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    2-piperazinopyrimidine derivatives
    5.
    发明授权
    2-piperazinopyrimidine derivatives 失效
    2-哌嗪基嘧啶衍生物

    公开(公告)号：US4742165A

    公开(公告)日：1988-05-03

    申请号：US865566

    申请日：1986-05-02

    申请人： Keiichi Yokoyama ,  Tatsuyoshi Ishida ,  Shigeru Isayama ,  Kohji Kato ,  Takumi Kitahara ,  Yoshiaki Furuya

    发明人： Keiichi Yokoyama ,  Tatsuyoshi Ishida ,  Shigeru Isayama ,  Kohji Kato ,  Takumi Kitahara ,  Yoshiaki Furuya

    IPC分类号： A01N43/60 ,  A01N43/90 ,  C07D239/84 ,  C07D471/04 ,  C07D487/04 ,  C07D239/70

    CPC分类号： C07D471/04 ,  A01N43/60 ,  A01N43/90 ,  C07D239/84 ,  C07D487/04

    摘要： The present invention relates to novel 2-piperazinopyrimidine derivatives represented by the following general formula [I] which are useful as, for example, an active ingredient of herbicides ##STR1## wherein R.sup.1 is a hydrogen atom or an aralkyl group and Y is one of the groups represented by the following general formulas [II] to [VII] ##STR2## (wherein a and b are positions to be bound to positions 4 and 5 of the pyrimidine ring of the formula [I], respectively; l.sub.1 and l.sub.2 each are an integer of 2 to 4; l.sub.3 is 2 or 0; l.sub.4 is 0 or 1, provided that l.sub.4 is 0 when l.sub.3 is 2 and l.sub.4 is 1 when l.sub.3 is 0; l.sub.5 is 2 or 3; l.sub.6 is 1 or 2; l.sub.7 is 2 or 3; R.sup.2 is a hydroxyl group or a toluenesulfonyloxy group; and R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each are a hydrogen atom or a lower alkyl group).

    摘要翻译： PCT No.PCT / JP85 / 00500 Sec。 371日期：1986年5月2日 102（e）日期1986年5月2日PCT提交1985年9月7日PCT公布。 出版物WO86 / 01798 1986年3月27日。本发明涉及由以下通式[I]表示的新的2-哌嗪基嘧啶衍生物，其可用作例如除草剂活性成分[I]，其中R 1为氢 原子或芳烷基，Y是由以下通式[II]至[VII]表示的基团之一。图像[II] <图像> [III]图像[IV] （VII）其中a和b分别是结合式[I]嘧啶环的位置4和5的位置; l1和l2分别是2至4的整数 l3为2或0; l4为0或1，条件是当l3为2时l4为0，当l3为0时，l4为1; l5为2或3; 16为1或2; 17为2或3; R2 是羟基或甲苯磺酰氧基; R3，R4，R5，R6和R7各自为氢原子或低级烷基）。

    Selective molecular excitation method and isotope separation method using the same, isotope analysis method, selective molecular excitation apparatus and isotope separation apparatus
    7.
    发明申请
    Selective molecular excitation method and isotope separation method using the same, isotope analysis method, selective molecular excitation apparatus and isotope separation apparatus 有权
    选择性分子激发法和同位素分离法使用同位素分析方法，选择性分子激发装置和同位素分离装置

    公开(公告)号：US20110073755A1

    公开(公告)日：2011-03-31

    申请号：US12923444

    申请日：2010-09-22

    申请人： Keiichi Yokoyama ,  Leo Matsuoka ,  Hiroshi Akagi ,  Tatsuya Kasajima ,  Masaaki Tsubouchi ,  Atsushi Yokoyama

    发明人： Keiichi Yokoyama ,  Leo Matsuoka ,  Hiroshi Akagi ,  Tatsuya Kasajima ,  Masaaki Tsubouchi ,  Atsushi Yokoyama

    IPC分类号： H01J49/00

    CPC分类号： B01D59/34

    摘要： Molecules of a specific species can be selectively excited among molecules of a plurality of species that show only a slight difference of mass. Energy levels can be displayed on a graph where the horizontal axis indicates excitation energy. Assume an instance where an electromagnetic wave showing a comb-shaped spectrum having a plurality of narrow bands as indicated by P1 through P14 and tuning with excitation energies corresponding to the rotational levels of molecule X is irradiated onto the molecule X. The molecule X can sequentially make transitions to higher energy levels by using an electromagnetic wave showing such a comb-shaped spectrum. The energy levels of molecule Y are not synchronized with the comb-shaped spectrum. The two ranges of Y4 through Y7 and Y12 through Y15 operate as gates and the molecule Y cannot make transition from a rotational level to another when a gate is found between them.

    摘要翻译： 可以在仅显示轻微质量差异的多种物种的分子中选择性地激发特定物种的分子。 能量水平可以显示在横轴表示激发能量的图形上。 假设示出具有如P1至P14所示的多个窄带的梳状光谱的电磁波并且对应于分子X的旋转电平的激发能量的调谐被照射到分子X上。分子X可以顺序地 通过使用显示这样的梳状光谱的电磁波使过渡到更高的能级。 分子Y的能级与梳状光谱不同步。 Y4至Y7和Y12至Y15的两个范围作为门进行操作，并且当在它们之间发现栅极时，分子Y不能从旋转电平转变为另一个。

    Methods for secretory production of proteins
    8.
    发明授权
    Methods for secretory production of proteins 有权
    分泌蛋白质的方法

    公开(公告)号：US07252972B2

    公开(公告)日：2007-08-07

    申请号：US10673860

    申请日：2003-09-30

    申请人： Yoshimi Kikuchi ,  Masayo Date ,  Yukiko Umezawa ,  Keiichi Yokoyama ,  Haruo Heima ,  Hiroshi Matsui

    发明人： Yoshimi Kikuchi ,  Masayo Date ,  Yukiko Umezawa ,  Keiichi Yokoyama ,  Haruo Heima ,  Hiroshi Matsui

    IPC分类号： C12P21/04 ,  C12N1/21

    CPC分类号： C07K14/36 ,  C07K5/1016 ,  C07K14/195 ,  C07K14/34 ,  C07K2319/00 ,  C12N15/77

    摘要： The object of the present invention is to provide a method of producing a heterologous protein by making a coryneform bacterium to produce and efficiently extracellularly secrete (secreto-production) an industrially useful heterologous protein. According to the present invention, a genetic construct is used where a gene sequence encoding an intended protein which is ligated to the downstream of a sequence encoding the signal peptide derived from a coryneform bacterium, the gene construct is introduced into a mutant coryneform bacterium which has a capacity of secreting the heterologous protein at least 2-fold higher than the wild type Corynebacterium glutamicum ATCC 13869, the mutant coryneform bacterium is cultured and the extracellularly released heterologous protein is recovered.

    摘要翻译： 本发明的目的是提供通过使棒状细菌产生并有效地细胞外分泌（分泌产生）工业上有用的异源蛋白质来产生异源蛋白质的方法。 根据本发明，使用遗传构建体，其中将编码预期蛋白质的基因序列连接到编码衍生自棒状杆菌型细菌的信号肽的序列的下游，所述基因构建体被引入到突变型棒状杆菌型细菌中 分泌异源蛋白质的能力比野生型谷氨酸棒杆菌ATCC 13869高至少2倍，培养突变棒杆菌型细菌，并回收细胞外释放的异源蛋白质。

    Method of producing microbial transglutaminase
    9.
    发明申请
    Method of producing microbial transglutaminase 有权
    微生物转谷氨酰胺酶的生产方法

    公开(公告)号：US20060019367A1

    公开(公告)日：2006-01-26

    申请号：US11218780

    申请日：2005-09-06

    申请人： Yukiko Umezawa ,  Keiichi Yokoyama ,  Yoshimi Kikuchi ,  Masayo Date ,  Norimasa Onishi

    发明人： Yukiko Umezawa ,  Keiichi Yokoyama ,  Yoshimi Kikuchi ,  Masayo Date ,  Norimasa Onishi

    IPC分类号： C12N9/50 ,  C12N9/10 ,  C07H21/04 ,  C12N15/74 ,  C12N1/21

    CPC分类号： C12N9/1044 ,  C12N9/6489

    摘要： The present invention provides a neutral metalloprotease from actinomycetes which selectively cleaves a pro-structure part of a microbial protransglutaminase and a gene encoding said neutral metalloprotease. An active microbial transglutaminase having the pro-structure part cleaved can be obtained by culturing a microorganism into which a gene encoding the neutral metalloprotease from actinomycetes according to the present invention has been introduced, where by producing the neutral metalloprotease from actinomycetes, and reacting it on a microbial protransglutaminase.

    摘要翻译： 本发明提供来自放线菌的中性金属蛋白酶，其选择性地切割微生物转谷氨酰胺酶的前体结构部分和编码所述中性金属蛋白酶的基因。 具有前体结构部分切割的活性微生物转谷氨酰胺酶可以通过培养从引入放线菌中产生中性金属蛋白酶的本发明的编码中性金属蛋白酶的基因的微生物获得，其中通过从放线菌产生中性金属蛋白酶， 微生物抗转谷氨酰胺酶。

    Fluorine-substituted cyclic carbonate and electrolytic solution and battery containing the same
    10.
    发明授权
    Fluorine-substituted cyclic carbonate and electrolytic solution and battery containing the same 有权
    氟取代的环状碳酸酯和电解液和含有它的电池

    公开(公告)号：US06180800B2

    公开(公告)日：2001-01-30

    申请号：US09436259

    申请日：1999-11-09

    申请人： Keiichi Yokoyama ,  Takako Koiso ,  Akio Hiwara

    发明人： Keiichi Yokoyama ,  Takako Koiso ,  Akio Hiwara

    IPC分类号： C07D31708

    CPC分类号： C07D317/36 ,  H01M6/164 ,  H01M10/052 ,  H01M10/0569 ,  H01M2300/0034

    摘要： Monofluoromethyl ethylene carbonate, difluoromethyl ethylene carbonate and trifluoromethyl ethylene carbonate are provided as novel compounds. These compounds are very useful as solvents because they are chemically and physically stable, have a high dielectric constant, can readily dissolve organic substances and have a wide application temperature range. These compounds have excellent charge and discharge cycle characteristics, have a high flash point, and are safe as non-aqueous elecytrolytes. Hence, batteries using these compounds withstand voltage and have excellent charge and discharge cycle characteristics.

    摘要翻译： 提供单氟甲基碳酸亚乙酯，二氟甲基碳酸亚乙酯和碳酸三氟甲酯作为新化合物。 这些化合物作为溶剂是非常有用的，因为它们是化学和物理稳定的，具有高介电常数，可以容易地溶解有机物质并具有广泛的应用温度范围。 这些化合物具有优异的充放电循环特性，具有高闪点，并且作为非水溶性电解质是安全的。 因此，使用这些化合物的电池耐受电压并且具有优异的充放电循环特性。