专利检索 ap:("James Winkler" OR "Stephen Fodor" OR "Christopher Buchko" OR "Debra Ross" OR "Lois Aldwin" OR "Douglas Modlin") AND inv:"Stephen Fodor" 第 1 页

1.

发明申请
Combinatorial strategies for polymer synthesis 审中-公开

公开(公告)号：US20050186683A1

公开(公告)日：2005-08-25

申请号：US10997136

申请日：2004-11-24

申请人： James Winkler , Stephen Fodor , Christopher Buchko , Debra Ross , Lois Aldwin , Douglas Modlin

发明人： James Winkler , Stephen Fodor , Christopher Buchko , Debra Ross , Lois Aldwin , Douglas Modlin

IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , G01N1/00

CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , Y10T436/255 , Y10T436/2575

摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.

2.

发明申请
Combinatorial strategies for polymer synthesis 审中-公开
标题翻译：聚合物合成的组合策略

公开(公告)号：US20050124000A1

公开(公告)日：2005-06-09

申请号：US10997740

申请日：2004-11-24

申请人： James Winkler , Stephen Fodor , Christopher Buchko , Debra Ross , Lois Aldwin , Douglas Modlin

发明人： James Winkler , Stephen Fodor , Christopher Buchko , Debra Ross , Lois Aldwin , Douglas Modlin

IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , B05D3/00 , C12M1/34 , C12Q1/68 , G01N33/53

CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , Y10T436/255 , Y10T436/2575

摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.

摘要翻译： 一种用于在基底（401）上形成大量聚合物阵列的方法和装置。根据本发明的优选方面，衬底与其中具有通道（409）的通道块（407）接触。所选择的试剂通过通道输送，基底通过旋转阶段（403）旋转，并且重复该过程以在基底上形成聚合物阵列。该方法可以与光导方法组合。

3.

发明申请
Combinatorial strategies for polymer synthesis 审中-公开

公开(公告)号：US20050186592A1

公开(公告)日：2005-08-25

申请号：US10997142

申请日：2004-11-24

申请人： James Winkler , Stephen Fodor , Christopher Buchko , Debra Ross , Lois Aldwin , Douglas Modlin

发明人： James Winkler , Stephen Fodor , Christopher Buchko , Debra Ross , Lois Aldwin , Douglas Modlin

IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , C12Q1/68 , C08F2/46 , C08J3/28 , G01N33/53

CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , Y10T436/255 , Y10T436/2575

摘要： A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.

4.

发明申请
Very large scale immobilized polymer synthesis 审中-公开

公开(公告)号：US20060210452A1

公开(公告)日：2006-09-21

申请号：US11212551

申请日：2005-08-25

申请人： Stephen Fodor , Lubert Stryer , James Winkler , Christopher Holmes , Dennis Solas

发明人： Stephen Fodor , Lubert Stryer , James Winkler , Christopher Holmes , Dennis Solas

IPC分类号： B01J19/00

CPC分类号： C08G69/00 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L7/52 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/042 , C07K1/045 , C07K1/047 , C07K1/062 , C07K7/06 , C07K17/06 , C07K17/14 , C12Q1/6809 , C12Q1/6816 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , C40B80/00 , G01N15/1475 , G01N21/253 , G01N21/6428 , G01N21/6452 , G03F7/00 , G03F7/26 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , H01L25/50 , H01L2924/0002 , Y02P20/55 , Y10S435/961 , Y10S435/968 , Y10S435/969 , Y10S435/973 , Y10S436/807 , Y10S436/809 , Y10T428/31971 , Y10T436/2575 , H01L2924/00

摘要： A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.

5.

发明申请
Methods for polymorphism identification and profiling 审中-公开
标题翻译：多态性识别和分析方法

公开(公告)号：US20060263807A1

公开(公告)日：2006-11-23

申请号：US11388199

申请日：2006-03-24

申请人： Robert Lipshutz , Stephen Fodor

发明人： Robert Lipshutz , Stephen Fodor

IPC分类号： C12Q1/68 , C07H21/04 , C12M1/34

CPC分类号： B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6827 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B60/14 , Y02A90/24 , C12Q2565/501 , C12Q2565/515 , C12Q2525/179

摘要： The invention provides methods of using probe arrays For polymorphism identification and profiling. Such methods entail constructing a first array of probes that span and are complementary to one or more known DNA sequences. This array is hybridized with nucleic acid samples from different individuals to identify a collection of polymorphisms. A second array is then constructed to determine a polymorphic profile of an individual at the collection of polymorphic sites. The polymorphic profile is useful for, e.g., genetic mapping, epidemiology, diagnosis and forensics.

摘要翻译： 本发明提供使用探针阵列的方法用于多态性鉴定和分析。这样的方法需要构建跨越并与一个或多个已知DNA序列互补的探针的第一阵列。该阵列与来自不同个体的核酸样品杂交以鉴定多态性的集合。然后构建第二阵列以确定在多态位点的收集处的个体的多态性轮廓。多态性谱可用于例如遗传图谱，流行病学，诊断和取证。

6.

发明申请
Sequencing of surface immobilized polymers utilizing microfluorescence detection 失效
标题翻译：利用微荧光检测法测定表面固定化聚合物

公开(公告)号：US20070105131A1

公开(公告)日：2007-05-10

申请号：US11446575

申请日：2006-06-02

申请人： William Dower , Stephen Fodor

发明人： William Dower , Stephen Fodor

IPC分类号： C12Q1/68

CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L7/52 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6804 , C12Q1/6809 , C12Q1/6816 , C12Q1/6823 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , C12Q2535/101 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G03F7/00 , G03F7/26 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , C12Q2537/157 , C12Q2533/101 , C12Q2565/537 , C12Q2563/107 , C12Q2565/513 , C12Q2537/143 , C12Q2565/518

摘要： Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal monomers are used to label polymers at defined positions on a solid substrate.

摘要翻译： 用于同时并行序列分析大量生物聚合物大分子的方法。装置和方法可以在重复化学中使用荧光标记物来测定固相固定化聚合物上的末端单体。专门识别末端单体的试剂用于在固体基质上的限定位置上标记聚合物。

7.

发明申请
Integrated nucleic acid diagnostic device 审中-公开
标题翻译：集成核酸诊断装置

公开(公告)号：US20050250199A1

公开(公告)日：2005-11-10

申请号：US11010841

申请日：2004-12-13

申请人： Rolfe Anderson , Robert Lipshutz , Richard Rava , Stephen Fodor

发明人： Rolfe Anderson , Robert Lipshutz , Richard Rava , Stephen Fodor

IPC分类号： C12N15/09 , B01F11/00 , B01F11/02 , B01F13/00 , B01F13/08 , B01F15/02 , B01L3/00 , B01L7/00 , C12M1/34 , C12N1/00 , G01N35/00 , G01N35/10

CPC分类号： B01F15/0201 , B01F11/0071 , B01F11/0266 , B01F13/005 , B01F13/0059 , B01F13/08 , B01F15/0238 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502784 , B01L7/52 , B01L9/527 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2300/087 , B01L2300/0883 , B01L2300/16 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , B01L2400/049 , B01L2400/084 , B01L2400/086 , G01N35/1095 , G01N2035/00158 , Y10T436/11 , Y10T436/118339 , Y10T436/25 , Y10T436/25375 , Y10T436/2575

摘要： The present invention provides a miniaturized integrated nucleic acid diagnostic device and system. The device of the invention is generally capable of performing one or more sample acquisition and preparation operations, in combination with one or more sample analysis operations. For example, the device can integrate several or all of the operations involved in sample acquisition and storage, sample preparation and sample analysis, within a single integrated unit. The device is useful in a variety of applications, and most notably, nucleic acid based diagnostic applications and de novo sequencing applications.

摘要翻译： 本发明提供了一种小型化的综合核酸诊断装置和系统。本发明的装置通常能够结合一个或多个样品分析操作来执行一个或多个样品采集和制备操作。例如，该设备可以在单个集成单元中集成样品采集和存储，样品制备和样品分析中涉及的几个或全部操作。该装置可用于各种应用，尤其是基于核酸的诊断应用和从头测序应用。