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公开(公告)号：US5618715A
公开(公告)日：1997-04-08
申请号：US75199
申请日：1993-06-10
申请人： Mohammed Shoyab , Joyce M. Zarling , Hans Marquardt , Marcia B. Hanson , Najma Malik , Peter S. Linsley , Timothy M. Rose , Anthony F. Purchio
发明人： Mohammed Shoyab , Joyce M. Zarling , Hans Marquardt , Marcia B. Hanson , Najma Malik , Peter S. Linsley , Timothy M. Rose , Anthony F. Purchio
IPC分类号： A61K38/00 , C07K14/07 , C07K14/475 , C07K14/495 , C07K14/52 , C07K16/22 , C07K16/24 , C12N15/62 , C12N15/73 , C12N5/00 , C07H17/00 , C12N15/00 , C12P21/06
CPC分类号： C07K14/005 , A61K38/191 , A61K38/204 , C07K14/475 , C07K14/495 , C07K14/52 , C07K14/522 , C07K16/22 , C07K16/24 , C12N15/625 , C12N15/73 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N2710/24122
摘要： Novel compositions comprising Oncostatin M and congeners thereof, as well as methods for their preparation and methods for their use are provided. The compositions may be prepared by isolation from natural sources, or by recombinant means in either prokaryotic or eukaryotic host cells. In addition, the DNA and polypeptide sequences for Oncostatin M are disclosed. The compositions find use in modulating growth of cells, in particular inhibition of tumor cell proliferation, and stimulation of normal cell growth, especially cells involved in hematopoiesis. Cell growth inhibition compositions may additionally include an adjunctive agent comprising at least one of a transforming growth factor, tumor necrosis factor, or an interferon. Receptors having high affinity for Oncostatin M may additionally be used to screen polypeptides for Oncostatin M-like activity. Methods for use of antibodies to the compositions and probes specific for Oncostatin M mRNA as a means for detecting tumor cells are also provided.
摘要翻译： 提供了包含制瘤素M及其同源物的新型组合物，以及其制备方法及其使用方法。 组合物可以通过从天然来源或通过重组方法在原核或真核宿主细胞中分离来制备。 此外，公开了制瘤素M的DNA和多肽序列。 该组合物可用于调节细胞的生长，特别是抑制肿瘤细胞增殖，刺激正常的细胞生长，特别是涉及造血的细胞。 细胞生长抑制组合物可另外包括包含转化生长因子，肿瘤坏死因子或干扰素中的至少一种的辅助剂。 对制瘤素M具有高亲和力的受体可以另外用于筛选多肽用于制瘤素M样活性。 还提供了使用针对制瘤素M mRNA特异性的组合物和探针的抗体作为肿瘤细胞检测手段的方法。
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公开(公告)号：US4714683A
公开(公告)日：1987-12-22
申请号：US694712
申请日：1985-01-25
IPC分类号： A61K38/00 , C07K14/47 , C07K16/18 , G01N33/53 , G01N33/534 , G01N33/577 , G01N33/68
CPC分类号： C07K14/4703 , C07K16/18 , A61K38/00 , Y10S436/804 , Y10S930/12
摘要： Polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The small molecular weight polypeptides are growth inhibitors for neoplastic cells without inhibiting normal cells. The polypeptides comprise specific regions which are highly conserved, separated by less conserved regions. The polypeptides find use in inhibiting neoplastic growth and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the neoplastic cell retarding polypeptides.
摘要翻译： 提供多肽，多核苷酸序列，DNA构建体和组合物用于制备和使用与脑中发现的天然存在的多肽相关的多肽。 小分子量多肽是不抑制正常细胞的肿瘤细胞的生长抑制剂。 多肽包含高度保守的特定区域，由较不保守的区域分开。 多肽可用于抑制肿瘤生长并检测多肽的受体。 结合多肽提供抗体，其可以一起使用或分开用于检测肿瘤细胞阻滞多肽的存在。
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公开(公告)号：US5907033A
公开(公告)日：1999-05-25
申请号：US678922
申请日：1996-07-12
CPC分类号： C07K16/24 , C07K2317/34 , C07K2319/75 , Y10S530/866
摘要： The present invention relates to monoclonal antibodies that define Oncostatin M, a novel cytokine. The monoclonal antibodies of the invention are capable of binding to Oncostatin M, inhibiting Oncostatin M receptor binding, and/or inhibiting Oncostatin M bioactivity. Such antibodies may be used to detect the presence at Oncostatin M and/or to modulate Oncostatin M bioactivities in an in vivo or in vitro system.
摘要翻译： 本发明涉及定义制瘤素M（一种新型细胞因子）的单克隆抗体。 本发明的单克隆抗体能够结合制瘤素M，抑制制瘤素M受体结合和/或抑制制瘤素M生物活性。 这样的抗体可用于检测制瘤素M中的存在和/或在体内或体外系统中调节制瘤素M生物活性。
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公开(公告)号：US5681930A
公开(公告)日：1997-10-28
申请号：US943387
申请日：1992-09-10
CPC分类号： C07K16/24 , C07K2317/34 , C07K2319/75 , Y10S530/866
摘要： The present invention relates to monoclonal antibodies that define Oncostatin M, a novel cytokine. The monoclonal antibodies of the invention are capable of binding to Oncostatin M, inhibiting Oncostatin M receptor binding, and/or inhibiting Oncostatin M bioactivity. Such antibodies may be used to detect the presence at Oncostatin M and/or to modulate Oncostatin M bioactivities in an in vivo or in vitro system.
摘要翻译： 本发明涉及定义制瘤素M（一种新型细胞因子）的单克隆抗体。 本发明的单克隆抗体能够结合制瘤素M，抑制制瘤素M受体结合和/或抑制制瘤素M生物活性。 这样的抗体可用于检测制瘤素M中的存在和/或在体内或体外系统中调节制瘤素M生物活性。
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公开(公告)号：US4806492A
公开(公告)日：1989-02-21
申请号：US766864
申请日：1985-08-15
IPC分类号： C12P21/08 , A61K38/00 , A61K39/395 , A61P9/00 , A61P25/20 , A61P25/26 , A61P35/00 , A61P37/00 , A61P43/00 , C07C43/23 , C07C323/16 , C07C323/20 , C07D323/00 , C07D405/12 , C07H21/04 , C07K1/14 , C07K1/20 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C12N15/00 , C12N15/09 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91 , G01N33/50 , G01N33/53 , G01N33/531 , G01N33/534
CPC分类号： C07D405/12 , C07C323/16 , C07C323/20 , C07C43/23 , C07D323/00 , C07K14/4703 , C07K16/18 , A61K38/00 , Y10S436/804 , Y10S436/813 , Y10S530/828 , Y10S530/839
摘要： Novel polypeptides, polynucleotide sequences, DNA constructs and compositions are provided for the preparation and use of polypeptides associated with naturally occurring polypeptides found in brains. The small molecular weight polypeptides are growth inhibitors for neoplastic cells without inhibiting normal cells. The polypeptides comprise specific regions which are highly conserved, separated by less conserved regions. The polypeptides find use in inhibiting neoplastic growth and detecting receptors for the polypeptides. Antibodies are provided in conjunction with the polypeptides, which may be used together or separately for detecting the presence of the neoplastic cell retarding polypeptides.
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公开(公告)号：US5965723A
公开(公告)日：1999-10-12
申请号：US431333
申请日：1995-04-27
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12 , C12N15/18
CPC分类号： C07K14/475 , A61K38/00
摘要： A novel family of growth regulatory proteins termed "epithelins" are described. The epithelins comprise several distinct members sharing significant structural homology. Two members of the epithelin family, epithelin 1 and epithelin 2, have been purified from natural sources. In addition, cDNA and PCR clones encoding mature and precursor epithelins from various chordate sources have been obtained and sequenced, including the complete human, mouse and rat epithelin precursors. The recombinant expression of rat epithelin precursor and mature forms is described. Purified epithelin 1 is a bifunctional growth regulator, capable of stimulating the growth of some cell types while inhibiting the growth of others. Purified epithelin 2 is functionally similar to epithelin 1 with respect to growth inhibitory bioactivity. In contrast, however, epithelin 2 is apparently not capable of eliciting the growth stimulatory activity characteristic of epithelin 1 and, in fact, antagonizes this epithelin 1 activity.
摘要翻译： 描述了称为“上皮蛋白”的新型生长调节蛋白家族。 上皮蛋白包含具有重要结构同源性的几个不同成员。 上皮蛋白家族的两个成员，上皮蛋白1和上皮蛋白2已经从天然来源中纯化出来。 此外，已经获得并测序了编码来自各种脊索动物来源的成熟和前体上皮蛋白的cDNA和PCR克隆，包括完整的人，小鼠和大鼠上皮蛋白前体。 描述了大鼠上皮蛋白前体和成熟形式的重组表达。 纯化的上皮蛋白1是双功能生长调节剂，其能够刺激一些细胞类型的生长，同时抑制其他细胞的生长。 纯化的上皮蛋白2在功能上类似于上皮蛋白1相对于生长抑制生物活性。 然而，相比之下，上皮蛋白2显然不能引发上皮蛋白1的特征性生长刺激活性，实际上拮抗了上皮蛋白1的活性。
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公开(公告)号：US5885961A
公开(公告)日：1999-03-23
申请号：US429998
申请日：1995-04-27
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12 , C12N15/18 , A61K38/18
CPC分类号： C07K14/475 , A61K38/00
摘要： A novel family of growth regulatory proteins termed "epithelins" are described. The epithelins comprise several distinct members sharing significant structural homology. Two members of the epithelin family, epithelin 1 and epithelin 2, have been purified from natural sources. In addition, cDNA and PCR clones encoding mature and precursor epithelins from various chordate sources have been obtained and sequenced, including the complete human, mouse and rat epithelin precursors. The recombinant expression of rat epithelin precursor and mature forms is described. Purified epithelin 1 s a bifunctional growth regulator, capable of stimulating the growth of some cell types while inhibiting the growth of others. Purified epithelin 2 is functionally similar to epithelin 1 with respect to growth inhibitory bioactivity. In contrast, however, epithelin 2 is apparently not capable of eliciting the growth stimulatory activity characteristic of epithelin 1 and, in fact, antagonizes this epithelin 1 activity.
摘要翻译： 描述了称为“上皮蛋白”的新型生长调节蛋白家族。 上皮蛋白包含具有重要结构同源性的几个不同成员。 上皮蛋白家族的两个成员，上皮蛋白1和上皮蛋白2已经从天然来源中纯化出来。 此外，已经获得并测序了编码来自各种脊索动物来源的成熟和前体上皮蛋白的cDNA和PCR克隆，包括完整的人，小鼠和大鼠上皮蛋白前体。 描述了大鼠上皮蛋白前体和成熟形式的重组表达。 纯化的上皮蛋白1是双功能生长调节剂，能够刺激一些细胞类型的生长，同时抑制其他细胞的生长。 纯化的上皮蛋白2在功能上类似于上皮蛋白1相对于生长抑制生物活性。 然而，相比之下，上皮蛋白2显然不能引发上皮蛋白1的特征性生长刺激活性，实际上拮抗了上皮蛋白1的活性。
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8.发明授权Fanphiregulins: a family of heparin-binding epithelial cell growth factors 失效Fanphiregulins：一类肝素结合上皮细胞生长因子
公开(公告)号：US5830995A
公开(公告)日：1998-11-03
申请号：US885089
申请日：1992-05-18
IPC分类号： C12N1/21 , A61K38/00 , A61K39/395 , A61P17/00 , A61P35/00 , A61P43/00 , C07H21/04 , C07K1/20 , C07K7/08 , C07K9/00 , C07K14/435 , C07K14/485 , C07K14/495 , C07K14/52 , C07K16/00 , C07K16/22 , C07K16/24 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/70 , C12N15/85 , C12P21/02 , C12P21/08 , C12R1/19
CPC分类号： C07K14/52 , C07K14/485 , C07K14/495 , C07K16/22 , C12N15/70 , C12N15/85 , A61K38/00 , C07K2319/02 , C12N2800/108
摘要： The present invention is directed to a family of heparin-binding epithelial cell growth factors termed amphiregulins (AR). In particular, it relates to the isolation of AR genes from different animal species, expression of the genes, identification of various forms of biologically active AR products, purification of the AR products, antibodies specific for AR, and uses of AR. AR is detectable in several normal human epithelial cells and in a high percentage of human colon cancers. In addition to stimulating the growth of these cultured epithelial cells, AR may have a wide range of applications including, but not limited to, accelerating the growth of normal epithelial cells. In some tumor cell lines, primarily of breast or ovarian carcinomas, AR serves as a direct growth inhibitor. On the other hand, AR may function as a growth stimulatory molecule in colorectal carcinomas and other pathologies of increased epithelial proliferation. In this regard AR may serve as a useful marker for disease staging and prognosis and reagents that specifically block AR may be of therapeutic use in controlling tumor cell growth and in disorders such as psoriasis.
摘要翻译： 本发明涉及称为安非他命（AR）的肝素结合上皮细胞生长因子家族。 特别涉及分离来自不同动物物种的AR基因，基因的表达，各种形式的生物活性AR产物的鉴定，AR产物的纯化，AR特异的抗体和AR的用途。 AR在几种正常的人上皮细胞和高百分比的人结肠癌中是可检测的。 除了刺激这些培养的上皮细胞的生长之外，AR可以具有广泛的应用，包括但不限于加速正常上皮细胞的生长。 在一些肿瘤细胞系中，主要是乳腺癌或卵巢癌，AR用作直接生长抑制剂。 另一方面，AR可能在结肠直肠癌和其他增加上皮细胞增殖的病理学中起到促生长分子的作用。 在这方面，AR可以用作疾病分期和预后的有用标志物，并且特异性阻断AR可能在控制肿瘤细胞生长和疾病如牛皮癣中具有治疗用途的试剂。
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公开(公告)号：US5811098A
公开(公告)日：1998-09-22
申请号：US484438
申请日：1995-06-07
申请人： Gregory D. Plowman , Jean-Michel Culouscou , Mohammed Shoyab , Clay B. Siegall , Ingegerd Hellstrom , Karl E. Hellstrom
发明人： Gregory D. Plowman , Jean-Michel Culouscou , Mohammed Shoyab , Clay B. Siegall , Ingegerd Hellstrom , Karl E. Hellstrom
IPC分类号： A61K47/48 , C07K14/475 , C07K16/28 , A61K39/00
CPC分类号： C07K14/4756 , A61K47/48561 , C07K16/2863 , G01N2333/4756
摘要： The molecular cloning, expression, and biological characteristics of a novel receptor tyrosine kinase related to the epidermal growth factor receptor, termed HER4/p180.sup.erbB4, are described. Antibodies to HER4 are disclosed. A HER4 ligand capable of inducing cellular differentiation of breast cancer cells is also disclosed. In view of the expression of HER4 in several human cancers and in certain tissues of neuronal and muscular origin, various diagnostic and therapeutic uses of HER4-derived and HER4-related biological compositions are provided.
摘要翻译： 描述了与表皮生长因子受体相关的新受体酪氨酸激酶的分子克隆，表达和生物学特征，称为HER4 / p180erbB4。 公开了HER4抗体。 还公开了能够诱导乳腺癌细胞的细胞分化的HER4配体。 鉴于HER4在几种人类癌症和神经元和肌肉起源的某些组织中的表达，提供了HER4衍生和HER4相关生物组合物的各种诊断和治疗用途。
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公开(公告)号：US5077312A
公开(公告)日：1991-12-31
申请号：US603520
申请日：1990-10-26
申请人： Mohammed Shoyab , George J. Todaro
发明人： Mohammed Shoyab , George J. Todaro
IPC分类号： A61K31/23 , G01N33/569
CPC分类号： G01N33/569 , A61K31/23
摘要： Neutral lipids are provided characterized by binding to phorboid and ingenoid receptors. These lipids are found in a wide variety of cellular sources as well as milk and may be isolated by specific extraction and chromatographic procedures. Depending upon the source, the glycerides may be mono- or di-glycerides, wherein the total number of carbon atoms of the fatty acids is in the range of 18 to 26, so that the monoglyceride has a fatty acid of at least 18 carbon atoms, while the di-glyceride has a fatty acid of at least 14 carbon atoms.
摘要翻译： 提供中性脂质，其特征在于结合到佛波和受体。 这些脂质存在于各种细胞来源以及牛奶中，并可通过特异性萃取和色谱法分离。 取决于来源，甘油酯可以是甘油单酯或二甘油酯，其中脂肪酸的总碳原子数在18至26的范围内，使得单酸甘油酯具有至少18个碳原子的脂肪酸 而甘油二酯具有至少14个碳原子的脂肪酸。
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