METHODS AND COMPOSITIONS FOR CELLULAR DRUG RELEASE
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR CELLULAR DRUG RELEASE 审中-公开
    细胞毒素释放的方法和组合物

    公开(公告)号:US20130164335A1

    公开(公告)日:2013-06-27

    申请号:US13338073

    申请日:2011-12-27

    摘要: Methods and compositions for producing a cellular drug release are disclosed. The method comprises: a) providing a composition comprising a therapeutically effective amount of a pharmacological agent adsorbed onto mesoporous hydroxyapatite (HAP) with hydrophobic surfaces; b) exposing the composition to a cell; c) causing entry of the mesoporous HAP into the cell and degradation of the HAP in the lysosomes of the cell and desorption of the agent from the mesoporous HAP; d) causing release of the desorbed agent from the lysosomes into the cytoplasm of the cell; and e) causing release of the desorbed agent to outside the cell. The composition comprises a) mesoporous HAP with hydrophobic surfaces; and b) a therapeutically effective amount of a pharmacological agent, adsorbed onto the hydrophobic surfaces of the mesoporous. HAP. The composition is characterized in that it constantly releases the agent in vivo for a period of at least 4 weeks.

    摘要翻译: 公开了用于产生细胞药物释放物的方法和组合物。 该方法包括:a)提供包含治疗有效量的吸附在具有疏水表面的介孔羟基磷灰石(HAP)上的药理学试剂的组合物; b)将组合物暴露于细胞; c)导致介孔HAP进入细胞并且细胞溶酶体中HAP的降解和药物从介孔HAP中的解吸; d)使解吸剂从溶酶体释放到细胞的细胞质中; 和e)引起解吸剂释放到细胞外。 该组合物包含a)具有疏水表面的中孔HAP; 和b)吸附在介孔的疏水表面上的治疗有效量的药理学试剂。 HAP。 该组合物的特征在于其在体内不断释放至少4周的时间。

    PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITING INFLAMMATION
    4.
    发明申请
    PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITING INFLAMMATION 有权
    药物组合物和抑制炎症的方法

    公开(公告)号:US20120108536A1

    公开(公告)日:2012-05-03

    申请号:US13024764

    申请日:2011-02-10

    IPC分类号: A61K31/715 A61P19/02

    摘要: A pharmaceutical composition for inhibiting inflammation, comprising (a) hyaluronic acid, (b) a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, and (c) a pharmaceutically acceptable carrier, is provided. Also provided is a method for inhibiting inflammation in a mammal, comprising administrating to the mammal an effective amount of a composition comprising (a) hyaluronic acid and (b) an HMG-CoA reductase inhibitor.

    摘要翻译: 一种用于抑制炎症的药物组合物,其包含(a)透明质酸,(b)3-羟基-3-甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂和(c)药学上可接受的载体。 还提供了抑制哺乳动物炎症的方法,其包括向哺乳动物施用有效量的组合物,其包含(a)透明质酸和(b)HMG-CoA还原酶抑制剂。

    Biocompatible bilayer porous matrix and preparation thereof
    7.
    发明申请
    Biocompatible bilayer porous matrix and preparation thereof 审中-公开
    生物相容双层多孔基质及其制备

    公开(公告)号:US20090186408A1

    公开(公告)日:2009-07-23

    申请号:US12010014

    申请日:2008-01-18

    IPC分类号: C12N5/02

    摘要: The present invention provides a biocompatible bilayer porous matrix and preparation thereof. The bilayer porous matrix is composed of gelatin, chondroitin 6 sulfate, and hyaluronic acid, also, prepared through freeze-drying technique at different temperature and time duration to form varied pore sizes on each layer. The present invention also provides a method of cell culture using the bilayer porous matrix.

    摘要翻译: 本发明提供生物相容性双层多孔基质及其制备方法。 双层多孔基质由明胶,硫酸软骨素6和透明质酸组成,也通过不同温度和时间的冷冻干燥技术制备,以在每层上形成不同的孔径。 本发明还提供了使用双层多孔基质的细胞培养方法。

    &agr;-TCP/HAP biphasic cement and its preparing process
    9.
    发明授权
    &agr;-TCP/HAP biphasic cement and its preparing process 有权
    α-TCP / HAP双相水泥及其制备方法

    公开(公告)号:US06338752B1

    公开(公告)日:2002-01-15

    申请号:US09553176

    申请日:2000-04-20

    IPC分类号: C04B1202

    摘要: A biphasic cement of &agr;-TCP/HAP is primarily composed of 30-60 wt % &agr;-tricalcium phosphate (Ca3(PO4)2, &agr;-TCP) and 40-70 wt % of hydroxyapatite (Ca10(PO4)6(OH)2, HAP). The biphasic cement of &agr;-TCP/HAP of the present invention is superior since it can set rapidly while soaking in a water solution. The present invention also provides a process for preparing the biphasic cement of &agr;-TCP/HAP, in which the composition of the biphasic cement of &agr;-TCP/HAP can be controlled.

    摘要翻译: α-TCP / HAP的双相水泥主要由30-60重量%的磷酸三钙(Ca3(PO4)2,α-TCP)和40-70重量%的羟基磷灰石(Ca10(PO4)6(OH) 2,HAP)。 本发明的α-TCP / HAP的双相水泥优异,因为它可以在浸泡在水溶液中时快速固化。 本发明还提供了一种制备α-TCP / HAP的双相水泥的方法,其中可以控制α-TCP / HAP的双相水泥的组成。