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1.发明授权Vascular anticoagulant proteins DNA which codes them, processer for preparing them and their use 失效编码它们的血管抗凝蛋白DNA，用于制备它们的处理器及其用途
公开(公告)号：US5837842A
公开(公告)日：1998-11-17
申请号：US376050
申请日：1995-01-23
申请人： Rudolf Hauptmann , Ingrid Maurer-Fogy , Gerhard Bodo , Peter Swetly , Christian Stratowa , Edgar Falkner , Gunther Adolf , Christiaan Maria Peter Reutelingsperger
发明人： Rudolf Hauptmann , Ingrid Maurer-Fogy , Gerhard Bodo , Peter Swetly , Christian Stratowa , Edgar Falkner , Gunther Adolf , Christiaan Maria Peter Reutelingsperger
IPC分类号： G01N33/50 , A61K35/14 , A61K38/00 , A61P7/02 , A61P29/00 , C07K1/20 , C07K14/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K19/00 , C12N1/20 , C12N5/10 , C12N15/09 , C12N15/70 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/86 , C07H21/04
CPC分类号： C12N15/70 , C07K14/4721 , C07K16/18 , G01N33/86 , A61K38/00
摘要： This invention relates to biologically active proteins, the DNA molecules coding for them, processes for preparing them and their use.
摘要翻译： 本发明涉及生物活性蛋白质，编码它们的DNA分子，其制备方法及其应用。
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2.发明授权Hybrid interferons, their use as pharmaceutical compositions and as intermediate products for the preparation of antibodies and the use thereof and processes for preparing them 失效混合干扰素，它们作为药物组合物的用途以及用于制备抗体的中间产物及其用途及其制备方法
公开(公告)号：US4917887A
公开(公告)日：1990-04-17
申请号：US23634
申请日：1987-03-09
申请人： Rudolf Hauptmann , Peter Swetly , Peter Meindl , Gunther Adolf , Edgar Falkner , Gerhard Bodo , Ingrid Maurer-Fogy
发明人： Rudolf Hauptmann , Peter Swetly , Peter Meindl , Gunther Adolf , Edgar Falkner , Gerhard Bodo , Ingrid Maurer-Fogy
IPC分类号： C07K14/005 , A61K38/00 , A61K38/21 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/195 , C07K14/52 , C07K14/555 , C07K14/56 , C07K16/00 , C07K16/24 , C07K17/10 , C12N1/20 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/20 , C12N15/70 , C12N15/81 , C12P21/00 , C12P21/02 , C12R1/125 , C12R1/19 , C12R1/38 , C12R1/425 , C12R1/91
CPC分类号： C12N15/70 , C07K14/555 , C07K14/56 , C07K16/249 , C12N15/81 , A61K38/00
摘要： This invention relates to new hybrid interferons consisting of part of an .alpha.-interferon and part of an omega interferon, the N-terminal Met or N-formyl-Met derivatives thereof and, if the peptide sequence of the hybrid interferon contains a glycosylation site, the N-glycosylated derivatives thereof, their use as pharmaceutical compositions and as intermediate products for immunizing experimental animals and processes for producing them,new monoclonal antibodies and their use in purifying .alpha. and omega-interferons, the hybrid cell lines which secrete them and processes for preparing them,a new process for purifying .alpha. and omega-interferons by means of a new antibody affinity column containing the above-mentioned new monoclonal antibodies, and processes for the preparation thereof,new hybrid plasmids for improving the expression of omega-interferons and new intermediate plasmids for preparing the new plasmids and processes for the preparation thereof.
摘要翻译： 本发明涉及由α-干扰素和ω-干扰素的一部分组成的新的杂合干扰素，其N-末端Met或N-甲酰基-Mc衍生物，如果杂合干扰素的肽序列含有糖基化位点， 其N-糖基化衍生物，它们作为药物组合物的用途和用于免疫实验动物的中间产物及其制备方法，新的单克隆抗体及其在纯化α和ω-干扰素中的用途，分泌它们的杂交细胞系和 制备它们，通过含有上述新单克隆抗体的新抗体亲和柱纯化α和ω-干扰素的新方法及其制备方法，用于改善ω-干扰素表达的新型杂合质粒和新的 用于制备新质粒的中间质粒及其制备方法。
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公开(公告)号：US5710027A
公开(公告)日：1998-01-20
申请号：US249671
申请日：1994-05-26
IPC分类号： C12N15/09 , C07K1/18 , C07K1/20 , C07K1/22 , C07K14/245 , C07K14/52 , C07K14/555 , C07K14/56 , C12N15/21 , C12N15/70 , C12P21/02 , C12R1/19
CPC分类号： C12N15/70 , C07K14/245 , C07K14/56 , C07K2319/02
摘要： Methods and vectors for expressing interferon-alpha (IFN-.alpha.) proteins in E. coli are provided. Use of a vector comprising an IFN-.alpha. sequence fused to an E. coli heat-stable enterotoxin signal sequence (STII) under the control of the E. coli phosphatase (phoA) promoter affords high levels of correctly-folded and -processed, biologically active IFN-.alpha. polypeptides.
摘要翻译： 提供了用于在大肠杆菌中表达干扰素-α（IFN-α）蛋白的方法和载体。 在大肠杆菌磷酸酶（phoA）启动子控制下，包含与大肠杆菌热稳定肠毒素信号序列（STII）融合的IFN-α序列的载体的使用提供了高水平的正确折叠和加工的生物学 活性IFN-α多肽。
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公开(公告)号：US06440693B1
公开(公告)日：2002-08-27
申请号：US08484307
申请日：1995-06-07
IPC分类号： C12N1509
CPC分类号： G01N33/57484 , A61K38/00 , C07K14/7151 , C12Q1/6886 , C12Q2600/136 , G01N33/6863 , Y02A50/473 , Y10S930/12 , Y10S930/144
摘要： DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
摘要翻译： 编码TNF结合蛋白的DNA序列和该蛋白质构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。 重组TNF结合蛋白用于药物制剂中，用于治疗TNF具有有害作用的适应症。 借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质 受体和/或其对TNF的生物活性的影响。
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公开(公告)号：US5240847A
公开(公告)日：1993-08-31
申请号：US167261
申请日：1988-03-11
申请人： Konrad Heckl , Walter Spevak , Elinborg Ostermann , Andreas Zophel , Edeltraud Krystek , Ingrid Maurer-Fogy , Maria J. Wiche-Castanon , Christian Stratowa , Rudolf Hauptmann
发明人： Konrad Heckl , Walter Spevak , Elinborg Ostermann , Andreas Zophel , Edeltraud Krystek , Ingrid Maurer-Fogy , Maria J. Wiche-Castanon , Christian Stratowa , Rudolf Hauptmann
IPC分类号： C12N1/20 , A61K38/44 , A61K38/45 , A61P29/00 , A61P37/08 , C07H21/04 , C07K14/00 , C12N1/16 , C12N1/19 , C12N1/21 , C12N9/02 , C12N15/09 , C12N15/53 , C12N15/62 , C12P21/00 , C12R1/19 , C12R1/865 , C12R1/91
CPC分类号： C12N9/0089 , C12N15/625 , C07K2319/02 , C07K2319/07
摘要： The present invention relates to a method of preparing human Mn-superoxide dismutase (hMn-SOD) by genetic engineering, the DNA sequences which code for this enzyme, suitable vectors which contain these DNA sequences and host cells which can express these DNA sequences, and the enzyme hMn-SOD itself. Suggestions as to the use of this enzyme are also described.
摘要翻译： 本发明涉及通过遗传工程制备人类Mn超氧化物歧化酶（hMn-SOD）的方法，编码该酶的DNA序列，含有这些DNA序列的合适载体和可表达这些DNA序列的宿主细胞，以及 酶hMn-SOD本身。 还描述了关于使用该酶的建议。
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公开(公告)号：US07264944B1
公开(公告)日：2007-09-04
申请号：US09525998
申请日：2000-03-15
CPC分类号： C07K14/7151 , A61K38/00 , C12Q1/6886 , C12Q2600/158 , G01N33/6863 , Y02A50/473
摘要： The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
摘要翻译： 本发明提供了编码TNF结合蛋白的DNA序列和该蛋白构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。 重组TNF结合蛋白用于治疗TNF具有有害作用的适应症的药物制剂中。 借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质 受体和/或其对TNF的生物活性的影响。
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公开(公告)号：US06294352B1
公开(公告)日：2001-09-25
申请号：US08383676
申请日：1995-02-01
IPC分类号： C12N1500
CPC分类号： G01N33/57484 , A61K38/00 , C07K14/7151 , C12Q1/6886 , C12Q2600/136 , G01N33/6863 , Y02A50/473 , Y10S930/12 , Y10S930/144
摘要： DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequence can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
摘要翻译： 编码TNF结合蛋白的DNA序列和该蛋白质构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。 重组TNF结合蛋白用于治疗TNF具有有害作用的适应症的药物制剂中。 借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质 受体和/或其对TNF的生物活性的影响。
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公开(公告)号：US06221675B1
公开(公告)日：2001-04-24
申请号：US08477639
申请日：1995-06-07
IPC分类号： G01N33566
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/7151 , C12Q1/6886 , C12Q2600/136 , G01N33/57484
摘要： DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF is receptor and/or for their effect on the biological activity of TNF.
摘要翻译： 编码TNF结合蛋白的DNA序列和该蛋白质构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。 借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质 是受体和/或其对TNF的生物活性的影响。
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9.发明授权Method of ameliorating the harmful effects of TNF using a polypeptide having the ability to bind to TNF 失效使用具有结合TNF能力的多肽来改善TNF的有害作用的方法公开(公告)号：US07282483B2
公开(公告)日：2007-10-16
申请号：US09898234
申请日：2001-07-03
IPC分类号： A61K38/16 , C07K14/715
CPC分类号： C07K14/7151 , A61K38/00 , C12Q1/6886 , C12Q2600/158 , G01N33/6863 , Y02A50/473
摘要： The present invention provides DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
摘要翻译： 本发明提供了编码TNF结合蛋白的DNA序列和该蛋白构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。 重组TNF结合蛋白用于治疗TNF具有有害作用的适应症的药物制剂中。 借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质 受体和/或其对TNF的生物活性的影响。
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10.发明授权Method of ameliorating the harmful effects of TNF using a polypeptide having the ability to bind to TNF 失效使用具有结合TNF能力的多肽来改善TNF的有害作用的方法公开(公告)号：US06417158B1
公开(公告)日：2002-07-09
申请号：US08477638
申请日：1995-06-07
IPC分类号： A61K3819
CPC分类号： G01N33/57484 , A61K38/00 , C07K14/7151 , C12Q1/6886 , C12Q2600/136 , G01N33/6863 , Y02A50/473 , Y10S930/12 , Y10S930/144
摘要： DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
摘要翻译： 编码TNF结合蛋白的DNA序列和该蛋白质构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。 重组TNF结合蛋白用于治疗TNF具有有害作用的适应症的药物制剂中。 借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质 受体和/或其对TNF的生物活性的影响。
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