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    Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase
    7.
    发明申请
    Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase 审中-公开
    对β-肾上腺素能受体和磷酸二酯酶具有抑制活性的强心药物

    公开(公告)号：US20070117978A1

    公开(公告)日：2007-05-24

    申请号：US10547930

    申请日：2003-12-23

    申请人： Gregory Hamilton ,  Harry Leighton

    发明人： Gregory Hamilton ,  Harry Leighton

    IPC分类号： A61K31/519 ,  A61K31/502 ,  A61K31/501 ,  A61K31/4745 ,  A61K31/4704 ,  C07D487/04 ,  C07D403/02

    CPC分类号： C07D215/227 ,  C07D233/70 ,  C07D487/04

    摘要： The present invention provides compounds possessing inhibitory activity against (3-adrenergic receptors and phosphodiesterase (PDE), including type 3 phosphodiesterase (PDE-3). The present invention further provides pharmaceutical compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for regulating calcium homeostasis, for treating a disease, disorder or condition in which disregulation of calcium homeostasis is implicated and for treating cardiovascular disease, stroke, epilepsy, an ophthalmic disorder or migraine.

    摘要翻译： 本发明提供对3-肾上腺素能受体和磷酸二酯酶（PDE）具有抑制活性的化合物，包括3型磷酸二酯酶（PDE-3），本发明还提供包含这些化合物的药物组合物，制备这些化合物的方法和方法 使用这种化合物来调节钙稳态，用于治疗涉及钙稳态失调的疾病，病症或病症，以及治疗心血管疾病，中风，癫痫，眼科障碍或偏头痛。

    Apparatus and method for providing program protection engineering, security management, and report preparation for sensitive and classified projects
    9.
    发明申请
    Apparatus and method for providing program protection engineering, security management, and report preparation for sensitive and classified projects 有权
    为敏感和分类项目提供程序保护工程，安全管理和报告准备的装置和方法

    公开(公告)号：US20070186283A1

    公开(公告)日：2007-08-09

    申请号：US11347285

    申请日：2006-02-06

    申请人： Kenneth Brumbaugh ,  Howard Low ,  Gregory Hamilton ,  James Davis ,  Wendy Fan

    发明人： Kenneth Brumbaugh ,  Howard Low ,  Gregory Hamilton ,  James Davis ,  Wendy Fan

    IPC分类号： G06F11/00

    CPC分类号： G06F21/577 ,  G06Q10/06 ,  G06Q10/06311

    摘要： An apparatus and method using a program protection engineering (P2E) toolkit to provide program protection engineering, security management, and report preparation for sensitive and classified projects. The P2E toolkit is an implementation of security policies, procedures, and methodologies associated with acquisition programs. Acquisition programs may range from large-scale classified systems for the government to sensitive corporate acquisition programs focusing on company proprietary or intellectual property issues. Specifically, the P2E toolkit provides end-to-end program protection engineering, security management, and report preparation for sensitive and classified programs throughout the program lifecycle, and assists security professionals and program managers to make appropriate decisions to protect their acquisition programs from compromise due to foreign intelligence threats or corporate/industrial espionage. The P2E toolkit enhances the traditional program management concerns of technical performance, schedule, and cost, by adding lifecycle protection as in integral component.

    摘要翻译： 一种使用程序保护工程（P2E）工具包的设备和方法，用于为敏感和分类项目提供程序保护工程，安全管理和报告准备。 P2E工具包是与采购计划相关的安全策略，程序和方法的实现。 收购计划可能范围从政府的大规模分类系统到专注于公司专有或知识产权问题的敏感企业收购计划。 具体来说，P2E工具包在整个程序生命周期中为敏感和分类程序提供端到端程序保护工程，安全管理和报告准备，并协助安全专业人员和程序管理人员做出适当决策，以保护其采集程序免受妥协 对外国情报威胁或企业/工业间谍活动。 P2E工具包通过将生命周期保护作为整体组件添加，增强了传统程序管理对技术性能，进度和成本的关注。