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    Dextran derivatives, preparation and medicinal applications
    5.
    发明授权
    Dextran derivatives, preparation and medicinal applications 失效
    葡聚糖衍生物，制剂和药物应用

    公开(公告)号：US06646120B1

    公开(公告)日：2003-11-11

    申请号：US09367111

    申请日：2000-09-26

    申请人： Frederic Chaubet ,  Remi Huynh ,  Latifa Dahri ,  Jose Correia ,  Marcel Jozefowicz ,  Jacqueline Jozefonvicz

    发明人： Frederic Chaubet ,  Remi Huynh ,  Latifa Dahri ,  Jose Correia ,  Marcel Jozefowicz ,  Jacqueline Jozefonvicz

    IPC分类号： C08B3702

    CPC分类号： C08B37/0021

    摘要： The invention concerns dextran derivatives, their applications as medicines with specific biological action, and their preparation method. Said derivatives correspond to the general formula DMCaBbSUcSd, in which: D represents a polysaccharide chain, preferably consisting of sequences of glucoside units, MC represents methylcarboxylate groups, B represents carboxymethylbenzylamide groups, Su represents sulphate groups, S represents sulphonate groups, a, b, c and d represent the degree of substitution (ds), respectively in groups, MC, B, Su and S; a being equal to 0 or ≧0.3, b being equal to 0 or ≧0.1, c being equal to 0 or ≧0.1 and d being equal to 0 or ≧0.1 provided that when d=0, a and/or b are not equal to 0, said products having homogeneity of chain size distribution, illustrated by a gauss elution profile symmetrical in high performance steric exclusion chromatography, and homogeneity in the distribution of charged chemical groups, illustrated by an elution profile with a single symmetrical peak in low pressure ion-exchange chromatography.

    摘要翻译： 本发明涉及葡聚糖衍生物，它们作为具有特定生物作用的药物的应用及其制备方法。 所述衍生物对应于通式DMCaBbSUcSd，其中：D表示多糖链，优选由葡萄糖苷单元序列组成，MC表示甲基羧酸酯基，B表示羧甲基苄基酰胺基，Su表示硫酸基，S表示磺酸酯基，a，b， c和d分别代表组，MC，B，Su和S的取代度（ds）; a等于0或> = 0.3，b等于0或> = 0.1，c等于0或> = 0.1，d等于0或> = 0.1，条件是当d = 0时，a和/或 b不等于0，所述产物具有链尺寸分布的均匀性，由高效空间排阻色谱中对称的高斯洗脱曲线所示，以及带电化学基团分布的均匀性，通过具有单个对称峰的洗脱曲线 在低压离子交换层析中。