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    Heteroaryl spiroethercycloalkyl tachykinin receptor antagonists
    9.
    发明授权
    Heteroaryl spiroethercycloalkyl tachykinin receptor antagonists 失效
    杂芳基螺醚醚环烷基速激肽受体拮抗剂

    公开(公告)号：US5929094A

    公开(公告)日：1999-07-27

    申请号：US956181

    申请日：1997-10-22

    申请人： Philippe Durette ,  Ihor Kopka ,  Malcolm MacCoss ,  Sander Mills

    发明人： Philippe Durette ,  Ihor Kopka ,  Malcolm MacCoss ,  Sander Mills

    IPC分类号： C07D405/04 ,  C07D405/10 ,  C07D405/14 ,  C07D413/04 ,  A61K31/44

    CPC分类号： C07D405/04 ,  C07D405/10 ,  C07D405/14 ,  C07D413/04

    摘要： The present invention is directed to certain novel compounds represented by structural formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.11, R.sup.12, R.sup.13, A, m, n and the dashed lines are defined herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.

    摘要翻译： 本发明涉及由结构式I表示的某些新型化合物或其药学上可接受的盐，其中R3，R6，R7，R8，R11，R12，R13，A，m，n和虚线在本文中定义。 本发明还涉及包含这些新化合物作为活性成分的药物制剂，以及新型化合物及其制剂在治疗某些疾病中的用途。 本发明化合物是速激肽受体拮抗剂，可用于治疗炎性疾病，疼痛或偏头痛，哮喘和呕吐。

    Fluorinated Pyrrolo[2,3-D]Pyrimidine Nucleosides for the Treatment of Rna-Dependent Rna Viral Infection
    10.
    发明申请
    Fluorinated Pyrrolo[2,3-D]Pyrimidine Nucleosides for the Treatment of Rna-Dependent Rna Viral Infection 审中-公开
    用于治疗Rna依赖性Rna病毒感染的氟化吡咯并[2,3-D]嘧啶核苷

    公开(公告)号：US20080280842A1

    公开(公告)日：2008-11-13

    申请号：US11664564

    申请日：2005-10-17

    申请人： Malcolm MacCoss ,  David B. Olsen ,  Joseph Leone ,  Philippe L. Durette

    发明人： Malcolm MacCoss ,  David B. Olsen ,  Joseph Leone ,  Philippe L. Durette

    IPC分类号： A61K31/7064 ,  C07H19/04 ,  A61P31/12

    CPC分类号： C07H19/14

    摘要： The present invention provides fluorinated pyrrolo[2,3,d]pyrimidine nucleoside compounds which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such fluorinated pyrrolo[2,3-d]pyrimidine nucleoside alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the fluorinated pyrrolo[2,3-d]pyrimidine nucleoside of the present invention.

    摘要翻译： 本发明提供了作为RNA依赖性RNA病毒聚合酶抑制剂的氟化吡咯并[2,3，d]嘧啶核苷化合物。 这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。 它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。 本发明还描述了含有这种氟化吡咯并[2,3-d]嘧啶核苷的药物组合物，或者与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合。 还公开了本发明的氟化吡咯并[2,3-d]嘧啶核苷抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。