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    Recombinant Spider Silk Protein Film and Method of Synthesizing
    3.
    发明申请
    Recombinant Spider Silk Protein Film and Method of Synthesizing 审中-公开
    重组蜘蛛丝蛋白膜及其合成方法

    公开(公告)号：US20150202651A1

    公开(公告)日：2015-07-23

    申请号：US14574235

    申请日：2014-12-17

    申请人： Randolph V. Lewis ,  Justin A. Jones ,  Chauncey L. Tucker

    发明人： Randolph V. Lewis ,  Justin A. Jones ,  Chauncey L. Tucker

    IPC分类号： B05D3/06 ,  A61K8/64 ,  A61K35/646 ,  B01D29/00 ,  A61L27/22 ,  G02B1/10 ,  C08J5/18 ,  B29C35/08 ,  A61Q19/00

    CPC分类号： B05D3/06 ,  A23V2002/00 ,  A61K8/0216 ,  A61K8/64 ,  A61K35/646 ,  A61K2800/10 ,  A61L27/227 ,  A61Q19/00 ,  B01D29/0093 ,  B29C35/08 ,  B29K2093/00 ,  B29L2007/00 ,  C08J5/18 ,  C08J2389/00 ,  G02B1/10 ,  Y10T428/31971 ,  Y10T442/20

    摘要： Methods for forming useful films using recombinant spider silk protein are discussed. In one embodiment, the method involves dissolving silk protein in a sufficient quantity to form a film suspended in a solvent. The solution is then mixed with a compound selected from water, acids, imidazole crosslinking agents, antibiotics, nanoparticles, surfactants and combinations thereof. Solubilisation of the protein in the solution is effected by microwave exposure. Once solubilized the microwave treated solution is poured onto a suitable substrate and dried in order to result in the final film, the protein may be plant, mammal or bacterially derived. The film has widespread use and can be combined with any one of a number of substrates, examples of which include: a cosmetic composition; a pharmaceutical or medical composition, drug delivery system, artificial cell, contact lens coating, sustained-release drug delivery system, artificial skin graft; food composition; automotive part; aeronautic component; computer or data storage device, building material, textile, filter material, membrane material, nanomaterial, electronic component and combinations thereof.

    摘要翻译： 讨论了使用重组蜘蛛丝蛋白形成有用膜的方法。 在一个实施方案中，该方法包括将丝蛋白溶解在足够的量中以形成悬浮在溶剂中的膜。 然后将溶液与选自水，酸，咪唑交联剂，抗生素，纳米颗粒，表面活性剂及其组合的化合物混合。 溶液中蛋白质的溶解是通过微波暴露来实现的。 一旦溶解，将微波处理的溶液倒入合适的底物上并干燥以产生最终的膜，蛋白质可以是植物，哺乳动物或细菌来源的。 该膜具有广泛的用途，并且可以与多种基材中的任一种组合，其实例包括：化妆品组合物; 药物或药物组合物，药物递送系统，人造细胞，隐形眼镜涂层，缓释药物递送系统，人造皮肤移植物; 食物成分; 汽车零件; 航空部件; 计算机或数据存储装置，建筑材料，纺织品，过滤材料，膜材料，纳米材料，电子部件及其组合。

    Methods and systems for using multiple data sets to analyze performance metrics of targeted companies
    7.
    发明授权
    Methods and systems for using multiple data sets to analyze performance metrics of targeted companies 有权
    使用多个数据集分析目标公司绩效指标的方法和系统

    公开(公告)号：US08380594B2

    公开(公告)日：2013-02-19

    申请号：US10972179

    申请日：2004-10-22

    申请人： Anthony Berkman ,  Seth Goldstein ,  Justin A Jones

    发明人： Anthony Berkman ,  Seth Goldstein ,  Justin A Jones

    IPC分类号： G06Q40/00

    CPC分类号： G06Q30/0201 ,  G06Q10/06393 ,  G06Q30/02 ,  G06Q40/00

    摘要： New and improved methods and systems for modeling the performance of selected company metrics. Multiple, non-traditional sets of objective data along with mathematical analytical techniques are used to provide transparency and visibility into company performance relating to the particular metrics. Company inflection points and changes in strategy may be identified. The performance of a company and/or the performance of a selected industry or industry sector may be analyzed.

    摘要翻译： 新的和改进的方法和系统，用于对所选公司指标的绩效进行建模。 使用多个非传统的客观数据集以及数学分析技术来提供与特定指标相关的公司绩效的透明度和可见度。 可以确定公司的拐点和策略的变化。 可以分析公司的表现和/或选定的行业或行业的表现。

    TRANSGENIC SILKWORMS EXPRESSING SPIDER SILK
    8.
    发明申请
    TRANSGENIC SILKWORMS EXPRESSING SPIDER SILK 审中-公开

    公开(公告)号：US20180288988A1

    公开(公告)日：2018-10-11

    申请号：US15942185

    申请日：2018-03-30

    申请人： Randolph V. Lewis ,  Lijin Xia ,  Xiaoli Zhang ,  Justin A. Jones

    发明人： Randolph V. Lewis ,  Lijin Xia ,  Xiaoli Zhang ,  Justin A. Jones

    IPC分类号： A01K67/033 ,  A01K67/04 ,  C12N15/85 ,  C12P21/02 ,  C07K14/435

    摘要： Transgenic silkworms stably expressing synthetic spider silk genes or composite silkworm/spider silk genes are disclosed. The exogenous spider silk genes are stably intergrated into a defined site of the fibroin heavy chain intron or a fibroin light chain intron of silkworms. Synthetic spider silk proteins and composite spider silk-silkworm genes and proteins are provided. The expression of exogenous spider silk genes is driven by the endogenous fibroin heavy chain promoter, improving the genetic stability of transgenic silkworms. The composite silkworm/spider silk fibers exhibit exceptional mechanical performance, compared to normal silkworm silk fibers and other transgenic silkworm fibers.