-
公开(公告)号：US20120309635A1
公开(公告)日：2012-12-06
申请号：US13588984
申请日：2012-08-17
Applicant: Linda Trinkle , R. Terry Dunlay , Bruce Edwards , Larry Sklar
Inventor： Linda Trinkle , R. Terry Dunlay , Bruce Edwards , Larry Sklar
CPC classification number: G01N15/14 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0684 , B01L2300/0829 , B01L2300/0832 , B01L2300/0877 , B01L2400/0481 , G01N15/1404 , G01N35/08 , G01N35/1067 , G01N35/1074 , G01N35/1095 , G01N2015/0019
Abstract: Embodiments of the present invention provide a system and method for analyzing a plurality of samples comprising obtaining with an autosampler a plurality of samples from a first plate having a plurality of sample wells wherein the autosampler has a plurality of probes for sampling a set of samples and wherein each probe of the plurality of probes is in communication with a separate flow cytometer via a separate conduit. The plurality of samples comprising particles is moved into a fluid flow stream for each separate conduit. Adjacent ones of the plurality of samples are separated from each other in the fluid flow stream by a separation gas, thereby forming a gas-separated fluid flow stream. The gas-separated fluid flow stream is independently guided to and through each separate flow cytometer.
Abstract translation: 本发明的实施方案提供了一种用于分析多个样品的系统和方法，包括用自动进样器从具有多个样品孔的第一板获得多个样品，其中所述自动进样器具有用于对一组样品进行取样的多个探针， 其中所述多个探针中的每个探针经由单独的导管与独立的流式细胞仪连通。 将包含颗粒的多个样品移动到用于每个单独管道的流体流动流中。 通过分离气体在流体流动流中将多个样品中的相邻的样品彼此分离，从而形成气体分离的流体流动流。 气体分离的流体流被独立地引导并通过每个单独的流式细胞仪。
-
2.发明授权Machine readable storage media for detecting distribution of macromolecules between nucleus and cytoplasm in cells 有权用于检测细胞中细胞核和细胞质之间大分子分布的机读存储介质公开(公告)号：US06671624B1
公开(公告)日：2003-12-30
申请号：US09724376
申请日：2000-11-27
Applicant: R. Terry Dunlay , D. Lansing Taylor , Albert H. Gough , Kenneth A. Giuliano
Inventor： R. Terry Dunlay , D. Lansing Taylor , Albert H. Gough , Kenneth A. Giuliano
IPC: G01N3348
CPC classification number: G01N15/1475 , B01J2219/00315 , B01J2219/00317 , B01J2219/00707 , B01J2219/00743 , B82Y5/00 , B82Y30/00 , C12Q1/68 , C12Q1/6813 , C40B60/14 , G01N35/00871 , G01N2015/1486 , G01N2015/1497 , C12Q2525/179
Abstract: The present invention provides systems, methods, and screens for an optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a high magnification fluorescence optical system, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
Abstract translation: 本发明提供用于细胞的光学系统分析的系统，方法和屏幕，以快速确定细胞中荧光标记的报道分子的分布，环境或活性，目的是筛选特定影响特定生物的那些化合物的大量化合物 功能。 本发明涉及在位置阵列中提供含有荧光报道分子的细胞，并用高倍放大荧光光学系统扫描每个位置中的多个细胞，将光学信息转换为数字数据，并利用数字数据确定分布，环境或活性 的荧光标记的报告分子在细胞中。 位置阵列可以是工业标准96孔或384孔微量滴定板或微板，其是具有位置微距阵列中的细胞的微孔板。 本发明包括用于处理，显示和存储数据的装置和计算机化方法。
-
公开(公告)号：US06620591B1
公开(公告)日：2003-09-16
申请号：US09293210
申请日：1999-04-16
Applicant: R. Terry Dunlay , D. Lansing Taylor
Inventor： R. Terry Dunlay , D. Lansing Taylor
IPC: G01N33533
CPC classification number: B82Y30/00 , B01J2219/00315 , B01J2219/00317 , B01J2219/00707 , B01J2219/00743 , B01L3/5085 , C12Q1/68 , C12Q1/6813 , C40B60/14 , G01N15/1475 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N33/5005 , G01N33/5035 , G01N33/582 , G01N2015/1486 , G01N2015/1497 , G01N2021/6419 , G01N2021/6482 , G02B21/16 , G02B21/365 , Y10S436/80 , Y10S436/807 , Y10S436/809 , Y10S977/795 , Y10S977/881 , Y10S977/92 , Y10S977/941 , Y10S977/942 , C12Q2525/179
Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
Abstract translation: 本发明涉及用于确定荧光标记的报道分子在细胞中的分布，环境或活性的光学系统，以筛选大量用于特定生物活性的化合物。 本发明涉及在荧光显微镜的阵列中提供含有荧光报告分子的细胞，并用荧光显微镜扫描各个位置的多个细胞，将光学信息转换为数字数据，并利用数字数据确定荧光的分布，环境或活性 标记的细胞中的报告分子。 位置阵列可以是工业标准96孔或384孔微量滴定板或微板，其是具有位置微距阵列中的细胞的微孔板。 本发明包括用于处理，显示和存储数据的装置和计算机化方法。
-
4.发明授权Automated method and system for setting image analysis parameters to control image analysis operations 有权用于设置图像分析参数以控制图像分析操作的自动方法和系统公开(公告)号：US08121383B2
公开(公告)日：2012-02-21
申请号：US12889496
申请日：2010-09-24
Applicant: Michael A. Sipe , R. Terry Dunlay
Inventor： Michael A. Sipe , R. Terry Dunlay
CPC classification number: G06T7/0012 , G06K9/00127 , G06T7/42 , G06T2207/20008 , G06T2207/20012 , G06T2207/20081 , G06T2207/30024
Abstract: A method and system for setting image analysis parameters to control image analysis operations. The method and system include collecting set of digital training images including a set of states for the set of digital training images. An objective function is defined to determine a relative quality of plural different parameter sets used for digital image analysis. Values for the plural different parameter sets that maximize (or minimize) the objective function are determined. The method and system increases a usability of high content screening technologies by reducing a required level of expertise required to configure digital image processing.
Abstract translation: 一种用于设置图像分析参数以控制图像分析操作的方法和系统。 该方法和系统包括收集数字训练图像的集合，包括用于该组数字训练图像的一组状态。 定义目标函数以确定用于数字图像分析的多个不同参数集的相对质量。 确定最大化（或最小化）目标函数的多个不同参数集的值。 该方法和系统通过减少配置数字图像处理所需的专业知识水平，增加了高内容筛选技术的可用性。
-
公开(公告)号：US07853409B2
公开(公告)日：2010-12-14
申请号：US11809937
申请日：2007-06-04
Applicant: R. Terry Dunlay , D. Lansing Taylor
Inventor： R. Terry Dunlay , D. Lansing Taylor
CPC classification number: B82Y30/00 , B01J2219/00315 , B01J2219/00317 , B01J2219/00707 , B01J2219/00743 , B01L3/5085 , C12Q1/68 , C12Q1/6813 , C40B60/14 , G01N15/1475 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N33/5005 , G01N33/5035 , G01N33/582 , G01N2015/1486 , G01N2015/1497 , G01N2021/6419 , G01N2021/6482 , G02B21/16 , G02B21/365 , Y10S436/80 , Y10S436/807 , Y10S436/809 , Y10S977/795 , Y10S977/881 , Y10S977/92 , Y10S977/941 , Y10S977/942 , C12Q2525/179
Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropatterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
Abstract translation: 本发明涉及用于确定荧光标记的报道分子在细胞中的分布，环境或活性的光学系统，以筛选大量用于特定生物活性的化合物。 本发明涉及在荧光显微镜的阵列中提供含有荧光报告分子的细胞，并用荧光显微镜扫描各个位置的多个细胞，将光学信息转换为数字数据，并利用数字数据确定荧光的分布，环境或活性 标记的细胞中的报告分子。 位置阵列可以是工业标准96孔或384孔微量滴定板或微板，其是具有位于微图案阵列中的细胞的微孔板。 本发明包括用于处理，显示和存储数据的装置和计算机化方法。
-
Patent Agency Ranking
6.发明授权公开(公告)号：US07117098B1
公开(公告)日：2006-10-03
申请号：US09723256
申请日：2000-11-27
Applicant: R. Terry Dunlay , D. Lansing Taylor , Albert H. Gough , Kenneth A. Giuliano
Inventor： R. Terry Dunlay , D. Lansing Taylor , Albert H. Gough , Kenneth A. Giuliano
CPC classification number: G01N21/6458 , G01N21/6428 , G01N21/6452 , G01N33/502 , G01N33/5035 , G01N2021/6417 , G01N2021/6439 , G01N2021/6482
Abstract: The present invention provides systems, methods, and screens for an optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a high magnification fluorescence optical system, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
Abstract translation: 本发明提供用于细胞的光学系统分析的系统，方法和屏幕，以快速确定细胞中荧光标记的报道分子的分布，环境或活性，目的是筛选特定影响特定生物的那些化合物的大量化合物 功能。 本发明涉及在位置阵列中提供含有荧光报道分子的细胞，并用高倍放大荧光光学系统扫描每个位置中的多个细胞，将光学信息转换为数字数据，并利用数字数据确定分布，环境或活性 的荧光标记的报告分子在细胞中。 位置阵列可以是工业标准96孔或384孔微量滴定板或微板，其是具有位置微距阵列中的细胞的微孔板。 本发明包括用于处理，显示和存储数据的装置和计算机化方法。
-
公开(公告)号：US06902883B2
公开(公告)日：2005-06-07
申请号：US10430534
申请日：2003-05-06
Applicant: R. Terry Dunlay , D. Lansing Taylor
Inventor： R. Terry Dunlay , D. Lansing Taylor
CPC classification number: B82Y30/00 , B01J2219/00315 , B01J2219/00317 , B01J2219/00707 , B01J2219/00743 , B01L3/5085 , C12Q1/68 , C12Q1/6813 , C40B60/14 , G01N15/1475 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N33/5005 , G01N33/5035 , G01N33/582 , G01N2015/1486 , G01N2015/1497 , G01N2021/6419 , G01N2021/6482 , G02B21/16 , G02B21/365 , Y10S436/80 , Y10S436/807 , Y10S436/809 , Y10S977/795 , Y10S977/881 , Y10S977/92 , Y10S977/941 , Y10S977/942 , C12Q2525/179
Abstract: The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involves providing cells containing fluorescent reporter molecules in an array of locations and scanning numerous cells in each location with a fluorescent microscope, converting the optical information into digital data, and utilizing the digital data to determine the distribution, environment or activity of the fluorescently labeled reporter molecules in the cells. The array of locations may be an industry standard 96 well or 384 well microtiter plate or a microplate which is a microplate having a cells in a micropaterned array of locations. The invention includes apparatus and computerized method for processing, displaying and storing the data.
Abstract translation: 本发明涉及用于确定荧光标记的报道分子在细胞中的分布，环境或活性的光学系统，以筛选大量用于特定生物活性的化合物。 本发明涉及在荧光显微镜的阵列中提供含有荧光报告分子的细胞，并用荧光显微镜扫描各个位置的多个细胞，将光学信息转换为数字数据，并利用数字数据确定荧光的分布，环境或活性 标记的细胞中的报告分子。 位置阵列可以是工业标准96孔或384孔微量滴定板或微板，其是具有位置微距阵列中的细胞的微孔板。 本发明包括用于处理，显示和存储数据的装置和计算机化方法。
-
公开(公告)号：US08024293B2
公开(公告)日：2011-09-20
申请号：US12189035
申请日：2008-08-08
Applicant: Keith S. Boyce , Brian K. McKenna , Phillip W. Glick , R. Terry Dunlay
Inventor： Keith S. Boyce , Brian K. McKenna , Phillip W. Glick , R. Terry Dunlay
IPC: G06F17/30
CPC classification number: G06K9/00127 , G01N15/1475 , G01N2015/1477 , G01N2015/1497 , G01N2035/00158 , Y10S707/99943 , Y10S707/99945
Abstract: Methods and system for efficient collection and storage of experimental data allow experimental data from high-throughput, feature-rich data collection systems, such as high-throughput cell data collection systems to be efficiently collected, stored, managed and displayed. The methods and system can be used, for example, for storing, managing, and displaying cell image data and cell feature data collected from microplates including multiple wells and a variety of bio-chips in which an experimental compound has been applied to a population of cells. The methods and system provide a flexible and scalable repository of experimental data including multiple databases at multiple locations including pass-through databases that can be easily managed and allows cell data to be analyzed, manipulated and archived. The methods and system may improve the identification, selection, validation and screening of new drug compounds that have been applied to populations of cells.
Abstract translation: 用于有效收集和存储实验数据的方法和系统允许来自高吞吐量，功能丰富的数据收集系统（例如高通量细胞数据收集系统）的实验数据被有效地收集，存储，管理和显示。 方法和系统可以用于例如存储，管理和显示从微孔板收集的细胞图像数据和细胞特征数据，所述微孔板包括多个孔和各种生物芯片，其中实验化合物已被应用于 细胞。 这些方法和系统提供了一个灵活和可扩展的实验数据库，包括多个位置的多个数据库，包括易于管理的直通数据库，并允许细胞数据进行分析，操作和归档。 方法和系统可以改善已经应用于细胞群体的新药物的鉴定，选择，验证和筛选。
-
公开(公告)号：US20080301202A1
公开(公告)日：2008-12-04
申请号：US12189035
申请日：2008-08-08
Applicant: Keith S. Boyce , Brian K. McKenna , Phillip W. Glick , R. Terry Dunlay
Inventor： Keith S. Boyce , Brian K. McKenna , Phillip W. Glick , R. Terry Dunlay
IPC: G06F17/30
CPC classification number: G06K9/00127 , G01N15/1475 , G01N2015/1477 , G01N2015/1497 , G01N2035/00158 , Y10S707/99943 , Y10S707/99945
Abstract: Methods and system for efficient collection and storage of experimental data allow experimental data from high-throughput, feature-rich data collection systems, such as high-throughput cell data collection systems to be efficiently collected, stored, managed and displayed. The methods and system can be used, for example, for storing, managing, and displaying cell image data and cell feature data collected from microplates including multiple wells and a variety of bio-chips in which an experimental compound has been applied to a population of cells. The methods and system provide a flexible and scalable repository of experimental data including multiple databases at multiple locations including pass-through databases that can be easily managed and allows cell data to be analyzed, manipulated and archived. The methods and system may improve the identification, selection, validation and screening of new drug compounds that have been applied to populations of cells.
Abstract translation: 用于有效收集和存储实验数据的方法和系统允许来自高吞吐量，功能丰富的数据收集系统（例如高通量细胞数据收集系统）的实验数据被有效地收集，存储，管理和显示。 方法和系统可以用于例如存储，管理和显示从微孔板收集的细胞图像数据和细胞特征数据，所述微孔板包括多个孔和各种生物芯片，其中实验化合物已被应用于 细胞。 这些方法和系统提供了一个灵活和可扩展的实验数据库，包括多个位置的多个数据库，包括易于管理的直通数据库，并允许细胞数据进行分析，操作和归档。 方法和系统可以改善已经应用于细胞群体的新药物的鉴定，选择，验证和筛选。
-
10.发明授权公开(公告)号：US09012235B2
公开(公告)日：2015-04-21
申请号：US13588984
申请日：2012-08-17
Applicant: Linda Trinkle , R. Terry Dunlay , Bruce Edwards , Larry Sklar
Inventor： Linda Trinkle , R. Terry Dunlay , Bruce Edwards , Larry Sklar
CPC classification number: G01N15/14 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0684 , B01L2300/0829 , B01L2300/0832 , B01L2300/0877 , B01L2400/0481 , G01N15/1404 , G01N35/08 , G01N35/1067 , G01N35/1074 , G01N35/1095 , G01N2015/0019
Abstract: Embodiments of the present invention provide a system and method for analyzing a plurality of samples comprising obtaining with an autosampler a plurality of samples from a first plate having a plurality of sample wells wherein the autosampler has a plurality of probes for sampling a set of samples and wherein each probe of the plurality of probes is in communication with a separate flow cytometer via a separate conduit. The plurality of samples comprising particles is moved into a fluid flow stream for each separate conduit. Adjacent ones of the plurality of samples are separated from each other in the fluid flow stream by a separation gas, thereby forming a gas-separated fluid flow stream. The gas-separated fluid flow stream is independently guided to and through each separate flow cytometer.
Abstract translation: 本发明的实施方案提供了一种用于分析多个样品的系统和方法，包括用自动进样器从具有多个样品孔的第一板获得多个样品，其中所述自动进样器具有用于对一组样品进行取样的多个探针， 其中所述多个探针中的每个探针经由单独的导管与独立的流式细胞仪连通。 将包含颗粒的多个样品移动到用于每个单独管道的流体流动流中。 通过分离气体在流体流动流中将多个样品中的相邻的样品彼此分离，从而形成气体分离的流体流动流。 气体分离的流体流被独立地引导并通过每个单独的流式细胞仪。
-
-
-
-
-
-
-
-
-
Search Results
24
records
(took 0.014 seconds)
