公开(公告)号：US20070091752A1

公开(公告)日：2007-04-26

申请号：US10554241

申请日：2005-02-22

申请人： Atsushi Watanabe ,  Junichi Horigome ,  Masayoshi Nagaya ,  Masatoshi Nishino ,  Susumu Seino ,  Masahiro Uchida

发明人： Atsushi Watanabe ,  Junichi Horigome ,  Masayoshi Nagaya ,  Masatoshi Nishino ,  Susumu Seino ,  Masahiro Uchida

IPC分类号： G11B7/00

CPC分类号： G11B7/00456 ,  G11B7/0045 ,  G11B7/00736 ,  G11B2007/0006

摘要： The present invention makes it possible to set an operating condition enabling the best recording characteristic to be obtained for any kind of recording media, even in the case where the recording medium is combined with any kind of drive devices. According to the present invention, even in the case where a unknown and new kind of recording medium is loaded into the drive device, a piece of first operating condition information for an optical system suitable for a combination of the drive device and the new kind of recording media is read from a specific read only area provided for the recording medium, and an operating condition enabling the best operating characteristic to be obtained is set by using the first operating condition information, as a result of which even in the case where any kind of recording medium and any kind of drive device are combined, the operating condition for enabling the best recording characteristic to be obtained for the recording medium, can be set in the drive device.

摘要翻译： 本发明即使在记录介质与任何种类的驱动装置组合的情况下，也可以为任何类型的记录介质设置能够获得最佳记录特性的操作条件。 根据本发明，即使在未知和新型的记录介质被装载到驱动装置中的情况下，也可以使用适于驱动装置和新型记录媒体的组合的光学系统的第一操作条件信息 从为记录介质提供的特定的只读区域读取记录介质，并且通过使用第一操作条件信息来设置能够获得最佳操作特性的操作条件，结果即使在任何类型的情况下 的记录介质和任何种类的驱动装置组合，可以在驱动装置中设置用于使记录介质获得最佳记录特性的操作条件。

公开(公告)号：US07440376B2

公开(公告)日：2008-10-21

申请号：US10554241

申请日：2005-02-22

申请人： Atsushi Watanabe ,  Junichi Horigome ,  Masayoshi Nagata ,  Masatoshi Nishino ,  Susumu Seino ,  Masahiro Uchida

发明人： Atsushi Watanabe ,  Junichi Horigome ,  Masayoshi Nagata ,  Masatoshi Nishino ,  Susumu Seino ,  Masahiro Uchida

IPC分类号： G11B5/09 ,  G11B7/24

CPC分类号： G11B7/00456 ,  G11B7/0045 ,  G11B7/00736 ,  G11B2007/0006

摘要： The present invention makes it possible to set an operating condition enabling the best recording characteristic to be obtained for any kind of recording media, even in the case where the recording medium is combined with any kind of drive devices. According to the present invention, even in the case where a unknown and new kind of recording medium is loaded into the drive device, a piece of first operating condition information for an optical system suitable for a combination of the drive device and the new kind of recording media is read from a specific read only area provided for the recording medium, and an operating condition enabling the best operating characteristic to be obtained is set by using the first operating condition information, as a result of which even in the case where any kind of recording medium and any kind of drive device are combined, the operating condition for enabling the best recording characteristic to be obtained for the recording medium, can be set in the drive device.

摘要翻译： 本发明即使在记录介质与任何种类的驱动装置组合的情况下，也可以为任何类型的记录介质设置能够获得最佳记录特性的操作条件。 根据本发明，即使在未知和新型的记录介质被装载到驱动装置中的情况下，也可以使用适于驱动装置和新型记录媒体的组合的光学系统的第一操作条件信息 从为记录介质提供的特定的只读区域读取记录介质，并且通过使用第一操作条件信息来设置能够获得最佳操作特性的操作条件，结果即使在任何类型的情况下 的记录介质和任何种类的驱动装置组合，可以在驱动装置中设置用于使记录介质获得最佳记录特性的操作条件。

公开(公告)号：US20050207299A1

公开(公告)日：2005-09-22

申请号：US11072519

申请日：2005-03-07

申请人： Shigeo Yamaguchi ,  Susumu Seino ,  Masatoshi Nishino ,  Junichi Horigome

发明人： Shigeo Yamaguchi ,  Susumu Seino ,  Masatoshi Nishino ,  Junichi Horigome

IPC分类号： G11B20/10 ,  G11B7/00 ,  G11B7/0045 ,  G11B7/005 ,  G11B7/125 ,  G11B7/1267 ,  G11B20/18

CPC分类号： G11B20/10009 ,  G11B7/1267

摘要： To realize a disk drive device capable of setting optimum recording power by obtaining amplitude information of a reproduced signal even when low recording power is used. A disk drive device for recording and reproducing data on/from an optical disk is provided with: a Viterbi decoding means for performing Viterbi decoding on a reproduced signal reproduced from an optical disk to decode data and creating status data representing a status transition in the Viterbi decoding; and a quality index creation means for calculating a differential value between an amplitude reference value corresponding to the status transition recognized from the status data and a reproduced signal value created by digitizing the reproduced signal and creating a quality index value representing quality of the reproduced signal based on the differential value. The quality index creation means obtains a quality index value with the amplitude reference value fixed to a prescribed value, to create an amplitude evaluation value representing the amplitude of the reproduced signal.

摘要翻译： 即使在使用低记录功率的情况下，通过获得再现信号的振幅信息来实现能够设定最佳记录功率的磁盘驱动装置。 一种用于在光盘上记录和再现数据的磁盘驱动装置具有：维特比解码装置，用于对从光盘再现的再现信号进行维特比解码，以解码数据并创建表示维特比（Viterbi）状态转变的状态数据 解码; 以及质量指标创建装置，用于计算与从状态数据识别的状态转变相对应的振幅参考值与通过数字化再现信号产生的再现信号值之间的差分值，并创建表示再现信号质量的质量指标值 对差分值。 质量指标创建装置获得将幅度参考值固定为规定值的质量指标值，以产生表示再现信号振幅的振幅评估值。

公开(公告)号：US20120082976A1

公开(公告)日：2012-04-05

申请号：US13264391

申请日：2010-04-15

申请人： Susumu Seino ,  Changliang Zhang ,  Megumi Kato ,  Tadao Shibazaki

发明人： Susumu Seino ,  Changliang Zhang ,  Megumi Kato ,  Tadao Shibazaki

IPC分类号： C12Q1/68 ,  C07K19/00 ,  C12N15/85 ,  C12N5/10 ,  C12N15/62 ,  C12N15/63

CPC分类号： C07K14/4702 ,  G01N33/5308 ,  G01N33/542 ,  G01N2333/62 ,  G01N2500/10

摘要： Disclosed are a novel method of screening for insulin secretion-potentiating agents as well as means for performing such screening. The means include a DNA encoding fluorescent-labeled Epac2 comprising two different DNAs encoding two different fluorescent proteins which emit fluorescent light with wavelength differing from each other and a DNA encoding Epac2 which are fused together in-frame, and the cells transformed with the DNA. Also disclosed is a method of screening insulin secretion-potentiating agents comprising bringing a candidate compound into contact with cells transformed with the said DNA, and detecting whether the compound binds to Epac2.

摘要翻译： 公开了一种筛选胰岛素分泌增强剂的新方法以及进行这种筛选的方法。 该方法包括编码荧光标记的Epac2的DNA，其包含两种不同的DNA，其编码两种不同的荧光蛋白，其发射彼此波长不同的荧光，以及编码融合在一起的Epac2的DNA，以及用DNA转化的细胞。 还公开了筛选胰岛素分泌增强剂的方法，包括使候选化合物与用所述DNA转化的细胞接触，并检测该化合物是否结合Epac2。

公开(公告)号：US20130210039A1

公开(公告)日：2013-08-15

申请号：US13819704

申请日：2011-07-13

申请人： Toshiya Matsubara ,  Makoto Watanabe ,  Susumu Seino ,  Kohtaro Minami ,  Osamu Nishimura ,  Ayako Mita

发明人： Toshiya Matsubara ,  Makoto Watanabe ,  Susumu Seino ,  Kohtaro Minami ,  Osamu Nishimura ,  Ayako Mita

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/475 ,  G01N2500/00 ,  G01N2500/10 ,  G01N2800/042

摘要： The present invention provides a marker capable of detecting insulin resistance and diabetes in a collected blood sample, a method for analyzing said marker, a method for screening a substance improving insulin resistance, and improving or suppressing diabetes. A blood insulin resistance marker and a blood diabetes marker, which comprises a polypeptide comprising at least 15 continuous amino acids in an amino acid sequence constituting progranulin. A method for analyzing a blood marker, which comprises the steps of: measuring a concentration of an insulin resistance marker or a diabetes marker in a collected blood sample; and comparing the measured concentration with a normal blood concentration of the marker. A method for screening a substance improving insulin resistance, and improving or suppressing diabetes, which comprises the steps of: administering a candidate substance to a living body expressing insulin resistance or suffering from diabetes; measuring a blood concentration of a marker in the living body after administration; and comparing the measured concentration of the marker with a blood concentration of the marker not administered with the candidate substance.

摘要翻译： 本发明提供能够检测收集的血液样品中的胰岛素抵抗和糖尿病的标记物，分析所述标记物的方法，用于筛选改善胰岛素抵抗的物质的方法，以及改善或抑制糖尿病。 一种血液胰岛素抵抗标记物和血液糖尿病标志物，其包含在构成颗粒体蛋白前体的氨基酸序列中包含至少15个连续氨基酸的多肽。 一种分析血液标记物的方法，包括以下步骤：测量所收集的血液样品中胰岛素抵抗标志物或糖尿病标志物的浓度; 并将测量的浓度与标记物的正常血液浓度进行比较。 一种筛选改善胰岛素抵抗的物质，改善或抑制糖尿病的方法，包括以下步骤：将候选物质施用于表达胰岛素抵抗或患有糖尿病的活体; 测定给药后的生物体中的标记物的血液浓度; 并将标记物的测定浓度与未施用候选物质的标记物的血液浓度进行比较。

公开(公告)号：US20060021073A1

公开(公告)日：2006-01-26

申请号：US11095668

申请日：2005-04-01

申请人： Susumu Seino ,  Takashi Miki ,  Toshihiko Iwanaga ,  Masanari Matsumoto

发明人： Susumu Seino ,  Takashi Miki ,  Toshihiko Iwanaga ,  Masanari Matsumoto

IPC分类号： A01K67/027 ,  C12N5/06

CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  C07K14/4702 ,  C12N2799/022

摘要： Disclosed are a mouse homozygous or heterozygous for the defect of the Noc2 gene, and a tissue and a cell of the mouse. The Noc2 knockout mice, which exhibit stress-related insulin hyposecretion and accumulation of secretory granules of increased size and irregular shape in exocrine cells, provide a test system used in the development of therapeutic drugs for related disorders.

摘要翻译： 公开了对于Noc2基因的缺陷，以及小鼠的组织和细胞的纯合子或杂合的小鼠。 在外分泌细胞中表现出应激相关胰岛素分泌减少和分泌型颗粒增大和不规则形状的Noc2敲除小鼠提供了用于开发相关疾病的治疗药物的测试系统。

公开(公告)号：US06956104B2

公开(公告)日：2005-10-18

申请号：US10180326

申请日：2002-06-27

申请人： Susumu Seino ,  Tadao Shibasaki ,  Nobuaki Ozaki

发明人： Susumu Seino ,  Tadao Shibasaki ,  Nobuaki Ozaki

IPC分类号： C12N15/09 ,  C07K14/435 ,  C07K14/47 ,  C07K16/18 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/53 ,  C07K14/00 ,  A61K38/00 ,  C12N15/00 ,  C12P21/04

CPC分类号： C07K14/4722

摘要： Provided is a protein used in the development of a therapeutic agent for neuron- or endocrine cell-related diseases, in which the transport system is involved. The protein has an amino acid sequence with one or more amino acids deleted, substituted, inserted or added relative to the amino acid sequence set forth under SEQ ID NO:1 in the Sequence Listing and which has a property to interact with GDP/GTP exchange factor II.

摘要翻译： 提供了用于开发涉及运输系统的神经元或内分泌细胞相关疾病的治疗剂的蛋白质。 蛋白质具有相对于序列表中SEQ ID NO：1所示的氨基酸序列缺失，取代，插入或添加的一个或多个氨基酸的氨基酸序列，其具有与GDP / GTP交换相互作用的性质 因素二。

公开(公告)号：US20070231897A1

公开(公告)日：2007-10-04

申请号：US11628202

申请日：2005-05-26

申请人： Susumu Seino ,  Kohtaro Minami ,  Masaaki Okuno ,  Kazumasa Miyawaki

发明人： Susumu Seino ,  Kohtaro Minami ,  Masaaki Okuno ,  Kazumasa Miyawaki

IPC分类号： C12N5/08 ,  C12N5/02

CPC分类号： C12N5/0676 ,  C12N2501/11 ,  C12N2501/117 ,  C12N2501/119 ,  C12N2501/12

摘要： Disclosed is a method for producing insulin secreting cells to be used in cell transplantation therapy of diabetes, by induction from pancreatic acinar cells in culture vessels. The method comprises culturing pancreatic acinar cells isolated from a mammal in a medium containing a growth factor, preferably epidermal growth factor, fibroblast growth factor and/or hepatocyte growth factor, to induce insulin secreting cells.

摘要翻译： 公开了通过从培养容器中的胰腺腺泡细胞诱导，用于产生用于糖尿病的细胞移植治疗的胰岛素分泌细胞的方法。 该方法包括在含有生长因子，优选表皮生长因子，成纤维细胞生长因子和/或肝细胞生长因子的培养基中培养从哺乳动物分离的胰腺腺泡细胞，以诱导胰岛素分泌细胞。

公开(公告)号：US06673899B2

公开(公告)日：2004-01-06

申请号：US09920804

申请日：2001-08-03

申请人： Susumu Seino ,  Hideki Yano ,  Changzheng Wang

发明人： Susumu Seino ,  Hideki Yano ,  Changzheng Wang

IPC分类号： C07K14705

CPC分类号： C07K14/705

摘要： The present invention discloses DNAs comprising nucleotide sequences set forth as SEQ ID NO:1 or NO:3 encoding Na+-driven Cl—/HCO3— exchanger, proteins comprising amino acid sequences set forth as SEQ ID NO:2 or NO:4, and their homologous proteins comprising an amino acid sequence having deletion, substitution, addition or insertion amino acids, which proteins, when expressed in a cell, functions as Na+-driven Cl—/HCO3— exchanger, and cells in which the proteins exogenously expressed.

摘要翻译： 本发明公开了包含编码Na +驱动的Cl- / HCO 3 - 交换体的SEQ ID NO：1或NO：3所示的核苷酸序列的DNA，包含SEQ ID NO：2或NO： 4及其包含具有缺失，取代，添加或插入氨基酸的氨基酸序列的同源蛋白质，当在细胞中表达时，这些蛋白质用作Na +驱动的Cl- / HCO 3 - 交换剂，以及其中 外源表达的蛋白质。

公开(公告)号：US06194634B1

公开(公告)日：2001-02-27

申请号：US09213864

申请日：1998-12-17

申请人： Susumu Seino ,  Takashi Miki ,  Junichi Miyazaki

发明人： Susumu Seino ,  Takashi Miki ,  Junichi Miyazaki

IPC分类号： A01K67027

CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306 ,  A01K2267/0362 ,  C07K14/705 ,  C12N2517/02

摘要： A Kir6.2 gene-defective, non-human mammal, a mouse in particular, its tissues and cells are provided, wherein the ATP-sensitive potassium channel Kir6.2 gene, one of the subunits of KATP channels essential for insulin secretion by pancreatic &bgr;-cells, is lost from one or both of the allelic loci.

摘要翻译： 提供了一种Kir6.2基因缺陷型非人类哺乳动物，特别是小鼠，其组织和细胞，其中ATP敏感性钾通道Kir6.2基因，胰岛素分泌所必需的KATP通道亚基之一 β细胞从一个或两个等位基因座丢失。