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公开(公告)号：US20140206956A1
公开(公告)日：2014-07-24
申请号：US14237019
申请日：2012-08-01
申请人： Elisha Rabinovitz , Zvika Gilad , Osnat Sella-Tavor , Amit Pascal
发明人： Elisha Rabinovitz , Zvika Gilad , Osnat Sella-Tavor , Amit Pascal
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1459 , A61B5/1473 , G01N33/53 , A61B5/07
CPC分类号： A61B5/14503 , A61B1/041 , A61B5/0084 , A61B5/061 , A61B5/07 , A61B5/1032 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/1473 , A61B5/6861 , A61B2562/0295 , A61B2562/162 , G01N21/6428 , G01N21/78 , G01N21/8483 , G01N33/5302 , G01N33/54386 , G01N33/558
摘要： In vivo devices, systems and methods for in vivo immunoassay include inserting into a patient's body lumen an in vivo diagnostic device comprising a housing. The housing of the device comprises a chamber, and a chromatography strip for immunoassay of a body lumen substance. The housing may further comprise a casing for the chromatography strip. The casing may comprise a first opening to allow entrance of in vivo liquids into the casing and a second opening into the chamber. The housing may further comprise a sensor to sense a property of the chromatography strip. Following insertion of the device into the patient's body, a sample is collected and the immunoassay is performed in vivo in areas of pathological lesions for a predetermined period of time. An in vivo image may be acquired or other data such as colorimetric or intensity data may be obtained from the chromatography strip.
摘要翻译： 用于体内免疫测定的体内装置，系统和方法包括将包括外壳的体内诊断装置插入患者体腔。 该装置的外壳包括室和用于体内物质的免疫测定的色谱条。 壳体还可以包括用于色谱条的壳体。 壳体可以包括允许体内液体进入壳体的第一开口和进入腔室的第二开口。 壳体还可以包括感测色谱条的性质的传感器。 在将装置插入患者体内后，收集样品，并在病理损伤区域内进行预定时间段的免疫测定。 可以获取体内图像，或者可以从色谱条获得其他数据，例如比色或强度数据。
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2.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer 有权核苷酸和氨基酸序列，以及其用于诊断卵巢癌的测定和方法公开(公告)号：US07906635B2
公开(公告)日：2011-03-15
申请号：US12354641
申请日：2009-01-15
申请人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad S. Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/156 , Y10T436/143333
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
摘要翻译： 卵巢癌的新型标志物既敏感又准确。 与卵巢正常组织相反，这些标志物特异性地在卵巢癌中过表达和/或差异表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与卵巢癌中可能诊断相关的信息。 本发明的标记物单独或组合显示卵巢癌与非癌状态之间的高度差异检测。
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3.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis 有权核苷酸和氨基酸序列，以及用于诊断的测定及其使用方法公开(公告)号：US07842459B2
公开(公告)日：2010-11-30
申请号：US11051646
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
发明人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
摘要翻译： 新型剪接变体核酸序列。 根据本发明的新型剪接变体及其核酸序列可任选地用于诊断如本文所述的变体可检测的疾病。
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4.发明授权Diagnostic markers, especially for in vivo imaging and assays and methods of use thereof 失效诊断标记，特别是用于体内成像和测定及其使用方法公开(公告)号：US07741433B2
公开(公告)日：2010-06-22
申请号：US11929570
申请日：2007-10-30
申请人： Sarah Pollock , Anat Cohen-Dayag , Osnat Sella-Tavor , Shirley Sameah-Greenwald , Shira Walach , Lily Bazak
发明人： Sarah Pollock , Anat Cohen-Dayag , Osnat Sella-Tavor , Shirley Sameah-Greenwald , Shira Walach , Lily Bazak
IPC分类号： C07K5/00
CPC分类号： C12Y304/21109 , C12N9/6424 , C12Q1/6886 , C12Q2600/106
摘要： Novel splice variants as diagnostic markers, preferably membrane-bound. The novel variants according to the present invention may optionally be used for diagnosis of Marker-detectable disease as described herein, optionally through immunohistochemistry.
摘要翻译： 新型剪接变体作为诊断标记，优选膜结合。 根据本发明的新型变体可任选地通过免疫组织化学方法用于本文所述的可标记可检测疾病的诊断。
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5.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis 有权新型核苷酸和氨基酸序列，以及用于诊断的测定和方法公开(公告)号：US20100120022A1
公开(公告)日：2010-05-13
申请号：US11051646
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
发明人： Michal Ayalon-Soffer , Sarah Pollock , Ronen Shemesh , Rotem Sorek , Zurit Levine , Zipi Shaqed , Amir Toporik , Gad S. Cojocaru , Dvir Dahary , Guy Kol , Pinchas Akiva , Amit Novik , Sergey Nemzer , Alexander Diber , Maxim Shklar , Osnat Sella-Tavor , Lily Bazak , Ariel Farkash , Yossi Cohen
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
摘要翻译： 新型剪接变体核酸序列。 根据本发明的新型剪接变体及其核酸序列可任选地用于诊断如本文所述的变体可检测的疾病。
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6.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease 失效核苷酸和氨基酸序列，以及其用于诊断心脏病的测定和方法公开(公告)号：US07714100B2
公开(公告)日：2010-05-11
申请号：US11978203
申请日：2007-10-29
申请人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
发明人： Yossi Cohen , Alexander Diber , Amir Toporik , Sarah Pollock , Zurit Levine , Michal Ayalon-Soffer , Gad S. Cojocaru , Amit Novik , Guy Kol , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Dvir Dahary , Ronen Shemesh
IPC分类号： A61K38/00
CPC分类号： C07K14/705 , C07H21/04 , C07K16/18 , C07K2317/34 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2800/324 , G01N2800/325 , G01N2800/327
摘要： Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of cardiac disease, including pathology and/or damage, including acute and/or chronic damage. The markers of the present invention, alone or in combination, show a high degree of differential detection between cardiac disease states and non-cardiac disease states.
摘要翻译： 心脏疾病的新型标志物既敏感又准确。 与其他类型的组织相反，这些标记在心脏组织中是有差别地和/或特异性表达的，任选地和优选地包括肌肉组织。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与心脏病的可能诊断相关的信息，包括病理学和/或损伤，包括急性和/或慢性损伤。 本发明的标记物单独或组合显示心脏疾病状态与非心脏疾病状态之间的高度差异检测。
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7.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of lung cancer 失效新型核苷酸和氨基酸序列，以及其用于诊断肺癌的测定和方法公开(公告)号：US20060046257A1
公开(公告)日：2006-03-02
申请号：US11051720
申请日：2005-01-27
申请人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad Cojocaru , Michal Ayalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
发明人： Sarah Pollock , Zurit Levine , Amit Novik , Dvir Dahary , Rotem Sorek , Amir Toporik , Shirley Sameah-Greenwald , Osnat Sella-Tavor , Alexander Diber , Gad Cojocaru , Michal Ayalon-Soffer , Shira Walach , Pinchas Akiva , Naomi Keren , Ronen Shemesh
IPC分类号： C12Q1/68
CPC分类号： G01N33/57423 , C12Q1/6886 , C12Q2600/112
摘要： Novel markers for lung cancer that are both sensitive and accurate. These markers are overexpressed in lung cancer specifically, as opposed to normal lung tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of lung cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between lung cancer and non-cancerous states.
摘要翻译： 肺癌的新型标志物既敏感又准确。 与正常肺组织相反，这些标志物特异性地在肺癌中过度表达。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与肺癌可能诊断相关的信息。 本发明的标记物单独或组合显示出肺癌和非癌状态之间的高度差异检测。
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8.发明申请公开(公告)号：US20060040278A1
公开(公告)日：2006-02-23
申请号：US11050857
申请日：2005-01-27
申请人： Gad Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
发明人： Gad Cojocaru , Sarah Pollock , Zurit Levine , Alexander Diber , Guy Kol , Amir Toporik , Rotem Sorek , Dvir Dahary , Michal Ayalon-Soffer , Pinchas Akiva , Amit Novik , Yossi Cohen , Osnat Sella-Tavor , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Maxim Shklar
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
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公开(公告)号：US08515507B2
公开(公告)日：2013-08-20
申请号：US12485665
申请日：2009-06-16
IPC分类号： A61B5/1455
CPC分类号： A61B5/0071 , A61B1/041 , A61B1/043 , A61B5/0084
摘要： Devices, systems and methods for detecting in vivo pathology are provided. An in vivo sensing device comprises a reacting layer with at least one type of binding agent attached thereon, a sensor configured for sensing an optical change occurring on the reacting substrate, and at least one illumination source. In-vivo fluids are in constant contact with the reacting substrate so that in vivo marker indicating pathology may bind to the binding agent attached onto the reacting layer and may be viewed by the sensor.
摘要翻译： 提供用于检测体内病理学的装置，系统和方法。 体内感测装置包括具有附着在其上的至少一种类型的粘合剂的反应层，被配置为感测在反应基底上发生的光学变化的传感器和至少一个照明源。 体内流体与反应底物恒定接触，使体内标记指示病理学可以结合附着在反应层上的结合剂并且可以由传感器观察。
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公开(公告)号：US20100075891A1
公开(公告)日：2010-03-25
申请号：US11043770
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。 还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，其使用本发明的新型多肽和多核苷酸作为诊断标记。
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