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    Column packing material and method for producing the same
    1.
    发明授权
    Column packing material and method for producing the same 有权
    柱填料及其制造方法

    公开(公告)号：US07329386B2

    公开(公告)日：2008-02-12

    申请号：US10398564

    申请日：2002-08-30

    申请人： Atsushi Kobayashi ,  Kazuko Takezawa ,  Hideki Takasaki ,  Taketoshi Kanda ,  Isao Tanaka ,  Tomoko Kimura ,  Yutaka Ohtsu

    发明人： Atsushi Kobayashi ,  Kazuko Takezawa ,  Hideki Takasaki ,  Taketoshi Kanda ,  Isao Tanaka ,  Tomoko Kimura ,  Yutaka Ohtsu

    IPC分类号： G01N30/56

    CPC分类号： B01J20/3227 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3217 ,  B01J20/3244 ,  B01J20/3272 ,  Y10T428/31612 ,  Y10T428/31663

    摘要： The first subject of this invention is a column packing material comprising: a silica gel having a silanol group; a first chemical modification group which is bound to said silanol group; a silicone polymer for coating the surface of said silica gel; and, a trimethylsilyl group which is bound to the silanol group on said silicone polymer and/or the silanol group on said silica gel. The second subject of this invention is a method for producing a column packing material comprising the following steps (A) to (C): (A) a step for introducing a first chemical modification group into a silanol group on the surface of a silica gel by reacting the silica gel with a silane coupling agent having said first chemical modification group; (B) a step for forming a silicone polymer coating on the surface of said silica gel by polymerizing one or more silicone compounds on the surface of the silica gel after step (A); and, (C) a step for trimethylsilylating a silanol group on said silicone polymer and/or a silanol group on said silica gel using an end-capping agent after step (B).

    摘要翻译： 本发明的第一主题是柱填充材料，其包括：具有硅烷醇基团的硅胶; 与所述硅烷醇基团结合的第一化学修饰基团; 用于涂覆所述硅胶表面的硅氧烷聚合物; 和与所述硅氧烷聚合物上的硅烷醇基和/或所述硅胶上的硅烷醇基结合的三甲基甲硅烷基。 本发明的第二个课题是制备柱填充材料的方法，其包括以下步骤（A）至（C）：（A）将第一化学修饰基团引入到硅胶表面的硅烷醇基中的步骤 使所述硅胶与具有所述第一化学修饰基团的硅烷偶联剂反应; （B）通过在步骤（A）之后在硅胶表面上聚合一种或多种硅氧烷化合物，在所述硅胶表面上形成硅氧烷聚合物涂层的步骤; 和（C）在步骤（B）之后使用封端剂在所述硅胶上的所述硅氧烷聚合物和/或硅烷醇基上硅烷醇化甲硅烷基化步骤。

    Packing material for liquid chromatography
    2.
    发明授权
    Packing material for liquid chromatography 失效
    液相色谱填充材料

    公开(公告)号：US4743377A

    公开(公告)日：1988-05-10

    申请号：US880757

    申请日：1986-06-30

    申请人： Yutaka Ohtsu ,  Hiroshi Fukui ,  Motokiyo Nakano ,  Okitsugu Nakata ,  Taketoshi Kanda ,  Isao Tanaka ,  Osamu Shirota ,  Junichi Koyama

    发明人： Yutaka Ohtsu ,  Hiroshi Fukui ,  Motokiyo Nakano ,  Okitsugu Nakata ,  Taketoshi Kanda ,  Isao Tanaka ,  Osamu Shirota ,  Junichi Koyama

    IPC分类号： B01J20/32 ,  B01D15/08

    CPC分类号： B01J20/286 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28078 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3282 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/58 ,  Y10T428/2995

    摘要： A packing material for liquid chromatography, comprising particles having a silicone polymer film coated on substantially the entire surface thereof, the packing material being produced by a process comprising the steps of:(a) bringing at least one silicone compound having the general formula (I):(R.sup.1 HSiO).sub.a (R.sup.2 R.sup.3 SiO).sub.b (R.sup.4 R.sup.5 R.sup.6 SiO.sub.1/2).sub.c (I) wherein R.sup.1, R.sup.2, and R.sup.3 represent, independently, a hydrocarbon residue having 1 to 10 carbon atoms, which may be substituted with at least one halogen atom, R.sup.4, R.sup.5, and R.sup.6 represent, independently, hydrogen or a hydrocarbon residue having 1 to 10 carbon atoms, which may be substituted with at least one halogen atom, a is zero or an integer of 1 or more, b is zero or an integer of 1 or more, c is zero or 2, and a+b+c is 3 to 300, into contact with particles, whereby the silicone compound is polymerized on substantially the entire surface of the particles, and(b) crosslinking unreacted Si--H groups in the presence of a catalyst, or(c) carrying out an addition reaction of a vinyl compound having up to 40 carbon atoms to unreacted Si--H groups.

    摘要翻译： 一种用于液相色谱的包装材料，包括在其基本上整个表面上涂覆有硅氧烷聚合物膜的颗粒，所述包装材料通过包括以下步骤的方法生产：（a）将至少一种具有通式（I ）：（R1HSiO）a（R2R3SiO）b（R4R5R6SiO1 / 2）c（I）其中R1，R2和R3独立地表示可以被至少一个卤素原子取代的具有1至10个碳原子的烃残基 ，R 4，R 5和R 6独立地表示氢或具有1〜10个碳原子的烃残基，其可被至少一个卤素原子取代，a为0或1以上的整数，b为0或a 1以上的整数，c为0或2，a + b + c为3〜300，与颗粒接触，由此使硅酮化合物在颗粒的基本整个表面上聚合，（b）将未反应的Si -H基团在催化剂存在下，或（c）进行添加 具有至多40个碳原子的乙烯基化合物与未反应的Si-H基团的反应。

    Liquid chromatography and column packing material
    8.
    发明授权
    Liquid chromatography and column packing material 有权
    液相色谱和色谱柱包装材料

    公开(公告)号：US06360589B1

    公开(公告)日：2002-03-26

    申请号：US09180880

    申请日：1998-11-25

    申请人： Taketoshi Kanda ,  Aya Ohkubo ,  Yutaka Ohtsu ,  Michihiro Yamaguchi

    发明人： Taketoshi Kanda ,  Aya Ohkubo ,  Yutaka Ohtsu ,  Michihiro Yamaguchi

    IPC分类号： G01N3000

    CPC分类号： B01J20/3261 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3219 ,  B01J39/17 ,  B01J39/26 ,  B01J2220/54 ,  G01N30/02 ,  G01N30/24 ,  G01N2030/085 ,  Y10T428/249953 ,  B01D15/36 ,  B01D15/362

    摘要： A liquid chromatograph and a column packing material effectively condensing cationic specimen and exhibiting a high resolution. The liquid chromatograph includes a pre-focusing column (30, 40) having a volume of less than 2.0 milliliters and packed with a column packing material, in which a porous support is coated by a silicone polymer having a Si—R—X (R is a spacer part, X is a sulfonic group) bond and a Si—R′ (R′ is a hydrophilic group) bond, wherein the specimen to be analyzed is supplied to the pre-focusing column in the state dispersed in a solvent for condensation. The condensed specimen is then separated in a separation column (16, 43) used for separating the specimen dispersed in the solvent, and the separated specimen is analyzed by a detector (17, 41).

    摘要翻译： 液相色谱仪和色谱柱填充材料有效冷凝阳离子样品并显示高分辨率。 液相色谱仪包括体积小于2.0毫升的预聚焦柱（30,40）并填充有柱填料，其中多孔载体由具有Si-RX的硅氧烷聚合物（R为 间隔部分，X是磺酸基）键和Si-R'（R'是亲水基团）键，其中待分析的试样以分散在用于冷凝的溶剂中的状态提供给预聚焦塔。 然后将冷凝的样品在用于分离分散在溶剂中的试样的分离塔（16,43）中分离，并通过检测器（17,41）分析分离的样品。