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公开(公告)号：US20150028196A1
公开(公告)日：2015-01-29
申请号：US14369121
申请日：2013-01-03
Applicant: Danielle Toutoungi , Matthew Hart , John Somerville , Jon Pearson , Max Allsworth , Richard Orrell , Antoni Negri , Jeremy Spinks , Martin Holden , Andrew H. Koehl , Alistair Taylor
Inventor： Danielle Toutoungi , Matthew Hart , John Somerville , Jon Pearson , Max Allsworth , Richard Orrell , Antoni Negri , Jeremy Spinks , Martin Holden , Andrew H. Koehl , Alistair Taylor
CPC classification number: H01J49/061 , G01N27/624 , H01J49/0018 , H01J49/068 , Y10T29/49147 , Y10T29/49149
Abstract: Ion filter for FAIMS fabricated using the LIGA technique. The ion filter is manufactured using a metal layer to form the ion channels and an insulating support layer to hold the structure rigidly together after separation of the metal layer into two electrodes.
Abstract translation: 使用LIGA技术制造的FAIMS离子过滤器。 使用金属层制造离子过滤器以形成离子通道和绝缘支撑层，以将金属层分离成两个电极之后将结构刚性地保持在一起。
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公开(公告)号：US20140061459A1
公开(公告)日：2014-03-06
申请号：US13852675
申请日：2013-03-28
Applicant: Ashley Wilks , Matthew Hart , Stephen Hartwell , Alison Hart , Lara Jamieson , Max Allsworth , John Somerville
Inventor： Ashley Wilks , Matthew Hart , Stephen Hartwell , Alison Hart , Lara Jamieson , Max Allsworth , John Somerville
IPC: G01N27/62
CPC classification number: G01N27/624 , G01N27/622
Abstract: An apparatus, system and method for detecting, identifying, classifying and/or quantifying chemical species in a gas flow using a micro-fabricated ion filter coupled to a system adapted to apply drive signals to the ion filter. Coupled to the ion filter is a system adapted to measure the output of the ion filter, which in turn is coupled to a system adapted to extract numerical parameters from the measured output of the ion filter to facilitate chemical detection, identification, classification and/or quantification of the gas flow.
Abstract translation: 一种用于使用耦合到适于将驱动信号施加到离子过滤器的系统的微制造离子过滤器来检测，识别，分类和/或定量气流中的化学物质的装置，系统和方法。 耦合到离子过滤器的系统是适于测量离子过滤器的输出的系统，该系统又耦合到适于从离子过滤器的测量输出提取数值参数的系统，以促进化学检测，识别，分类和/或 气流量化。
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公开(公告)号：US20050096485A1
公开(公告)日：2005-05-05
申请号：US10825881
申请日：2004-04-16
Applicant: Thomas Scanlan , Matthew Hart , David Grandy , James Bunzow , Mononori Miyakawa , Edwin Tan , Katherine Suchland
Inventor： Thomas Scanlan , Matthew Hart , David Grandy , James Bunzow , Mononori Miyakawa , Edwin Tan , Katherine Suchland
IPC: A61K20060101 , A61K31/135 , A61K31/137 , A61K31/277 , A61K31/35 , C07C211/27 , C07C215/52 , C07C215/54 , C07C217/20 , C07C217/60 , C07C233/77 , C07C235/50 , C07C235/60 , C07C323/32
CPC classification number: C07C217/60 , C07C215/52 , C07C217/16 , C07C217/20 , C07C217/54 , C07C235/50 , C07C235/60 , C07C255/37 , C07C271/16 , C07C271/20
Abstract: Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed
Abstract translation: 公开了甲状腺胺衍生物和类似物，使用这些化合物的方法，以及含有它们的药物组合物。 还公开了制备这些化合物的方法
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公开(公告)号：US20100148051A1
公开(公告)日：2010-06-17
申请号：US12442921
申请日：2007-09-25
Applicant: Matthew Hart , Andrew Koehl
Inventor： Matthew Hart , Andrew Koehl
CPC classification number: H01J49/061 , G01N27/622 , H01J49/0018 , H01J49/421
Abstract: An ion filter (10) for use in ion mobility spectrometry is described, together with a method for manufacturing the filter. The filter (10) is manufactured by removing portions from a monolithic structure to form a pair of electrodes which remain mechanically connected. The connecting portion (22) provides sufficient electrical impedance between the electrodes to effectively electrically separate the electrodes. The connecting portion may be doped or chemically modified to obtain a desired impedance, or this may be obtained through appropriate selection of physical dimensions.
Abstract translation: 与用于制造过滤器的方法一起描述了用于离子迁移谱的离子过滤器（10）。 过滤器（10）通过从单片结构中移除部分以形成保持机械连接的一对电极来制造。 连接部分（22）在电极之间提供足够的电阻抗以有效地电分离电极。 连接部分可以被掺杂或化学修饰以获得期望的阻抗，或者这可以通过适当选择物理尺寸来获得。
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公开(公告)号：US06989232B2
公开(公告)日：2006-01-24
申请号：US09939853
申请日：2001-08-27
Applicant: Catherine E. Burgess , Pamela B. Conley , William M. Grosse , Matthew Hart , Ramesh Kekuda , Richard A. Shimkets , Kimberly A. Spytek , Edward Szekeres, Jr. , James E. Tomlinson , James N. Topper , Ruey-Bin Yang
Inventor： Catherine E. Burgess , Pamela B. Conley , William M. Grosse , Matthew Hart , Ramesh Kekuda , Richard A. Shimkets , Kimberly A. Spytek , Edward Szekeres, Jr. , James E. Tomlinson , James N. Topper , Ruey-Bin Yang
IPC: C12Q1/68
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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Patent Agency Ranking
公开(公告)号：US09443709B2
公开(公告)日：2016-09-13
申请号：US14355481
申请日：2012-11-16
Applicant: Max Allsworth , Matthew Hart , John Somerville
Inventor： Max Allsworth , Matthew Hart , John Somerville
IPC: H01J49/16
CPC classification number: H01J49/168 , G01N27/624
Abstract: A corona discharge ionizer device which emits ions generated by corona discharge to a gas flow to be ionized includes a discharge electrode having a pin configured tip portion. A second grid electrode positioned at a spaced distance from the discharge electrode is provided. The grid electrode is preferably formed from a sheet configured material which has at least one hole formed therein adapted and configured to permit the gas flow to pass therethrough. A power supply is coupled to the discharge electrode and grid electrode configured cause ion emission from the discharge electrode. The power supply is preferably an alternating current power supply configured to produce an alternating electric field region in close proximity to the tip portion of the discharge electrode sufficient to cause avalanche breakdown in the gas flowing in close proximity to the tip portion of the discharge electrode.
Abstract translation: 将通过电晕放电产生的离子发射到待离子化的气流的电晕放电电离器装置包括具有引脚配置的尖端部分的放电电极。 提供了与放电电极间隔开距离的第二栅电极。 栅格电极优选由片状构造材料形成，该片材构造材料具有形成在其中的至少一个孔，其适于并构造成允许气体流过其中。 电源耦合到放电电极，配置的栅电极引起来自放电电极的离子发射。 电源优选地是交流电源，其被配置为产生紧邻放电电极的尖端部分的交变电场区域，足以使得在靠近放电电极的尖端部分流动的气体中引起雪崩击穿。
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公开(公告)号：US20070059764A1
公开(公告)日：2007-03-15
申请号：US11229431
申请日：2005-09-15
Applicant: Matthew Hart , Horn Lin , Jay Eversole
Inventor： Matthew Hart , Horn Lin , Jay Eversole
CPC classification number: G01N33/54386 , G01N15/1459 , G01N2015/0046
Abstract: A device having an air sampler, an electrospray apparatus, and a fluorescence excitation and detection system. The air sampler is capable of moving air suspected of containing a biological or chemical aerosol particle into a chamber. The electrospray apparatus is capable of spraying a charged solution into the chamber to coat the aerosol particles with a coating. The solution has a fluorescent-labeled biological or chemical marker capable of specific binding to the aerosol particle. The fluorescence system is capable of detecting fluorescence of the fluorescent label in the coating. A method of detecting the aerosol particle by: moving air suspected of containing the aerosol particle into a chamber; spraying the charged solution into the chamber with an electrospray apparatus, such that a coating of the solution is formed around the particle; exciting the fluorescent label; and detecting fluorescence of the fluorescent label.
Abstract translation: 具有空气采样器，电喷射装置和荧光激发和检测系统的装置。 空气取样器能够将怀疑含有生物或化学气溶胶颗粒的空气移动到室中。 电喷射装置能够将带电溶液喷射到室中以用涂层涂覆气溶胶颗粒。 该溶液具有能够特异性结合气溶胶颗粒的荧光标记的生物或化学标记。 荧光系统能够检测涂层中荧光标记的荧光。 一种通过以下步骤检测气溶胶颗粒的方法：将怀疑含有气溶胶颗粒的空气移动到室中; 用电喷雾装置将带电溶液喷射到室中，使得在颗粒周围形成溶液的涂层; 激发荧光标签; 并检测荧光标记物的荧光。
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公开(公告)号：US09366649B2
公开(公告)日：2016-06-14
申请号：US13852675
申请日：2013-03-28
Applicant: Ashley Wilks , Matthew Hart , Stephen Hartwell , Alison Hart , Lara Jamieson , Max Allsworth , John Somerville
Inventor： Ashley Wilks , Matthew Hart , Stephen Hartwell , Alison Hart , Lara Jamieson , Max Allsworth , John Somerville
CPC classification number: G01N27/624 , G01N27/622
Abstract: An apparatus, system and method for detecting, identifying, classifying and/or quantifying chemical species in a gas flow using a micro-fabricated ion filter coupled to a system adapted to apply drive signals to the ion filter. Coupled to the ion filter is a system adapted to measure the output of the ion filter, which in turn is coupled to a system adapted to extract numerical parameters from the measured output of the ion filter to facilitate chemical detection, identification, classification and/or quantification of the gas flow.
Abstract translation: 一种用于使用耦合到适于将驱动信号施加到离子过滤器的系统的微制造离子过滤器来检测，识别，分类和/或定量气流中的化学物质的装置，系统和方法。 耦合到离子过滤器的系统是适于测量离子过滤器的输出的系统，该系统又耦合到适于从离子过滤器的测量输出提取数值参数的系统，以促进化学检测，识别，分类和/或 气流量化。
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公开(公告)号：US09177769B2
公开(公告)日：2015-11-03
申请号：US12442921
申请日：2007-09-25
Applicant: Matthew Hart , Andrew Koehl
Inventor： Matthew Hart , Andrew Koehl
CPC classification number: H01J49/061 , G01N27/622 , H01J49/0018 , H01J49/421
Abstract: An ion filter (10) for use in ion mobility spectrometry is described, together with a method for manufacturing the filter. The filter (10) is manufactured by removing portions from a monolithic structure to form a pair of electrodes which remain mechanically connected. The connecting portion (22) provides sufficient electrical impedance between the electrodes to effectively electrically separate the electrodes. The connecting portion may be doped or chemically modified to obtain a desired impedance, or this may be obtained through appropriate selection of physical dimensions.
Abstract translation: 与用于制造过滤器的方法一起描述了用于离子迁移谱的离子过滤器（10）。 过滤器（10）通过从单片结构中移除部分以形成保持机械连接的一对电极来制造。 连接部分（22）在电极之间提供足够的电阻抗以有效地电分离电极。 连接部分可以被掺杂或化学修饰以获得期望的阻抗，或者这可以通过适当选择物理尺寸来获得。
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公开(公告)号：US07981365B2
公开(公告)日：2011-07-19
申请号：US11229431
申请日：2005-09-15
Applicant: Matthew Hart , Horn Bond Lin , Jay Eversole
Inventor： Matthew Hart , Horn Bond Lin , Jay Eversole
IPC: G01N30/96
CPC classification number: G01N33/54386 , G01N15/1459 , G01N2015/0046
Abstract: A device having an air sampler, an electrospray apparatus, and a fluorescence excitation and detection system. The air sampler is capable of moving air suspected of containing a biological or chemical aerosol particle into a chamber. The electrospray apparatus is capable of spraying a charged solution into the chamber to coat the aerosol particles with a coating. The solution has a fluorescent-labeled biological or chemical marker capable of specific binding to the aerosol particle. The fluorescence system is capable of detecting fluorescence of the fluorescent label in the coating. A method of detecting the aerosol particle by: moving air suspected of containing the aerosol particle into a chamber; spraying the charged solution into the chamber with an electrospray apparatus, such that a coating of the solution is formed around the particle; exciting the fluorescent label; and detecting fluorescence of the fluorescent label.
Abstract translation: 具有空气采样器，电喷射装置和荧光激发和检测系统的装置。 空气取样器能够将怀疑含有生物或化学气溶胶颗粒的空气移动到室中。 电喷射装置能够将带电溶液喷射到室中以用涂层涂覆气溶胶颗粒。 该溶液具有能够特异性结合气溶胶颗粒的荧光标记的生物或化学标记。 荧光系统能够检测涂层中荧光标记的荧光。 一种通过以下步骤检测气溶胶颗粒的方法：将怀疑含有气溶胶颗粒的空气移动到室中; 用电喷雾装置将带电溶液喷射到室中，使得在颗粒周围形成溶液的涂层; 激发荧光标签; 并检测荧光标记物的荧光。
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