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    PROCESS FOR IDENTIFYING EXISTENCE OF SINGLE NUCLEOTIDE POLYMORPHISM WITHOUT DNA SEQUENCING
    1.
    发明申请
    PROCESS FOR IDENTIFYING EXISTENCE OF SINGLE NUCLEOTIDE POLYMORPHISM WITHOUT DNA SEQUENCING 审中-公开
    没有DNA序列识别单核多核苷酸存在的方法

    公开(公告)号：US20080227212A1

    公开(公告)日：2008-09-18

    申请号：US12049679

    申请日：2008-03-17

    申请人： Gafur Zainiev ,  Inlik Zainiev ,  Timur Zainiev

    发明人： Gafur Zainiev ,  Inlik Zainiev ,  Timur Zainiev

    IPC分类号： G01N33/00

    CPC分类号： C12Q1/6827 ,  Y10T436/143333 ,  C12Q2565/629 ,  C12Q2527/137

    摘要： A process for detecting the presence of a mutation in an oligonucleotide strand such as a DNA strand from a gene without the need for DNA sequencing is provided. The inventive process provides a rapid pre-test to screen for the presence or absence of a mutation in a target gene of a subject to determine whether laborious sequencing protocols are required to further characterize a mutation. The inventive process provides a rapid screening protocol for identifying and detecting a genetic mutation in a patient who presents with a disease

    摘要翻译： 提供了检测寡核苷酸链中的突变的存在的方法，例如来自基因的DNA链，而不需要进行DNA测序。 本发明的方法提供了快速预检测以筛选受试者靶基因中突变的存在或不存在，以确定是否需要费力的测序方案来进一步表征突变。 本发明的方法提供用于鉴定和检测患有疾病的患者中的遗传突变的快速筛选方案

    Design of high power pulsed flash lamps
    2.
    发明授权
    Design of high power pulsed flash lamps 失效
    大功率脉冲闪光灯的设计

    公开(公告)号：US07423367B2

    公开(公告)日：2008-09-09

    申请号：US11466798

    申请日：2006-08-24

    申请人： Robert M. Lantis ,  Boris Zlotin ,  Peter Ulan ,  Vladimir Proseanic ,  Gafur Zainiev

    发明人： Robert M. Lantis ,  Boris Zlotin ,  Peter Ulan ,  Vladimir Proseanic ,  Gafur Zainiev

    IPC分类号： H01J19/12

    CPC分类号： H01J61/80 ,  H01J5/48 ,  H01J61/073 ,  H01J61/30 ,  H01J61/33 ,  H01J61/34 ,  H01J61/50 ,  H01J61/52 ,  H01J61/90 ,  H01J61/95

    摘要： Broadband output high power pulsed flash lamps are useful in many applications, and when specifically optimized, can become an excellent source of ultraviolet (UV) light, which is particularly useful for photo-chemically-induced materials processing applications. Multiple factors involved with the production of high-energy light pulses can in certain cases adversely affect the ultraviolet lamp operation, thereby resulting in the development of micro cracks in lamp envelopes and subsequent limitation in lamp lifetime. Similar factors can be responsible for an increased absorption of UV radiation by lamp components and degradation of lamp efficiency. This invention describes new pulsed flash lamp designs that enable a new generation of high power and performance as required by, for example, many large-scale photo-processing applications. This invention uniquely and advantageously mitigates the development of micro-cracks and failure, and produces dramatically improved electrical efficiency, stability of lamp optical characteristics, and service lifetime.

    摘要翻译： 宽带输出高功率脉冲闪光灯在许多应用中是有用的，当被特别优化时，可以成为紫外线（UV）光的优良来源，这对于光化学诱导的材料处理应用尤其有用。 与高能量光脉冲相关的多个因素在某些情况下可能对紫外线灯的操作产生不利影响，从而导致灯泡内的微裂纹的发展和灯寿命的限制。 类似的因素可能导致灯组件对UV辐射的吸收增加和灯效率的降低。 本发明描述了新的脉冲闪光灯设计，其能够实现例如许多大规模照相处理应用所要求的新一代高功率和性能。 本发明独特且有利地减轻微裂纹和破裂的发展，并且产生显着提高的电效率，灯的光学特性的稳定性和使用寿命。

    NUCLEIC ACID ARRAY WITH RELEASEABLE NUCLEIC ACID PROBES
    4.
    发明申请
    NUCLEIC ACID ARRAY WITH RELEASEABLE NUCLEIC ACID PROBES 审中-公开
    核酸序列与可释放的核酸探针

    公开(公告)号：US20090286694A1

    公开(公告)日：2009-11-19

    申请号：US12511751

    申请日：2009-07-29

    申请人： Gafur Zainiev ,  Inlik Zainieva

    发明人： Gafur Zainiev ,  Inlik Zainieva

    IPC分类号： C40B30/04 ,  C40B40/08

    CPC分类号： B01L3/5025 ,  B01J2219/00358 ,  B01J2219/00644 ,  B01J2219/00653 ,  B01J2219/00722 ,  B01L3/5027 ,  B01L3/502753 ,  B01L3/50851 ,  B01L7/52 ,  B01L2300/069 ,  C12Q1/6813 ,  C12Q2565/125 ,  C12Q2547/107 ,  C12Q2537/149

    摘要： A process is provided for identifying a complementary target nucleic acid. The process includes the hybridization of a nucleic acid probe to a carrier to form a nucleic acid probe-carrier complex. The complex is placed in a compartment bounded by a media permeable to the nucleic acid probe and exclusive of both the carrier and the complex. The complex is then denatured, with the nucleic acid probe transported through the media and into contact with the target nucleic acid. The nucleic acid probe hybridizes to the complementary target nucleic acid to yield a probe-target double stranded complex. A non-complementary nucleic acid probe, independent probe-target complex is returned to the compartment and given an opportunity to rehybridize to the carrier. A determination as to whether at least one of the complementary target nucleic acid or the carrier is present as a complex provides information as to probe sequences complementary to the target nucleic acid.

    摘要翻译： 提供了用于鉴定互补靶核酸的方法。 该方法包括将核酸探针与载体杂交以形成核酸探针 - 载体复合物。 将复合物置于由可渗透核酸探针的介质限定的区域中，并且不包括载体和复合物两者。 然后将复合物变性，核酸探针通过培养基传输并与靶核酸接触。 核酸探针与互补靶核酸杂交以产生探针 - 靶双链复合物。 将非互补核酸探针，独立的探针 - 靶复合物返回到隔室，给予再载体载体的机会。 作为复合物存在至少一种互补靶核酸或载体的确定提供了与靶核酸互补的探针序列的信息。

    PROCESS FOR SELF-ASSEMBLY OF STRUCTURES IN A LIQUID
    5.
    发明申请
    PROCESS FOR SELF-ASSEMBLY OF STRUCTURES IN A LIQUID 审中-公开
    液体中自组织的方法

    公开(公告)号：US20080241836A1

    公开(公告)日：2008-10-02

    申请号：US11927891

    申请日：2008-03-31

    申请人： Gafur Zainiev ,  Inlik Zainiev ,  Timur Zainiev

    发明人： Gafur Zainiev ,  Inlik Zainiev ,  Timur Zainiev

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12M1/00

    CPC分类号： C12P19/34 ,  B01L3/5027 ,  C12Q1/6869 ,  C12Q2565/501 ,  C12Q2521/101

    摘要： A process and apparatus for self-assembling a number of elements and determining their sequence is provided. In the field of DNA analysis, an iterative process is disclosed wherein an apparatus with a set of reaction chambers in which a species of recognition element nucleotides are differentially added and subjected to a polymerization reaction allows recognition of which species is next in sequence on a template strand by the effect that synthesis has on a detecting template as measured by a detector in a detection area. Stepwise addition of the identified species then determines if an element repeat exists. The process is repeated until the entire structure is complete and the sequence identified.

    摘要翻译： 提供了一种用于自组装多个元件并确定其顺序的过程和装置。 在DNA分析领域中，公开了一种迭代方法，其中具有一组反应室的装置，其中识别元件核苷酸的种类被差异添加并进行聚合反应允许在模板上依次识别下一个物种 通过检测区域中的检测器测量的合成对检测模板的影响。 逐步添加所识别的物种然后确定元素重复是否存在。 重复该过程，直到整个结构完成并确定序列。

    NUCLEIC ACID ARRAY WITH RELEASEABLE NUCLEIC ACID PROBES
    6.
    发明申请
    NUCLEIC ACID ARRAY WITH RELEASEABLE NUCLEIC ACID PROBES 审中-公开
    核酸序列与可释放的核酸探针

    公开(公告)号：US20080044822A1

    公开(公告)日：2008-02-21

    申请号：US11465875

    申请日：2006-08-21

    申请人： Gafur Zainiev ,  Inlik Zainieva

    发明人： Gafur Zainiev ,  Inlik Zainieva

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6813 ,  B01J2219/00358 ,  B01J2219/00644 ,  B01J2219/00653 ,  B01J2219/00722 ,  B01L3/5027 ,  C12Q2565/125 ,  C12Q2547/107 ,  C12Q2537/149

    摘要： A process is provided for identifying a complementary target nucleic acid. The process includes the hybridization of a nucleic acid probe to a carrier to form a nucleic acid probe-carrier complex. The complex is placed in a compartment bounded by a media permeable to the nucleic acid probe and exclusive of both the carrier and the complex. The complex is then denatured, with the nucleic acid probe transported through the media and into contact with the target nucleic acid. The nucleic acid probe hybridizes to the complementary target nucleic acid to yield a probe-target double stranded complex. A non-complementary nucleic acid probe, independent probe-target complex is returned to the compartment and given an opportunity to rehybridize to the carrier. A determination as to whether at least one of the complementary target nucleic acid or the carrier is present as a complex provides information as to probe sequences complementary to the target nucleic acid.

    摘要翻译： 提供了用于鉴定互补靶核酸的方法。 该方法包括将核酸探针与载体杂交以形成核酸探针 - 载体复合物。 将复合物置于由可渗透核酸探针的介质限定的区域中，并且不包括载体和复合物两者。 然后将复合物变性，核酸探针通过培养基传输并与靶核酸接触。 核酸探针与互补靶核酸杂交以产生探针 - 靶双链复合物。 将非互补核酸探针，独立的探针 - 靶复合物返回到隔室，给予再载体载体的机会。 作为复合物存在至少一种互补靶核酸或载体的确定提供了与靶核酸互补的探针序列的信息。

    NUCLEIC ACID ARRAY HAVING FIXED NUCLEIC ACID ANTI-PROBES AND COMPLEMENTARY FREE NUCLEIC ACID PROBES
    7.
    发明申请
    NUCLEIC ACID ARRAY HAVING FIXED NUCLEIC ACID ANTI-PROBES AND COMPLEMENTARY FREE NUCLEIC ACID PROBES 审中-公开
    具有固定核酸抗原探针和完全免费的核酸探针的核酸阵列

    公开(公告)号：US20080044821A1

    公开(公告)日：2008-02-21

    申请号：US11465870

    申请日：2006-08-21

    申请人： Gafur Zainiev ,  Inlik Zainiev

    发明人： Gafur Zainiev ,  Inlik Zainiev

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6837 ,  C12Q2537/161

    摘要： A process for identifying a complementary nucleic acid probe to a target nucleic acid involves forming an array of spots where each spot of the array has an immobilized nucleic acid anti-probe to which is hybridized a nucleic acid probe. The array of the anti-probe-probe complex is denatured. The nucleic acid probes are then moved into a target chamber that includes a target nucleic acid. Hybridization conditions are established to form double-stranded complexation between the target nucleic acid and nucleic acid probes in instances where the target nucleic acid has a sequence complementary. The nucleic acid probes noncomplementary to the target nucleic acid are allowed to rehybridize with anti-probes. Determining whether the anti-probe spots exposed to nucleic acid probes noncomplementary to the target nucleic acid are single stranded after exposure to noncomplementary nucleic acid probes provides information as to target nucleic acid sequence.

    摘要翻译： 用于鉴定靶核酸的互补核酸探针的方法包括形成阵列阵列，其中阵列的每个点具有与核酸探针杂交的固定的核酸抗探针。 抗探针 - 探针复合物的阵列变性。 然后将核酸探针移动到包括靶核酸的靶室中。 建立杂交条件以在目标核酸具有序列互补性的情况下在靶核酸和核酸探针之间形成双链复合。 允许与靶核酸不互补的核酸探针用抗探针重新杂化。 确定在暴露于非互补核酸探针之后，暴露于与靶核酸不互补的核酸探针的抗探针点是单链提供关于靶核酸序列的信息。

    Process for identifying existence of single nucleotide polymorphism without DNA sequencing
    9.
    发明授权
    Process for identifying existence of single nucleotide polymorphism without DNA sequencing 有权
    识别单核苷酸多态性存在而不进行DNA测序的方法

    公开(公告)号：US08153403B1

    公开(公告)日：2012-04-10

    申请号：US12714974

    申请日：2010-03-01

    申请人： Gafur Zainiev ,  Inlik Zainiev ,  Timur Zainiev

    发明人： Gafur Zainiev ,  Inlik Zainiev ,  Timur Zainiev

    IPC分类号： C12P19/34 ,  C12Q1/68

    CPC分类号： C12Q1/6827 ,  C12Q2565/629 ,  C12Q2527/137

    摘要： A process for detecting the presence of a mutation in an oligonucleotide strand such as a DNA strand from a gene without the need for DNA sequencing is provided. The inventive process provides a rapid pre-test to screen for the presence or absence of a mutation in a target gene of a subject to determine whether laborious sequencing protocols are required to further characterize a mutation. The inventive process provides a rapid screening protocol for identifying and detecting a genetic mutation in a patient who presents with a disease.

    摘要翻译： 提供了检测寡核苷酸链中的突变的存在的方法，例如来自基因的DNA链，而不需要进行DNA测序。 本发明的方法提供了快速预检测以筛选受试者靶基因中突变的存在或不存在，以确定是否需要费力的测序方案来进一步表征突变。 本发明的方法提供用于鉴定和检测患有疾病的患者中的遗传突变的快速筛选方案。

    SELF-CONTAINED PARTICLE SEPARATOR DEVICE
    10.
    发明申请
    SELF-CONTAINED PARTICLE SEPARATOR DEVICE 审中-公开
    自含颗粒分离装置

    公开(公告)号：US20100108621A1

    公开(公告)日：2010-05-06

    申请号：US12535318

    申请日：2009-08-04

    申请人： Gafur Zainiev

    发明人： Gafur Zainiev

    IPC分类号： B01D63/04 ,  B01D43/00

    CPC分类号： B01D63/062 ,  B01D39/1692 ,  B01D39/18 ,  B01D63/087 ,  B01D2239/065 ,  B01D2313/50 ,  B01D2315/08

    摘要： A concentrator of particles dissolved or suspended in a liquid includes a top surface having a hole array therethrough and a bottom surface fused to the top surface to define an intermediate volume accessed only through the hole array. A concentrator of particles dissolved or suspended in a liquid is also provided that has an inner channel and an exterior surface and a tube having a hole array providing liquid communication between the inner channel and the exterior surface. A liquid-impermeable sheath surrounds the hole array and forms a seal to the exterior surface to define a volume between said sheath and the exterior surface. A process for concentrating particles from a liquid with these concentrators is also provided.

    摘要翻译： 溶解或悬浮在液体中的颗粒的浓缩器包括具有穿过其中的孔的顶表面和与顶表面熔合的底表面，以限定仅通过孔阵列访问的中间体积。 还提供了溶解或悬浮在液体中的颗粒的浓缩器，其具有内部通道和外部表面，以及具有提供内部通道和外部表面之间的液体连通的孔阵列的管。 液体不可渗透的护套围绕孔阵列并且形成到外表面的密封以限定所述护套和外表面之间的体积。 还提供了用这些浓缩器从液体中浓缩颗粒的方法。