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公开(公告)号：US20180015398A1
公开(公告)日：2018-01-18
申请号：US15644986
申请日：2017-07-10
Applicant: Canon U.S. Life Sciences, Inc.
Inventor： Joshua Mull , Owen Lu , Eric Schneider , Collin Grimes , Jamie Kendall , Franklin Francis Regan, IV , Ralph McCann , Scott Sundberg , Makoto Ogusu , Sean Ison , Jared Spaniol , Shulin Zeng , Ivor Knight
IPC: B01D35/147 , B01D35/153 , B01D35/30
CPC classification number: B01D35/147 , B01D35/153 , B01D35/30 , B01D2201/302 , B01L3/0289 , B01L2200/06 , B01L2200/10 , B01L2200/16 , B01L2400/049 , B01L2400/0622 , G01N1/00 , G01N35/10
Abstract: The present invention relates to systems and methods for preparing a fluidic cartridge for use in an analyzer device. In one non-limiting aspect, the present invention provides a method of preparing a fluidic cartridge for use in an analyzer device. The method may include controlling valves and a vacuum pump of a priming station to evacuate air from a fluidic cartridge loaded in the priming station. The method may include controlling the valves and the vacuum pump to draw priming fluid into sipper wells and channels of the loaded fluidic cartridge. In another non-limiting aspect, the present invention provides a priming station for preparing a fluidic cartridge for use in an analyzer device. The priming station may include a vacuum pump, a priming manifold assembly, and a controller. The priming manifold assembly may be configured to interface with a fluidic cartridge loaded in the priming station.
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2.发明申请公开(公告)号：US20160051985A1
公开(公告)日：2016-02-25
申请号：US14833939
申请日：2015-08-24
Applicant: Canon U.S. Life Sciences, Inc.
Inventor： Ivor T. KNIGHT , Kenton C. Hasson , Johnathan S. Coursey , Hongye Liang , Sami Kanderian , Gregory H. Owen , Weidong Cao , Ying-Xin Wang , Scott Corey , Ben Lane , Conrad Laskowski , Alex Flamm , Brian Murphy , Eric Schneider , Takayoshi Hanagata , Hiroshi Inoue , Shulin Zeng , Brian Bean , Franklin Regan
CPC classification number: B01L3/502746 , B01L3/502784 , B01L7/52 , B01L7/525 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0487 , C12Q1/686 , G01N21/77 , G01N35/08 , G01N35/1095 , G01N2021/7786 , C12Q2561/113 , C12Q2565/629
Abstract: The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.
Abstract translation: 本发明涉及用于在聚合酶链反应（PCR）和热熔体应用中实时处理核酸的系统和方法。 根据本发明的一个方面，提供了用于多重核酸测定的快速连续处理的系统。 在一个实施例中，该系统包括但不限于：具有微流体（流通）通道的微流控筒，荧光成像系统，温度测量和控制系统; 压力测量和控制系统，用于将可变气动压力施加到微流控筒; 用于容纳多个试剂（例如，孔板）的储存装置; 液体处理系统，包括至少一个用于将试剂混合物抽吸，混合和分配到微流控盒的机器人移液器; 用于数据存储，处理和输出的系统; 和一个系统控制器来协调各种设备和功能。
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公开(公告)号：US10092902B2
公开(公告)日：2018-10-09
申请号：US14860124
申请日：2015-09-21
Applicant: Canon U.S. Life Sciences, Inc.
Inventor： Ray Tsao , Hiroshi Inoue , Shulin Zeng , Brian Murphy , Kenton C. Hasson
Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.
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公开(公告)号：US20130224845A1
公开(公告)日：2013-08-29
申请号：US13677711
申请日：2012-11-15
Applicant: Canon U.S. Life Sciences, Inc.
Inventor： Ray Tsao , Hiroshi Inoue , Shulin Zeng , Brian Murphy , Kenton C. Hasson
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L3/502723 , B01L9/527 , B01L2200/021 , B01L2200/027 , B01L2300/0816 , B01L2300/0867 , G01N35/1095 , G01N2035/1034
Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.
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公开(公告)号：US10226772B2
公开(公告)日：2019-03-12
申请号：US15056475
申请日：2016-02-29
Applicant: Canon U.S. Life Sciences, Inc.
Inventor： Gregory A. Dale , Shulin Zeng , Kenton C. Hasson
Abstract: The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.
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Patent Agency Ranking
公开(公告)号：US09427736B2
公开(公告)日：2016-08-30
申请号：US14606392
申请日：2015-01-27
Applicant: Canon U.S. Life Sciences, Inc.
Inventor： Shulin Zeng , Gregory A. Dale
CPC classification number: B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2200/10 , B01L2300/0861 , B01L2300/0867 , B01L2300/12 , B01L2300/14 , B01L2400/049 , B01L2400/0666 , F16K99/0001 , F16K2099/0084 , F16K2099/0086 , Y10T137/0396 , Y10T137/2191 , Y10T137/86083 , Y10T137/87249
Abstract: A system and method for controlling fluid flow within a microchannel includes a fluid circuit comprising a fluid outlet well and one or more fluid inlet wells, all in communication with a microchannel. A negative pressure differential is applied to the outlet well and fluid flow from an inlet well into the microchannel is controlled by opening or closing the inlet well to atmospheric pressure. To stop fluid flow from the inlet well, a negative pressure differential may be applied to the inlet well to equalize pressure between the inlet and outlet wells. By sequentially opening and closing different inlet wells to atmosphere, controlled amounts of different reagents can be serially introduced into the microchannel.
Abstract translation: 用于控制微通道内的流体流动的系统和方法包括流体回路，流体回路包括流体出口井和一个或多个流体入口井，全部与微通道连通。 对出口井施加负压差，并且通过将入口井打开或关闭到大气压力来控制从入口井到微通道的流体流动。 为了阻止流体从入口井流出，负压差可以施加到入口井以平衡入口和出口孔之间的压力。 通过依次打开和关闭不同的入口孔到大气中，控制量的不同试剂可以连续地引入微通道。
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公开(公告)号：US09138744B2
公开(公告)日：2015-09-22
申请号：US14524701
申请日：2014-10-27
Applicant: Canon U.S. Life Sciences, Inc.
Inventor： Ray Tsao , Hiroshi Inoue , Shulin Zeng , Brian Murphy , Kenton C. Hasson
CPC classification number: B01L3/502715 , B01L3/502723 , B01L9/527 , B01L2200/021 , B01L2200/027 , B01L2300/0816 , B01L2300/0867 , G01N35/1095 , G01N2035/1034
Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.
Abstract translation: 用于微流控芯片的接口盒，具有微流程工艺通道和在工艺通道的相对端处的流体连接孔，提供辅助流体结构，包括流体流动通道和输入和/或废气井，其将反应流体混合和/或输送到 流体连接孔并进入微流体芯片的过程通道。
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公开(公告)号：US08871156B2
公开(公告)日：2014-10-28
申请号：US13677711
申请日：2012-11-15
Applicant: Canon U.S. Life Sciences, Inc.
Inventor： Ray Tsao , Hiroshi Inoue , Shulin Zeng , Brian Murphy , Kenton C. Hasson
CPC classification number: B01L3/502715 , B01L3/502723 , B01L9/527 , B01L2200/021 , B01L2200/027 , B01L2300/0816 , B01L2300/0867 , G01N35/1095 , G01N2035/1034
Abstract: An interface cartridge for a microfluidic chip, with microfluidic process channels and fluidic connection holes at opposed ends of the process channels, provides ancillary fluid structure, including fluid flow channels and input and/or waste wells, which mix and/or convey reaction fluids to the fluidic connection holes and into the process channels of the microfluidic chip.
Abstract translation: 用于微流控芯片的接口盒，具有微流程工艺通道和在工艺通道的相对端处的流体连接孔，提供辅助流体结构，包括流体流动通道和输入和/或废气井，其将反应流体混合和/或输送到 流体连接孔并进入微流体芯片的过程通道。
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公开(公告)号：US10363558B2
公开(公告)日：2019-07-30
申请号：US14833939
申请日：2015-08-24
Applicant: Canon U.S. Life Sciences, Inc.
Inventor： Ivor T. Knight , Kenton C. Hasson , Johnathan S. Coursey , Hongye Liang , Sami Kanderian , Gregory H. Owen , Weidong Cao , Ying-Xin Wang , Scott Corey , Ben Lane , Conrad Laskowski , Alex Flamm , Brian Murphy , Eric Schneider , Takayoshi Hanagata , Hiroshi Inoue , Shulin Zeng , Brian Bean , Franklin Regan
Abstract: The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.
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10.发明申请公开(公告)号：US20170327867A1
公开(公告)日：2017-11-16
申请号：US15389372
申请日：2016-12-22
Applicant: Canon U.S. Life Sciences, Inc.
Inventor： Abhijit Dohale , Arvind Virmani , Brian Scrivens , Christopher Sneeder , Denis Alias , George Maltezos , Hanyoup Kim , Harini Shandilya , Hongye Liang , Jason Zsak , Johnathan Stuart Coursey , Kenton C. Hasson , Melissa Gosse , Shulin Zeng , Yasuyuki Numajiri , Makoto Ogusu , Yoichi Murakami , Kunihiro Sakai
CPC classification number: C12Q1/6806 , B01L3/502 , B01L3/5021 , B01L3/502715 , B01L3/508 , B01L7/52 , B01L2200/0605 , B01L2200/0684 , B01L2200/16 , B01L2300/042 , B01L2300/0654 , B01L2300/0681 , B01L2300/087 , B01L2300/0896 , B01L2300/123 , B01L2300/168 , B01L2300/1827 , B01L2400/0478 , B01L2400/0487 , B01L2400/0605 , B01L2400/0683 , B01L2400/0688 , C12Q1/686 , G01N1/40
Abstract: The present invention relates to sample-to-answer systems, devices, cartridges, and method of using the same for detecting the presence of microorganisms in a sample, such as bacteria.
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