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1.发明授权Miniature implantable array and stimulation system suitable for eyelid stimulation 有权微型可植入阵列和刺激系统适用于眼睑刺激公开(公告)号：US06792314B2
公开(公告)日：2004-09-14
申请号：US10160804
申请日：2002-05-31
IPC分类号： A61N105
CPC分类号： A61N1/0543 , A61N1/04
摘要： An implantable miniature eyelid electrode apparatus that causes a paralyzed eyelid to close or open by passing an electrical stimulating current to a nerve or muscle, is comprised of a longitudinally flexible, nonconductive body containing electrodes that pass an electrical signal to the nearby nerve or muscle, which closes or opens the eyelid. The apparatus is electrically actuated by a source that may be located remotely from the apparatus. The electrical signal passes along wires from the source to the apparatus. The apparatus is biocompatible with the environment in the living tissue and is electrically insulated from the surrounding tissue, except where the electrodes contact the living tissue. The apparatus is very small and is not obvious to visual inspection when implanted.
摘要翻译： 通过将电刺激电流传递到神经或肌肉而导致瘫痪的眼睑闭合或打开的可植入微型眼睑电极装置包括纵向柔性的不导电体，其包含将电信号传递到附近的神经或肌肉的电极， 它关闭或打开眼睑。 该设备由可以远离设备的源定位的电源电致动。 电信号通过电线从源到设备。 该装置与活体组织中的环境生物相容，并且与周围组织电绝缘，除了电极接触活组织之外。 该装置非常小，并且在植入时目视检查并不明显。
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2.发明授权Electrically sensing and stimulating system for placement of a nerve stimulator or sensor 有权用于放置神经刺激器或传感器的电感和刺激系统公开(公告)号：US06829508B2
公开(公告)日：2004-12-07
申请号：US10116619
申请日：2002-04-04
IPC分类号： A61N105
CPC分类号： A61N1/08 , A61B17/3468 , A61N1/0551
摘要： An electrically sensing and stimulating outer sheath for ensuring accurate surgical placement of a microsensor or a microstimulator near a nerve in living tissue is disclosed. The electrically sensing outer sheath may also be used to verify the function of the microstimulator or microsensor during surgical placement but before the outer sheath is removed. In the event that the microstimulator is not optimally placed near the nerve, or if the microstimulator is malfunctioning, this can be determined prior to removal of the outer sheath, thus reducing the possibility of nerve or tissue damage that might be incurred during a separate operation to remove the microstimulator.
摘要翻译： 公开了一种用于确保精细手术放置生物组织中神经附近的微传感器或微型刺激器的电感和刺激外护套。 电感外护套还可以用于在外科手术放置期间，但在外护套被移除之前验证微刺激器或微传感器的功能。 在微型刺激器没有被最佳地放置在神经附近的情况下，或者如果微型刺激器发生故障，则可以在去除外鞘之前确定这一点，从而减少在单独操作期间可能引起的神经或组织损伤的可能性 去除微型激励器。
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公开(公告)号：US07071546B2
公开(公告)日：2006-07-04
申请号：US10345013
申请日：2003-03-12
申请人： Kate E. Fey , Charles L. Byers , Lee J. Mandell
发明人： Kate E. Fey , Charles L. Byers , Lee J. Mandell
IPC分类号： H01L23/02
CPC分类号： H01L25/0657 , H01L23/481 , H01L2224/05571 , H01L2224/05573 , H01L2224/13025 , H01L2224/131 , H01L2224/14181 , H01L2224/16146 , H01L2225/06513 , H01L2225/0652 , H01L2225/06541 , H01L2225/06572 , Y10T29/53104 , H01L2924/014
摘要： An apparatus and packaging method for stacking a plurality of integrated circuit substrates, i.e., substrates having integrated circuits formed as integral portions of the substrates, which provides interconnection paths through the substrates to simplify electrical connections between the integrated circuits while facilitating minimization of the volume and customization of the three dimensional package size to conform to the available internal space within a housing, e.g., one used in an implantabie device where package volume is at a premium. Furthermore, an internal cavity can be created by the stacked formation that is suitable for mounting of a surface mount device, e.g., a crystal or the like.
摘要翻译： 一种用于堆叠多个集成电路基板的装置和封装方法，即具有形成为基板的整体部分的集成电路的基板，其提供穿过基板的互连路径，以简化集成电路之间的电连接，同时有助于最小化该体积， 定制三维包装尺寸以符合壳体内的可用内部空间，例如，在包装体积较高的植入装置中使用的尺寸。 此外，可以通过适合于安装诸如晶体等的表面安装装置的层叠结构来产生内部空腔。
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公开(公告)号：US06738672B2
公开(公告)日：2004-05-18
申请号：US09971848
申请日：2001-10-04
IPC分类号： A61N105
CPC分类号： A61N1/3752 , A61N1/05
摘要： The invention discloses methods of making electrical connections in living tissue between an electrically conductive wire and an implantable miniature device. The device may either stimulate muscles or nerves in the body or detect signals and transmit these signals outside the body or transmit the signals for use at another location within the body. The device is comprised of an electrically insulating or electrically conductive case with at least one electrode for transmitting electrical signals. The electrodes and the wire-electrode connections are protected from the aggressive environment within the body to avoid corrosion of the electrode and to avoid damage to the living tissue surrounding the device.
摘要翻译： 本发明公开了在导电线和可植入微型装置之间的生物组织中进行电连接的方法。 该装置可以刺激身体中的肌肉或神经，或者检测信号并将这些信号传输到身体外部，或者传输信号以在体内的另一位置使用。 该装置由具有至少一个用于传输电信号的电极的电绝缘或导电壳体组成。 电极和线电极连接被保护免受身体内的侵蚀性环境，以避免电极的腐蚀并且避免损坏设备周围的活体组织。
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公开(公告)号：US08336191B1
公开(公告)日：2012-12-25
申请号：US11833887
申请日：2007-08-03
IPC分类号： H04R31/00
CPC分类号： H03H9/54 , H01L2224/48227 , H01L2224/48465 , H03H9/1021 , H05K13/04 , Y10T29/49005 , Y10T29/49007 , Y10T29/4908 , H01L2924/00
摘要： An electronics filter circuit includes an electromechanical resonator that is mounted directly to the surface of a silicon integrated circuit, rather than being a surface mounted or leaded filter can on a circuit board. This filter circuit allows the integrated circuit electronic package to be significantly smaller than a conventional electromechanical resonator package. The electromechanical resonator may be protected during processing and during use with a protective cover that is made of a material such as titanium. The protective cover is attached to the integrated circuit chip.
摘要翻译： 电子滤波器电路包括直接安装到硅集成电路的表面的机电谐振器，而不是在电路板上的表面安装或引线的过滤器罐。 该滤波器电路允许集成电路电子封装显着小于常规机电谐振器封装。 机械共振器可以在加工期间和使用期间由诸如钛的材料制成的保护盖保护。 保护盖连接到集成电路芯片。
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公开(公告)号：US06989200B2
公开(公告)日：2006-01-24
申请号：US10697149
申请日：2003-10-30
IPC分类号： B32B15/04 , B32B15/16 , B23K1/00 , B23K103/08 , B23K103/16
CPC分类号： B23K35/007 , B23K35/3033 , B23K35/325 , B23K35/38 , C04B37/023 , C04B37/026 , C04B2237/122 , C04B2237/708 , Y10T428/12535 , Y10T428/12611 , Y10T428/12632 , Y10T428/12812 , Y10T428/12875 , Y10T428/12944
摘要： The invention is a method of bonding a ceramic part to a metal part by heating a component assembly comprised of the metal part, the ceramic part, and a compatible interlayer material such as titanium-nickel alloy placed between the two parts and heated at a temperature that is greater than the eutectic temperature of the interlayer material, where alloys, intermetallics or solid solution formed between the metal part and the metal interlayer material, but that is less than the melting point of either the ceramic part or the metal part. The component assembly is held in intimate contact at temperature in a non-reactive atmosphere for a sufficient time to develop a hermetic and strong bond between the ceramic part and the metal part. The bonded component assembly is optionally treated with acid to remove unwanted materials, to assure a biocompatible component assembly for implantation in living tissue.
摘要翻译： 本发明是一种通过加热由金属部件，陶瓷部件和相容的中间层材料（例如放置在两部分之间的钛 - 镍合金）的组件组件将陶瓷部件接合到金属部件并在温度下加热的方法 大于中间层材料的共熔温度，其中在金属部件和金属夹层材料之间形成合金，金属间化合物或固溶体，但小于陶瓷部件或金属部件的熔点。 组件组件在非反应性气氛中的温度下保持紧密接触足够的时间以在陶瓷部件和金属部件之间形成气密和牢固的结合。 任选地用酸处理粘合组分组合物以除去不想要的材料，以确保用于植入生物体组织的生物相容性组分组件。
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公开(公告)号：US07271525B2
公开(公告)日：2007-09-18
申请号：US11111306
申请日：2005-04-20
IPC分类号： H01L41/08
CPC分类号： H03H9/54 , H01L2224/48227 , H01L2224/48465 , H03H9/1021 , H05K13/04 , Y10T29/49005 , Y10T29/49007 , Y10T29/4908 , H01L2924/00
摘要： An electronics filter circuit includes an electromechanical resonator that is mounted directly to the surface of a silicon integrated circuit, rather than being a surface mounted or leaded filter can on a circuit board. This filter circuit allows the integrated circuit electronic package to be significantly smaller than a conventional electromechanical resonator package. The electromechanical resonator may be protected during processing and during use with a protective cover that is made of a material such as titanium. The protective cover is attached to the integrated circuit chip.
摘要翻译： 电子滤波器电路包括直接安装到硅集成电路的表面的机电谐振器，而不是在电路板上的表面安装或引线的过滤器罐。 该滤波器电路允许集成电路电子封装显着小于常规机电谐振器封装。 机械共振器可以在加工期间和使用期间由诸如钛的材料制成的保护盖保护。 保护盖连接到集成电路芯片。
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公开(公告)号：US06935897B2
公开(公告)日：2005-08-30
申请号：US10759340
申请日：2004-01-16
IPC分类号： A61N1/05 , H01R13/22 , H01R13/52 , H01R13/66 , H01R33/945
CPC分类号： H01R13/22 , A61N1/05 , A61N1/37205 , H01R13/5224
摘要： A connector (1) and method of making electrical connection between an electrical conductor (7, 11) and a removable electrical device (2). The connector (7, 11) is an elastic material, such as silicone, that is both compatible with the environment and is an electrical insulator. It forces contact between the electrical device (2) and integral contacts (10, 13) in the connector (1) by virtue of its elasticity. The electrodes (4, 6) and the electrical connections are protected from the environment to avoid electrical leakage or corrosion of the electrodes (4, 6).
摘要翻译： 一种连接器（1）以及在电导体（7,11）和可拆卸电气装置（2）之间进行电连接的方法。 连接器（7,11）是与环境兼容并且是电绝缘体的诸如硅树脂的弹性材料。 它通过其弹性来强制电气装置（2）和连接器（1）中的整体触头（10,13）之间的接触。 电极（4,6）和电连接被保护免受环境的影响，以避免电极（4,6）的电泄漏或腐蚀。
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公开(公告)号：US06498043B1
公开(公告)日：2002-12-24
申请号：US09718782
申请日：2000-11-22
IPC分类号： H01L2100
CPC分类号： A61N1/36585 , A61B5/0031 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/4839 , A61B2560/0219 , A61M5/1723 , A61N1/05 , A61N1/372 , A61N1/3754 , H01L23/3107 , H01L29/0657 , H01L2924/0002 , H01L2924/19041 , H01L2924/00
摘要： An implantable substrate sensor has electronic circuitry and electrodes formed on opposite sides of a substrate. A protective coating covers the substrate, effectively hermetically sealing the electronic circuitry under the coating. Exposed areas of the electrodes are selectively left uncovered by the protective coating, thereby allowing such electrodes to be exposed to body tissue and fluids when the sensor is implanted in living tissue. The substrate on which the electronic circuitry and electrodes are formed is the same substrate or “chip” on which an integrated circuit (IC) is formed, which integrated circuit contains the desired electronic circuitry. Such approach eliminates the need for an hermetically sealed lid or cover to cover hybrid electronic circuitry, and allows the sensor to be made much thinner than would otherwise be possible. In one embodiment, two such substrate sensors may be placed back-to-back, with the electrodes facing outward. As required, capacitors that form part of the sensor's electronic circuits are formed on the substrate by placing metalization layers and a dielectric in vacant areas of the substrate surface.
摘要翻译： 可植入衬底传感器具有形成在衬底的相对侧上的电子电路和电极。 保护涂层覆盖基材，有效地气密地密封涂层下的电子电路。 电极的暴露区域选择性地被保护涂层覆盖，从而当传感器植入生物体组织时允许这样的电极暴露于身体组织和流体。 其上形成有电子电路和电极的基板是形成有集成电路（IC）的相同的基板或“芯片”，该集成电路包含所需的电子电路。 这种方法消除了密封的盖或盖以覆盖混合电子电路的需要，并且允许传感器制造得比其他可能的薄得多。 在一个实施例中，两个这样的衬底传感器可以背对背放置，电极面向外。 根据需要，通过将金属化层和电介质放置在基板表面的空的区域中，形成在传感器的电子电路的一部分的电容器。
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10.发明授权Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces 有权可植入的基于酶的监测系统由于改进的外表面而具有改善的寿命公开(公告)号：US06477395B2
公开(公告)日：2002-11-05
申请号：US09395434
申请日：1999-09-14
IPC分类号： A61B500
CPC分类号： A61B5/14865 , A61B5/14532
摘要： An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
摘要翻译： 提供了一种适用于长期体内使用的可植入酶的监测系统，用于测量规定物质如葡萄糖的浓度。 在一个实施方案中，可植入酶基监测系统包括至少一个传感器组件，围绕传感器组件的外部膜并且在其中具有窗口，以及固定到外部膜并覆盖窗户的聚合物窗口盖。 优选地，监测系统的外膜是硅树脂，窗罩是甲基丙烯酸2-羟乙酯（HEMA），甲基丙烯酸N，N，N-二甲基氨基乙酯（DMAEMA）和甲基丙烯酸（MA）的聚合物。 本文还提供了一种植入式酶基监测系统，其具有至少一个传感器组件，围绕传感器组件的外膜和固定到外膜外表面的涂层，其中该涂层抗凝血和蛋白质结合到外部 外膜表面。 优选地，涂层是80:20摩尔比的聚乙二醇（PEG）和肝素。 最后，本文提供了一种涂覆可植入酶基监测系统的外膜的外表面的方法，包括以下步骤：通过等离子体蚀刻在硅氧烷表面上形成羟基; 使硅氧烷表面与氨基官能化硅烷反应，从而在硅氧烷表面上形成氨基; 同时将聚乙二醇（PEG）和肝素共价结合到氨基上; 并将肝素离子结合到监测系统表面。
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