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    SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION OF DNA
    8.
    发明申请
    SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION OF DNA 有权

    公开(公告)号：US20150225779A1

    公开(公告)日：2015-08-13

    申请号：US14697036

    申请日：2015-04-27

    Applicant: Canon U.S. Life Sciences, Inc.

    Inventor： Kenton C. Hasson

    IPC: C12Q1/68

    CPC classification number: C12Q1/686

    Abstract: A system and method for amplifying and detecting nucleic acids are disclosed. In one embodiment, the system includes: a microfluidic device comprising a channel for receiving a sample of solution containing real-time PCR reagents; a temperature control system configured to cycle the temperature of the sample; an excitation source for illuminating the sample; a fiber optic probe comprising (i) an optical fiber having a distal end and a proximal end and (ii) a probe head connected to the distal end of the optical fiber and positioned between the distal end of the optical fiber and the channel; and a detector configured to detect emissions exiting the proximal end of the optical fiber.

    Microfluidic chip features for optical and thermal isolation
    9.
    发明授权
    Microfluidic chip features for optical and thermal isolation 有权
    微流控芯片功能用于光学和热隔离

    公开(公告)号：US08852527B2

    公开(公告)日：2014-10-07

    申请号：US13674528

    申请日：2012-11-12

    Applicant: Canon U.S. Life Sciences, Inc.

    Inventor： Bradley S. Thomas ,  Johnathan S. Coursey ,  Kenton C. Hasson ,  Hongye Liang

    IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  B01L7/00 ,  B01L3/00 ,  G01N21/03

    CPC classification number: C12Q1/686 ,  B01L3/5027 ,  B01L7/52 ,  B01L2300/0858 ,  B01L2300/18 ,  G01N21/0303 ,  Y10T436/11

    Abstract: A microfluidic chip includes microfluidic channels, elements for thermally and optically isolating the microfluidic channels, and elements for enhancing the detection of optical signal emitted from the microfluidic channels. The thermal and optical isolation elements may comprise barrier channels interposed between adjacently-arranged pairs of microfluidic channels for preventing thermal and optical cross-talk between the adjacent microfluidic channels. The isolation element may alternatively comprise reflective film embedded in the microfluidic chip between the adjacent microfluidic channels. The signal enhancement elements comprise structures disposed adjacent to the microfluidic channels that reflect light passing through or emitted from the microfluidic channel in a direction toward a detector. The structures may comprise channels or a faceted surface that redirects the light by total internal reflection or reflective film material embedded in the microfluidic chip.

    Abstract translation: 微流体芯片包括微流体通道，用于热和光学隔离微流体通道的元件以及用于增强从微流体通道发射的光信号的检测的元件。 热隔离元件和光学隔离元件可以包括插入在相邻布置的微流体通道对之间的阻挡通道，用于防止相邻的微流体通道之间的热和光学串扰。 隔离元件可以可选地包括嵌入在相邻微流体通道之间的微流体芯片中的反射膜。 信号增强元件包括邻近微流体通道设置的结构，其反射在朝向检测器的方向上通过微流体通道或从微流体通道发射的光。 结构可以包括通过嵌入在微流体芯片中的全内反射或反射膜材料来重定向光的通道或多面的表面。

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