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公开(公告)号：US20160016140A1
公开(公告)日：2016-01-21
申请号：US14804675
申请日：2015-07-21
CPC分类号： B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
摘要： The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
摘要翻译： 本发明提供用于执行综合分析的系统，设备，方法和套件。 综合分析可以包括样品处理，库构建，扩增和测序。 集成分析可以在一个或多个流体连接的模块中进行。 一个或多个模块可以由计算机控制和/或自动化。 可以对组织样品，临床样品或环境样品进行综合分析。 集成分析系统可以具有紧凑的格式，并在指定的时间段内返回结果。
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公开(公告)号：US20130203634A1
公开(公告)日：2013-08-08
申请号：US13202884
申请日：2011-08-20
IPC分类号： C12Q1/68
CPC分类号： B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
摘要： The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
摘要翻译： 本发明提供用于执行综合分析的系统，设备，方法和套件。 综合分析可以包括样品处理，库构建，扩增和测序。 集成分析可以在一个或多个流体连接的模块中进行。 一个或多个模块可以由计算机控制和/或自动化。 可以对组织样品，临床样品或环境样品进行综合分析。 集成分析系统可以具有紧凑的格式，并在指定的时间段内返回结果。
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3.发明申请UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 有权通用样品制备系统及其在综合分析系统中的应用公开(公告)号：US20110005932A1
公开(公告)日：2011-01-13
申请号：US12795515
申请日：2010-06-07
申请人： Stevan B. JOVANOVICH , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
发明人： Stevan B. JOVANOVICH , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
IPC分类号： G01N27/447 , H01J5/16 , G01J1/58 , G01N21/64
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
摘要翻译： 本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。 例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。 该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。 在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。 在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。 墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。 该系统适合不超过10英尺3的外壳。 并且可以是封闭的，便携式的和/或电池供电的系统。 该系统可用于在不到4小时内从原始样品进行分析。
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公开(公告)号：US08394642B2
公开(公告)日：2013-03-12
申请号：US12795515
申请日：2010-06-07
申请人： Stevan B. Jovanovich , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
发明人： Stevan B. Jovanovich , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
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公开(公告)号：US08388908B2
公开(公告)日：2013-03-05
申请号：US12789186
申请日：2010-05-27
CPC分类号： F16K99/0015 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , B33Y80/00 , F16K99/0001 , F16K2099/0073 , Y10T137/0318 , Y10T137/2224 , Y10T137/87716 , Y10T156/10 , Y10T436/11 , Y10T436/2575
摘要： This invention provides fluidic devices, in particular microfluidic devices, with diaphragm valves having low failure rates. Low failure rates are achieved by inhibiting sticking of the diaphragm to functional surfaces such as valve seats, valve chamber and fluidic channels and conduits. One way to implement this is to provide exposed surfaces facing the diaphragm, particularly valve seats, with a low energy material, such as a noble metal, a perfluorinated polymer, a self-assembled monolayer, hard diamond, diamond-like carbon or a metal oxide. In other embodiments, the valves are provided with ridges and the diaphragm is adhered to the fluidic or actuation layer with an adhesive material.
摘要翻译： 本发明提供具有低故障率的隔膜阀的流体装置，特别是微流体装置。 通过抑制膜片到诸如阀座，阀室和流体通道和管道的功能表面的粘附来实现低故障率。 实现这一点的一种方法是提供面向隔膜，特别是阀座的暴露表面，其具有低能材料，例如贵金属，全氟化聚合物，自组装单层，硬金刚石，类金刚石碳或金属 氧化物。 在其他实施例中，阀设置有脊，并且隔膜用粘合剂材料粘附到流体或致动层。
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公开(公告)号：US20100303687A1
公开(公告)日：2010-12-02
申请号：US12789186
申请日：2010-05-27
CPC分类号： F16K99/0015 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , B33Y80/00 , F16K99/0001 , F16K2099/0073 , Y10T137/0318 , Y10T137/2224 , Y10T137/87716 , Y10T156/10 , Y10T436/11 , Y10T436/2575
摘要： This invention provides fluidic devices, in particular microfluidic devices, with diaphragm valves having low failure rates. Low failure rates are achieved by inhibiting sticking of the diaphragm to functional surfaces such as valve seats, valve chamber and fluidic channels and conduits. One way to implement this is to provide exposed surfaces facing the diaphragm, particularly valve seats, with a low energy material, such as a noble metal, a perfluorinated polymer, a self-assembled monolayer, hard diamond, diamond-like carbon or a metal oxide. In other embodiments, the valves are provided with ridges and the diaphragm is adhered to the fluidic or actuation layer with an adhesive material.
摘要翻译： 本发明提供具有低故障率的隔膜阀的流体装置，特别是微流体装置。 通过抑制膜片到诸如阀座，阀室和流体通道和管道的功能表面的粘附来实现低故障率。 实现这一点的一种方法是提供面向隔膜，特别是阀座的暴露表面，其具有低能材料，例如贵金属，全氟化聚合物，自组装单层，硬金刚石，类金刚石碳或金属 氧化物。 在其他实施例中，阀设置有脊，并且隔膜用粘合剂材料粘附到流体或致动层。
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公开(公告)号：US20120181460A1
公开(公告)日：2012-07-19
申请号：US13349832
申请日：2012-01-13
申请人： David Eberhart , Ezra Van Gelder
发明人： David Eberhart , Ezra Van Gelder
IPC分类号： F16K31/00
CPC分类号： F16K99/0015 , F16K99/0026 , F16K99/0059
摘要： This invention provides a device comprising at least one diaphragm valve actuated by a hydraulic actuation system. The device comprises a fluidics layer, an actuation layer and an elastic layer sandwiched between the fluidics layer and the actuation layer. The diaphragm valve comprises: a valve inlet and valve outlet comprised in the fluidics layer; a valve seat; a diaphragm comprised in the elastic layer; and an actuator. The diaphragm is actuatable to move into contact or out of contact with the valve seat, thereby closing or opening the diaphragm valve. The actuator comprises: a hydraulic conduit; a translator; and an incompressible fluid contained within the hydraulic conduit, wherein the incompressible fluid communicates with the translator and with the diaphragm. Translation of the translator transmits pressure through the incompressible fluid to actuate the diaphragm. The invention also provides systems including elements to operate the device and methods of using the device.
摘要翻译： 本发明提供了一种包括由液压致动系统致动的至少一个隔膜阀的装置。 该装置包括流体层，致动层和夹在流体层和致动层之间的弹性层。 隔膜阀包括：流体层中包括的阀入口和阀出口; 阀座; 包括在弹性层中的隔膜; 和致动器。 隔膜可致动以与阀座接触或脱离接触，从而关闭或打开隔膜阀。 致动器包括：液压管道; 翻译员 以及包含在液压管道内的不可压缩流体，其中不可压缩流体与平移器和隔膜连通。 翻译器的翻译通过不可压缩流体传递压力以致动隔膜。 本发明还提供了包括用于操作设备的元件和使用该设备的方法的系统。
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公开(公告)号：US20110240127A1
公开(公告)日：2011-10-06
申请号：US13075165
申请日：2011-03-29
申请人： David Eberhart , Ezra Van Gelder
发明人： David Eberhart , Ezra Van Gelder
CPC分类号： F16K99/0015 , B01J2219/00353 , B01J2219/00389 , B01J2219/00398 , B01J2219/00722 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/0861 , B01L2300/123 , B01L2300/165 , B01L2400/0655 , C40B50/08 , C40B60/14 , F16K99/0059 , Y10T137/0318 , Y10T137/8593 , Y10T428/13 , Y10T428/1397
摘要： In one aspect this invention provides an article fabricated in one piece comprising at least one aperture through the piece, wherein the aperture defines a non-microfluidic volume, and a microfluidic channel formed in a surface of the piece onto which the aperture opens, wherein the channel is in fluidic communication with the aperture, wherein the aperture and the microfluidic channel define a fluidic circuit.
摘要翻译： 在一个方面，本发明提供了一件制造的制品，其包括穿过该片的至少一个孔，其中孔限定非微流体体积，以及形成在该孔的开口的孔的表面中的微流体通道，其中， 通道与孔流体连通，其中孔径和微流体通道限定流体回路。
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公开(公告)号：US20110126911A1
公开(公告)日：2011-06-02
申请号：US12949623
申请日：2010-11-18
申请人： Boris Kobrin , Iuliu I. Blaga , William Nielsen , Shize D. Qi , Ezra Van Gelder
发明人： Boris Kobrin , Iuliu I. Blaga , William Nielsen , Shize D. Qi , Ezra Van Gelder
CPC分类号： F16K99/0001 , B01F11/0071 , B01F13/0059 , B32B7/02 , B32B9/04 , B33Y80/00 , F16K99/0015 , F16K99/0059 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T137/0318 , Y10T137/2213 , Y10T137/86453 , Y10T137/87249 , Y10T156/1039 , Y10T428/31504
摘要： This invention provides composite plastic articles and methods of making them. The articles can be fluidic or microfluidic devices having fluidic conduits and, optionally, pneumatic conduits that regulate flow in the fluidic conduits. The articles comprise a first substrate coated with a layer of a material that comprises, or onto which have been introduced, reactive groups. For example, the substrate can be a plastic coated with an oxide or a siloxane onto which hydroxyl groups have been introduced. These articles are covalently bonded with other articles comprising reactive groups on their surfaces, for example, polysiloxanes treated to have silanol groups. Certain articles have specified locations on their surfaces that are not bonded to the other piece. For example, the coating can be removed from these locations before bonding. Such locations can be useful as functional elements of various devices, such as valve seats in valves of microfluidic devices.
摘要翻译： 本发明提供复合塑料制品及其制造方法。 制品可以是具有流体导管的流体或微流体装置，以及可选地调节流体管道中的流动的气动导管。 制品包括涂覆有材料层的第一基材，其包含或已经引入反应性基团的材料层。 例如，基底可以是涂覆有已经引入羟基的氧化物或硅氧烷的塑料。 这些制品与其表面上包含反应性基团的其它制品共价键合，例如被处理为具有硅烷醇基团的聚硅氧烷。 某些物品在其表面上指定了未粘结到另一件的位置。 例如，可以在粘合之前从这些位置去除涂层。 这样的位置可以用作各种装置的功能元件，例如微流体装置的阀中的阀座。
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公开(公告)号：US08512538B2
公开(公告)日：2013-08-20
申请号：US13113968
申请日：2011-05-23
申请人： Lars Majlof , Ezra Van Gelder
发明人： Lars Majlof , Ezra Van Gelder
IPC分类号： G05D23/00 , G01N27/447 , G01N27/453
CPC分类号： G01N27/44708
摘要： This invention provides a capillary electrophoresis device in which capillaries are thermally regulated on a thermally responsive electrical path attached to an electrically insulating circuit board. This invention also provides an optical scanner useful for scanning an array of capillaries. A laser, optical detector and optical selector are in an arrangement that allows the optical detector to selectively detect an optical signal from any one or more of the plurality of electrophoresis capillaries.
摘要翻译： 本发明提供一种毛细管电泳装置，其中毛细管在附着于电绝缘电路板的热响应电路上进行热调节。 本发明还提供了一种用于扫描毛细管阵列的光学扫描仪。 激光器，光学检测器和光学选择器处于允许光学检测器选择性地检测来自多个电泳毛细管中的一个或多个的光学信号的布置。
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