公开(公告)号：US4839279A

公开(公告)日：1989-06-13

申请号：US749425

申请日：1985-06-27

申请人： Akira Kosaka ,  Sawao Murao ,  Kenichi Hirano ,  Noriaki Tanaka ,  Kuniyoshi Matsunaga

发明人： Akira Kosaka ,  Sawao Murao ,  Kenichi Hirano ,  Noriaki Tanaka ,  Kuniyoshi Matsunaga

IPC分类号： C12Q1/26 ,  C12Q1/54 ,  C12Q1/60 ,  C12Q1/62

CPC分类号： C12Q1/62 ,  C12Q1/26 ,  C12Q1/54 ,  C12Q1/60 ,  Y10S436/811 ,  Y10S436/815 ,  Y10S436/825 ,  Y10T436/103332 ,  Y10T436/144444 ,  Y10T436/146666 ,  Y10T436/25125

摘要： A novel enzyme of bilirubin oxidase and a conventional enzyme of laccase are found to oxidize bilirubin to biliverdin without formation of hydrogen peroxide, thereby permitting the content of conjugated bilirubin in biological fluid to be quantitatively determined by reacting therewith the bilirubin oxidase of a microorganism of genus Myrothecium origin, and also permitting the content of total bilirubin in biological fluid to be quantitatively determined by reacting therewith such a bilirubin oxidase or laccase in the presence of a specific additive compound.

摘要翻译： 发现胆红素氧化酶的新型酶和漆酶的常规酶将胆红素氧化成胆绿素而不形成过氧化氢，从而通过与生物液体中的微生物的胆红素氧化酶反应来定量地测定生物液中的共轭胆红素含量 通过与特定的添加剂化合物的存在下的胆红素氧化酶或漆酶反应，可以定量测定生物体液中总胆红素的含量。

公开(公告)号：US4554249A

公开(公告)日：1985-11-19

申请号：US436385

申请日：1982-10-25

申请人： Akira Kosaka ,  Sawao Murao ,  Kenichi Hirano ,  Noriaki Tanaka ,  Kuniyoshi Matsunaga

发明人： Akira Kosaka ,  Sawao Murao ,  Kenichi Hirano ,  Noriaki Tanaka ,  Kuniyoshi Matsunaga

IPC分类号： C12Q1/26 ,  C12Q1/54 ,  C12Q1/60 ,  C12Q1/62 ,  C07G17/00 ,  C12N9/02

CPC分类号： C12Q1/62 ,  C12Q1/26 ,  C12Q1/54 ,  C12Q1/60 ,  Y10S436/811 ,  Y10S436/815 ,  Y10S436/825 ,  Y10T436/103332 ,  Y10T436/144444 ,  Y10T436/146666 ,  Y10T436/25125

摘要： A novel enzyme of bilirubin oxidase produced by a genus Myrothecium or genus Coprinus origin microorganism and a conventional enzyme of laccase are found, in the presence of a specific additive compound, e.g. a surface active agent, aromatic carboxylic acid, sulfa drug or protease, to oxidize both conjugated and unconjugated bilirubin in biological fluid to biliverdin without formation of hydrogen peroxide, such that in the case of conventional enzymatic methods of the quantitative determination of glucose, cholesterol, neutral fats, free fatty acids, phospholipids or uric acid all existing together with bilirubin in biological fluid, the usual interference with such determination, as otherwise caused by bilirubin coexisting in such fluid, can be prevented by adding such a bilirubin oxidase or laccase together with such a specific additive compound to the determinative reaction system.

摘要翻译： 在特定的添加剂化合物的存在下，发现了由黑曲霉属或鬼伞属起源微生物和常规酶漆酶产生的胆红素氧化酶的新型酶。 表面活性剂，芳族羧酸，磺胺药物或蛋白酶，以将生物液体中的共轭和非共轭胆红素氧化成胆绿素而不形成过氧化氢，使得在常规的酶法测定葡萄糖，胆固醇， 中性脂肪，游离脂肪酸，磷脂或尿酸都与生物液体中的胆红素一起存在，通过将这种胆红素共存在这种流体中的其他方式引起的这种测定的通常干扰可以通过将这样的胆红素氧化酶或漆酶与 这种特定的添加剂化合物与决定性反应体系。

公开(公告)号：US20130068945A1

公开(公告)日：2013-03-21

申请号：US13700795

申请日：2011-05-30

申请人： Noriaki Tanaka ,  Masahiro Kohno ,  Emiko Sato ,  Kouichi Fujiwara

发明人： Noriaki Tanaka ,  Masahiro Kohno ,  Emiko Sato ,  Kouichi Fujiwara

IPC分类号： A61B5/00

CPC分类号： H01J49/0431 ,  A61B5/0059 ,  G01N30/34 ,  G01N30/7233 ,  G01N33/6893 ,  G01N2030/045 ,  G01N2030/8813 ,  G01N2800/347

摘要： This invention provides a method or device for determining the stage of chronic kidney disease.The present invention relates to a method for determining a stage of chronic kidney disease in a subject suffering from kidney disease, the method comprising the steps of: (A-1) measuring the content of at least one marker selected from the group consisting of markers (1) to (16) in a specimen from the subject, (B-1) determining the stage indicated by each marker by comparing the content of the at least one marker in the specimen from the subject, which has been measured in step (A-1), with a reference content range determined in each stage, and (C-1) determining that when each marker indicates the same stage, which has been determined in step (A-1), the chronic kidney disease in the subject is in that stage.

摘要翻译： 本发明提供了一种用于确定慢性肾脏疾病阶段的方法或装置。 本发明涉及一种用于确定患有肾脏疾病的受试者的慢性肾脏疾病阶段的方法，所述方法包括以下步骤：（A-1）测量选自标记物中的至少一种标志物的含量 （B-1）通过比较在步骤（1）中测量的来自受试者的标本中的至少一个标记物的含量来确定每个标记物指示的阶段（B-1） A-1），每个阶段确定参考含量范围，和（C-1）确定当每个标记指示在步骤（A-1）中确定的相同阶段时，受试者中的慢性肾脏疾病 在那个阶段

公开(公告)号：US08358954B2

公开(公告)日：2013-01-22

申请号：US12604464

申请日：2009-10-23

申请人： Noriaki Tanaka

发明人： Noriaki Tanaka

IPC分类号： G03G21/16 ,  G03G21/18

CPC分类号： G03G15/553 ,  G03G15/556 ,  G03G21/1842

摘要： An image forming apparatus includes a cartridge including at least one of an image bearing member and a developing device; a main assembly including an opening; an openable member movable between a closed position in which the opening is covered and an open position in which the opening is exposed; and a movable member for supporting the cartridge. The movable member is movable between an inside position in which the cartridge is located inside the main assembly and a pulled out position in which the movable member is outwardly pulled out from the main assembly. The openable member is prevented, from moving from the open position to the closed position, in a state in which the movable member is located outside the open position but is movable from the open position to the closed position in a state in which the movable member is located at the open position.

摘要翻译： 图像形成装置包括：包括图像承载部件和显影装置中的至少一个的盒; 包括开口的主组件; 可打开构件，其在所述开口被覆盖的关闭位置和所述开口被暴露的打开位置之间移动; 以及用于支撑盒的可动构件。 可移动部件可以在其中盒位于主组件内部的内部位置和可移动部件从主组件向外拉出的拉出位置之间移动。 在可动构件位于打开位置外部的状态下，可打开构件从打开位置移动到关闭位置，但是在可动构件的状态下可从打开位置移动到关闭位置 位于开放位置。

公开(公告)号：US20110097714A1

公开(公告)日：2011-04-28

申请号：US12602094

申请日：2008-06-03

申请人： Takeshi Nagasaka ,  Nagahide Matsubara ,  Hiromi Sasamoto ,  Noriaki Tanaka

发明人： Takeshi Nagasaka ,  Nagahide Matsubara ,  Hiromi Sasamoto ,  Noriaki Tanaka

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6827 ,  C12Q1/686 ,  C12Q2545/114 ,  C12Q2531/113 ,  C12Q2525/161 ,  C12Q2521/331 ,  C12Q2525/207

摘要： The object of the present invention is to provide a gene amplification method, wherein the method can amplify both methylated and unmethylated nucleic acids present in a biological sample, and further regulate the amplification ratio of the methylated and/or unmethylated nucleic acid as needed. Such objects can be solved by an amplification method using a nonspecific primer which can hybridize both with methylated and unmethylated nucleic acids and a specific primer which specifically hybridizes with either methylated or unmethylated nucleic acid, and further by an amplification method which can change the amplification ratio of methylated or unmethylated nucleic acid by changing the mixing rate of these primers.

摘要翻译： 本发明的目的是提供一种基因扩增方法，其中该方法可以扩增存在于生物样品中的甲基化和非甲基化核酸，并根据需要进一步调控甲基化和/或非甲基化核酸的扩增比。 可以通过使用可以与甲基化和非甲基化核酸杂交的非特异性引物的扩增方法和与甲基化或非甲基化核酸特异性杂交的特异性引物进一步通过扩增方法来解决这些目的，进一步通过可以改变扩增比的扩增方法 的甲基化或非甲基化核酸通过改变这些引物的混合速率。

公开(公告)号：US07919080B2

公开(公告)日：2011-04-05

申请号：US11984006

申请日：2007-11-13

申请人： Naoya Kobayashi ,  Noriaki Tanaka ,  Teru Okitsu ,  Ji-Won Yoon ,  Hee-Sook Jun ,  Seungjin Shin

发明人： Naoya Kobayashi ,  Noriaki Tanaka ,  Teru Okitsu ,  Ji-Won Yoon ,  Hee-Sook Jun ,  Seungjin Shin

IPC分类号： A01N63/00 ,  A01N65/00 ,  A61K48/00

CPC分类号： C12N15/907 ,  A61K35/12 ,  A61K48/00 ,  C07K14/62 ,  C12N5/067 ,  C12N15/63 ,  C12N2501/70 ,  C12N2510/00 ,  C12N2510/04

摘要： The present invention provides a cell line which can be substituted for β cells in human mature pancreatic islets and express insulin in a glucose-concentration dependent manner, and enables the easy obtainment of the number of cells which meets the demand. The present invention also provides a therapeutical cell preparation for treating diabetes. The cell lines of the present invention can be obtained by integrating both a nucleotide sequence encoding tamoxifen-induced Cre recombinase and a nucleotide sequence encoding insulin regulated by glucose-sensitive promoter into the chromosome in a human immortalized hepatic cell line FERM BP-7498 containing the TERT gene inserted in between a pair of LoxP sequences.

摘要翻译： 本发明提供可以代替“bgr”的细胞系。 人成熟胰岛中的细胞并以葡萄糖浓度依赖的方式表达胰岛素，并且能够容易地获得满足需求的细胞数量。 本发明还提供了治疗糖尿病的治疗细胞制剂。 本发明的细胞系可以通过将编码他莫昔芬诱导的Cre重组酶的核苷酸序列与编码由葡萄糖敏感性启动子调节的胰岛素的核苷酸序列整合到人永生化肝细胞系FERM BP-7498中而获得，所述人类永生化肝细胞系FERM BP-7498含有 TERT基因插入一对LoxP序列之间。

公开(公告)号：US07590766B2

公开(公告)日：2009-09-15

申请号：US11878544

申请日：2007-07-25

申请人： Noriaki Tanaka

发明人： Noriaki Tanaka

IPC分类号： G06F3/00

CPC分类号： G06F3/1285 ,  G06F3/1204 ,  G06F3/1228 ,  G06F3/1255 ,  G06F3/1264

摘要： An image processing system includes: a receiving section that receives print information including at least a first control command indicating a first print setting and a second control command embedded in a document to be printed and indicating a second print setting; an interpreting section that interprets the first control command and the second control command; and a controller that performs a control so as to prohibit execution of processing based on one of the first control command and the second control command when the interpreting section determines that both of the first control command and the second control command cannot be concurrently executed.

摘要翻译： 图像处理系统包括：接收部分，其接收包括至少指示第一打印设置的第一控制命令和嵌入在要打印的文档中并指示第二打印设置的第二控制命令的打印信息; 解释部分，其解释第一控制命令和第二控制命令; 以及控制器，当所述解释部确定不能同时执行所述第一控制命令和所述第二控制命令两者时，执行控制以便基于所述第一控制命令和所述第二控制命令中的一个禁止执行处理。

公开(公告)号：US07033744B2

公开(公告)日：2006-04-25

申请号：US10169085

申请日：2002-03-15

申请人： Naoya Kobayashi ,  Philippe Leboulch ,  Noriaki Tanaka ,  Toshiyoshi Fujiwara ,  Toshinori Totsugawa

发明人： Naoya Kobayashi ,  Philippe Leboulch ,  Noriaki Tanaka ,  Toshiyoshi Fujiwara ,  Toshinori Totsugawa

IPC分类号： A01N1/00

CPC分类号： C12N5/067 ,  A61K35/12 ,  C12N2510/02 ,  C12N2510/04

摘要： The present invention provides a method comprising a step of transferring a cell proliferation factor gene into a mammalian liver cell to obtain an immortalized liver cell, a step of proliferating the immortalized liver cell, and a step of removing the cell proliferation factor gene from the immortalized liver cell; a large number of liver cells obtained thereby; and a treating agent and a artificial liver comprising obtained liver cell.

摘要翻译： 本发明提供一种方法，其包括将细胞增殖因子基因转移到哺乳动物肝细胞中以获得永生化肝细胞，增殖永生化肝细胞的步骤和从永生化细胞中除去细胞增殖因子基因的步骤 肝细胞; 由此获得大量肝细胞; 以及包含获得的肝细胞的处理剂和人造肝。

公开(公告)号：US06647216B2

公开(公告)日：2003-11-11

申请号：US10086719

申请日：2002-03-04

申请人： Noriaki Tanaka

发明人： Noriaki Tanaka

IPC分类号： G03G1520

CPC分类号： G03G15/2035 ,  G03G2215/20 ,  G03G2215/2035

摘要： An image forming apparatus includes: a fixing device having a nip portion in which a recording material having an unfixed image is nipped and conveyed and the unfixed image is fixed to the recording material; a pressure applying device for applying a pressure to the nip portion; a pressure release device for releasing the pressure in the nip portion; and a detection device for detecting a presence or absence of the recording material. When the pressure in the nip portion is released by the pressure release device, the detection device outputs a detection result representing the presence of the recording material. The pressure release device have a plurality of levers for releasing the pressure and the levers are arranged at both ends of the fixing device in a direction perpendicular to a moving direction of the recording material.

公开(公告)号：US06355282B1

公开(公告)日：2002-03-12

申请号：US09182212

申请日：1998-10-30

申请人： Shigeharu Mori ,  Kimihiko Sato ,  Noriaki Tanaka

发明人： Shigeharu Mori ,  Kimihiko Sato ,  Noriaki Tanaka

IPC分类号： A21D200

CPC分类号： A21D8/042

摘要： A dough composition containing not less than 15 units of a raw starch decomposing enzyme per kilogram of a raw material to be baked, which may further contain glucose oxidase and/or hemicellulase. The characteristics of the dough composition are improved to provide baked products which have improved softness and are slow in getting hard.

摘要翻译： 一种生面团组合物，每公斤待烘焙的原料含有不少于15单位的生淀粉分解酶，其可以进一步含有葡萄糖氧化酶和/或半纤维素酶。 提高面团组合物的特性以提供具有改善的柔软度并且变硬的缓慢的烘焙产品。