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1.发明授权公开(公告)号：US06878700B1
公开(公告)日：2005-04-12
申请号：US09541795
申请日：2000-03-31
申请人： James Link , Gang Liu , ZhongHua Pei , Tom von Geldern , Martin Winn , Zhili Xin , Steven A. Boyd , Gui-Dong Zhu , Jennifer C. Freeman , Indrani W. Gunawardana , Michael A. Staeger , Hwan-Soo Jae , John K. Lynch , Sheldon Wang
发明人： James Link , Gang Liu , ZhongHua Pei , Tom von Geldern , Martin Winn , Zhili Xin , Steven A. Boyd , Gui-Dong Zhu , Jennifer C. Freeman , Indrani W. Gunawardana , Michael A. Staeger , Hwan-Soo Jae , John K. Lynch , Sheldon Wang
IPC分类号： A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D241/04 , C07D295/185 , C07D295/26 , C07D401/04 , C07D521/00 , A61K31/33 , A61K31/415 , C07D221/02 , C07D265/30 , C07D319/00
CPC分类号： C07D207/27 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D401/04
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译： 本发明涉及可用于治疗炎性和免疫疾病的新型肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。
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2.发明授权
公开(公告)号：US6110922A
公开(公告)日：2000-08-29
申请号：US222491
申请日：1998-12-29
申请人： James Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
发明人： James Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
IPC分类号： C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/505 , A61K31/405 , C07C319/00 , C07D239/70 , C07D319/14
CPC分类号： C07D207/27 , C07C323/62 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10 , C07C2101/02 , C07C2101/04 , C07C2101/08
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译： 本发明涉及可用于治疗炎性和免疫疾病的新颖的肉桂酰胺化合物，包含这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。
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公开(公告)号：USRE39197E1
公开(公告)日：2006-07-18
申请号：US10356794
申请日：2002-08-29
申请人： James T. Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
发明人： James T. Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
IPC分类号： A61K31/505 , A61K31/405 , C07D239/70 , C07D319/14 , C07D319/00
CPC分类号： C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
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4.发明申请公开(公告)号：US20050250768A1
公开(公告)日：2005-11-10
申请号：US10921965
申请日：2004-08-20
申请人： James Link , Gang Liu , ZhongHua Pei , Tom Geldern , Martin Winn , Zhili Xin , Steven Boyd , Gui-Dong Zhu , Jennifer Freeman , Indrani Gunawardana , Michael Staeger , Hwan-Soo Jae , John Lynch , Sheldon Wang
发明人： James Link , Gang Liu , ZhongHua Pei , Tom Geldern , Martin Winn , Zhili Xin , Steven Boyd , Gui-Dong Zhu , Jennifer Freeman , Indrani Gunawardana , Michael Staeger , Hwan-Soo Jae , John Lynch , Sheldon Wang
IPC分类号： A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D241/04 , C07D295/185 , C07D295/26 , C07D401/04 , C07D521/00
CPC分类号： C07D207/27 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D401/04
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译： 本发明涉及可用于治疗炎症和免疫疾病的新颖的肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫反应的方法。
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公开(公告)号：US06329534B1
公开(公告)日：2001-12-11
申请号：US09654322
申请日：2000-09-01
申请人： Philip R. Kym , Benjamin C. Lane , John K. Pratt , Tom Von Geldern , Martin Winn , Jehrod Brenneman , Jyoti R. Patel , David L. Arendsen , Irini Akritopoulou-Zanze
发明人： Philip R. Kym , Benjamin C. Lane , John K. Pratt , Tom Von Geldern , Martin Winn , Jehrod Brenneman , Jyoti R. Patel , David L. Arendsen , Irini Akritopoulou-Zanze
IPC分类号： C07D31180
CPC分类号： C07D407/04 , C07D311/80 , C07D409/04
摘要： Compounds of formula I are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 式I化合物可用于治疗II型糖尿病，肥胖症，高血糖症，葡萄糖清除率不足，高胰岛素血症，高甘油三酯血症和高循环糖皮质激素水平，化合物的制剂，含该化合物的组合物，以及使用该化合物的治疗方法。
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公开(公告)号：US06593480B2
公开(公告)日：2003-07-15
申请号：US09795998
申请日：2001-02-28
申请人： Philip R. Kym , Benjamin C. Lane , John K. Pratt , Tom Von Geldern , Martin Winn , Jehrod Brenneman , Jyoti R. Patel , David L. Arendsen , Irini Akritopoulou-Zanze , Kimba L. Ashworth , Kresna Hartandi
发明人： Philip R. Kym , Benjamin C. Lane , John K. Pratt , Tom Von Geldern , Martin Winn , Jehrod Brenneman , Jyoti R. Patel , David L. Arendsen , Irini Akritopoulou-Zanze , Kimba L. Ashworth , Kresna Hartandi
IPC分类号： C07D31180
CPC分类号： C07D407/04 , C07D311/80 , C07D409/04
摘要： Compounds of formula I are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 式I化合物可用于治疗II型糖尿病，肥胖症，高血糖症，葡萄糖清除率不足，高胰岛素血症，高甘油三酯血症和高循环糖皮质激素水平，化合物的制剂，含该化合物的组合物，以及使用该化合物的治疗方法。
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公开(公告)号：US07365093B2
公开(公告)日：2008-04-29
申请号：US11063476
申请日：2005-02-23
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号： A01N43/36 , C07D405/00
CPC分类号： C07D207/16 , C07D405/04 , C07D405/14 , C07D413/14
摘要： A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译： 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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公开(公告)号：US07208517B1
公开(公告)日：2007-04-24
申请号：US09653563
申请日：2000-08-31
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King , Todd J. Janus , Robert J. Padley
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King , Todd J. Janus , Robert J. Padley
IPC分类号： A61K31/40
CPC分类号： A61K31/40
摘要： A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, a method of antagonizing endothelin, methods for the inhibition of bone metastases, methods for the prevention of growth of new metastases, methods for the inhibition of bone turnover, and methods for the prevention of bone loss in patients, including cancer patients, using an endothelin ET-A receptor antagonist.
摘要翻译： 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，拮抗内皮素的方法，抑制骨转移的方法，预防生长的方法 的新转移，抑制骨转换的方法，以及使用内皮素ET-A受体拮抗剂预防患者（包括癌症患者）的骨丢失的方法。
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公开(公告)号：US06946481B1
公开(公告)日：2005-09-20
申请号：US10266270
申请日：2002-10-08
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号： A61K31/40 , C07D207/00 , C07D405/04
CPC分类号： C07D405/04
摘要： A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译： 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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公开(公告)号：US6162927A
公开(公告)日：2000-12-19
申请号：US905913
申请日：1997-08-04
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen , Bruce G. Szczepankiewicz , Kenneth J. Henry , Gang Liu , Steven J. Wittenberger , Steven A. King
IPC分类号： C07D207/16 , C07D207/26 , C07D207/27 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07F9/572 , C07F9/59 , C07D405/02 , C07D405/06 , A61K41/30 , A61N9/06 , A61N9/10
CPC分类号： C07D207/27 , C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07F9/572 , C07F9/59
摘要： A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译： 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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