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    PROCESS FOR THE PREPARATION OF 4-BROMOPHENYL DERIVATIVES
    1.
    发明申请
    PROCESS FOR THE PREPARATION OF 4-BROMOPHENYL DERIVATIVES 审中-公开
    制备4-溴苯衍生物的方法

    公开(公告)号：US20110155950A1

    公开(公告)日：2011-06-30

    申请号：US13056692

    申请日：2009-07-30

    申请人： Andreas Lindenmaier ,  Martin Vogt ,  Gerhard Beck ,  Achim Bührer

    发明人： Andreas Lindenmaier ,  Martin Vogt ,  Gerhard Beck ,  Achim Bührer

    IPC分类号： C09K3/00

    CPC分类号： C07C41/22 ,  Y02P20/582 ,  C07C43/225

    摘要： Disclosed is a process for the preparation of a mixture of 4-bromophenyl derivatives (compound of formula (2)) and 2,4-dibromophenyl derivatives (compound of formula (3)) comprising the steps of [1] reacting in a two-phase (liquid-liquid) system a bromide containing source with a phenyl derivative (formula (1)) in the presence of an excess of an oxidizing agent, an acid, and optionally a catalyst selected from vanadium pentoxide and ammonium heptamolybdate forming 4-bromo- (compound of formula (2)) and 2,4-dibromo derivatives (compound of formula (3)) and as intermediate product the 2-bromo derivative (compound of formula (4)) which reacts in step [2] to the 2,4-dibromo derivative (formula (3)) according to the following reaction scheme 2 wherein R1 is hydroxy; C1-C5alkoxy; or —NR2R3; and R2 and R3 independently from each other are hydrogen; or C1-C5alkyl.

    摘要翻译： 公开了一种制备4-溴苯基衍生物（式（2）化合物）和2,4-二溴苯基衍生物（式（3）化合物）的混合物的方法，包括以下步骤：[1] 相（液 - 液）体系含有苯基衍生物（式（1））的溴化物源在过量的氧化剂，酸和任选的催化剂存在下，选自五氧化二钒和七钼酸铵，形成4-溴 - （式（2）的化合物）和2,4-二溴衍生物（式（3）的化合物），作为在步骤[2]中反应的2-溴衍生物（式（4）的化合物）作为中间产物，与 2,4-二溴衍生物（式（3）），其中R 1是羟基; C1-C5烷氧基; 或-NR2R3; R2和R3彼此独立地为氢; 或C 1 -C 5烷基。

    Process for the preparation of metal complex dyes
    8.
    发明授权
    Process for the preparation of metal complex dyes 失效
    制备金属复合染料的方法

    公开(公告)号：US5209832A

    公开(公告)日：1993-05-11

    申请号：US805428

    申请日：1991-12-11

    申请人： Wilhelm Schmidt ,  Gerhard Beck

    发明人： Wilhelm Schmidt ,  Gerhard Beck

    IPC分类号： C09B45/01 ,  C09B45/08 ,  C09B45/10 ,  C09B45/12 ,  C09B45/20 ,  C09B55/00

    CPC分类号： C09B45/01 ,  C09B45/20

    摘要： The invention relates to a process for the preparation of a metal complex dye under production conditions, which comprises reacting at least one dye with a metal donor, adding said metal donor or said dye discontinuously before the end point of the metallizing is reached, and determining the end of the metallizing voltametrically.The process makes it possible to prepare metal complex dyes in good yield and purity.

    摘要翻译： 本发明涉及在生产条件下制备金属络合物染料的方法，该方法包括使至少一种染料与金属供体反应，在达到金属化终点之前不连续地加入所述金属供体或所述染料，并确定 金属化电压的结束。 该方法使得可以以良好的产率和纯度制备金属络合染料。

    6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia
    9.
    发明授权
    6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia 失效
    6-苯氧基甲基-4-羟基四氢吡喃-2-酮和6-硫代氧甲基-4-羟基四氢吡喃-2-酮及相应的二羟基羧酸衍生物，盐和酯，以及治疗高胆固醇血症

    公开(公告)号：US5166171A

    公开(公告)日：1992-11-24

    申请号：US680613

    申请日：1991-04-02

    申请人： Heiner Jendralla ,  Gunther Wess ,  Wilhelm Bartmann ,  Gerhard Beck

    发明人： Heiner Jendralla ,  Gunther Wess ,  Wilhelm Bartmann ,  Gerhard Beck

    IPC分类号： C07C59/68 ,  C07C323/09 ,  C07D309/30

    CPC分类号： C07C59/68 ,  C07C323/09 ,  C07D309/30 ,  Y10S514/824

    摘要： 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, processes for the preparation of these compounds, their use as pharmaceuticals, pharmaceutical preparations and novel phenols and thiophenols Compounds of the general formula I ##STR1## and the corresponding open-chain dihydroxycarboxylic acids of the formula II ##STR2## in which X, Y and Z have the meanings given, and pharmacologically tolerated salts thereof with bases and pharmacologically tolerated esters thereof, processes for the preparation of these compounds, their use as pharmaceuticals and pharmaceutical preparations are described. Novel phenols and thiophenols of the formula III ##STR3## in which X, Y and Z have the meanings given, are also described.

    摘要翻译： 6-苯氧基甲基-4-羟基四氢吡喃-2-酮和6-噻吩氧基甲基-4-羟基四氢吡喃-2-酮以及相应的二羟基羧酸衍生物，盐和酯，用于制备这些化合物的方法，它们作为药物，药物制剂和 新型酚类和噻吩类化合物通式Ⅰ的化合物及其相应的式Ⅱ的开环二羟基羧酸，其中X，Y和Z具有给定的含义，其药理学上可容许的盐与碱和 描述了其药理学耐受的酯，制备这些化合物的方法，它们作为药物和药物制剂的用途。 还描述了其中X，Y和Z具有给定的含义的式III“III”的新型酚类和噻吩类。