公开(公告)号：US20100311614A1

公开(公告)日：2010-12-09

申请号：US12815832

申请日：2010-06-15

Applicant: Jean I. Montagu ,  Roger Dowd ,  David Root

Inventor： Jean I. Montagu ,  Roger Dowd ,  David Root

IPC: C40B40/02 ,  B05D3/06 ,  B05D3/02 ,  B05D1/18 ,  C40B40/00 ,  C40B40/06 ,  C40B40/08 ,  C40B40/10

CPC classification number: G01N33/544 ,  G01N33/54366

Abstract: An immobilizing device for biological material comprises a rigid support (12) carrying a substrate layer (20, 20′) of polymer having biological immobilizing properties, e.g. for amino and nucleic acids. Substantially solid ultra-thin substrate layers (20′) having a thickness less than about 5 micron, preferably between about 0.1 and 0.5 micron, and microporous, ultra-thin substrate layers (20′) having a thickness less than about 5 micron, preferably less than 3 micron, 2 or 1 micron are shown, which may be segmented by isolating moats M. The substrate layer is on a microscope slide (302), round disc (122), bio-cassette, at the bottom of a well of a multiwell plate, and as a coating inside a tube. Fluorescence or luminescence intensity and geometric calibration spots (420) are shown. Reading is enhanced by the intensity calibration spots (420) to enable normalization of readings under uneven illumination conditions, as when reading by dark field, side illumination mode. The reference spots are shown being printed simultaneously with printing an array of biological spots or with the same equipment. Methods of forming layers of the device include controlled drawing from a bath of coating composition and drying, and spinning of C-D shaped substrates. Post-forming treatment is shown by corona treatment and radiation. Adherent metal oxides (14), silica-based materials and other materials are used to unite layers of the composite. In multiwell plates the oxide promotes joining of a bottom plate (95, 95′) and upper, well-defining structure (94) of dissimilar material. The oxides (14) also provide beneficial opacity to prevent light entering the glass support, for applying potential to the substrate, etc.

Abstract translation: 用于生物材料的固定装置包括承载具有生物固定性质的聚合物的基底层（20,20'）的刚性支撑体（12），例如。 用于氨基和核酸。 具有厚度小于约5微米，优选约0.1至0.5微米的基本上固体的超薄基底层（20'）和厚度小于约5微米的微孔，超薄基底层（20'），优选地 示出了小于3微米，2或1微米，其可以通过分离护羊M分段。基底层在显微镜载玻片（302），圆盘（122），生物盒，在孔的底部 多孔板，以及管内的涂层。 显示荧光或发光强度和几何校准点（420）。 通过强度校准点（420）增强读数，以使得在不均匀照射条件下的读数正常化，如通过暗场，侧面照明模式读取。 参考点被显示为同时印刷生物斑点阵列或用相同的设备打印。 形成装置层的方法包括从涂料组合物的浴中进行控制拉伸和干燥，以及C-D形基材的纺丝。 后处理通过电晕处理和辐射显示。 使用粘附金属氧化物（14），二氧化硅基材料和其他材料来组合复合材料层。 在多孔板中，氧化物促进底板（95,95'）和不同材料的上部，良好限定结构（94）的接合。 氧化物（14）还提供有益的不透明性，以防止光进入玻璃支撑体，以将电位施加到基底等。

公开(公告)号：US07158224B2

公开(公告)日：2007-01-02

申请号：US10311820

申请日：2001-06-25

Applicant: Jean I. Montagu

Inventor： Jean I. Montagu

IPC: G01N21/01

CPC classification number: G01N21/648 ,  B01L2300/0654 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/0346 ,  G01N2021/6419 ,  G01N2021/6478 ,  G02B3/005 ,  G02B3/0068 ,  G02B21/002

Abstract: A device for optical examination of biological materials using radiation of a selected wavelength includes a substrate having a first surface and a second surface opposite to the first surface. The first surface includes a dense array of micro-optical elements arranged to provide increased intensity radiation or evanescent radiation. The first surface is in close proximity to the biological material being examined.

Abstract translation: 使用所选波长的辐射进行生物材料的光学检查的装置包括具有与第一表面相对的第一表面和第二表面的基板。 第一表面包括密集阵列的微光学元件，其布置成提供增强的辐射或渐逝辐射。 第一个表面紧邻被检查的生物材料。

公开(公告)号：US07095032B2

公开(公告)日：2006-08-22

申请号：US11145529

申请日：2005-06-03

Applicant: Jean I. Montagu ,  James W. Overbeck

Inventor： Jean I. Montagu ,  James W. Overbeck

IPC: G01N21/64

CPC classification number: G01N21/6458 ,  G01N21/6428 ,  G01N21/6452 ,  G02B21/16

Abstract: Microscopes, including viewing and other microscopic systems, employ a hinged, tiltable plate to adjust focus on a flat object such as a microscope slide or biochip by motion, achieved by tilting, which is substantially normal to the focus point on the plane of the object. By employing two such tiltable arrangements, relatively long scan lines of e.g., flying objective, single pixel on-axis scanning can be accommodated. The tilting support plate is specifically constructed to provide tailored locations for different objects in series along the Y axis of the plate. The plate can accommodate beaters and cooled plates and/or the flat object being examined. In a fluorescence scanning microscope, locations are specifically adapted to receive microscope slides and biochip cartridges such as Affymetrix's “Gene Chip®”. A scanning microscope under computer control, employing such a focusing action, enables unattended scanning of biochips with a simple and economical instrument. Also shown are flexure-mounting of a support plate to define the hinge axis, techniques for automatically determining position and focus, and a rotatably oscillating flying micro-objective scanner combined with the tilting plane focus system. Construction and control techniques are shown that realize simple and accurate focusing. Methods of examination of biological materials are disclosed. Simple and efficient focused scanning with a flying micro-objective of ordered arrays of nucleotides and nucleic acid fragments carried upon a microscope slide or other substrate is disclosed. Quantified fluorescence imaging is economically achieved by combined use of the described scanning and focusing arrangement and use of simple and accurate calibration modules respectively for example for Affymetrix's “Gene Chip” microarray modules and for microscope slides.

Abstract translation: 显微镜，包括观察和其他微观系统，采用铰接的可倾斜板，以通过倾斜来调节焦点在诸如显微镜载玻片或生物芯片的平面物体上，该倾斜基本上垂直于物体平面上的焦点 。 通过采用两个这样的可倾斜布置，例如飞行物镜的相对长的扫描线可以容纳单个像素的轴上扫描。 倾斜支撑板被特别地构造成为沿着板的Y轴串联的不同物体提供定制的位置。 该板可以容纳冲击器和冷却板和/或被检查的平面物体。 在荧光扫描显微镜中，位置特别适用于接收显微镜幻灯片和生物芯片盒，如Affymetrix的“Gene Chip”。 采用这种聚焦作用的计算机控制下的扫描显微镜可以通过简单经济的仪器进行无人值守的生物芯片扫描。 还示出了支撑板的弯曲安装以限定铰链轴线，用于自动确定位置和焦点的技术以及与倾斜平面聚焦系统组合的可旋转摆动的飞行微型物体扫描仪。 显示了实现简单准确聚焦的结构和控制技术。 公开了生物材料的检测方法。 公开了用显微镜载玻片或其它基底上携带的核苷酸和核酸片段的有序阵列的飞行微观目标的简单有效的聚焦扫描。 通过组合使用所述的扫描和聚焦装置以及分别使用简单且精确的校准模块，例如Affymetrix的“Gene Chip”微阵列模块和显微镜幻灯片，经济地实现了定量荧光成像。

公开(公告)号：US06269846B1

公开(公告)日：2001-08-07

申请号：US09122216

申请日：1998-07-24

Applicant: James W. Overbeck ,  Peter T. Flowers ,  Jean I. Montagu ,  Myles L. Mace ,  Peter Honkanen

Inventor： James W. Overbeck ,  Peter T. Flowers ,  Jean I. Montagu ,  Myles L. Mace ,  Peter Honkanen

IPC: B05C100

CPC classification number: B01L3/0244 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00364 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00691 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/0251 ,  B01L9/52 ,  B01L9/547 ,  B01L2200/025 ,  B01L2300/161 ,  B01L2400/022 ,  B01L2400/028 ,  B82Y30/00 ,  C40B60/14 ,  G01N21/6452 ,  G01N21/6458 ,  G01N35/1065 ,  G01N2035/1034 ,  G01N2035/1037 ,  G02B21/0036 ,  G02B21/0048 ,  G02B21/0072 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/34 ,  Y10T436/2575

Abstract: A fluid deposit assembly mounted on a carrier for depositing minute drops of fluid at selected locations upon a substrate, comprising a deposit element having an exposed tip of diameter of 0.3 mm or less constructed and arranged to carry and deposit drops of fluid upon the substrate, stable lateral reference surfaces or surface portions exposed for engagement by the deposit element, the surfaces or surface portions being constructed and arranged to prevent X, Y displacement of the deposit element relative to the carrier when the deposit element is urged thereagainst and design for urging the deposit element against the reference surfaces or surface portions at least at the time that the deposit element approaches a substrate to deposit a fluid drop. The reference surfaces or surface portions and the design for urging are cooperating to precisely position the deposit tip in a precisely desired position as it contacts the substrate. The deposit element is shown as the tip of an axially moveable pin. The reference surface portion is shown, among others, as a surface of revolution whose axis is disposed at a predetermined position relative to the carrier. A mobile supply in the form of a multiwell plate is moved under computer control to be a close companion of the deposit device, enabling rapid deposit action and avoidance of evaporative effects that can alter the consistency of dots in the array being formed. The device can deposit one dot on top of another from fluid in a mobile multiwell plate that moves to be close to the deposit device.

Abstract translation: 一种安装在载体上的流体沉积组件，用于在基板上的选定位置处沉积微滴流体，包括具有直径为0.3mm或更小的露出尖端的沉积元件，该沉积元件构造和布置成将流体的液滴携带并沉积在基底上， 稳定的横向参考表面或暴露以由沉积元件接合的表面部分，所述表面或表面部分被构造和布置成防止当沉积元件被推动时沉积元件相对于载体的X，Y位移，并设计成用于推动 至少在沉积元件接近基底以沉积流体液滴时，沉积元件抵靠参考表面或表面部分。 参考表面或表面部分以及用于施加的设计被配合以将沉积尖端精确地定位在接触基板的精确期望位置。沉积元件​​被示出为可轴向移动的销的尖端。 参考表面部分除其他外被示出为其轴线相对于载体设置在预定位置的旋转表面。 多孔板形式的移动电源在计算机控制下移动成为沉积装置的紧密配合，使得能够快速沉积动作并避免可能改变正在形成的阵列中的点的一致性的蒸发效应。 该装置可以将移动的多孔板中的流体上的另一个点放置在靠近沉积装置的位置。

公开(公告)号：US5235180A

公开(公告)日：1993-08-10

申请号：US847774

申请日：1992-03-05

Applicant: Jean I. Montagu

Inventor： Jean I. Montagu

IPC: G01D5/34

CPC classification number: G01D5/34

Abstract: An analog optical position transducer for detecting angular position of a rotatable member of a motor. The transducer includes a plurality of sensing surfaces placed in one frame of reference and a modulator located in another frame of reference, one of the frames of reference being stationary and the other moving with the rotatable member. The relative angular position of the two frames of reference is determined from the amount of light varied by the modulator and detected by the sensing surfaces. The modulator employs a radiation source which is located on a diffusive surface or which irradiates the diffusive surface of the modulator. Radiation emitted from the diffusive surface is modulated by the modulator depending on the relative position of the modulator and the sensing surfaces. A lens focuses the emitted radiation onto the sensing surfaces. The sensing surfaces are symmetrically arranged about an axis passing through the center of rotation of the rotor, and their relative distribution with respect to the surfaces of the modulator enables differential detection. An analog circuit connected to the sensing surfaces continuously determines the angular position of the rotatable member from the amount of light detected at each of the sensing surfaces. The system is effective to accurately position a mirror in a high speed laser scanner.

Abstract translation: 一种模拟光学位置传感器，用于检测电动机的可旋转构件的角位置。 换能器包括放置在一个参考框架中的多个感测表面和位于另一参考系的调制器中，一个参考框架是固定的，另一个框架与可旋转构件一起移动。 两个参考系的相对角位置由调制器改变的光量并由检测表面检测确定。 调制器采用辐射源，辐射源位于漫射表面上或照射调制器的漫射表面。 根据调制器和检测表面的相对位置，由调制器调制从扩散表面发射的辐射。 透镜将发射的辐射聚焦到感测表面上。 感测表面围绕通过转子旋转中心的轴对称地布置，并且它们相对于调制器表面的相对分布使得能够进行差分检测。 连接到感测表面的模拟电路从在每个感测表面处检测到的光量连续地确定可旋转构件的角位置。 该系统有效地准确地将镜子定位在高速激光扫描仪中。

公开(公告)号：US4694212A

公开(公告)日：1987-09-15

申请号：US842623

申请日：1986-03-21

Applicant: Jean I. Montagu

Inventor： Jean I. Montagu

IPC: F16C25/08 ,  F16C39/06 ,  H02K7/09 ,  H02K33/14 ,  H02K7/08

CPC classification number: F16C25/08 ,  F16C39/06 ,  H02K33/14 ,  H02K7/09

Abstract: Radial free play is reduced in rotor bearings of a limited rotation electromechanical actuator of the kind having a stator assembly with a plurality of stator pole faces, a rotor with a plurality of rotor pole faces, two bearings supporting opposite ends of the rotor and means for establishing magnetic flux across the gaps. In various aspects, the stator and rotor pole faces are cylindrical and the central axis of the rotor pole faces is tilted relative to the central axis of the stator pole faces; a region of a gap between the stator and rotor pole faces produces both the radial free-play-reducing forces and at least part of the driving torque; the gap rotor varies in size along its length but nowhere is so great as to have an effectively infinite reluctance; the gap varies continuously along its length; and each bearing has radial free play equal to at least 10% of twice the difference in the diameters of the stator and rotor pole faces.

Abstract translation: 具有具有多个定子极面的定子组件，具有多个转子极面的转子和支撑转子相对端的两个轴承的有限旋转机电致动器的转子轴承中的径向游隙减小，以及用于 在间隙上建立磁通量。 在各个方面，定子和转子极面是圆柱形的，转子极面的中心轴线相对于定子极面的中心轴线倾斜; 定子和转子极面之间的间隙的区域产生径向游隙减小力和驱动扭矩的至少一部分; 间隙转子的尺寸沿其长度变化，但是无法如此大以至于具有无限的磁阻; 间隙沿其长度不断变化; 并且每个轴承具有等于定子和转子极面的直径差的两倍的至少10％的径向游隙。

公开(公告)号：US4462014A

公开(公告)日：1984-07-24

申请号：US402432

申请日：1982-07-28

Applicant: Jean I. Montagu

Inventor： Jean I. Montagu

IPC: H01F7/14

CPC classification number: H01F7/145

Abstract: A limited-rotation actuator in which the rotor pole faces and corresponding stator pole faces are spaced apart along the axis of rotation, the rotor pole faces are permeably connected by a flux path having an axial component through the rotor, and the rotor and stator pole faces each subtend an angle of between about 90.degree. and about 180.degree. around the axis. The invention enables wide angle excursions of the rotor and inexpensive fabrication.

Abstract translation: 转子极面与对应的定子极面沿着旋转轴线间隔开的有限旋转致动器，转子极面通过具有通过转子的轴向分量的磁通路径可渗透地连接，转子和定子极 面对每个对象围绕轴线约90°至约180°之间的角度。 本发明能够实现转子的广角偏移和廉价的制造。

公开(公告)号：US4185215A

公开(公告)日：1980-01-22

申请号：US904910

申请日：1978-05-11

Applicant: Jean I. Montagu

Inventor： Jean I. Montagu

IPC: H02K21/12 ,  H02K7/116 ,  H02K21/14 ,  H02K7/10

CPC classification number: H02K21/145 ,  H02K7/116 ,  H02K2201/12

Abstract: A subfractional horsepower permanent magnet synchronous motor comprises an annular stator and a cup-form permanent magnet rotor defining an internal cylindrical volume. The rotor is supported for rotation within the stator about the axis of the motor and with an annular air gap between the stator and the cup-form rotor, and means including a stator coil is adapted to be energized to rotate the rotor relative to the stator. An output shaft coaxial with the rotor extends outwardly from one end of the stator, and a stationary support bushing for the output shaft extends into the internal volume defined by the rotor. A gear train is mounted in the space between the inward end of the support bushing and the closed end of the cup-form rotor, and is coupled between the rotor and the output shaft to provide a predetermined speed reduction ratio between the rotor and the output shaft. The gear train comprises at least three gear members, a first gear member cantilever mounted from the stationary support bushing, a second gear member cantilever mounted from the closed end of the cup-form rotor, and a third gear member mounted from said output shaft, one of the gear members comprising a cluster of two gears mounted in offset relation to the output shaft and the other two gear members being coaxial with the output shaft.

Abstract translation: 一个次级马力永磁同步电动机包括环形定子和限定内圆柱体积的杯形永磁转子。 转子被支撑成围绕电动机的轴线在定子内旋转，并且在定子和杯形转子之间具有环形空气间隙，并且包括定子线圈的装置适于通电以相对于定子旋转转子 。 与转子同轴的输出轴从定子的一端向外延伸，并且用于输出轴的固定支撑衬套延伸到由转子限定的内部容积中。 齿轮系安装在支撑衬套的内端和杯形转子的封闭端之间的空间中，并且联接在转子和输出轴之间以在转子和输出端之间提供预定的减速比 轴。 齿轮系包括至少三个齿轮构件，从固定支撑衬套安装的第一齿轮构件悬臂，从杯形转子的封闭端安装的第二齿轮构件悬臂和从所述输出轴安装的第三齿轮构件， 齿轮构件中的一个包括以输出轴偏置安装的两个齿轮组，而另外两个齿轮构件与输出轴同轴。

公开(公告)号：US20220330859A1

公开(公告)日：2022-10-20

申请号：US17803101

申请日：2022-02-07

Applicant: Jean I. Montagu

Inventor： Jean I. Montagu ,  William Bell ,  Sasha Montagu

IPC: A61B5/15 ,  G01N33/49 ,  A61B5/153 ,  A61B5/154 ,  B01D61/22 ,  A61M1/02 ,  G01N33/48 ,  B01D71/04

Abstract: An independent blood filter device depends on flow geometry to deliver blood serum or plasma free of detrimental levels of hemoglobin. It depends critically on an upstream flow rate or pressure differential limiting control element or device that limits the rate of change of pressure differential across the filter element. Pre-evacuated versions can be used to simultaneously draw blood from a living being and provide pressure differential across the filter element between an evacuated collector and a supply end open to atmosphere. A unit pressurized by hand motion employs the external shape of a partially filled blood collection tube as a piston to produce pressure in advance of the control element or device to create the pressure differential across the filter element to a collector vented to atmosphere. The control element or device is disclosed in numerous forms, including specially sized flow constrictions and compliant arrangements.

公开(公告)号：US20140042094A1

公开(公告)日：2014-02-13

申请号：US13829424

申请日：2013-03-14

Applicant: JEAN I. MONTAGU

Inventor： Jean I. Montagu ,  William Bell ,  Sasha Montagu

IPC: B01D61/22

CPC classification number: A61B5/150755 ,  A61B5/1411 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/15074 ,  A61B5/150946 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/154 ,  A61B5/155 ,  A61M1/0259 ,  B01D61/22 ,  B01D71/04 ,  G01N33/48 ,  G01N33/491

Abstract: An independent blood filter device depends on flow geometry to deliver blood serum or plasma free of detrimental levels of hemoglobin. It depends critically on an upstream flow rate or pressure differential limiting control element or device that limits the rate of change of pressure differential across the filter element. Pre-evacuated versions can be used to simultaneously draw blood from a living being and provide pressure differential across the filter element between an evacuated collector and a supply end open to atmosphere. A unit pressurized by hand motion employs the external shape of a partially filled blood collection tube as a piston to produce pressure in advance of the control element or device to create the pressure differential across the filter element to a collector vented to atmosphere. The control element or device is disclosed in numerous forms, including specially sized flow constrictions and compliant arrangements.

Abstract translation: 独立的血液过滤装置取决于流动几何形状，以输送不含血红蛋白有害水平的血清或血浆。 它严重依赖于限制过滤元件上的压差变化率的上游流量或压差限制控制元件或装置。 可以使用预抽真空的方式同时从生活中吸取血液，并在抽真空的收集器和向大气开放的供应端之间跨过滤元件提供压力差。 通过手动加压的单元采用部分填充的采血管的外部形状作为活塞，以在控制元件或装置之前产生压力，以产生跨越过滤元件的压力差到通向大气的收集器。 控制元件或装置以多种形式公开，包括特别尺寸的流动收缩和顺应装置。