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公开(公告)号：US20080087826A1
公开(公告)日：2008-04-17
申请号：US11928715
申请日：2007-10-30
申请人： Timothy Harris , Philip Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley Lapidus
发明人： Timothy Harris , Philip Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley Lapidus
CPC分类号： G01N21/648 , C12Q1/6869 , G01N21/6458 , G01N2021/6419 , G02B2207/113 , C12Q2565/102 , C12Q2563/107 , C12Q2523/313
摘要： In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.
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公开(公告)号：US08367377B2
公开(公告)日：2013-02-05
申请号：US12618991
申请日：2009-11-16
CPC分类号： C12Q1/68 , B01J19/0046 , B01J2219/00432 , B01J2219/00436 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00707 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C12Q1/6874 , C12Q2549/125
摘要： Methods of the invention comprise methods and devices for nucleic acid sequence determination. Generally, the invention relates to preparing a substrate for sequencing a target nucleic acid.
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公开(公告)号：US07635562B2
公开(公告)日：2009-12-22
申请号：US11137928
申请日：2005-05-25
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , B01J19/0046 , B01J2219/00432 , B01J2219/00436 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00707 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C12Q1/6874 , C12Q2549/125
摘要： Methods of the invention comprise methods and devices for nucleic acid sequence determination. Generally, the invention relates to preparing a substrate for sequencing a target nucleic acid.
摘要翻译： 本发明的方法包括用于核酸序列测定的方法和装置。 通常，本发明涉及制备用于测序靶核酸的底物。
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公开(公告)号：US20060019276A1
公开(公告)日：2006-01-26
申请号：US11137928
申请日：2005-05-25
申请人： Timothy Harris , Philip Buzby , Mirna Jarosz , James DiMeo , Jaime Gill
发明人： Timothy Harris , Philip Buzby , Mirna Jarosz , James DiMeo , Jaime Gill
CPC分类号： C12Q1/68 , B01J19/0046 , B01J2219/00432 , B01J2219/00436 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00707 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C12Q1/6874 , C12Q2549/125
摘要： Methods of the invention comprise methods and devices for nucleic acid sequence determination. Generally, the invention relates to preparing a substrate for sequencing a target nucleic acid.
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5.发明申请公开(公告)号：US20080246949A1
公开(公告)日：2008-10-09
申请号：US11928727
申请日：2007-10-30
申请人： Timothy D. Harris , Philip R. Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley N. Lapidus
发明人： Timothy D. Harris , Philip R. Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley N. Lapidus
CPC分类号： G01N21/645 , G01J3/10 , G01J3/36 , G01J3/4406 , G01N21/552 , G01N21/6428 , G01N21/6456 , G01N2021/6419 , G01N2021/6421 , G02B21/16 , G02B2207/113
摘要： In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.
摘要翻译： 一方面，本发明涉及一种使用全内反射来分析单个分子的存在的装置。 在一个实施方案中，用于单分子分析的装置包括具有位于其上的样品的载体; 两个不同波长的光源，用于通过全内反射物镜将光引导到样品上的准直器; 接收器，用于响应于光接收由样品中的单个分子产生的荧光发射; 以及用于检测荧光发射中的每个波长的检测器。 在另一个实施例中，该装置还包括聚焦激光器，用于保持物体在样本上的焦点。
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6.发明申请公开(公告)号：US20080088823A1
公开(公告)日：2008-04-17
申请号：US11849088
申请日：2007-08-31
申请人： Timothy Harris , Philip Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley Lapidus
发明人： Timothy Harris , Philip Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley Lapidus
CPC分类号： G01N21/645 , G01J3/10 , G01J3/36 , G01J3/4406 , G01N21/552 , G01N21/6428 , G01N21/6456 , G01N2021/6419 , G01N2021/6421 , G02B21/16 , G02B2207/113
摘要： In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.
摘要翻译： 一方面，本发明涉及一种使用全内反射来分析单个分子的存在的装置。 在一个实施方案中，用于单分子分析的装置包括具有位于其上的样品的载体; 两个不同波长的光源，用于通过全内反射物镜将光引导到样品上的准直器; 接收器，用于响应于光接收由样品中的单个分子产生的荧光发射; 以及用于检测荧光发射中的每个波长的检测器。 在另一个实施例中，该装置还包括聚焦激光器，用于保持物体在样本上的焦点。
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公开(公告)号：US20100227321A1
公开(公告)日：2010-09-09
申请号：US12618991
申请日：2009-11-16
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , B01J19/0046 , B01J2219/00432 , B01J2219/00436 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00527 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00707 , B01J2219/00722 , B82Y30/00 , C12Q1/6837 , C12Q1/6874 , C12Q2549/125
摘要： Methods of the invention comprise methods and devices for nucleic acid sequence determination. Generally, the invention relates to preparing a substrate for sequencing a target nucleic acid
摘要翻译： 本发明的方法包括用于核酸序列测定的方法和装置。 通常，本发明涉及制备用于测序靶核酸的底物
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8.发明申请公开(公告)号：US20070070349A1
公开(公告)日：2007-03-29
申请号：US11234420
申请日：2005-09-23
申请人： Timothy Harris , Philip Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley Lapidus
发明人： Timothy Harris , Philip Buzby , Mirna Jarosz , Jaime Gill , Howard Weiss , Stanley Lapidus
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , G01J3/10 , G01J3/36 , G01J3/4406 , G01N21/552 , G01N21/6428 , G01N21/6456 , G01N2021/6419 , G01N2021/6421 , G02B21/16 , G02B2207/113
摘要： In one aspect the invention relates to an apparatus for analyzing the presence of a single molecule using total internal reflection. In one embodiment an apparatus for single molecule analysis includes a support having a sample located thereon; two sources of light at distinct wavelengths, a collimator for directing the light onto the sample through a total internal reflection objective; a receiver for receiving a fluorescent emission produced by a single molecule in the sample in response to the light; and a detector for detecting each of the wavelengths in the fluorescent emission. In another embodiment the apparatus further comprises a focusing laser for maintaining focus of the objective on the sample.
摘要翻译： 一方面，本发明涉及一种使用全内反射来分析单个分子的存在的装置。 在一个实施方案中，用于单分子分析的装置包括具有位于其上的样品的载体; 两个不同波长的光源，用于通过全内反射物镜将光引导到样品上的准直器; 接收器，用于响应于光接收由样品中的单个分子产生的荧光发射; 以及用于检测荧光发射中的每个波长的检测器。 在另一个实施例中，该装置还包括聚焦激光器，用于保持物体在样本上的焦点。
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