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公开(公告)号:US08529935B2
公开(公告)日:2013-09-10
申请号:US13147153
申请日:2010-01-29
申请人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano , Enzo Meani , Edgardo Cremascoli
发明人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano , Enzo Meani , Edgardo Cremascoli
IPC分类号: A61F2/00 , A61K33/00 , A61K6/083 , A61K31/70 , A61K31/715 , A61K31/65 , A61K31/497 , A61K31/44 , A61K33/38 , A61K33/34 , A61P31/00
CPC分类号: C08L5/08 , A61L27/34 , A61L27/52 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/406 , A61L2300/604 , C08B37/0072
摘要: The present invention relates to hydrogels endowed with antibacterial properties, to be used for injection in damaged bones or in the production of antibacterial coatings of prostheses for implant in the human or animal body, obtained by loading with antibacterial agents hydrogels formed by derivatives of hyaluronic acid; the invention also relates to a kit of parts for producing the antibacterial hydrogels.
摘要翻译: 本发明涉及具有抗菌特性的水凝胶,用于在受损骨骼中注射或用于人体或动物体内植入假体的抗菌涂层的制备,其通过装载抗菌剂由透明质酸衍生物形成的水凝胶 ; 本发明还涉及用于生产抗菌水凝胶的试剂盒。
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公开(公告)号:US20120025880A1
公开(公告)日:2012-02-02
申请号:US13191329
申请日:2011-07-26
申请人: Luca Romano , Alessandro Venca , Stefano Dal Toso , Antonio Milani , Brian Brunn
发明人: Luca Romano , Alessandro Venca , Stefano Dal Toso , Antonio Milani , Brian Brunn
IPC分类号: H03L7/08
CPC分类号: H03L7/08 , H03L7/07 , H03L7/0805 , H03L7/0816 , H03L7/16 , H03L7/1976
摘要: In one embodiment, an apparatus includes a jitter generator configured to receive a reference clock; add jitter to the reference clock; and output the reference clock with the included jitter to a phase lock loop (PLL). The PLL is used to generate a local oscillator (LO) signal for a transceiver. A jitter controller outputs a signal to the jitter generator to control a characteristic of the jitter added to the reference clock. The reference clock with the added jitter is used to reduce a fractional spur caused by a radio frequency (RF) attacker coupling into the PLL.
摘要翻译: 在一个实施例中,一种装置包括被配置为接收参考时钟的抖动发生器; 将抖动添加到参考时钟; 并将包含抖动的参考时钟输出到锁相环(PLL)。 PLL用于为收发器产生本地振荡器(LO)信号。 抖动控制器向抖动发生器输出信号,以控制添加到参考时钟的抖动特性。 具有增加的抖动的参考时钟用于减少由耦合到PLL的射频(RF)攻击者引起的分数杂散。
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公开(公告)号:US20130129800A1
公开(公告)日:2013-05-23
申请号:US13813422
申请日:2011-07-29
申请人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano' , Enzo Meani , Edgardo Cremascoli
发明人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano' , Enzo Meani , Edgardo Cremascoli
IPC分类号: A61K47/36
CPC分类号: A61K47/36 , A61L27/20 , A61L27/34 , A61L27/52 , A61L27/54 , A61L2300/258 , A61L2300/402 , A61L2300/414 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
摘要: The present invention relates to hydrogels based on hyaluronic acid based derivatives, that are more resistant than hyaluronic acid alone towards chemical and enzymatic degradation and are endowed with a mix of chemical and mechanical properties such that they are of optimal use in several surgeries, for instance for injection in bone fractures or cavities and for the production of coatings of prostheses in orthopedic surgery, as fillers in cosmetic and maxillo-facial surgery, as anti-adhesion barrier in the prevention of postoperative adhesions in abdominal and abdominal/pelvic surgery, and in general surgery. These hydrogels can be loaded with several different kinds of compounds having pharmacological and biological activity, that are then released from the hydrogel in the site of intervention.
摘要翻译: 本发明涉及基于透明质酸的衍生物的水凝胶,其比单独的透明质酸对化学和酶降解更具抗性,并且具有化学和机械性质的混合物,使得它们在几种手术中是最佳用途,例如 用于骨折或腔内注射和用于在整形外科手术中生产假体涂层,作为化妆品和上颌面手术中的填充剂,作为防止腹部和腹部/骨盆手术中术后粘连的抗粘连屏障,以及 一般手术。 这些水凝胶可以装载几种具有药理和生物活性的化合物,然后在介入部位从水凝胶中释放。
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公开(公告)号:US08421542B2
公开(公告)日:2013-04-16
申请号:US13104404
申请日:2011-05-10
申请人: Luca Romano , Randy Tsang
发明人: Luca Romano , Randy Tsang
IPC分类号: H03L7/08
CPC分类号: H03L7/099 , H03J2200/10 , H03L7/085 , H03L7/103 , H03L7/12 , H03L2207/06
摘要: Aspects of the disclosure provide a phase-locked loop (PLL). The PLL includes a voltage-controlled oscillator (VCO), a detector module, and a ramp module. The VCO has a first capacitor unit and a second capacitor unit. The VCO is configured to generate an oscillating signal having a frequency based on a first capacitance of the first capacitor unit and a second capacitance of the second capacitor unit. The detector module is configured to generate a voltage signal as a function of the oscillating signal and a reference signal. The voltage signal is used to control the first capacitor unit to stabilize the frequency of the oscillating signal. The ramp module is configured to generate a ramp signal based on the voltage signal. The ramp signal is used to control the second capacitor unit to ramp the second capacitance from a first value to a second value.
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公开(公告)号:US08400197B2
公开(公告)日:2013-03-19
申请号:US13191329
申请日:2011-07-26
申请人: Luca Romano , Alessandro Venca , Stefano Dal Toso , Antonio Milani , Brian Brunn
发明人: Luca Romano , Alessandro Venca , Stefano Dal Toso , Antonio Milani , Brian Brunn
IPC分类号: H03L7/06
CPC分类号: H03L7/08 , H03L7/07 , H03L7/0805 , H03L7/0816 , H03L7/16 , H03L7/1976
摘要: In one embodiment, an apparatus includes a jitter generator configured to receive a reference clock; add jitter to the reference clock; and output the reference clock with the included jitter to a phase lock loop (PLL). The PLL is used to generate a local oscillator (LO) signal for a transceiver. A jitter controller outputs a signal to the jitter generator to control a characteristic of the jitter added to the reference clock. The reference clock with the added jitter is used to reduce a fractional spur caused by a radio frequency (RF) attacker coupling into the PLL.
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公开(公告)号:US20120019327A1
公开(公告)日:2012-01-26
申请号:US13104404
申请日:2011-05-10
申请人: Luca ROMANO , Randy Tsang
发明人: Luca ROMANO , Randy Tsang
IPC分类号: H03L7/00
CPC分类号: H03L7/099 , H03J2200/10 , H03L7/085 , H03L7/103 , H03L7/12 , H03L2207/06
摘要: Aspects of the disclosure provide a phase-locked loop (PLL). The PLL includes a voltage-controlled oscillator (VCO), a detector module, and a ramp module. The VCO has a first capacitor unit and a second capacitor unit. The VCO is configured to generate an oscillating signal having a frequency based on a first capacitance of the first capacitor unit and a second capacitance of the second capacitor unit. The detector module is configured to generate a voltage signal as a function of the oscillating signal and a reference signal. The voltage signal is used to control the first capacitor unit to stabilize the frequency of the oscillating signal. The ramp module is configured to generate a ramp signal based on the voltage signal. The ramp signal is used to control the second capacitor unit to ramp the second capacitance from a first value to a second value.
摘要翻译: 本公开的方面提供了锁相环(PLL)。 PLL包括压控振荡器(VCO),检测器模块和斜坡模块。 VCO具有第一电容器单元和第二电容器单元。 VCO被配置为产生具有基于第一电容器单元的第一电容的频率和第二电容器单元的第二电容的振荡信号。 检测器模块被配置为产生作为振荡信号和参考信号的函数的电压信号。 电压信号用于控制第一电容器单元以稳定振荡信号的频率。 斜坡模块被配置为基于电压信号产生斜坡信号。 斜坡信号用于控制第二电容器单元以将第二电容从第一值斜坡化为第二值。
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公开(公告)号:US09283283B2
公开(公告)日:2016-03-15
申请号:US13813422
申请日:2011-07-29
申请人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano′ , Enzo Meani , Edgardo Cremascoli
发明人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano′ , Enzo Meani , Edgardo Cremascoli
IPC分类号: A61K47/36 , A61L27/20 , A61L27/34 , A61L27/52 , A61L27/54 , C08B37/08 , C08J3/075 , C08L5/08
CPC分类号: A61K47/36 , A61L27/20 , A61L27/34 , A61L27/52 , A61L27/54 , A61L2300/258 , A61L2300/402 , A61L2300/414 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08
摘要: The present invention relates to hydrogels based on hyaluronic acid based derivatives, that are more resistant than hyaluronic acid alone towards chemical and enzymatic degradation and are endowed with a mix of chemical and mechanical properties such that they are of optimal use in several surgeries, for instance for injection in bone fractures or cavities and for the production of coatings of prostheses in orthopedic surgery, as fillers in cosmetic and maxillo-facial surgery, as anti-adhesion barrier in the prevention of postoperative adhesions in abdominal and abdominal/pelvic surgery, and in general surgery. These hydrogels can be loaded with several different kinds of compounds having pharmacological and biological activity, that are then released from the hydrogel in the site of intervention.
摘要翻译: 本发明涉及基于透明质酸的衍生物的水凝胶,其比单独的透明质酸对化学和酶降解更具抗性,并且具有化学和机械性质的混合物,使得它们在几种手术中是最佳用途,例如 用于骨折或腔内注射和用于在整形外科手术中生产假体涂层,作为化妆品和上颌面手术中的填充剂,作为防止腹部和腹部/骨盆手术中术后粘连的抗粘连屏障,以及 一般手术。 这些水凝胶可以装载几种具有药理和生物活性的化合物,然后在介入部位从水凝胶中释放。
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公开(公告)号:US20110280921A1
公开(公告)日:2011-11-17
申请号:US13147153
申请日:2010-01-29
申请人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano , Enzo Meani , Edgardo Cremascoli
发明人: Gaetano Giammona , Giovanna Pitarresi , Fabio Palumbo , Carlo Luca Romano , Enzo Meani , Edgardo Cremascoli
IPC分类号: A61K9/00 , A61K33/34 , A61K33/30 , A61K33/24 , B05D1/00 , A61K38/14 , A61K31/7036 , A61K31/7048 , A61K31/702 , A61K31/65 , A61K31/5365 , A61K31/496 , A61K31/4409 , A61K31/343 , A61K31/132 , A61P31/04 , A61P31/10 , B05D1/18 , B05D1/02 , A61K33/38
CPC分类号: C08L5/08 , A61L27/34 , A61L27/52 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/406 , A61L2300/604 , C08B37/0072
摘要: The present invention relates to hydrogels endowed with antibacterial properties, to be used for injection in damaged bones or in the production of antibacterial coatings of prostheses for implant in the human or animal body, obtained by loading with antibacterial agents hydrogels formed by derivatives of hyaluronic acid; the invention also relates to a kit of parts for producing the antibacterial hydrogels.
摘要翻译: 本发明涉及具有抗菌特性的水凝胶,用于在受损骨骼中注射或用于人体或动物体内植入假体的抗菌涂层的制备,其通过装载抗菌剂由透明质酸衍生物形成的水凝胶 ; 本发明还涉及用于生产抗菌水凝胶的试剂盒。
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