公开(公告)号：US20050182128A1

公开(公告)日：2005-08-18

申请号：US10504636

申请日：2003-02-13

申请人： Stephen Lam ,  Calum Macaulay ,  Jean Le Riche ,  Yulia Dyachkova ,  Andy Coldman ,  Martial Guillaud ,  Ernest Hawk ,  Marie-Odile Christen ,  Adi Gazdar

发明人： Stephen Lam ,  Calum Macaulay ,  Jean Le Riche ,  Yulia Dyachkova ,  Andy Coldman ,  Martial Guillaud ,  Ernest Hawk ,  Marie-Odile Christen ,  Adi Gazdar

IPC分类号： C07D339/04 ,  A61K31/381 ,  A61K31/385 ,  A61P11/00 ,  A61P35/00

CPC分类号： A61K31/385

摘要： The present invention relates to the use of 5-(p-methoxyphenyl)-1,2-dithiole-3-thione or of a pharmaceutical derivative thereof for the preparation of a medicament for preventing lung cancer in a mammalian subject, especially for preventing or reducing the appearance of new dysplastic lesions, or the progression of pre-existing dysplastic lesions in the subject, or for improving regression of existing dysplastic lesions.

摘要翻译： 本发明涉及5-（对甲氧基苯基）-1,2-二硫代-3-硫酮或其药物衍生物在制备用于预防哺乳动物受试者肺癌的药物中的用途，特别是用于预防或 减少新的发育不良病变的出现，或者在受试者中存在先发生发育不良的病变，或改善现有发育不良病变的消退。

公开(公告)号：US5507287A

公开(公告)日：1996-04-16

申请号：US428494

申请日：1995-04-27

申请人： Branko Palcic ,  Calum MacAulay ,  Bruno Jaggi ,  Stephen Lam ,  Amedeus E. Profio ,  Jaclyn Hung

发明人： Branko Palcic ,  Calum MacAulay ,  Bruno Jaggi ,  Stephen Lam ,  Amedeus E. Profio ,  Jaclyn Hung

IPC分类号： A61B1/00 ,  A61B1/04 ,  A61B5/00 ,  A61B1/06 ,  A61B1/267 ,  G01N21/64

CPC分类号： A61B1/043 ,  A61B1/00186 ,  A61B1/042 ,  A61B1/0638 ,  A61B1/0646 ,  A61B5/0071 ,  A61B5/0084 ,  A61B1/063 ,  G01N2021/6463

摘要： Apparatus for imaging diseases in tissue comprising a light source for generating excitation light that includes wavelengths capable of generating characteristic autofluorescence for abnormal and normal tissue. A fibreoptic illuminating light guide is used to illuminate tissue with light that includes at least the excitation light thereby exciting the tissue to emit the characteristic autofluorescence. An imaging bundle collects emitted autofluorescence light from the tissue. The autofluorescence light is filtered into spectral bands in which the autofluorescence intensity for abnormal tissue is substantially different from normal tissue and the autofluorescence intensity for abnormal tissue is substantially similar to normal tissue. An optical system is used to intercept the filtered autofluorescence light to acquire at least two filtered emitted autofluorescence images of the tissue. The acquired images are displayed in real time on a display monitor in such a manner as to delineate abnormal and normal tissue.

摘要翻译： 用于在组织中成像疾病的装置，包括用于产生激发光的光源，所述激发光包括能够产生用于异常和正常组织的特征性自发荧光的波长。 光纤照明光导用于用至少包括激发光的光照射组织，从而激发组织以发出特征自发荧光。 成像束从组织中收集发射的自发荧光。 自发荧光被过滤到光谱带，其中异常组织的自发荧光强度与正常组织基本不同，异常组织的自发荧光强度基本上与正常组织相似。 光学系统用于截取滤波的自发荧光以获得组织的至少两个经滤波的发射的自发荧光图像。 所获取的图像以描绘异常和正常组织的方式在显示监视器上实时显示。

公开(公告)号：US5827190A

公开(公告)日：1998-10-27

申请号：US699607

申请日：1996-08-19

申请人： Branko Palcic ,  Calum MacAulay ,  Stephen Lam ,  Bruno Jaggi

发明人： Branko Palcic ,  Calum MacAulay ,  Stephen Lam ,  Bruno Jaggi

IPC分类号： A61B10/00 ,  A61B1/00 ,  A61B1/05 ,  A61B5/00 ,  G01N21/64 ,  A61B6/00

CPC分类号： A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

摘要： An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light image provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.

摘要翻译： 提出了一种用于成像组织疾病成像的装置和方法。 该装置采用光源产生激发光以激发组织以产生自发荧光并产生照明光，以从组织产生反射和反向散射光（汇流光）。 光传感器用于接收自发荧光和汇流光以收集自发荧光图像和汇流光图像。 滤光器用于将自发荧光图像整合在一定波长范围内，其中正常组织的自发荧光强度基本上不同于患病组织的自发荧光强度，以建立组织的集成自发荧光图像。 汇款光图像提供背景图像以归一化自发荧光图像，以解决由于距离，角度和照明强度的变化引起的图像不均匀性。 监视器显示集成的自发荧光图像和汇流光图像以产生其中患病组织与正常组织区分开的标准化图像。 光学传感器可以安装在插入体腔的内窥镜探针的末端附近。 还公开了使用集成荧光图像和归一化汇款图像对患病组织进行成像的方法。

公开(公告)号：US5590660A

公开(公告)日：1997-01-07

申请号：US218662

申请日：1994-03-28

申请人： Calum MacAulay ,  Branko Palcic ,  Stephen Lam ,  Bruno Jaggi

发明人： Calum MacAulay ,  Branko Palcic ,  Stephen Lam ,  Bruno Jaggi

IPC分类号： A61B10/00 ,  A61B1/00 ,  A61B1/05 ,  A61B5/00 ,  G01N21/64 ,  A61B1/06 ,  A61B6/00

CPC分类号： A61B1/043 ,  A61B1/05 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  H04N2005/2255

摘要： An apparatus and method for imaging diseases in tissue are presented. The apparatus employs a light source for producing excitation light to excite the tissue to generate autofluorescence light and for producing illumination light to generate reflected and back scattered light (remittance light) from the tissue. Optical sensors are used to receive the autofluorescence light and the remittance light to collect an autofluorescence light image and a remittance light image. A filter acts to integrate the autofluorescence image over a range of wavelengths in which the autofluorescence intensity for normal tissue is substantially different from the autofluorescence intensity for diseased tissue to establish an integrated autofluorescence image of the tissue. The remittance light image provides a background image to normalize the autofluorescence image to account for image non-uniformity due to changes in distance, angle and illumination intensity. A monitor displays the integrated autofluorescence image and the remittance light image to produce a normalized image in which diseased tissue is distinguishable from normal tissue. The optical sensor can be installed adjacent the end of an endoscope probe inserted into a body cavity. A method for imaging diseased tissue using an integrated fluorescence image and a normalizing remittance image is also disclosed.

摘要翻译： 提出了一种用于成像组织疾病成像的装置和方法。 该装置采用光源产生激发光以激发组织以产生自发荧光并产生照明光，以从组织产生反射和反向散射光（汇流光）。 光传感器用于接收自发荧光和汇流光以收集自发荧光图像和汇流光图像。 滤光器用于将自发荧光图像整合在一定波长范围内，其中正常组织的自发荧光强度基本上不同于患病组织的自发荧光强度，以建立组织的集成自发荧光图像。 汇款光图像提供背景图像以归一化自发荧光图像，以解决由于距离，角度和照明强度的变化引起的图像不均匀性。 监视器显示集成的自发荧光图像和汇流光图像以产生其中患病组织与正常组织区分开的标准化图像。 光学传感器可以安装在插入体腔的内窥镜探针的末端附近。 还公开了使用集成荧光图像和归一化汇款图像对患病组织进行成像的方法。

公开(公告)号：US20100248290A1

公开(公告)日：2010-09-30

申请号：US12743042

申请日：2008-11-24

申请人： Stephen Lam ,  John Yee ,  Michael Kuzyk ,  Don Sin ,  Marianne Dorthy Sadar ,  Carl Martin Tammemagi

发明人： Stephen Lam ,  John Yee ,  Michael Kuzyk ,  Don Sin ,  Marianne Dorthy Sadar ,  Carl Martin Tammemagi

IPC分类号： G01N33/68 ,  C12Q1/02

CPC分类号： G01N33/57423 ,  G01N2800/50 ,  G01N2800/52

摘要： A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment with curative intent is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with the a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.

摘要翻译： 描述了一种用于检测肺癌的方法，包括检测来自患有发展为肺癌风险的受试者的生物样品中CTAP III相关生物标志物的升高水平。 此外，描述了用于预测受试者中发展肺癌的风险的方法，包括检测来自受试者的生物样品中CTAP III相关生物标志物的升高水平。 另外，描述了以治愈意图监测肺癌治疗成功的方法，其包括检测来自接受肺癌治疗的受试者的生物样品中的CTAP III相关生物标志物的水平，以与从受试者获得的先前水平进行比较 。 多变量分析可纳入这些方法，评估年龄，性别，吸烟史，吸烟状况，吸烟家族史，教育水平，COPD，社会经济状况，体重指数和肺功能等临床或人口学危险因素。 描述了用于进行这种方法的套件。

公开(公告)号：US06826424B1

公开(公告)日：2004-11-30

申请号：US09741731

申请日：2000-12-19

申请人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

发明人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

IPC分类号： A61B505

CPC分类号： G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

摘要： Methods and apparatus for contemporaneous measurements of electromagnetic radiation with multiple measuring devices, for producing a high diagnostic sensitivity image while achieving high diagnostic specificity with spectroscopy, for producing illumination for fluorescence/NIR reflectance imaging and white light reflectance imaging, all with the same sensors are disclosed. The method may involve selectively adjusting a gain of an imaging device in at least one wavelength band relative to a gain in at least one other band to produce an optimized image of an object, and may also involve producing a first reflectance signal in a first NIR wavelength band, and producing a second reflectance signal in a second NIR band such that an absorption coefficient ratio of oxyhemoglobin to deoxyhemoglobin in the second wavelength band differs from that in the first wavelength band, to permit the first and second reflectance signals to be used to produce a tissue oxygenation image.

摘要翻译： 用于同时测量具有多个测量装置的电磁辐射的方法和装置，用于产生高诊断灵敏度图像，同时通过光谱法实现高诊断特异性，用于产生用于荧光/ NIR反射成像的照明和具有相同传感器的白光反射成像 披露 该方法可以包括相对于至少一个其他频带中的增益选择性地调节成像装置在至少一个波长带中的增益，以产生对象的优化图像，并且还可以涉及在第一NIR中产生第一反射信号 并且在第二NIR带中产生第二反射信号，使得第二波长带中的氧合血红蛋白与脱氧血红蛋白的吸收系数比与第一波长带的吸收系数比不同，以允许将第一和第二反射信号用于 产生组织氧合图像。

公开(公告)号：US08728823B2

公开(公告)日：2014-05-20

申请号：US12743042

申请日：2008-11-24

申请人： Stephen Lam ,  John Yee ,  Michael Kuzyk ,  Don Sin ,  Marianne Dorthy Sadar ,  Carl Martin Tammemagi

发明人： Stephen Lam ,  John Yee ,  Michael Kuzyk ,  Don Sin ,  Marianne Dorthy Sadar ,  Carl Martin Tammemagi

IPC分类号： G01N33/00 ,  G01N33/566

CPC分类号： G01N33/57423 ,  G01N2800/50 ,  G01N2800/52

摘要： A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.

摘要翻译： 描述了一种用于检测肺癌的方法，包括检测来自患有发展为肺癌风险的受试者的生物样品中CTAP III相关生物标志物的升高水平。 此外，描述了用于预测受试者中发展肺癌的风险的方法，包括检测来自受试者的生物样品中CTAP III相关生物标志物的升高水平。 此外，描述了监测肺癌治疗成功的方法，其包括检测来自接受肺癌治疗的受试者的生物样品中的CTAP III相关生物标志物的水平，以与从受试者获得的先前水平进行比较。 多变量分析可纳入这些方法，评估年龄，性别，吸烟史，吸烟状况，吸烟家族史，教育水平，COPD，社会经济状况，体重指数和肺功能等临床或人口学危险因素。 描述了用于进行这种方法的套件。

公开(公告)号：US20130231573A1

公开(公告)日：2013-09-05

申请号：US13521218

申请日：2011-01-21

申请人： Haishan Zeng ,  Michael Short ,  Stephen Lam ,  Annette McWilliams

发明人： Haishan Zeng ,  Michael Short ,  Stephen Lam ,  Annette McWilliams

IPC分类号： A61B5/00

CPC分类号： A61B5/0075 ,  A61B5/0071 ,  A61B5/0084 ,  G01N21/65

摘要： Near-infrared Raman spectroscopy can be applied to identify preneoplastic lesions of the bronchial tree. Real-time in vivo Raman spectra of lung tissues may be obtained with a fiber optic catheter passed down the instrument channel of a bronchoscope. Using prototype apparatus, preneoplastic lesions were detected with sensitivity and specificity of 96 and 91% respectively. The use of Raman spectroscopy apparatus and methods in conjunction with other bronchoscopy imaging modalities can substantially reduce the number of false positive results.

摘要翻译： 近红外拉曼光谱可用于鉴定支气管树瘤的肿瘤前病变。 肺组织的实时体内拉曼光谱可以通过沿支气管镜仪器通道向下传播的光纤导管获得。 使用原型装置，分别检测到96和91％的敏感性和特异性的癌前病变。 使用拉曼光谱设备和方法与其他支气管镜检查成像模式联合可以大大减少假阳性结果的数量。

公开(公告)号：US07253894B2

公开(公告)日：2007-08-07

申请号：US11053263

申请日：2005-02-07

申请人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

发明人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

IPC分类号： G01J3/28

CPC分类号： G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

摘要： Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

摘要翻译： 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。

公开(公告)号：US07115841B2

公开(公告)日：2006-10-03

申请号：US11057965

申请日：2005-02-14

申请人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

发明人： Haishan Zeng ,  Stephen Lam ,  Branko Mihael Palcic

IPC分类号： H05B3/02

CPC分类号： G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0235 ,  G01J3/0243 ,  G01J3/0289 ,  G01J3/10 ,  G01J3/36 ,  G01N23/223 ,  G01N2223/076

摘要： Optical systems that provide for simultaneous images and spectra from an object, such as a tissue sample, an industrial object such as a computer chip, or any other object that can be viewed with an optical system such as a microscope, endoscope, telescope or camera. In some embodiments, the systems provide multiple images corresponding to various desired wavelength ranges within an original image of the object, as well as, if desired, directional pointer(s) that can provide both an identification of the precise location from which a spectrum is being obtained, as well as enhancing the ability to point the device.

摘要翻译： 提供来自物体的同时图像和光谱的光学系统，例如组织样本，诸如计算机芯片的工业对象或可以用诸如显微镜，内窥镜，望远镜或照相机的光学系统观察的任何其它物体 。 在一些实施例中，系统提供对应于对象的原始图像内的各种期望波长范围的多个图像，以及如果需要的方向指针，其可以提供频谱的精确位置的识别 获得，以及增强指向设备的能力。