公开(公告)号：US20070284012A1

公开(公告)日：2007-12-13

申请号：US11805698

申请日：2007-05-24

申请人： Barry Smith ,  Martin Garthaffner ,  Ahmet Ercelebi ,  Steven Spiers ,  Jeremy Straight

发明人： Barry Smith ,  Martin Garthaffner ,  Ahmet Ercelebi ,  Steven Spiers ,  Jeremy Straight

IPC分类号： B65B1/04 ,  B65B1/16

CPC分类号： B65B1/366 ,  A24D3/0225

摘要： A machine and process function to fill cavities with metered amounts of particulate material. An applicator wheel includes a series of equally spaced apart peripheral pockets each having a perforated bottom wall, and a vacuum manifold inside the wheel includes a vacuum chamber for supplying vacuum to the perforated bottom walls of the pockets as the wheel rotates. Particulate material from a filling chamber of such material outside the wheel is withdrawn into the pockets by the vacuum chamber. A downstream vacuum relief on the vacuum manifold functions to discharge particulate material from the pockets into the cavities at a predetermined discharge location on the wheel. Adjustment structure is connected to rotatably adjust the position of the vacuum manifold within the applicator wheel to thereby advance or retard the discharge location depending upon the speed of the machine.

摘要翻译： 机器和过程功能，用计量的颗粒材料填充空腔。 施加器轮包括一系列等间隔开的周边袋，每个凹槽具有穿孔的底壁，并且车轮内部的真空歧管包括用于在轮旋转时向袋的穿孔底壁提供真空的真空室。 来自轮外的这种材料的填充室的颗粒材料通过真空室被抽出到袋中。 真空歧管上的下游真空释放装置用于将颗粒材料从凹穴排出到在车轮上的预定排放位置处的空腔中。 连接调整结构，以可旋转地调节涂抹轮内的真空歧管的位置，从而根据机器的速度前进或延缓排出位置。

公开(公告)号：US20050112228A1

公开(公告)日：2005-05-26

申请号：US10967665

申请日：2004-10-18

申请人： Barry Smith ,  Steve Spiers ,  Jeremy Straight ,  Janet Thompson ,  Ahmet Ercelebi ,  Martin Garthaffner ,  Lisa Rogers

发明人： Barry Smith ,  Steve Spiers ,  Jeremy Straight ,  Janet Thompson ,  Ahmet Ercelebi ,  Martin Garthaffner ,  Lisa Rogers

IPC分类号： B65B1/36 ,  B29C55/28

CPC分类号： A24D3/0225 ,  B65B1/366

摘要： Apparatus and method for filling spaced apart cavities with particulate material include a transport for moving the cavities along a path of travel. The cavities are partially filled with particulate material at an upstream location while applying vacuum underneath each cavity during such partial filling. The partially filled cavities are then completely filled with a downstream deposit of particulate material while applying vacuum to the upper sides of each cavity during such filling. The combination of vacuum applied underneath the cavity during partial fill and vacuum applied to the top sides of the cavity during complete fill produces approximately 100% cavity fill with minimal extraneous scatter of particulate material.

摘要翻译： 用颗粒材料填充间隔开的空腔的装置和方法包括用于沿着行进路径移动空腔的输送器。 在这样的部分填充期间，空腔在上游位置部分地填充有颗粒材料，同时在每个腔体的下方施加真空。 然后，在填充期间，将部分填充的空腔完全填充有颗粒材料的下游沉积物，同时在每个空腔的上侧施加真空。 在完全填充期间，在部分填充和真空中施加到空腔顶部的真空下的真空的组合产生大约100％的空腔填充，颗粒材料的最小的外来散射。

公开(公告)号：US20060112963A1

公开(公告)日：2006-06-01

申请号：US11268291

申请日：2005-11-04

申请人： George Scott ,  Martin Garthaffner ,  Steven Spiers ,  Steven Rinehart ,  Barry Smith ,  James Evans

发明人： George Scott ,  Martin Garthaffner ,  Steven Spiers ,  Steven Rinehart ,  Barry Smith ,  James Evans

IPC分类号： A24D3/06

CPC分类号： A24D3/0216 ,  A24D3/0225 ,  A24D3/0287

摘要： Process and apparatus for the mass production of compound cigarette filters function to deposit granular filter material into the open ends of vertically oriented filter tubes. Predetermined amounts of diverse granular material are withdrawn by suction from sources of such material, and these amounts are deposited into the tubes. Solid filter segments seal the granular material within the tube. After one half of each filter tube is filled with granular material and sealed, the tube is inverted and the opposite end is filled in substantially the same manner. When cut in half each filter tube produces two cigarette filters.

公开(公告)号：US20070102102A1

公开(公告)日：2007-05-10

申请号：US11642150

申请日：2006-12-20

申请人： Edmond Cadieux ,  Steve Campbell ,  James Evans ,  Steven Rinehart ,  G. Scott ,  Barry Smith ,  Steven Spiers ,  Linwood Carneal ,  Hubert Goodman ,  Joshua Roby

发明人： Edmond Cadieux ,  Steve Campbell ,  James Evans ,  Steven Rinehart ,  G. Scott ,  Barry Smith ,  Steven Spiers ,  Linwood Carneal ,  Hubert Goodman ,  Joshua Roby

IPC分类号： B29C65/00

CPC分类号： B65B61/202 ,  Y10T156/1051 ,  Y10T156/1746

摘要： A machine for folding and applying onserts onto consumer goods such as cigarette packs comprises a continuous roll of preprinted onserts and a transverse cutter assembly for cutting onsert segments from the continuous roll. Each onsert segment includes a pair of side-by-side preprinted onserts. A buckle folder receives each cut onsert segment and folds that segment along at least one transverse fold line. A longitudinal cutter assembly longitudinally cuts each folded onsert segment into two individual onserts. A transport system serially receives the individual folded onserts and moves the onserts along dual diverging paths where a pair of spaced apart lug belt conveyors receives the onserts from the discharge end of the transport system. Each lug belt conveyor includes spaced apart transverse lugs along the length thereof against which the onserts are positioned. A pair of spaced apart applicator wheels transfers the onserts from the conveyors onto spaced apart consumer goods traveling past the applicator wheels.

摘要翻译： 用于折叠和应用到消费品如香烟包装上的机器包括连续的预先印刷的卷筒和用于从连续辊上切割片段的横向切割器组件。 每个插入片段包括一对并排的预打印插件。 一个带扣文件夹接收每个切割的插入段，并沿着至少一个横向折线折叠该段。 纵向切割器组件将每个折叠的插入片段纵向切割成两个独立的插片。 传送系统串联地接收各个折叠的片塞，并沿着双发散路径移动插座，其中一对间隔开的凸耳带式输送机从输送系统的排出端接收插头。 每个凸耳带式输送机包括沿着其长度的间隔开的横向凸耳，其上安置有插头。 一对间隔开的施加轮将输送机上的插头转移到经过涂抹器轮的间隔开的消费品上。

公开(公告)号：USRE39542E1

公开(公告)日：2007-04-03

申请号：US10336442

申请日：2003-01-02

申请人： Kanti Jain ,  Albert L. Rubin ,  Barry Smith

发明人： Kanti Jain ,  Albert L. Rubin ,  Barry Smith

IPC分类号： A61K35/12 ,  C12N11/02 ,  C12N11/10 ,  C12N5/00 ,  C12N5/08

CPC分类号： C12N11/04 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/5036 ,  A61K35/39 ,  A61K38/00 ,  A61K2035/126 ,  C12N5/0012 ,  C12N5/0677 ,  C12N2533/54 ,  C12N2533/76

摘要： Biological agents such as secretory cells are encapsulated in a hydrophilic gel made of agarose or collagen-agarose and gelatin sponge-agarose combinations. In a preferred embodiment, semi-solid beads are formed from a suspension containing collagen, agarose and secretory cells such as pancreatic islets, the collagen is polymerized to form solid, agarose-collagen beads and the solid beads are coated with agarose. Coating is preferably by rolling the solid beads in about 5-10% agarose, contacting the rolled beads with mineral oil and washing oil from the beads. Beads containing secretory cells can be transplanted into a mammal to treat a condition caused by impaired secretory cell function.

摘要翻译： 生物制剂如分泌细胞被包封在由琼脂糖或胶原 - 琼脂糖和明胶海绵 - 琼脂糖组合制成的亲水凝胶中。 在优选的实施方案中，半固体珠粒由含有胶原蛋白，琼脂糖和分泌细胞例如胰岛的悬浮液形成，胶原聚合形成固体，琼脂糖胶原珠粒，固体珠粒用琼脂糖涂覆。 涂覆优选通过在约5-10％的琼脂糖中滚动固体珠粒，使滚珠与矿物油接触并从珠粒洗涤油。 含有分泌细胞的珠可以移植到哺乳动物中以治疗由分泌细胞功能受损引起的病症。

公开(公告)号：US20060216278A1

公开(公告)日：2006-09-28

申请号：US11447405

申请日：2006-06-05

申请人： Bryan Conn ,  Barry Smith ,  Albert Rubin ,  Kurt Stenzel

发明人： Bryan Conn ,  Barry Smith ,  Albert Rubin ,  Kurt Stenzel

IPC分类号： A61K48/00 ,  C12N5/08

CPC分类号： C12N5/0693 ,  A01N1/0205 ,  A01N1/0231 ,  A61K35/13 ,  A61K35/545 ,  C12N5/0012 ,  C12N5/0606 ,  C12N2502/02 ,  C12N2533/76

摘要： The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.

摘要翻译： 本发明特别涉及干细胞，特别是胚胎干细胞。 已经发现，当这些干细胞被捕获使得其增殖被抑制时，它们产生抑制其它非包埋细胞（包括干细胞，肿瘤和/或过度增殖，但是其他正常细胞）增殖的材料。 也已经发现，截留的癌细胞将产生抑制干细胞增殖的物质。 此外，已经发现，干细胞的捕获抑制其分化，因此捕获过程可以用作长期存储装置，用于保持至少一部分包埋细胞的未分化状态。

公开(公告)号：US07041504B2

公开(公告)日：2006-05-09

申请号：US09735073

申请日：2000-12-12

申请人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

发明人： Shirin Asina ,  Kanti Jain ,  Albert L. Rubin ,  Barry Smith ,  Kurt Stenzel

IPC分类号： C12N5/06 ,  C12N5/08 ,  C12N11/10 ,  C12N11/04 ,  A61K35/12

CPC分类号： A61K35/13 ,  A61K35/36 ,  C12N5/0693 ,  C12N11/04

摘要： Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

摘要翻译： 描述了含有限制性癌细胞的物质组成。 当受限制时，细胞产生意想不到的高量的抑制癌细胞增殖的材料。 这种现象跨越癌症类型和种类。 还描述了制备这些组合物的方法及其用途。

公开(公告)号：US20050229698A1

公开(公告)日：2005-10-20

申请号：US11103699

申请日：2005-04-11

申请人： Michael Beecroft ,  Marian Szczesniak ,  Barry Smith ,  John Matsumoto ,  James Ferguson

发明人： Michael Beecroft ,  Marian Szczesniak ,  Barry Smith ,  John Matsumoto ,  James Ferguson

IPC分类号： G01F23/00 ,  G01J3/02 ,  G01J3/42 ,  G01N21/31 ,  G01N21/33 ,  G01N21/35 ,  G01N21/55

CPC分类号： G01J3/02 ,  G01J3/0208 ,  G01J3/0235 ,  G01J3/0254 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0283 ,  G01J3/0291 ,  G01J3/42 ,  G01N21/31 ,  G01N21/33 ,  G01N21/3504 ,  G01N21/552 ,  G01N21/645 ,  G01N2021/3595 ,  G01N2201/0221 ,  G01N2201/065

摘要： A hand-held portable modular spectrometer unit. The unit includes a detachable head containing a light source and optical components for detecting spectral information from light reflected from or transmitted through a target and a processor for converting the detected spectral information into digital information. The unit also includes a plug-in rechargeable power supply and a control module for controlling the components in the measurement head. The controller includes a computer processor for analyzing the digital information produced by the measurement head and a display monitor for displaying spectral information produced by the control unit. In preferred embodiments the plug-in rechargeable power supply is a 12-volt off-the-shelf power-tool rechargeable battery unit. In preferred embodiments several measuring heads are available. These include a gas cell measuring head, a surface reflectance measuring head that includes and integrating sphere, a specular reflectance measuring head, a grazing angle measuring head, an attenuated total reflectance measuring head, a diffuse reflection measuring head, a non-volatile residues measuring head, a liquid transmission cell measuring head and a fluorescence measuring head. Each of these measurement heads includes a spectrometer. Several types of spectrometers are available including those based on filters, prisms, gratings and interferometers. The unit can operate in a wide range of wavelengths including the infrared, visible and ultraviolet spectral ranges.

摘要翻译： 手持便携式模块化光谱仪单元。 该单元包括一个包含光源的可拆卸头和用于从由目标反射或透过目标的光检测光谱信息的光学部件和用于将检测到的光谱信息转换为数字信息的处理器。 该装置还包括插入式可充电电源和用于控制测量头部件的控制模块。 控制器包括用于分析测量头产生的数字信息的计算机处理器和用于显示控制单元产生的频谱信息的显示监视器。 在优选实施例中，插入式可再充电电源是12伏现货电动工具可再充电电池单元。 在优选实施例中，可以使用多个测量头。 这些包括气体电池测量头，包括和积分球的表面反射测量头，镜面反射测量头，掠角测量头，衰减全反射测量头，漫反射测量头，非挥发性残留测量 头，液体传播细胞测量头和荧光测量头。 这些测量头中的每一个包括光谱仪。 可以使用几种类型的光谱仪，包括基于滤光片，棱镜，光栅和干涉仪的光谱仪。 该单元可以在宽范围的波长范围内工作，包括红外线，可见光谱和紫外光谱范围。

公开(公告)号：US20050133482A1

公开(公告)日：2005-06-23

申请号：US11010479

申请日：2004-12-14

申请人： Daniel Clark ,  Barry Smith

发明人： Daniel Clark ,  Barry Smith

IPC分类号： B23K9/04 ,  B23K10/02 ,  B23K15/00 ,  B23K26/34 ,  B23K35/32 ,  B23K37/04 ,  B23Q1/03 ,  B23Q3/10 ,  C21D1/30 ,  C21D1/44 ,  C21D1/70 ,  C21D9/00 ,  C21D9/50

CPC分类号： B23K9/044 ,  B23K10/027 ,  B23K15/0086 ,  B23K26/32 ,  B23K26/342 ,  B23K35/0261 ,  B23K35/325 ,  B23K35/383 ,  B23K37/04 ,  B23K37/0461 ,  B23K2103/08 ,  B23K2103/14 ,  B23K2103/50 ,  C21D1/30 ,  C21D1/70 ,  C21D9/0025 ,  C21D9/50

摘要： A substrate (33) is clamped into a fixture (32) and material is deposited thereon to form a complex article (40). The article (40) produced is packed, using ceramic inserts (42) and a coating (41). The packing (42) ensures that the article (40) maintains its true shape and allows for expansion during the subsequent heat treatment process. The packed article (40), mounted on the fixture (32), is then placed in a box (44), encased in a granular material (43) and heated. It is heated to a temperature sufficient to relieve stresses and is maintained at this temperature for a time period such that the stresses in the article (40) are relieved.

摘要翻译： 将基材（33）夹紧到固定装置（32）中，并将材料沉积在其上以形成复杂制品（40）。 所制造的制品（40）使用陶瓷插入件（42）和涂层（41）进行包装。 包装（42）确保制品（40）保持其真实形状并且允许在随后的热处理过程中的膨胀。 然后将安装在固定装置（32）上的包装物品（40）放置在箱体（44）中，装在颗粒状材料（43）中并加热。 将其加热到足以缓解应力的温度并在该温度下保持一段时间，使得制品（40）中的应力得以缓解。

公开(公告)号：US20050053586A1

公开(公告)日：2005-03-10

申请号：US10655275

申请日：2003-09-04

申请人： Bryan Conn ,  Barry Smith ,  Albert Rubin ,  Kurt Stenzel

发明人： Bryan Conn ,  Barry Smith ,  Albert Rubin ,  Kurt Stenzel

IPC分类号： C12N5/074 ,  A01N1/02 ,  A61K35/13 ,  A61K35/14 ,  A61K35/48 ,  A61K35/545 ,  A61K48/00 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0789 ,  C12N5/08

CPC分类号： C12N5/0693 ,  A01N1/0205 ,  A01N1/0231 ,  A61K35/13 ,  A61K35/545 ,  C12N5/0012 ,  C12N5/0606 ,  C12N2502/02 ,  C12N2533/76

摘要： The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.

摘要翻译： 本发明特别涉及干细胞，胚胎干细胞。 已经发现，当这些干细胞被捕获使得其增殖被抑制时，它们产生抑制其它非包埋细胞（包括干细胞，肿瘤和/或过度增殖，但是其他正常细胞）增殖的材料。 也已经发现，截留的癌细胞将产生抑制干细胞增殖的物质。 此外，已经发现，干细胞的捕获抑制其分化，因此捕获过程可以用作长期存储装置，用于保持至少一部分包埋细胞的未分化状态。