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    Articles having bioactive surfaces and solvent-free methods of preparation thereof
    1.
    发明申请
    Articles having bioactive surfaces and solvent-free methods of preparation thereof 有权
    具有生物活性表面和无溶剂制备方法的制品

    公开(公告)号：US20050255327A1

    公开(公告)日：2005-11-17

    申请号：US11129318

    申请日：2005-05-16

    申请人： Bryce Chaney ,  David Montgomery ,  Ross Jacobson

    发明人： Bryce Chaney ,  David Montgomery ,  Ross Jacobson

    IPC分类号： B32B9/04

    CPC分类号： A61L31/16 ,  A61L27/54 ,  A61L31/10 ,  A61L33/0088 ,  A61L2300/00 ,  G01N33/54353

    摘要： Methods for preparing articles having a bioactive surface comprising treating a substrate to form free reactive groups, depositing a monomer onto the treated substrate, and covalently immobilizing a biologically functional molecule onto the deposited monomer. Additional embodiments include methods for the deposition of the monomer onto the treated substrate in a solvent-free environment. Further embodiments include articles having surfaces prepared using the methods described herein. Additional embodiments include articles prepared using the methods described herein.

    摘要翻译： 用于制备具有生物活性表面的制品的方法包括处理底物以形成游离反应性基团，将单体沉积在经处理的底物上，并将生物功能性分子共价固定在沉积的单体上。 另外的实施方案包括在无溶剂环境中将单体沉积到经处理的基材上的方法。 另外的实施方案包括具有使用本文所述方法制备的表面的制品。 另外的实施方案包括使用本文所述的方法制备的制品。

    Articles having bioactive surfaces and solvent-free methods of preparation thereof
    2.
    发明授权
    Articles having bioactive surfaces and solvent-free methods of preparation thereof 有权
    具有生物活性表面和无溶剂制备方法的制品

    公开(公告)号：US07815922B2

    公开(公告)日：2010-10-19

    申请号：US11129318

    申请日：2005-05-16

    申请人： Bryce Chaney ,  David Montgomery ,  Ross W. Jacobson

    发明人： Bryce Chaney ,  David Montgomery ,  Ross W. Jacobson

    IPC分类号： A61K9/00 ,  A61K31/74 ,  A61K47/48 ,  A61F2/00 ,  A61K47/30 ,  C23C16/00

    CPC分类号： A61L31/16 ,  A61L27/54 ,  A61L31/10 ,  A61L33/0088 ,  A61L2300/00 ,  G01N33/54353

    摘要： Methods for preparing articles having a bioactive surface comprising treating a substrate to form free reactive groups, depositing a monomer onto the treated substrate, and covalently immobilizing a biologically functional molecule onto the deposited monomer. Additional embodiments include methods for the deposition of the monomer onto the treated substrate in a solvent-free environment. Further embodiments include articles having surfaces prepared using the methods described herein. Additional embodiments include articles prepared using the methods described herein.

    摘要翻译： 用于制备具有生物活性表面的制品的方法包括处理底物以形成游离反应性基团，将单体沉积在经处理的底物上，并将生物功能性分子共价固定在沉积的单体上。 另外的实施方案包括在无溶剂环境中将单体沉积到经处理的基材上的方法。 另外的实施方案包括具有使用本文所述方法制备的表面的制品。 另外的实施方案包括使用本文所述的方法制备的制品。

    Methods of surface modification of a flexible substrate to enhance cell adhesion
    3.
    发明申请
    Methods of surface modification of a flexible substrate to enhance cell adhesion 有权
    柔性基材的表面改性方法，以增强细胞粘附力

    公开(公告)号：US20050058842A1

    公开(公告)日：2005-03-17

    申请号：US10660760

    申请日：2003-09-12

    申请人： Andrea Liebmann-Vinson ,  Bryce Chaney

    发明人： Andrea Liebmann-Vinson ,  Bryce Chaney

    IPC分类号： B05D1/18 ,  B05D3/12 ,  C12M3/00 ,  C12N5/00 ,  B32B25/20

    CPC分类号： B82Y30/00 ,  B05D1/185 ,  B05D3/12 ,  B05D2201/00 ,  C12M25/14 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2533/50 ,  Y10T428/31663

    摘要： The present invention provides methods of producing a surface with enhanced cell-adhesive properties comprising applying a stress to a polymeric matrix. The strained matrix is then modified by grafting a self-assembled monolayer onto the strained matrix, with the self-assembled monolayer comprising at least one exposed functional group. At least one cell-adhesive molecule can then be coupled to the at least one exposed functional group on the self-assembled monolayer to produce a surface with enhanced cell-adhesive properties.

    摘要翻译： 本发明提供了生产具有增强的电池粘合性能的表面的方法，包括向聚合物基质施加应力。 然后通过将自组装单层接枝到应变基质上来修饰应变基质，其中自组装单层包含至少一个暴露的官能团。 然后可以将至少一个细胞粘附分子与自组装单层上的至少一个暴露的官能团偶联以产生具有增强的细胞粘附性质的表面。

    Automated media optimization technology
    6.
    发明申请
    Automated media optimization technology 审中-公开
    自动化媒体优化技术

    公开(公告)号：US20050154534A1

    公开(公告)日：2005-07-14

    申请号：US10755684

    申请日：2004-01-13

    申请人： Perry Haaland ,  Bryce Chaney ,  Stacy Holdread

    发明人： Perry Haaland ,  Bryce Chaney ,  Stacy Holdread

    IPC分类号： G01N1/28 ,  G01N33/48 ,  G01N33/50 ,  G01N35/10 ,  G06F19/00

    CPC分类号： G01N33/5023 ,  G01N33/5008 ,  G01N33/5044 ,  G01N35/1011 ,  G01N2001/282

    摘要： An automated system and method for identifying agents capable of eliciting a phenotypic change in a cell-type. The method includes the steps of providing a statistical design including generic factor names, factor levels and experimental runs, and utilizing a software program to generate a computer representation of the statistical design by automatically mapping the identities of the agents to the generic factor names, concentrations or amounts of the agents to the factor levels, and the locations of the receptacles to the experimental runs. The method also includes placing different mixtures of single agents, such as peptones, into receptacles in the array based on the computer representation of the statistical design, contacting the placed mixtures with cells, acquiring experimental data from the contacted cells, and utilizing a processor including an algorithm for comparing the acquired data with the statistical design to identify peptone combinations and concentrations that optimize cell culture conditions.

    摘要翻译： 用于鉴定能够引发细胞型表型变化的试剂的自动化系统和方法。 该方法包括以下步骤：提供包括通用因子名称，因子水平和实验运行的统计设计，以及利用软件程序通过将代理的身份自动映射到通用因子名称，浓度来生成统计设计的计算机表示 或剂量到因子水平的量，以及容器到实验运行的位置。 该方法还包括基于统计设计的计算机表示将单个试剂（例如胨）的不同混合物放置在阵列中的容器中，将放置的混合物与细胞接触，从接触的细胞获取实验数据，以及使用包括 用于将获取的数据与统计设计进行比较以鉴定优化细胞培养条件的蛋白胨组合和浓度的算法。

    Methods of surface modification to enhance cell adhesion
    10.
    发明申请
    Methods of surface modification to enhance cell adhesion 审中-公开
    表面改性方法增强细胞粘附力

    公开(公告)号：US20050059140A1

    公开(公告)日：2005-03-17

    申请号：US10660759

    申请日：2003-09-12

    申请人： Andrea Liebmann-Vinson ,  Bryce Chaney

    发明人： Andrea Liebmann-Vinson ,  Bryce Chaney

    IPC分类号： C12N5/00 ,  C12N11/06 ,  C12N11/16 ,  G01N33/543

    CPC分类号： B82Y30/00 ,  B82Y15/00 ,  C12N5/0068 ,  C12N11/06 ,  C12N11/16 ,  C12N2533/30 ,  C12N2533/52 ,  G01N33/54353 ,  G01N33/54393 ,  G01N2610/00

    摘要： The current invention relates to methods of producing a surface with enhanced cell-adhesive properties comprising treating a pre-formed surface such that at least one intermediate reactive group is exposed on the surface. The exposed intermediate reactive group is then reacted to create a self-assembled monolayer, comprising at least one reactive group. The self-assembled monolayer is created non-mechanically. The reactive group is then coupled to at least one cell-adhesive molecule. The current invention also relates to cell culture devices comprising at least one oxygen-sensing compound and a cell-adhesive molecule.

    摘要翻译： 本发明涉及生产具有增强的电池 - 粘合性能的表面的方法，包括处理预成形表面，使得至少一个中间反应性基团暴露在表面上。 然后暴露的中间反应性基团反应以产生包含至少一个反应性基团的自组装单层。 自组装单层是非机械的。 然后将反应性基团偶联至至少一种细胞粘附分子。 本发明还涉及包含至少一种氧传感化合物和细胞粘附分子的细胞培养装置。