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    Method And Apparatus For Forming Microstructures
    1.
    发明申请
    Method And Apparatus For Forming Microstructures 审中-公开
    用于形成微结构的方法和装置

    公开(公告)号：US20080307849A1

    公开(公告)日：2008-12-18

    申请号：US11791567

    申请日：2004-11-26

    申请人： Chee Yen Lim ,  Yuan Xu ,  Hbaieb Kais ,  Yuan Ling Christina Tan

    发明人： Chee Yen Lim ,  Yuan Xu ,  Hbaieb Kais ,  Yuan Ling Christina Tan

    IPC分类号： B26F1/14 ,  B05D3/12 ,  C25D5/34 ,  B05C21/00 ,  C25D17/00 ,  B26F1/24

    CPC分类号： A61M37/0015 ,  A61M2037/0053 ,  B21G1/08 ,  B21J13/02 ,  B21K23/00

    摘要： A method of micro forming an array of microstructures comprising: advancing a punch having an array of protrusions (620) towards a sheet of material (640) disposed between the punch (620) and a die (630), each protrusion (625) shaped to deform the sheet of material (640) into a corresponding microstructure; providing a holder for holding the sheet of material (640) in place; and punching the sheet of material (640) with the protrusions on the punch (620) to form the array of microstructures on the sheet of material (640).

    摘要翻译： 一种微观形成微结构阵列的方法，其特征在于，包括：朝向设置在冲头（620）和模具（630）之间的材料片（640）前进具有突起阵列（620）的冲头，每个凸起（625）成形 使所述材料片（640）变形成相应的微结构; 提供用于将材料片（640）保持在适当位置的保持器; 以及用所述冲头（620）上的突起冲压所述材料片（640）以在所述材料片（640）上形成所述微结构阵列。

    Methods and moulds for use in fabricating side-ported microneedles
    2.
    发明申请
    Methods and moulds for use in fabricating side-ported microneedles 失效
    用于制造侧端微针的方法和模具

    公开(公告)号：US20100305516A1

    公开(公告)日：2010-12-02

    申请号：US10592559

    申请日：2004-03-12

    申请人： Yuan Xu ,  Minghua Wang ,  Mei Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

    发明人： Yuan Xu ,  Minghua Wang ,  Mei Ma Chen ,  Zhongli Li ,  Chee Yen Lim ,  Pei Ying Joyce Tan

    IPC分类号： A61M5/00 ,  B22C9/22 ,  B29C33/42 ,  C25D1/00

    CPC分类号： B29C33/0061 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C33/301 ,  B29C33/3857 ,  B29C33/40 ,  B29C33/424 ,  B29C33/56 ,  B29C59/026 ,  B29C2791/001 ,  B29C2793/0009 ,  B29L2031/756 ,  B29L2031/759 ,  B81B2201/055 ,  B81C99/009 ,  C25D1/02 ,  Y10T29/49885 ,  Y10T29/4998 ,  Y10T29/49982 ,  Y10T29/49984 ,  Y10T29/49986 ,  Y10T29/49988

    摘要： Side-ported microneedles are produced from a suitably shaped microneedle mould (40). A microneedle mould base (32) is made with a number of microneedle mould recesses (30) in it. One surface of the microneedle mould base (32) is coated with a seed layer (34). The microneedle mould base (32) contains two microneedle mould sheets (24, 26), which are separated to gain access to an internal surface of one of the microneedle mould sheets (24, 26). Side-port forming channels (38) are formed on one of the internal surfaces, intersecting with the recesses (30) within the relevant microneedle mould sheet (24). The two microneedle mould sheets (24, 26) are placed back together and joined together as a unitary microneedle mould (40). The microneedles are formed in the recesses (30) by depositing a microneedle layer (44) therein and on the surface with the seed layer (34). The microneedle layer (44) fails to deposit at side-port forming holes (42) where the side-port forming channels (38) intersect the recesses (30), which result in side-ports (46) in the moulded microneedles (52).

    摘要翻译： 由适当形状的微针模具（40）制造侧端微针。 微针模具基座（32）在其中形成有许多微针模具凹槽（30）。 微针模具基座（32）的一个表面涂覆有种子层（34）。 微针模具基座（32）包含两个微针模具片（24,26），它们分开以进入其中一个微针模板（24,26）的内表面。 侧孔形成通道（38）形成在与相关微针模板（24）内的凹部（30）相交的一个内表面上。 将两个微针模具片（24,26）放置在一起并作为整体式微针模具（40）连接在一起。 通过在其中放置微针层（44）并在种子层（34）的表面上，在凹部（30）中形成微针。 该微针层（44）不能沉积在侧孔形成通道（42）处，其中侧孔形成通道（38）与凹槽（30）相交，这导致模制微针（52）中的侧端口（46） ）。

    Silicone hydrogel contact lenses
    5.
    发明授权
    Silicone hydrogel contact lenses 有权
    硅胶水凝胶隐形眼镜

    公开(公告)号：US09296159B2

    公开(公告)日：2016-03-29

    申请号：US13983306

    申请日：2012-02-23

    申请人： Ying Zheng ,  Yuan Xu ,  Junhao Ge ,  Charles A. Francis ,  Yuan Sun ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Hongjin Qiu ,  Li Yao ,  Arthur Back

    发明人： Ying Zheng ,  Yuan Xu ,  Junhao Ge ,  Charles A. Francis ,  Yuan Sun ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Hongjin Qiu ,  Li Yao ,  Arthur Back

    IPC分类号： G02B1/04 ,  B29D11/00 ,  C08F290/06

    CPC分类号： B29D11/00125 ,  B29D11/0025 ,  C08F290/068 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

    摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer, or at least one hydrophilic vinyl ether-containing monomer, or both, wherein, when the at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, and when the at least one hydrophilic vinyl ether-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

    摘要翻译： 衍生自包含至少一种硅氧烷单体和至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体或至少一种亲水乙烯基醚的单体或两者的可聚合组合物的硅氧烷水凝胶隐形眼镜，其中当在 在可聚合组合物中存在至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体，其存在量为1至20单位份重量，并且当至少一种亲水乙烯基醚单体存在于 可聚合组合物的含量为1〜20单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

    Silicone Hydrogel Contact Lenses
    7.
    发明申请
    Silicone Hydrogel Contact Lenses 有权
    硅胶水凝胶隐形眼镜

    公开(公告)号：US20140009735A1

    公开(公告)日：2014-01-09

    申请号：US13983306

    申请日：2012-02-23

    申请人： Ying Zheng ,  Yuan Xu ,  Junhao Ge ,  Charles A. Francis ,  Yuan Sun ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Hongjin Qiu ,  Li Yao ,  Arthur Back

    发明人： Ying Zheng ,  Yuan Xu ,  Junhao Ge ,  Charles A. Francis ,  Yuan Sun ,  Yuwen Liu ,  Charlie Chen ,  Ye Hong ,  Hongjin Qiu ,  Li Yao ,  Arthur Back

    IPC分类号： G02B1/04 ,  B29D11/00

    CPC分类号： B29D11/00125 ,  B29D11/0025 ,  C08F290/068 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

    摘要： Silicone hydrogel contact lenses that are derived from a polymerizable composition including at least one siloxane monomer and at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer, or at least one hydrophilic vinyl ether-containing monomer, or both, wherein, when the at least one hydrophobic ethylene glycol methyl ether methacrylate-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, and when the at least one hydrophilic vinyl ether-containing monomer is present in the polymerizable composition, it is present in an amount of from 1 to 20 unit parts by weight, are described. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

    摘要翻译： 衍生自包含至少一种硅氧烷单体和至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体或至少一种亲水乙烯基醚的单体或两者的可聚合组合物的硅氧烷水凝胶隐形眼镜，其中当在 在可聚合组合物中存在至少一种疏水性乙二醇甲基醚甲基丙烯酸酯单体，其存在量为1至20单位份重量，并且当至少一种亲水乙烯基醚单体存在于 可聚合组合物的含量为1〜20单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。

    Dimensionally Stable Silicone Hydrogel Contact Lenses
    9.
    发明申请
    Dimensionally Stable Silicone Hydrogel Contact Lenses 有权
    尺寸稳定的硅胶水凝胶隐形眼镜

    公开(公告)号：US20120220743A1

    公开(公告)日：2012-08-30

    申请号：US13404034

    申请日：2012-02-24

    申请人： Charles A. Francis ,  Ying Zheng ,  Yuan Xu ,  Li Yao ,  Arthur Back ,  Ye Hong ,  Charlie Chen

    发明人： Charles A. Francis ,  Ying Zheng ,  Yuan Xu ,  Li Yao ,  Arthur Back ,  Ye Hong ,  Charlie Chen

    IPC分类号： C08F230/08

    CPC分类号： C08F230/08 ,  C08F222/1006

    摘要： Dimensionally stable silicone hydrogel contact lenses are described. The lenses are derived from a polymerizable composition including a first siloxane monomer represented by formula (1): wherein m of formula (1) represents one integer from 3 to 10, n of formula (1) represents one integer from 1 to 10, R1 of formula (1) is an alkyl group having from 1 to 4 carbon atoms, and each R2 of formula (1) is independently either a hydrogen atom or a methyl group; the lenses also include units derived from a second siloxane monomer represented by formula (2): wherein R1 of formula (2) is selected from either hydrogen atom or a methyl group; R2 of formula (2) is selected from either of hydrogen atom or a hydrocarbon group having 1 to 4 carbon atoms; m of formula (2) represents an integer of from 0 to 10; n of formula (2) represents an integer of from 4 to 100; a and b represent integers of 1 or more; a+b is equal to 20-500; b/(a+b) is equal to 0.01-0.22; the configuration of siloxane units includes a random configuration, the second siloxane monomer having a number average molecular weight of at least 3,000 daltons that is present in the polymerizable composition in an amount such that ratio of the first siloxane monomer to the second siloxane monomer is at least 2:1 based on unit parts by weight. Batches of silicone hydrogel contact lenses and methods of making silicone hydrogel contact lenses are also described.

    摘要翻译： 描述了尺寸稳定的硅酮水凝胶隐形眼镜。 透镜衍生自包含由式（1）表示的第一硅氧烷单体的可聚合组合物：其中式（1）的m表示3至10的一个整数，式（1）的n表示1至10的整数，R 1 式（1）的烷基是碳原子数为1〜4的烷基，式（1）的各R 2独立地为氢原子或甲基。 透镜还包括衍生自由式（2）表示的第二硅氧烷单体的单元：其中式（2）的R 1选自氢原子或甲基; 式（2）的R2选自氢原子或碳原子数为1〜4的烃基; 式（2）的m表示0〜10的整数， 式（2）的n表示4〜100的整数， a和b表示1以上的整数; a + b等于20-500; b /（a + b）等于0.01-0.22; 硅氧烷单元的构型包括随机构型，第二硅氧烷单体的数均分子量为至少3,000道尔顿，其存在于可聚合组合物中，其量使得第一硅氧烷单体与第二硅氧烷单体的比率在 至少2：1，单位重量份。 还描述了硅胶水凝胶隐形眼镜的批次和制造硅酮水凝胶隐形眼镜的方法。