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公开(公告)号：US08324180B2
公开(公告)日：2012-12-04
申请号：US12755106
申请日：2010-04-06
申请人： Sergei Belyakov , Bridget Duvall , Dana Ferraris , Gregory Hamilton , Mark Vaal
发明人： Sergei Belyakov , Bridget Duvall , Dana Ferraris , Gregory Hamilton , Mark Vaal
IPC分类号： A61K31/7052 , A61P35/00 , C07H19/04
CPC分类号： C07H19/04 , A61K31/7052
摘要： Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.
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公开(公告)号：US20100279966A1
公开(公告)日：2010-11-04
申请号：US12755106
申请日：2010-04-06
申请人： Sergei BELYAKOV , Bridget DUVALL , Dana FERRARIS , Gregory HAMILTON , Mark VAAL
发明人： Sergei BELYAKOV , Bridget DUVALL , Dana FERRARIS , Gregory HAMILTON , Mark VAAL
IPC分类号： A61K31/7052 , C07H19/04 , A61P35/00
CPC分类号： C07H19/04 , A61K31/7052
摘要： Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.
摘要翻译： 本文提供了用于抑制负责灭活治疗化合物的脱氨酶的化合物及其使用方法。
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公开(公告)号：US08329665B2
公开(公告)日：2012-12-11
申请号：US12755116
申请日：2010-04-06
申请人： Sergei Belyakov , Bridget Duvall , Dana Ferraris , Gregory Hamilton , Mark Vaal
发明人： Sergei Belyakov , Bridget Duvall , Dana Ferraris , Gregory Hamilton , Mark Vaal
IPC分类号： A61K31/7072 , A61K31/7052 , A61P35/00 , A61P35/02
CPC分类号： A61K45/06 , A61K31/551 , A61K31/7052 , A61K31/706 , A61K31/7068 , A61K2300/00
摘要： Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.
摘要翻译： 本文提供了用于抑制负责灭活治疗化合物的脱氨酶的化合物及其使用方法。
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公开(公告)号：US08329666B2
公开(公告)日：2012-12-11
申请号：US12755122
申请日：2010-04-06
申请人： Sergei Belyakov , Bridget Duvall , Dana Ferraris , Gregory Hamilton , Mark Vaal
发明人： Sergei Belyakov , Bridget Duvall , Dana Ferraris , Gregory Hamilton , Mark Vaal
IPC分类号： A61K31/706 , A61P35/00
CPC分类号： A61K45/06 , A61K31/551 , A61K31/7052 , A61K31/7068 , A61K2300/00
摘要： Provided herein are methods of treating cancer comprising administering decitabine in combination with compounds that inhibit the deamination enzyme responsible for the inactivation of decitabine.
摘要翻译： 本文提供了治疗癌症的方法，包括将抑制脱氨酶的化合物与地西他滨灭活化合物组合施用地西他滨。
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公开(公告)号：US20050070719A1
公开(公告)日：2005-03-31
申请号：US10499675
申请日：2002-12-26
申请人： Sergei Belyakov , Gregory Hamilton , David Hurst , Vincent Kalish , Weixing Li , Eric Wang , Douglas Wilkinson , Yong-Qian Wu , Weizheng Xu
发明人： Sergei Belyakov , Gregory Hamilton , David Hurst , Vincent Kalish , Weixing Li , Eric Wang , Douglas Wilkinson , Yong-Qian Wu , Weizheng Xu
IPC分类号： C07D295/18 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/404 , A61K31/426 , A61K31/427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K38/00 , A61K45/00 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , A61P15/00 , A61P15/16 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/06 , A61P39/02 , A61P41/00 , A61P43/00 , C07D205/04 , C07D207/04 , C07D207/16 , C07D207/20 , C07D207/22 , C07D209/18 , C07D209/42 , C07D209/46 , C07D209/48 , C07D217/14 , C07D217/16 , C07D217/22 , C07D217/26 , C07D233/60 , C07D263/06 , C07D277/04 , C07D277/06 , C07D295/125 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07K5/078 , C07K5/097
CPC分类号： C07D209/48 , A61K38/00 , C04B35/632 , C07D205/04 , C07D207/04 , C07D207/16 , C07D207/20 , C07D207/22 , C07D209/42 , C07D209/46 , C07D217/14 , C07D217/16 , C07D217/26 , C07D263/06 , C07D277/04 , C07D277/06 , C07D295/125 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07K5/06156 , C07K5/0821
摘要： Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.
摘要翻译： 提供了二肽基肽酶IV（DPP IV）的新型抑制剂，包含治疗有效量的新型DPP IV抑制剂的药物组合物，以及治疗医学病症的新方法。 本文描述的DPP IV的新型抑制剂可用于治疗神经障碍，糖尿病，炎症性疾病如关节炎，肥胖症，骨质疏松症以及可用DPP IV抑制剂治疗的其他列举的病症。
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公开(公告)号：US06656971B2
公开(公告)日：2003-12-02
申请号：US10057203
申请日：2002-01-25
申请人： Yong-Qian Wu , Sergei Belyakov , Gregory S. Hamilton , David Limburg , Joseph P. Steiner , Mark Vaal , Ling Wei , Douglas Wilkinson
发明人： Yong-Qian Wu , Sergei Belyakov , Gregory S. Hamilton , David Limburg , Joseph P. Steiner , Mark Vaal , Ling Wei , Douglas Wilkinson
IPC分类号： A61K31166
CPC分类号： C07D209/48 , A61K31/325 , C07C233/29 , C07C233/66 , C07C233/75 , C07C233/76 , C07C235/42 , C07C235/56 , C07C243/38 , C07C255/54 , C07C275/42 , C07C311/46 , C07C311/48 , C07C335/18 , C07C335/36 , C07C337/06 , C07C2602/10 , C07D213/56 , C07D213/74 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/135 , Y02A50/409 , Y02A50/411 , Y02A50/421 , Y02A50/422 , Y02A50/423
摘要： The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.
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公开(公告)号：US20100279977A1
公开(公告)日：2010-11-04
申请号：US12755116
申请日：2010-04-06
申请人： Sergei BELYAKOV , Bridget DUVALL , Dana FERRARIS , Gregory HAMILTON , Mark VAAL
发明人： Sergei BELYAKOV , Bridget DUVALL , Dana FERRARIS , Gregory HAMILTON , Mark VAAL
IPC分类号： A61K31/7072 , A61K31/7052 , A61K31/7068 , A61P35/00 , A61P35/02
CPC分类号： A61K45/06 , A61K31/551 , A61K31/7052 , A61K31/706 , A61K31/7068 , A61K2300/00
摘要： Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.
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公开(公告)号：US20100279967A1
公开(公告)日：2010-11-04
申请号：US12755122
申请日：2010-04-06
申请人： Sergei BELYAKOV , Bridget DUVALL , Dana FERRARIS , Gregory HAMILTON , Mark VAAL
发明人： Sergei BELYAKOV , Bridget DUVALL , Dana FERRARIS , Gregory HAMILTON , Mark VAAL
IPC分类号： A61K31/706 , A61P35/00
CPC分类号： A61K45/06 , A61K31/551 , A61K31/7052 , A61K31/7068 , A61K2300/00
摘要： Provided herein are methods of treating cancer comprising administering decitabine in combination with compounds that inhibit the deamination enzyme responsible for the inactivation of decitabine.
摘要翻译： 本文提供了治疗癌症的方法，包括将抑制脱氨酶的化合物与地西他滨灭活化合物组合施用地西他滨。
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