas R. Palmer

    IPC分类号： E21B36/00 ,  C10G1/00

    CPC分类号： E21B36/008 ,  C10G1/002 ,  C10G1/02 ,  C10G49/22 ,  C10G70/046 ,  C10G2300/4037 ,  E21B43/24

    摘要： Systems and methods for hydrotreating a liquid fraction of a shale oil stream using hydrogen gas that is concentrated from a gaseous fraction of the shale oil stream. The systems and methods include providing a portion of the gaseous fraction to a sorptive separation assembly and separating a concentrated hydrogen stream from the portion of the gaseous fraction within the sorptive separation assembly. The system and methods further include providing the concentrated hydrogen stream and the liquid fraction to a hydrotreater and reacting the concentrated hydrogen stream with the liquid fraction within the hydrotreater to produce the hydrotreated liquid stream. The systems and methods may include generating the shale oil stream within a subterranean formation using an in situ process, such as an in situ shale oil conversion process and/or providing a supplemental hydrogen stream to the hydrotreater.

    摘要翻译： 使用从页岩油流的气体部分浓缩的氢气加氢处理页岩油流的液体馏分的系统和方法。 该系统和方法包括将一部分气态馏分提供给吸附分离组件，并将浓缩的氢气流与吸附分离组件内气态馏分的部分分离。 该系统和方法还包括将浓缩的氢气流和液体馏分提供给加氢处理器，并使浓缩的氢流与加氢处理器内的液体馏分反应以产生加氢处理的液体流。 系统和方法可以包括使用原位过程（例如原位页岩油转化方法）和/或向加氢处理器提供补充氢气流，在地层内产生页岩油流。

    Method of Processing a Bituminous Feed By Staged Addition of a Bridging Liquid
    7.
    发明申请
    Method of Processing a Bituminous Feed By Staged Addition of a Bridging Liquid 审中-公开
    通过分段添加桥接液处理沥青进料的方法

    公开(公告)号：US20140262964A1

    公开(公告)日：2014-09-18

    申请号：US14112203

    申请日：2012-03-09

    申请人： Lu Han ,  Brian C. Speirs ,  Olusola B. Adeyinka ,  Thomas R. Palmer ,  Emilio Alvarez ,  Anjaneya S. Kovvali ,  David C. Rennard ,  Fritz Pierre, JR.

    发明人： Lu Han ,  Brian C. Speirs ,  Olusola B. Adeyinka ,  Thomas R. Palmer ,  Emilio Alvarez ,  Anjaneya S. Kovvali ,  David C. Rennard ,  Fritz Pierre, JR.

    IPC分类号： C10G1/04

    CPC分类号： C10G1/045 ,  C10G1/04 ,  C10G2300/44 ,  C10G2300/805

    摘要： The present disclosure relates to a method of processing a bituminous feed. The bituminous feed is contacted with an extraction liquor to form a slurry. A bridging liquid is added to the slurry in at least two stages and solids within the slurry are agitated to form an agglomerated slurry comprising agglomerated solids and a low solids bitumen extract. The agglomerates are then separated from the low solids bitumen extract. Potential benefits may include the production of smaller and more uniform agglomerates. The former may lead to higher bitumen recoveries and the latter may improve the solid-liquid separation rate. The bridging liquid may be added in an area of relatively high shear rates. Between stages of bridging liquid addition, agglomerates may be removed.

    摘要翻译： 本公开涉及一种处理沥青进料的方法。 沥青进料与萃取液接触以形成浆料。 将桥连液体至少两个阶段加入到浆料中，搅拌浆料内的固体以形成包含附聚固体和低固体沥青提取物的附聚浆料。 然后将聚集体与低固体沥青提取物分离。 潜在的益处可能包括生产更小和更均匀的团块。 前者可能导致更高的沥青回收率，后者可能提高固液分离速率。 桥接液体可以在相对高的剪切速率的区域中加入。 在桥接液体添加的阶段之间，可以除去附聚物。

    Method of Processing Tailings from Solvent-Based Hydrocarbon Extraction
    8.
    发明申请
    Method of Processing Tailings from Solvent-Based Hydrocarbon Extraction 审中-公开
    从溶剂型烃萃取处理尾矿的方法

    公开(公告)号：US20140209512A1

    公开(公告)日：2014-07-31

    申请号：US14236052

    申请日：2012-08-08

    申请人： Emilio Alvarez ,  David C. Rennard ,  Thomas R. Palmer ,  Justin D. Pace ,  Anjaneya S. Kovvali

    发明人： Emilio Alvarez ,  David C. Rennard ,  Thomas R. Palmer ,  Justin D. Pace ,  Anjaneya S. Kovvali

    IPC分类号： C10G1/04

    CPC分类号： C10G1/04 ,  B07B1/00 ,  B07B13/003 ,  B07B13/04 ,  B08B3/04 ,  B08B3/08 ,  C10G1/045

    摘要： Described is a method of processing a bituminous feed. The bituminous feed is solvent extracted to form a bitumen-rich stream and a bitumen-lean stream. Solvent is recovered from the bitumen-rich stream to form a bitumen product. Solvent and water are recovered from the bitumen-lean stream to form dry tailings with a moisture content of less than 40 wt.%. The dry tailings are separated into at least two streams, each stream having a moisture content of less than 40 wt. %, based on at least one physical or chemical property. At least one of the at least two streams is then used at an oil sands mine site. In this way, the dry tailings may be used more effectively.

    摘要翻译： 描述了一种处理沥青进料的方法。 沥青进料被溶剂萃取以形成富含沥青的料流和贫沥青料流。 从富含沥青的流中回收溶剂以形成沥青产物。 从贫沥青料流中回收溶剂和水以形成水分含量低于40重量％的干尾矿。 将干尾矿分离成至少两股，每条料流的含水量小于40wt。 基于至少一种物理或化学性质。 然后在油砂矿场使用至少两条流中的至少一条。 以这种方式，可以更有效地使用干尾矿。

    Method of Processing a Bituminous Feed Using Agglomeration in a Pipeline
    9.
    发明申请
    Method of Processing a Bituminous Feed Using Agglomeration in a Pipeline 审中-公开
    在管道中使用聚集处理沥青进料的方法

    公开(公告)号：US20140054201A1

    公开(公告)日：2014-02-27

    申请号：US14112552

    申请日：2012-03-09

    申请人： Olusola B. Adeyinka ,  Brian C. Speirs ,  Fritz Pierre, JR. ,  Payman Esmaeili ,  Emilio Alvarez ,  Anjaneya S. Kovvali ,  Thomas R. Palmer

    发明人： Olusola B. Adeyinka ,  Brian C. Speirs ,  Fritz Pierre, JR. ,  Payman Esmaeili ,  Emilio Alvarez ,  Anjaneya S. Kovvali ,  Thomas R. Palmer

    IPC分类号： C10G1/04

    CPC分类号： C10G1/045 ,  B01D21/01 ,  B01D21/32 ,  C10G1/04 ,  C10G21/003 ,  C10G2300/44 ,  C10G2300/805

    摘要： The present disclosure relates to a method of processing a bituminous feed. The bituminous feed is contacted with an extraction liquor to form a slurry. The slurry is then flowed through a pipeline. A bridging liquid is added to the slurry to assist agglomeration. Agitation is also used to assist agglomeration. The result is an agglomerated slurry comprising agglomerates and a low solids bitumen extract. The agglomerates are then separated from the low solids bitumen extract. Performing the agglomeration in a pipeline as opposed to in a conventional agitating vessel may provide certain advantages, such as improved sealing in order to contain the potentially flammable mixture of oil sands slurry from the atmosphere, production of smaller and more uniform agglomerates due to improved mixing of the bridging liquid into the oil sands slurry, and the flexibility to have a long residence time for the extraction and agglomeration processes.

    摘要翻译： 本公开涉及一种处理沥青进料的方法。 沥青进料与萃取液接触以形成浆料。 然后将浆料流过管道。 将桥连液体加入到浆料中以辅助凝聚。 搅拌也用于辅助凝聚。 其结果是包含附聚物和低固体沥青提取物的聚集浆料。 然后将聚集体与低固体沥青提取物分离。 与常规搅拌容器相比，在管道中进行凝聚可以提供某些优点，例如改进的密封以便容纳来自大气的油砂浆料的潜在可燃混合物，由于改进的混合产生更小和更均匀的附聚物 的桥接液体进入油砂浆料，并且具有用于萃取和附聚过程的长停留时间的柔性。