公开(公告)号：US20060165350A1

公开(公告)日：2006-07-27

申请号：US10516810

申请日：2003-06-04

Applicant: Grigory Gelikonov ,  Valentin Gelikonov ,  Alexey Myakov ,  Felix Feldchtein

Inventor： Grigory Gelikonov ,  Valentin Gelikonov ,  Alexey Myakov ,  Felix Feldchtein

IPC: G02B6/32

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0084 ,  G01B9/02002 ,  G01B9/0205 ,  G01B9/02063 ,  G01B9/0209 ,  G01B2290/65 ,  G01N21/4795 ,  G02B9/06 ,  G02B17/0856 ,  G02B23/2407

Abstract: The invention relates to studies of internal structures of objects with the aid of optical means. According to the invention an optical system (15) of the delivering device for low coherence optical radiation, in a particular embodiment, an optical fiber probe (8), includes at least two lens components (19), (20), which have a positive focal power and are positioned substantionally confocally. This ensures a constant propagation time for the low coherence optical radiation propagating from a given point of the transverse scanning surface (28) or (39) to a corresponding conjugate point of the image plane (22). That provides elimination of the transverse scanning related aberration of the optical path length for low coherence optical radiation directed towards the object (11) both for a flat transverse scanning surface (28) and for a transverse scanning surface (39) having a curvature. In another embodiment, together with the substantionally confocal arrangement of lens components (19), (20), the longitudinal scanning is performed by varying the optical path length for the low coherence optical radiation propagating from the transverse scanning surface (28) to the optical system (15), i.e., from the end face (17) of the distal part (18) of the optical fiber (14) to the optical system (15). To achieve this, a device for longitudinal scanning (10) is incorporated into the optical fiber probe (8). This ensures a corresponding shift of the focusing position of the low coherence optical radiation during longitudinal scanning, i.e., allows for alignment of the focusing position of the low coherence optical radiation with the position of the coherence gate and, consequently, their simultaneous movement.

Abstract translation: 本发明涉及借助于光学装置对物体内部结构的研究。 根据本发明，在特定实施例中，用于低相干光辐射的传送装置的光学系统（15）包括至少两个透镜组件（19），（20），其具有 积极的焦点力量，并且实质上是一致的。 这确保了从横向扫描表面（28）或（39）的给定点传播到图像平面（22）的对应共轭点的低相干光辐射的恒定传播时间。 这为平面横向扫描表面（28）和具有曲率的横向扫描表面（39）提供针对朝向物体（11）的低相干光辐射的光路长度的横向扫描相关像差的消除。 在另一个实施例中，与透镜部件（19），（20）的实质共焦布置一起，通过改变从横向扫描表面（28）传播到光学器件的低相干光辐射的光程长度来执行纵向扫描 系统（15），即从光纤（14）的远端部分（18）的端面（17）到光学系统（15）。 为了实现这一点，用于纵向扫描的装置（10）被并入到光纤探针（8）中。 这确保了在纵向扫描期间低相干光辐射的聚焦位置的相应偏移，即允许低相干光辐射的聚焦位置与相干门的位置对准，并因此允许其同时移动。

公开(公告)号：US20050275836A1

公开(公告)日：2005-12-15

申请号：US11152936

申请日：2005-06-15

Applicant: Felix Feldchtein ,  J. Breedlove ,  Stephanie Harrington

Inventor： Felix Feldchtein ,  J. Breedlove ,  Stephanie Harrington

IPC: G01J1/10 ,  G01N21/27 ,  G01N21/47

CPC classification number: G01N21/274 ,  G01N21/27 ,  G01N21/278 ,  G01N21/4795

Abstract: An optical measurement device calibration tool includes an optical probe suitable for calibrating various optical imaging devices, for example, low coherence reflectometers and optical coherence tomography devices. In a preferred embodiment the calibration tool comprises a container containing a calibration substance with stable optical scattering and absorption properties. The calibration substance includes a gel, paste or grease substance and is covered a protective seal, which is at least partially transparent providing optical contact between the optical probe and the calibration substance. The protective seal is covered with a viscous complementary material. Another protective seal made at least partially removable is placed above the viscous complementary material and may serve as a cover for the container. The calibration tool maintains the advantages of calibration tools using liquids and solid states as calibration substance and is more cost-effective and more convenient for calibrating optical measuring devices such as in medical applications.

Abstract translation: 光学测量装置校准工具包括适于校准各种光学成像装置的光学探针，例如低相干反射计和光学相干断层摄影装置。 在优选实施例中，校准工具包括容纳具有稳定的光散射和吸收特性的校准物质的容器。 校准物质包括凝胶，糊剂或油脂物质，并被覆盖保护性密封件，该保护性密封件至少部分透明，提供光学探针与校准物质之间的光学接触。 保护性密封件用粘性补充材料覆盖。 至少部分可移除的另一个保护性密封件放置在粘性互补材料上方，并可用作容器的盖子。 该校准工具保持了使用液体和固态作为校准物质的校准工具的优点，并且对于校准诸如医疗应用中的光学测量装置更为经济高效并且更方便。

公开(公告)号：US20050073691A1

公开(公告)日：2005-04-07

申请号：US10418424

申请日：2003-04-18

Applicant: Valentin Gelikonov ,  Grigory Gelikonov ,  Natalia Gladkova ,  Natalia Shahova ,  Felix Feldchtein ,  Alexander Sergeev

Inventor： Valentin Gelikonov ,  Grigory Gelikonov ,  Natalia Gladkova ,  Natalia Shahova ,  Felix Feldchtein ,  Alexander Sergeev

IPC: G01N21/17 ,  A61B1/005 ,  A61B5/00 ,  A61B6/08 ,  A61B10/00 ,  G01B9/02 ,  G01B9/04 ,  G02B26/10

CPC classification number: A61B5/6852 ,  A61B1/00096 ,  A61B1/00172 ,  A61B1/00177 ,  A61B1/00183 ,  A61B1/005 ,  A61B5/0066 ,  G01B9/02002 ,  G01B9/0205 ,  G01B9/02091 ,  G01B9/04 ,  G01B2290/65 ,  G02B26/10

Abstract: In a method for in vivo diagnostics of a biological tissue covered with epithelium an image of the biological tissue is acquired with the aid of a beam in the visible or near IR range directed towards a biological tissue by visualizing the intensity of optical radiation backscattered by the biological tissue. The basal membrane of said biological tissue, which separates the epithelium from an underlying stroma, is identified in the acquired image and diagnostics is performed on basis of the form of the basal membrane. For diagnostics of biological tissue lining the surface of cavities and internal organs of a patient a miniature optical fiber probe is inserted into the patient's cavity. The probe may be placed at a distal end of an endoscope instrumental channel. Acquired images show that a biological tissue covered with healthy epithelium has a smooth basal membrane, which separates stratified squamous epithelium from underlying connective tissue, while pathological regions of biological tissue are characterized by a change in the shape of the basal membrane, or violation of its integrity, or its absolute destruction. Using low coherent optical radiation for implementing the developed method ensures high spatial in-depth resolution.

Abstract translation: 在用上皮覆盖的生物组织进行体内诊断的方法中，借助于可见或接近IR范围内的束，通过可视化由背景散射的光辐射的强度获得生物组织的图像， 生物组织。 在所获取的图像中鉴定所述生物组织的基底膜，其将上皮与潜在基质分离，并且基于基底膜的形式进行诊断。 为了诊断患者空腔和内脏器官表面的生物组织，将微型光纤探针插入病人的腔内。 探针可以放置在内窥镜器械通道的远端。 获得的图像显示，用健康上皮覆盖的生物组织具有平滑的基底膜，其将分层的鳞状上皮与下层结缔组织分开，而生物组织的病理区域的特征在于基底膜形状的变化，或违反其 诚信或绝对破坏。 使用低相干光辐射实现开发的方法确保高空间深度分辨率。

公开(公告)号：US20070115476A1

公开(公告)日：2007-05-24

申请号：US11539719

申请日：2006-10-09

Applicant: Felix Feldchtein ,  Grigory Gelikonov

Inventor： Felix Feldchtein ,  Grigory Gelikonov

IPC: G01B9/02 ,  G01B11/02

CPC classification number: G01N21/4795 ,  G01B9/02044 ,  G01B9/02057 ,  G01B9/02065 ,  G01B9/02078 ,  G01B9/02091 ,  G01B2290/70

Abstract: Common path frequency domain optical coherence reflectometry/tomography devices include a portion of optical fiber with predetermined optical properties adapted for producing two eigen modes of the optical radiation propagating therethrough with a predetermined optical path length difference. The two replicas of the optical radiation outgoing from the portion of the optical fiber are then delivered to an associated sample by an optical fiber probe. The tip of the optical fiber serves as a reference reflector and also serves as a combining element that produces a combination optical radiation by combining an optical radiation returning from the associated sample with a reference optical radiation reflected from the reference reflector. The topology of the devices allows for registering a cross-polarized or a parallel-polarized component of the optical radiation reflected or backscattered from the associated sample. Having the optical path length difference for the two eigen modes of the optical radiation (which is an equivalent of an interferometer offset in previously known devices) differ from the reference offset in the devices of the present invention allows for relieving the requirements to the spectral resolution of the FD OCT engine and/or data acquisition and processing system, and substantially eliminates depth ambiguity problems.

Abstract translation: 公共路径频域光学相干反射/断层摄影装置包括具有预定光学特性的光纤的一部分，其适于产生具有预定光程长度差异的在其中传播的光辐射的两个本征模。 然后从光纤部分出射的光辐射的两个副本通过光纤探针传送到相关样品。 光纤的尖端用作参考反射器，并且还用作通过组合从相关样品返回的光辐射与从参考反射器反射的参考光辐射而产生组合光辐射的组合元件。 器件的拓扑结构允许记录从相关样品反射或反向散射的光辐射的交叉极化或平行偏振分量。 对于本发明的装置中的光辐射的两个本征模式的光程长度差（其等同于先前已知的装置中的干涉仪偏移）不同于参考偏移允许将要求减轻到光谱分辨率 的FD OCT引擎和/或数据采集和处理系统，并且基本上消除了深度歧义问题。

公开(公告)号：US20070109554A1

公开(公告)日：2007-05-17

申请号：US11559238

申请日：2006-11-13

Applicant: Felix Feldchtein ,  Valentin Gelikonov ,  Grigory Gelikonov

Inventor： Felix Feldchtein ,  Valentin Gelikonov ,  Grigory Gelikonov

IPC: G01B9/02

CPC classification number: G01B9/02057 ,  G01B9/0201 ,  G01B9/02011 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/23 ,  G01N21/49

Abstract: Polarization-sensitive optical coherence devices for obtaining birefringence information are presented. The polarization state of the optical radiation outgoing from the optical radiation source is controlled such that the polarization state of the optical radiation incident on a sample has a 45 degrees angle with respect to the anisotropy axis of the sample. A combination optical radiation is produced in a secondary interferometer by combining a sample portion with a reference portion of optical radiation reflected from a tip of an optical fiber of the optical fiber probe. Subject to a preset optical path length difference of the arms of the secondary interferometer, a cross-polarized, and/or a parallel-polarized component of the combined optical radiation, are selected. Time domain and frequency domain registration are provided. The performance of the device is substantially independent from the orientation of the optical fiber probe with respect to the sample.

Abstract translation: 提出了用于获得双折射信息的偏振敏感光学相干装置。 控制从光辐射源出射的光辐射的偏振状态，使得入射到样品上的光辐射的偏振状态相对于样品的各向异性轴具有45度的角度。 通过将样品部分与从光纤探针的光纤的尖端反射的光辐射的参考部分组合，在二次干涉仪中产生组合光辐射。 受到二次干涉仪的臂的预设光程长度差异，组合光辐射的交叉极化和/或平行偏振分量的选择。 提供时域和频域注册。 器件的性能基本上与光纤探针相对于样品的取向无关。

公开(公告)号：US20080089641A1

公开(公告)日：2008-04-17

申请号：US11866810

申请日：2007-10-03

Applicant: Felix FELDCHTEIN

Inventor： Felix FELDCHTEIN

IPC: G02B26/10 ,  G02B6/26 ,  G02B6/32

CPC classification number: G02B26/108 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/6852

Abstract: A forward looking optical fiber probe includes an optoelectronic lateral scanner that provides circular scanning using a single pass-through optical motor and a single rotating deflector. The optical fiber is kept stationary while circular scanning is provided by an optically transparent rotating deflector intersected by the optical radiation. The arrangement allows for hermetically sealing the optical fiber probe for disinfection, sterilization and clinical use in a clean environment in general. The design is suited to be used in a miniature forward looking optical fiber probe and has a potential for advanced manufacturing and assembling process.

Abstract translation: 前视光纤探头包括光电横向扫描器，其使用单个直通光学电机和单个旋转偏转器提供圆形扫描。 光纤保持静止，同时通过与光辐射相交的光学透明旋转偏转器提供圆形扫描。 该布置允许在一般的清洁环境中密封光纤探针以进行消毒，灭菌和临床应用。 该设计适用于微型前视光纤探头，具有先进的制造和组装工艺的潜力。

公开(公告)号：US20080055603A1

公开(公告)日：2008-03-06

申请号：US11850399

申请日：2007-09-05

Applicant: Paul AMAZEEN ,  Felix Feldchtein

Inventor： Paul AMAZEEN ,  Felix Feldchtein

IPC: G01N21/47

CPC classification number: G01N21/4795

Abstract: Provided are common path frequency domain and time domain OCT systems and methods that use non-specular reference reflection for obtaining internal depth profiles and depth resolved images of samples. Further provided is a delivering device for optical radiation, preferably implemented as an optical fiber probe with a partially optically transparent non-specular reflector placed in the vicinity of an associated sample. High frequency fringes are substantially reduced and a stable power level of the reference reflection is provided over the lateral scanning range. The partially optically transparent non-specular reflector is implemented as a coating placed on the interior surface of the optical probe window including spots of a metal, or a dielectric coating, separated by elements of another coating or just spaces of a clean substrate. In an alternative embodiment, the scattering elements are made 3-dimensional, having, for example, a spherical shape.

Abstract translation: 提供了通用路径频域和时域OCT系统和方法，其使用非镜面参考反射来获得样本的内部深度分布和深度分辨图像。 还提供了用于光辐射的递送装置，优选地实现为具有放置在相关样品附近的部分光学透明的非镜面反射器的光纤探针。 高频条纹基本上减少，并且横向扫描范围提供参考反射的稳定功率水平。 部分光学透明的非镜面反射器被实施为放置在光学探针窗口的内表面上的涂层，包括由另一涂层的元件或洁净基底的空间分开的金属或电介质涂层的斑点。 在替代实施例中，散射元件被制成三维的，具有例如球形。

公开(公告)号：US20070008545A1

公开(公告)日：2007-01-11

申请号：US11456414

申请日：2006-07-10

Applicant: Felix Feldchtein ,  Grigory Gelikonov

Inventor： Felix Feldchtein ,  Grigory Gelikonov

IPC: G01B9/02 ,  G01B11/02

CPC classification number: G01B9/02065 ,  A61B5/0066 ,  A61B5/6852 ,  G01B9/02044 ,  G01B9/02057 ,  G01B9/02078 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/4795

Abstract: Common path frequency domain optical coherence reflectometry/tomography devices with an additional interferometer are suggested. The additional interferometer offset is adjusted such, that it is ether less than the reference offset, or exceeds the distance from the reference reflector to the distal boundary of the longitudinal range of interest. This adjustment allows for relieving the requirements to the spectral resolution of the frequency domain optical coherence reflectometry/tomography engine and/or speed of the data acquisition and processing system, and eliminates depth ambiguity problems. The new topology allows for including a phase or frequency modulator in an arm of the additional interferometer improving the signal-to-noise ratio of the devices. The modulator is also capable of substantially eliminating mirror ambiguity, DC artifacts, and autocorrelation artifacts. The interference signal is produced either in the interferometer or inside of the optical fiber probe leading to the sample.

Abstract translation: 建议使用带有附加干涉仪的共路径频域光学相干反射/断层成像装置。 调整附加的干涉仪偏移，使得其比参考偏移小，或者超过距参考反射器到感兴趣的纵向范围的远端边界的距离。 该调整允许缓解对频域光学相干反射/断层摄影引擎的光谱分辨率和/或数据采集和处理系统的速度的要求，并消除深度歧义问题。 新的拓扑结构允许在附加干涉仪的臂中包括相位或频率调制器来提高器件的信噪比。 调制器还能够基本上消除镜像歧义，DC伪影和自相关伪影。 在干涉仪中产生干涉信号，或者在通过样品的光纤探针的内部产生干扰信号。

公开(公告)号：USD776819S1

公开(公告)日：2017-01-17

申请号：US29416242

申请日：2012-03-20

Applicant: Alexander Vybornov ,  Felix Feldchtein ,  Paul Dunleavy ,  Gregory Altshuler ,  James Varney ,  Bryan Hotaling ,  John MacNeill ,  Scott Leclerc

Designer： Alexander Vybornov ,  Felix Feldchtein ,  Paul Dunleavy ,  Gregory Altshuler ,  James Varney ,  Bryan Hotaling ,  John MacNeill ,  Scott Leclerc

公开(公告)号：US20070109553A1

公开(公告)日：2007-05-17

申请号：US11559226

申请日：2006-11-13

Applicant: Felix Feldchtein ,  Valentin Gelikonov ,  Grigory Gelikonov

Inventor： Felix Feldchtein ,  Valentin Gelikonov ,  Grigory Gelikonov

IPC: G01B9/02

CPC classification number: G01B9/02027 ,  A61B5/0066 ,  A61B5/6852 ,  G01B9/02057 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/70 ,  G01N21/21 ,  G01N2021/4792

Abstract: Polarization sensitive common path OCT/OCR devices are presented. Optical radiation from a source is converted into two cross-polarized replicas propagating therethrough with a predetermined optical path length difference. The two cross-polarized replicas are then delivered to an associated sample by a delivering device, which is, preferably, an optical fiber probe. A combination optical radiation is produced in at least one secondary interferometer by combining a corresponding portion of an optical radiation returning from the associated sample with a reference optical radiation reflected from a tip of an optical fiber of the optical fiber probe. Subject to a preset optical path length difference of the arms of the at least one secondary interferometer, a cross-polarized component, and/or a parallel-polarized component of the combined optical radiation, are selected. The topology of the devices allows for time domain, as well as for frequency domain registration.

Abstract translation: 介绍了极化敏感的通用路径OCT / OCR设备。 来自源的光学辐射被转换为以预定光程长度差传播通过其中的两个交叉极化复制品。 然后通过递送装置将两个交叉极化复制品递送到相关样品，该装置优选地是光纤探针。 通过将从相关样品返回的光学辐射的对应部分与从光纤探针的光纤的尖端反射的参考光辐射组合，在至少一个次级干涉仪中产生组合光辐射。 受到所述至少一个次级干涉仪的臂的预设光程长度差异，组合光辐射的交叉偏振分量和/或平行偏振分量的选择。 设备的拓扑结构允许时域，以及频域注册。