公开(公告)号：US07341782B2

公开(公告)日：2008-03-11

申请号：US10665432

申请日：2003-09-22

申请人： Hideaki Naruse ,  Taisei Nishimi

发明人： Hideaki Naruse ,  Taisei Nishimi

IPC分类号： H01J1/62 ,  C09K9/04 ,  B32B9/04

CPC分类号： H05B33/04 ,  C08K9/04 ,  C08K2201/008 ,  H01L51/5253 ,  Y10S428/917 ,  Y10T428/31504

摘要： A polymer composition includes a polymer having a glass transition temperature of 120° C. to 400° C. as a simple substance of the polymer and an organic modified layered silicate having a decomposition starting temperature of 190° C. to 350° C. and contained in the polymer. (1) A film including the polymer composition, (2) a gas barrier film including the film and an organic/inorganic hybrid layer obtained by the sol-gel method and provided on the film, (3) a substrate comprising the film or the gas barrier film, and (4) an image display device comprising at least an anode, a light-emitting organic thin film layer and a cathode on the film or the gas barrier film are also disclosed. A polymer composition having both superior heat resistance and superior gas baffler properties, a film comprising the polymer composition, and a gas baffler film having the film, as well as a substrate and image display device exhibiting superior precision and durability are provided.

摘要翻译： 聚合物组合物包括作为聚合物的单体的玻璃化转变温度为120℃至400℃的聚合物和分解开始温度为190℃至350℃的有机改性层状硅酸盐，以及 包含在聚合物中。 （1）包含聚合物组合物的膜，（2）包含该膜的阻气膜和通过溶胶 - 凝胶法获得并提供在该膜上的有机/无机混合层，（3）包含该膜或 气体阻隔膜，以及（4）还包括在膜或阻气膜上至少包含阳极，发光有机薄膜层和阴极的图像显示装置。 提供具有优异的耐热性和优异的气体挡板性能的聚合物组合物，包含聚合物组合物的膜和具有该膜的气体挡板膜，以及显示出优异的精度和耐久性的基板和图像显示装置。

公开(公告)号：US08585972B2

公开(公告)日：2013-11-19

申请号：US12778555

申请日：2010-05-12

申请人： Taisei Nishimi ,  Toshihide Ezoe ,  Toshiaki Kubo ,  Hidetoshi Tomita

发明人： Taisei Nishimi ,  Toshihide Ezoe ,  Toshiaki Kubo ,  Hidetoshi Tomita

IPC分类号： G01N33/53

CPC分类号： G01N33/54353 ,  G01N33/54373

摘要： One object of the present invention is to provide a biosensor and a production method therefor, by which hydrogel that enables immobilization of a physiologically active substance can be conveniently produced using safe raw materials. The present invention provides a biosensor which comprises a substrate having a metal layer on its surface, wherein a hydrophilic polymer having a reactive functional group capable of reacting with a hydroxyl group or an amino group of a physiologically active substance is bound to the metal layer directly or indirectly via an intermediate layer.

摘要翻译： 本发明的一个目的是提供一种生物传感器及其生产方法，通过该生物传感器及其生产方法，可以使用安全的原料方便地生产能够固定生理活性物质的水凝胶。 本发明提供一种生物传感器，其包括在其表面具有金属层的基材，其中具有能够与生理活性物质的羟基或氨基反应的反应性官能团的亲水性聚合物直接结合到金属层 或间接经由中间层。

公开(公告)号：US07928191B2

公开(公告)日：2011-04-19

申请号：US12201594

申请日：2008-08-29

申请人： Koichi Minami ,  Yohsuke Takeuchi ,  Taisei Nishimi

发明人： Koichi Minami ,  Yohsuke Takeuchi ,  Taisei Nishimi

IPC分类号： C07K1/16

CPC分类号： G01N33/54353 ,  C07K1/22 ,  G01N33/54386 ,  G01N33/54393

摘要： A method for purifying bioactive substances includes the steps of: causing a bioactive substance having histidine units to contact media, each constituted by a substrate, ligands which are physically attached to the surface of the substrate, and Cu(II) or Fe(II) metal ions which are covalently bonded to the ligands; causing the bioactive substance to covalently bond with the metal ions via the histidine units; and washing the media with an amount of 1 nmol/L to 10 mmol/L imidazole derivative solution 60 times the volume of the media or greater. In the case that the metal ions are Cu(II), the bioactive substance which has covalently bonded with the Cu(II) via the histidine units are recovered by one of a 10 mmol/L to 1 mol/L imidazole derivative solution and a 0.5 mmol/L to 5 mol/L EDTA solution.

摘要翻译： 净化生物活性物质的方法包括以下步骤：使具有组氨酸单元的生物活性物质与底物接触的介质，物理上附着于基材表面的配体和Cu（II）或Fe（II） 与配体共价键合的金属离子; 使生物活性物质通过组氨酸单元与金属离子共价键合; 并用介质的体积为60倍量的1nmol / L至10mmol / L的咪唑衍生物溶液洗涤培养基。 在金属离子为Cu（II）的情况下，通过组氨酸单元与Cu（II）共价键合的生物活性物质由10mmol / L至1mol / L的咪唑衍生物溶液中的一种回收， 0.5 mmol / L至5 mol / L EDTA溶液。

公开(公告)号：US20080188010A1

公开(公告)日：2008-08-07

申请号：US12022606

申请日：2008-01-30

申请人： Yukou Saitoh ,  Toshihide Ezoe ,  Taisei Nishimi

发明人： Yukou Saitoh ,  Toshihide Ezoe ,  Taisei Nishimi

IPC分类号： G01N33/551 ,  B01J19/00

CPC分类号： G01N33/54373

摘要： It is an object of the present invention to provide a biosensor substrate that prevents non-specific adsorption and is used for immobilizing a physiologically active substance. The present invention provides a biosensor substrate which comprises an inorganic oxide film and a hydrophilic polymer having a physiologically active substance-immobilizing group on the substrate, wherein the hydrophilic polymer is bound to the inorganic oxide film through a low molecular compound.

摘要翻译： 本发明的目的是提供一种防止非特异性吸附并用于固定生理活性物质的生物传感器基板。 本发明提供一种生物传感器基板，其包含无机氧化物膜和在基板上具有生理活性物质固定基团的亲水性聚合物，其中亲水性聚合物通过低分子化合物与无机氧化物膜结合。

公开(公告)号：US20060246512A1

公开(公告)日：2006-11-02

申请号：US11377554

申请日：2006-03-17

申请人： Toshihide Ezoe ,  Taisei Nishimi ,  Yukou Saito

发明人： Toshihide Ezoe ,  Taisei Nishimi ,  Yukou Saito

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： C12Q1/002 ,  G01N21/553 ,  G01N21/554 ,  G01N33/5438 ,  Y10S436/805

摘要： It is an object of the present invention to provide a biosensor, wherein non-specific adsorption on a surface that does not retain a physiologically active substance (reference unit) is suppressed. The present invention provides a biosensor which comprises a substrate having at least two types of surfaces on a single plane, wherein at least one of said surfaces does not retain a physiologically active substance, and wherein at least two types of hydrophilic compounds with different molecular weights are bound to said surface that does not retain a physiologically active substance.

摘要翻译： 本发明的目的是提供一种生物传感器，其中抑制了不保留生理活性物质（参考单元）的表面上的非特异性吸附。 本发明提供了一种生物传感器，其包括在单个平面上具有至少两种类型的表面的基底，其中所述表面中的至少一个不保留生理活性物质，并且其中至少两种具有不同分子量的亲水性化合物 结合到不保留生理活性物质的所述表面。

公开(公告)号：US20060040410A1

公开(公告)日：2006-02-23

申请号：US11205183

申请日：2005-08-17

申请人： Taisei Nishimi ,  Toshihide Ezoe ,  Toshiaki Kubo

发明人： Taisei Nishimi ,  Toshihide Ezoe ,  Toshiaki Kubo

IPC分类号： C12M1/34 ,  G01N33/553

CPC分类号： G01N33/54393 ,  G01N33/54373

摘要： It is an object of the present invention to provide a technique of converting carboxylic acid into an active ester with no generation of air bubbles and a technique of stabilizing the obtained active ester. The present invention provides a biosensor wherein a carboxyl group existing on the surface of a substrate thereof is activated with any one compound selected from an uronium salt, a phosphonium salt or a triazine derivative which are defined in the present application, so as to form a carboxylic acid amide group.

摘要翻译： 本发明的目的是提供一种不产生气泡而将羧酸转化成活性酯的技术，以及稳定所得活性酯的技术。 本发明提供一种生物传感器，其中存在于其底物表面上的羧基由选自本申请中定义的铀盐，鏻盐或三嗪衍生物的任何一种化合物活化，从而形成 羧酸酰胺基。

公开(公告)号：US08367213B2

公开(公告)日：2013-02-05

申请号：US12442978

申请日：2007-09-28

申请人： Taisei Nishimi ,  Satoshi Hoshi ,  Morihito Ikeda ,  Takashi Kubo ,  Satoshi Tanaka

发明人： Taisei Nishimi ,  Satoshi Hoshi ,  Morihito Ikeda ,  Takashi Kubo ,  Satoshi Tanaka

IPC分类号： B32B9/04

CPC分类号： G01N33/54393 ,  B01L3/50 ,  B01L2300/165 ,  C08J7/047 ,  C08J2483/00 ,  Y10T428/31504 ,  Y10T428/31663 ,  Y10T428/31667 ,  Y10T428/31725 ,  Y10T428/31855 ,  Y10T428/31971

摘要： An object of the present invention is to provide a biochemical instrument having a surface that can simultaneously inhibit adsorption of a biopolymer and that of a hydrophobic low-molecular-weight compound. The present invention provides a biochemical instrument comprising a region that inhibits adsorption of a hydrophobic low-molecular-weight compound and a region that inhibits adsorption of a biopolymer on the surface of a water-insoluble material.

摘要翻译： 本发明的目的是提供一种具有能够同时抑制生物聚合物和疏水性低分子量化合物的吸附的表面的生物化学仪器。 本发明提供了一种生物化学仪器，其包括抑制疏水性低分子量化合物的吸附的区域和抑制生物聚合物吸附在水不溶性材料表面上的区域。

公开(公告)号：US07964414B2

公开(公告)日：2011-06-21

申请号：US11377554

申请日：2006-03-17

申请人： Toshihide Ezoe ,  Taisei Nishimi ,  Yukou Saito

发明人： Toshihide Ezoe ,  Taisei Nishimi ,  Yukou Saito

IPC分类号： G01N33/543 ,  C12M1/34

CPC分类号： C12Q1/002 ,  G01N21/553 ,  G01N21/554 ,  G01N33/5438 ,  Y10S436/805

摘要： The present invention provides a biosensor, wherein non-specific adsorption on a surface that does not retain a physiologically active substance (reference unit) is suppressed. The biosensor of the invention includes a substrate having at least two types of surfaces on a single plane, wherein at least one of the surfaces does not retain a physiologically active substance, and wherein at least two types of hydrophilic compounds with different molecular weights are bound to the surface that does not retain a physiologically active substance.

摘要翻译： 本发明提供一种生物传感器，其中抑制了不保留生理活性物质（参考单元）的表面上的非特异性吸附。 本发明的生物传感器包括在单个平面上具有至少两种类型的表面的基底，其中至少一个表面不保留生理活性物质，并且其中至少两种具有不同分子量的亲水性化合物被结合 到没有保留生理活性物质的表面。

公开(公告)号：US20100035071A1

公开(公告)日：2010-02-11

申请号：US12442978

申请日：2007-09-28

申请人： Taisei Nishimi ,  Satoshi Hoshi ,  Morihito Ikeda ,  Takashi Kubo ,  Satoshi Tanaka

发明人： Taisei Nishimi ,  Satoshi Hoshi ,  Morihito Ikeda ,  Takashi Kubo ,  Satoshi Tanaka

IPC分类号： B32B9/04 ,  B32B27/28 ,  B32B27/34 ,  B32B27/30 ,  B32B27/00 ,  B05D3/00

CPC分类号： G01N33/54393 ,  B01L3/50 ,  B01L2300/165 ,  C08J7/047 ,  C08J2483/00 ,  Y10T428/31504 ,  Y10T428/31663 ,  Y10T428/31667 ,  Y10T428/31725 ,  Y10T428/31855 ,  Y10T428/31971

摘要： An object of the present invention is to provide a biochemical instrument having a surface that can simultaneously inhibit adsorption of a biopolymer and that of a hydrophobic low-molecular-weight compound. The present invention provides a biochemical instrument comprising a region that inhibits adsorption of a hydrophobic low-molecular-weight compound and a region that inhibits adsorption of a biopolymer on the surface of a water-insoluble material.

摘要翻译： 本发明的目的是提供一种具有能够同时抑制生物聚合物和疏水性低分子量化合物的吸附的表面的生物化学仪器。 本发明提供了一种生物化学仪器，其包括抑制疏水性低分子量化合物的吸附的区域和抑制生物聚合物吸附在水不溶性材料表面上的区域。

公开(公告)号：US20090239381A1

公开(公告)日：2009-09-24

申请号：US12405755

申请日：2009-03-17

申请人： Taisei Nishimi ,  Kenichi Ishizuka

发明人： Taisei Nishimi ,  Kenichi Ishizuka

IPC分类号： H01L21/311 ,  B32B3/26 ,  H01L21/308 ,  B05D5/12

CPC分类号： H01L21/3086 ,  B01D61/14 ,  B01D69/02 ,  B01D69/141 ,  B01D71/24 ,  B01D71/26 ,  B01D71/28 ,  B01D71/40 ,  B01D71/80 ,  B01D2325/021 ,  B05D3/007 ,  B05D5/00 ,  B81C1/00031 ,  B81C2201/0149 ,  B81C2201/0198 ,  B82Y30/00 ,  Y10T428/249953 ,  Y10T428/249975

摘要： A porous film which is formed using a block copolymer composed of a water-soluble polymer and a water-insoluble polymer, has nanometer-size pores, and in which a desired functional polymer is present on the pore inner walls is provided. The porous film includes a microphase-separated morphology including a continuous phase which is composed primarily of a water-insoluble polymer A, and a plurality of cylindrical microdomains which are composed primarily of a water-soluble polymer B incompatible with the water-insoluble polymer A, distributed within the continuous phase and oriented perpendicular to a surface of the film. The cylindrical microdomains contain therein pores having a cylindrical shape and an average diameter of between 1 and 200 nm.

摘要翻译： 使用由水溶性聚合物和水不溶性聚合物构成的嵌段共聚物形成的多孔膜具有纳米尺寸的孔，其中在孔内壁上存在所需的官能聚合物。 多孔膜包括微相分离的形态，其包括主要由水不溶性聚合物A组成的连续相和主要由与水不溶性聚合物A不相容的水溶性聚合物B组成的多个圆筒状微区 分布在连续相中并垂直于膜的表面定向。 圆柱形微畴中包含具有圆柱形和平均直径在1至200nm之间的孔。