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    Optical detection apparatus for chemical analyses of small volumes of samples
    1.
    发明授权
    Optical detection apparatus for chemical analyses of small volumes of samples 有权
    用于小批量样品化学分析的光学检测装置

    公开(公告)号：US6084683A

    公开(公告)日：2000-07-04

    申请号：US194523

    申请日：1998-11-25

    申请人： Alfredo Emilio Bruno ,  Steven Mark Barnard ,  Markus Ehrat ,  Reinhard Volkel ,  Philippe Nussbaum ,  Hans Peter Herzig

    发明人： Alfredo Emilio Bruno ,  Steven Mark Barnard ,  Markus Ehrat ,  Reinhard Volkel ,  Philippe Nussbaum ,  Hans Peter Herzig

    IPC分类号： G01N21/64 ,  G01N21/03

    CPC分类号： G01N21/03 ,  G01N2021/0346

    摘要： Optical detection apparatus for chemical analyses of small volumes of samples has light sources (21) to emit induction light, a measuring cell (7) for the sample, photoelectric sensing elements (22) to receive light coming form the sample in the measuring cell (7), as well as beam-conducting means for the induction light or the light from the sample. In the apparatus, several essentially planar, laminar components (2-7) are arranged in a sandwich structure, whereby the components (2-7) contain the light sources (21), the measuring cell (7), the photoelectric sensing elements (22), and also the beam conducting means.

    摘要翻译： PCT No.PCT / EP97 / 02745 Sec。 371日期：1998年11月25日 102（e）1998年11月25日日期PCT提交1997年5月27日PCT公布。 WO97 / 45718 PCT公开号 日期1997年12月4日用于小体积样品的化学分析的光学检测装置具有发射感光的光源（21），用于样品的测量单元（7），用于接收来自样品的光的光电感测元件（22） 在测量单元（7）中，以及用于感应光或来自样品的光的光束传导装置。 在该设备中，几个基本上平面的层状部件（2-7）被布置成夹层结构，由此部件（2-7）包含光源（21），测量单元（7），光电感测元件 22），以及光束传导装置。

    FLOW CELL ARRAY AND THE UTILIZATION THEREOF FOR MULTIANALYTE DETERMINATION
    2.
    发明申请
    FLOW CELL ARRAY AND THE UTILIZATION THEREOF FOR MULTIANALYTE DETERMINATION 有权
    流量池阵列及其多用途测定的应用

    公开(公告)号：US20100130370A1

    公开(公告)日：2010-05-27

    申请号：US12695553

    申请日：2010-01-28

    申请人： Eveline Schurmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Mtthias Kresbach ,  Michael Pawlak ,  Nania Graciela Scharer-Hernandez ,  Eginhard Schick

    发明人： Eveline Schurmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Mtthias Kresbach ,  Michael Pawlak ,  Nania Graciela Scharer-Hernandez ,  Eginhard Schick

    IPC分类号： C40B30/00 ,  C40B60/12

    CPC分类号： B01L3/5025 ,  G01N21/05 ,  G01N21/253 ,  G01N2021/0346

    摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.

    摘要翻译： 提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置 对应于样品室的（几何）布置，与基板结合。 该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。 一个或多个样品室的布置包括基板和与基板组合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和 一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法 制造及其使用。

    Flow cell array and the utilization thereof for multianalyte determination
    4.
    发明授权
    Flow cell array and the utilization thereof for multianalyte determination 有权
    流量池阵列及其在多分辨率测定中的应用

    公开(公告)号：US08053225B2

    公开(公告)日：2011-11-08

    申请号：US12695553

    申请日：2010-01-28

    申请人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    发明人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    IPC分类号： C12M1/34 ,  C12M3/00

    CPC分类号： B01L3/5025 ,  G01N21/05 ,  G01N21/253 ,  G01N2021/0346

    摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.

    摘要翻译： 提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置 对应于样品室的（几何）布置，与基板结合。 该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。 一个或多个样本室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和 一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法 制造及其使用。

    Kit and method for determining a plurality of analytes
    7.
    发明授权
    Kit and method for determining a plurality of analytes 有权
    用于确定多种分析物的试剂盒和方法

    公开(公告)号：US07396675B2

    公开(公告)日：2008-07-08

    申请号：US10296851

    申请日：2001-05-25

    申请人： Michael Pawlak ,  Eginhard Schick ,  Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Eveline Schürmann-Mader ,  Martin Andreas Bopp

    发明人： Michael Pawlak ,  Eginhard Schick ,  Andreas Peter Abel ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Eveline Schürmann-Mader ,  Martin Andreas Bopp

    IPC分类号： G01N33/543 ,  G01N33/551

    CPC分类号： G01N21/6452 ,  B01L3/5085 ,  G01N21/648 ,  G01N33/54373 ,  G01N2021/6441 ,  G01N2021/6482 ,  Y10S435/808 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/808

    摘要： The invention is related to different embodiments of a kit for the simultaneous qualitative and/or quantitative determination of a multitude of analytes comprising a sensor platform comprising an optical thin-film waveguide with a layer (a) transparent at least at an excitation wavelength on a layer (b) with lower refractive index than layer (a), also transparent at least at said excitation wavelength, and at least one grating structure (c) modulated in said layer (a), for the incoupling of said excitation light into layer (a), at least one array of biological or biochemical or synthetic recognition elements immobilized in discrete measurement areas (d) directly or by means of an adhesion-promoting layer on layer (a), for specific recognition and/or binding of said analytes and/or for specific interaction with said analytes, means for laterally resolved referencing of the excitation light intensity available in the measurement areas, and optionally means for the calibration of one or more luminescences generated in the near-field of layer (a) as a consequence of the binding of one or more analytes or of the specific interaction with one or more analytes, wherein a liquid sample to be analyzed for said analytes is brought into contact with said measurement areas on said sensor platform either directly or after mixture with further reagents. The invention is also related to analytical systems based on a kit according to the invention and to methods for the determination of one or more analytes, based on said kit, and to use thereof.

    摘要翻译： 本发明涉及用于同时定性和/或定量测定大量分析物的试剂盒的不同实施方案，其包括传感器平台，所述传感器平台包括具有至少在激发波长上透明的层（a）的光学薄膜波导 至少在所述激发波长下透明的至少一个光栅结构（c），用于将所述激发光转换成层（a）的至少一个光栅结构（c） a），直接或通过层（a）上的粘附促进层固定在离散测量区域（d）中的生物或生化或合成识别元件的至少一个阵列，用于特异性识别和/或结合所述分析物和 /或用于与所述分析物的特异性相互作用，用于横向分辨参考测量区域中可用的激发光强度的装置，以及可选地用于校准一个或多个 由于一种或多种分析物的结合或与一种或多种分析物的特异性相互作用的结合而在层（a）的近场产生的矿物发光，其中待分析的液体样品与所述分析物接触 所述测量区域在所述传感器平台上直接或与其它试剂混合之后。 本发明还涉及基于根据本发明的试剂盒的分析系统和基于所述试剂盒测定一种或多种分析物的方法及其用途。

    Flow cell array and the utilization thereof for multianalyte determination
    8.
    发明授权
    Flow cell array and the utilization thereof for multianalyte determination 失效
    流量池阵列及其在多分辨率测定中的应用

    公开(公告)号：US07678565B2

    公开(公告)日：2010-03-16

    申请号：US12071526

    申请日：2008-02-21

    申请人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    发明人： Eveline Schürmann-Mader ,  Andreas Peter Abel ,  Martin Andreas Bopp ,  Gert Ludwig Duveneck ,  Markus Ehrat ,  Gerhard Matthias Kresbach ,  Michael Pawlak ,  Nania Graciela Schärer-Hernández ,  Eginhard Schick

    IPC分类号： C12M1/34 ,  C12M3/00

    CPC分类号： B01L3/5025 ,  G01N21/05 ,  G01N21/253 ,  G01N2021/0346

    摘要： A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to the (geometrical) arrangement of the sample compartments, combined with the base plate. The arrangement allows for supplying to or removing from the sample compartments, which can be arranged at a high quantity on a small base area, even very small amounts of samples or reagents. An arrangement of one or more sample compartments includes a base plate and a body combined with the base plate in such a way that one or more recesses for generation of one or more flow cells fluidically sealed against one another, each with at least one inlet and one outlet, are formed between the base plate and the body, wherein at least one outlet of each flow cell is joined with a reservoir fluidically connected with the flow cell, the reservoir being operable to receive liquid exiting the flow cell, besides methods for its manufacturing and their use.

    摘要翻译： 提供了流动池的一维或二维布置，作为样品室阵列的一部分，每个样品室的至少一个入口和出口由基板和主体形成，具有空间凹陷的布置 对应于样品室的（几何）布置，与基板结合。 该装置允许从样品室供应或从样品室中取出，样品室可以大量排列在小的基底区域上，甚至是非常少量的样品或试剂。 一个或多个样本室的布置包括基板和与基板结合的主体，使得一个或多个凹槽用于产生流体密封的一个或多个流动池，每个具有至少一个入口和 一个出口形成在基板和主体之间，其中每个流动池的至少一个出口与与流动池流体连接的储存器连接，储存器可操作以接收离开流动池的液体，除了其用于其的方法 制造及其使用。

    Grating waveguide structure for reinforcing an excitation field and use thereof
    9.
    发明申请
    Grating waveguide structure for reinforcing an excitation field and use thereof 审中-公开
    用于加强激励场的光栅波导结构及其用途

    公开(公告)号：US20090224173A1

    公开(公告)日：2009-09-10

    申请号：US12318568

    申请日：2008-12-31

    申请人： Gert Ludwig Duveneck ,  Martin Andreas Bopp ,  Michael Pawlak ,  Markus Ehrat ,  Gerd Marowsky

    发明人： Gert Ludwig Duveneck ,  Martin Andreas Bopp ,  Michael Pawlak ,  Markus Ehrat ,  Gerd Marowsky

    IPC分类号： G01J1/58 ,  G02F1/01

    CPC分类号： G01N21/648 ,  G01N21/6428 ,  G01N21/774 ,  G01N2021/6419 ,  G01N2021/7786 ,  G02B6/124

    摘要： The invention relates to a variable embodiment of a grating waveguide structure, based on a planar thin-film waveguide with a first optically transparent layer (a) on a second optically transparent layer (b) having a lower refractive index than layer (a), and a grating structure (c) modulated in layer (a), wherein the intensity of an excitation light irradiated at the resonance angle for incoupling into layer (a) is enhanced by at least a factor of 100 on layer (a) and within layer (a), at least in the region of the grating structure (c), in comparison with the intensity of said excitation light on a substrate surface without incoupling of the excitation light. The invention also relates to an optical system with an excitation light source and an embodiment of a grating waveguide structure according to the invention, and to a method for enhancing an excitation light intensity, and to the use thereof in bioanalytical detection processes, in non-linear optics or in telecommunications or communications industry.

    摘要翻译： 本发明涉及一种基于具有比层（a）折射率低的第二光学透明层（b）上具有第一光学透明层（a）的平面薄膜波导的光栅波导结构的可变实施例， 以及在层（a）中调制的光栅结构（c），其中以共耦合角度照射到层（a）中的激发光的强度在层（a）上至少增加100倍，并且在层 （a），至少在光栅结构（c）的区域中，与衬底表面上的所述激发光的强度相比较，而不会激发激发光的耦合。 本发明还涉及具有激发光源和根据本发明的光栅波导结构的实施例的光学系统，以及用于增强激发光强度的方法及其在生物分析检测过程中的用途， 线性光学或电信或通信行业。

    Grating waveguide structure for multi-analyte determinations and the use thereof
    10.
    发明申请
    Grating waveguide structure for multi-analyte determinations and the use thereof 审中-公开
    用于多分析物测定的光栅波导结构及其用途

    公开(公告)号：US20090054263A1

    公开(公告)日：2009-02-26

    申请号：US12222212

    申请日：2008-08-05

    申请人： Michael Pawlak ,  Markus Ehrat ,  Gert Ludwig Duveneck ,  Martin Andreas Bopp

    发明人： Michael Pawlak ,  Markus Ehrat ,  Gert Ludwig Duveneck ,  Martin Andreas Bopp

    IPC分类号： C40B30/10 ,  C40B60/12

    CPC分类号： G01N21/7743 ,  G01N33/54373

    摘要： The invention relates to variable embodiments of a grating waveguide structure which enables to determine locally resolved changes of the resonance conditions for the incoupling of an excitation light into the waveguiding layer (a) of a stratified optical waveguide by means of a grating structure (c) modulated in said layer (a) or for outcoupling of a light guided in layer (a). The inventive system comprises arrays of measurement areas produced on the grating waveguide structure having different immobilized biological or biochemical or synthetic recognition elements for simultaneously binding and determining one or more analytes, wherein said excitation light is simultaneously irradiated onto an entire array of measurement areas, and the degree of satisfaction of the resonance condition for the incoupling of light into the layer (a) towards said measurement areas is simultaneously measured. The invention also relates to an optical system comprising at least one excitation light source and at least one locally resolving detector and, optionally, positioning elements for altering the angle of incidence of the excitation light onto the inventive grating waveguide structure. The invention additionally relates to a corresponding measuring method and to the use thereof. Surprisingly, it has been found that the inventive method is well-suited as an imaging detection method with high local resolution and sensitivity.

    摘要翻译： 本发明涉及光栅波导结构的可变实施例，其能够通过光栅结构（c）确定激发光进入分层光波导的波导层（a）的谐振条件的局部解析变化， 在所述层（a）中调制或者在层（a）中引导的光的外耦合。 本发明的系统包括在光栅波导结构上产生的具有不同的固定的生物或生物化学或合成识别元件的测量区域的阵列，用于同时结合和确定一种或多种分析物，其中所述激发光同时照射到整个测量区域阵列上，以及 同时测量对于朝向所述测量区域将光耦合到层（a）中的共振条件的满足程度。 本发明还涉及一种光学系统，其包括至少一个激发光源和至少一个局部分辨检测器以及可选地用于将激发光的入射角改变到本发明的光栅波导结构上的定位元件。 本发明还涉及相应的测量方法及其用途。 令人惊讶的是，已经发现本发明的方法非常适合作为具有高的局部分辨率和灵敏度的成像检测方法。