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1.发明授权Pyrimidines and pharmaceutically acceptable salts thereof useful in treatment of neurological disorders 失效嘧啶类及其药学上可接受的盐可用于治疗神经障碍
公开(公告)号：US5304555A
公开(公告)日：1994-04-19
申请号：US600171
申请日：1990-10-19
申请人： Akira Awaya , Kazutoshi Horikomi , Tadayuki Sasaki , Hisashi Kobayashi , Akira Mizuchi , Takuo Nakano , Ikuo Tomino , Shintaro Araki , Mitsuyuki Takesue , Koji Kato , Keiichi Yokoyama
发明人： Akira Awaya , Kazutoshi Horikomi , Tadayuki Sasaki , Hisashi Kobayashi , Akira Mizuchi , Takuo Nakano , Ikuo Tomino , Shintaro Araki , Mitsuyuki Takesue , Koji Kato , Keiichi Yokoyama
IPC分类号： C07D239/48 , C07D487/04 , C07D279/12 , A61K31/54
CPC分类号： C07D239/48 , C07D487/04
摘要： This invention provides novel pyrimidines or their pharmaceutically acceptable salts thereof and process for preparation thereof. The novel compounds are useful for neurological diseases of the peripheral and central nervous systems of animals.
摘要翻译： 本发明提供新的嘧啶或其药学上可接受的盐及其制备方法。 该新化合物可用于动物的外周和中枢神经系统的神经疾病。
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公开(公告)号：US4959368A
公开(公告)日：1990-09-25
申请号：US130533
申请日：1987-10-22
申请人： Akira Awaya , Takuo Nakano , Hisashi Kobayashi , Ken E. Tan , Kazutoshi Horikomi , Tadayuki Sasaki , Keiichi Yokoyama , Hiroyasu Ohno , Kozi Kato , Takumi Kitahara , Ikuo Tomino , Shigeru Isayama
发明人： Akira Awaya , Takuo Nakano , Hisashi Kobayashi , Ken E. Tan , Kazutoshi Horikomi , Tadayuki Sasaki , Keiichi Yokoyama , Hiroyasu Ohno , Kozi Kato , Takumi Kitahara , Ikuo Tomino , Shigeru Isayama
IPC分类号： A61K31/505 , A61K31/506 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/70 , C07D239/84 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07D239/47 , C07D239/48 , C07D239/70 , C07D239/84 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要： A pharmaceutical composition comprising a pyrimidine represented by the following formula ##STR1## wherein R.sup.1 represents a hydrogen atom, an acyl group having 2 to 4 carbon atoms, an alkoxycarbonyl group having 2 to 5 carbon atoms, an alkoxycarbonylmethyl group having 3 to 5 carbon atoms, a 3,4-dimethoxybenzoyl group or a 3,4-methylenedioxybenzyl group,R.sup.2 represents a hydrogen atom, an amino group, a monoalkylamino group having 1 to 4 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or an alkoxycarbonyl group having 2 to 4 carbon atoms,R.sup.3 represents a hydrogen atom, an alkoxycarbonyl group having 2 to 4 carbon atoms, a dialkylaminocarbonyl group having 1 to 9 carbon atoms in each alkyl moiety, an alkoxy group having 1 to 5 carbon atoms, or a hydroxyethyl group, R.sup.2 and R.sup.3, together with the carbon atoms to which they are bonded, may form a 5- to 7-membered carbocyclic ring or a heterocyclic ring having N, O or S as the hetero atom, and R.sup.4 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkylthio group having 1 to 4 carbon atoms,or a pharmaceutically acceptable salt thereof. The above active compound has activities of promoting growth of nerve cells, forming neurites, and restoring motor functions, and is useful as an agent for treating diseases of peripheral and central nerves.
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3.发明授权
公开(公告)号：US5288706A
公开(公告)日：1994-02-22
申请号：US019347
申请日：1993-02-18
CPC分类号： A61K38/08 , Y10S514/866
摘要： A medicament for prevention and remedy of diseases of pancreas and others is disclosed, which is characterized by containing as an effective ingredient thereof a nonapeptide having the following amino acid configuration:pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asnor an ester and amide at the carboxyl group of the C-terminal of the asparagine or a pharmacologically acceptable salt thereof.
摘要翻译： PCT No.PCT / JP88 / 01317 Sec。 371日期1989年8月18日 102（e）日期1989年8月18日PCT提交1988年12月23日PCT公布。 出版物WO89 / 06136 公开了一种用于预防和治疗胰腺及其它疾病的药物，其特征在于含有具有以下氨基酸构型的非肽作为其有效成分：pGlu-Ala-Lys-Ser-Gln -Gly-Gly-Ser-Asn或天冬酰胺C末端的羧基上的酯和酰胺或其药理学上可接受的盐。
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公开(公告)号：US4963653A
公开(公告)日：1990-10-16
申请号：US372708
申请日：1989-06-28
申请人： Yoshitaka Nagai , Shohei Shibayama , Masaaki Numata , Shoji Yoshimura , Makoto Tanaka , Masayoshi Ito , Akira Awaya , Hisashi Kobayashi , Hayao Abe , Yusaku Ishizuka , Tomoya Ogawa
发明人： Yoshitaka Nagai , Shohei Shibayama , Masaaki Numata , Shoji Yoshimura , Makoto Tanaka , Masayoshi Ito , Akira Awaya , Hisashi Kobayashi , Hayao Abe , Yusaku Ishizuka , Tomoya Ogawa
摘要： A sialic acid-bonded octapeptide represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or an acetyl group; and R' represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein disclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.
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公开(公告)号：US5352665A
公开(公告)日：1994-10-04
申请号：US91745
申请日：1993-07-15
申请人： Akira Awaya , Hisashi Kobayashi , Yusaku Ishizuka , Hayao Abe
发明人： Akira Awaya , Hisashi Kobayashi , Yusaku Ishizuka , Hayao Abe
摘要： A medicament for prevention and remedy of diseases caused by the infection of viruses is disclosed, which is characterized by containing as an effective ingredient thereof a nonapeptide having the following amino acid configuration:pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn or an ester and an amide at the carboxyl group of the C-terminal of the asparagine or a pharmacologically acceptable salt thereof.
摘要翻译： 公开了用于预防和治疗由病毒感染引起的疾病的药物，其特征在于含有具有以下氨基酸构型的非肽作为其有效成分：pGlu-Ala-Lys-Ser-Gln-Gly-Gly- Ser-Asn或天冬酰胺C末端的羧基上的酯和酰胺或其药理学上可接受的盐。
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公开(公告)号：US20230243591A1
公开(公告)日：2023-08-03
申请号：US18299313
申请日：2023-04-12
申请人： Hisashi Kobayashi
发明人： Hisashi Kobayashi
IPC分类号： F27D17/00 , F28D17/02 , F27D99/00 , C03B5/237 , F23D99/00 , F23L15/02 , F23C7/06 , F23D14/66
CPC分类号： F27D17/004 , F28D17/02 , F27D99/0033 , F27D17/002 , C03B5/237 , F23D91/02 , F23L15/02 , F23C7/06 , F23D14/66 , F28D2021/0057
摘要： A pressurized cavity is provided around at least a portion or all of a regenerator, within which gas such as flue gas is maintained at a pressure in excess of the pressure within the regenerator, to protect against leakage of gas through the walls of the regenerator.
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公开(公告)号：US10746469B2
公开(公告)日：2020-08-18
申请号：US15859819
申请日：2018-01-02
申请人： Hisashi Kobayashi
发明人： Hisashi Kobayashi
IPC分类号： F27D17/00 , F28D17/02 , F27D99/00 , C03B5/237 , F23D99/00 , F23L15/02 , F23C7/06 , F23D14/66 , F28D21/00
摘要： A pressurized cavity is provided around at least a portion or all of a regenerator, within which gas such as flue gas is maintained at a pressure in excess of the pressure within the regenerator, to protect against leakage of gas through the walls of the regenerator.
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公开(公告)号：US10273178B2
公开(公告)日：2019-04-30
申请号：US14970907
申请日：2015-12-16
摘要： A glassmelting furnace is provided in which the burners are elevated above the glassmelt surface and are oriented at an angle upwards relative to the glassmelt surface.
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公开(公告)号：US20160370005A1
公开(公告)日：2016-12-22
申请号：US15183879
申请日：2016-06-16
申请人： Kuang-Tsai Wu , Hisashi Kobayashi
发明人： Kuang-Tsai Wu , Hisashi Kobayashi
IPC分类号： F23L7/00 , B01J7/02 , B01J19/00 , F23J15/00 , C10L3/00 , F23B30/00 , F23B70/00 , C01B3/34 , C10J3/82
CPC分类号： F23L7/007 , B01J7/02 , B01J19/0046 , B01J2219/00054 , B01J2219/00756 , C01B3/34 , C01B3/36 , C01B2203/0216 , C01B2203/0222 , C01B2203/06 , C01B2203/0827 , C01B2203/0883 , C01B2203/1235 , C01B2203/141 , C01B2203/84 , C03B5/2353 , C03B5/237 , C10J3/82 , C10J2300/1618 , C10J2300/1634 , C10J2300/165 , C10J2300/1884 , C10L3/00 , C10L2200/0277 , C10L2200/0281 , C10L2200/0286 , C10L2200/0407 , C10L2290/02 , C10L2290/04 , C10L2290/06 , F23B5/02 , F23B70/00 , F23C2900/99011 , F23J15/00 , F23J15/08 , F23K2401/10 , F23L15/02 , F27D99/0033 , F27D2017/005 , F27D2019/0031 , Y02E20/344 , Y02E20/348 , Y02P10/143 , Y02P20/124 , Y02P20/129 , Y02P40/535 , Y02P40/55
摘要： Operation of a thermochemical regenerator to generate soot or to increase the amount of soot generated improves the performance of a furnace with which the thermochemical regenerator is operated.
摘要翻译： 热化学再生器的操作以产生烟灰或增加产生的烟灰量提高了热化学再生器运行的炉的性能。
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公开(公告)号：US20140338577A1
公开(公告)日：2014-11-20
申请号：US14448824
申请日：2014-07-31
CPC分类号： F23L7/007 , F22B1/18 , F23G5/00 , F23G5/44 , F23G5/442 , F23G7/10 , F23G2206/203 , F23G2207/30 , F23G2209/26 , F23G2900/7003 , F23G2900/7012 , F23L2900/07007 , Y02E20/12 , Y02E20/344 , Y02E50/12
摘要： The energy output of a power plant combustion chamber that combusts fuel comprising biomass as all or part of the fuel can be increased by feeding oxygen into the combustion chamber so that said fuel is in contact with gaseous oxidant whose oxygen content exceeds that of air by up to 5 vol. % above that of air.
摘要翻译： 可以通过将氧气供入到燃烧室中来燃烧包含生物质作为全部或部分燃料的发电厂燃烧室的能量输出，使得所述燃料与氧气含量超过空气的气态氧化剂接触 至5体积 ％高于空气。
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