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    RAPID PATHOGEN DIAGNOSTIC DEVICE AND METHOD
    1.
    发明申请
    RAPID PATHOGEN DIAGNOSTIC DEVICE AND METHOD 审中-公开
    快速病理诊断装置及方法

    公开(公告)号：US20130157283A1

    公开(公告)日：2013-06-20

    申请号：US13522800

    申请日：2011-01-19

    申请人： Chong Wing Yung ,  Donald E. Ingber ,  Ryan Mcomber Cooper ,  Frank Vollmer ,  Karel Domansky ,  Daniel Christopher Leslie ,  Michael Super

    发明人： Chong Wing Yung ,  Donald E. Ingber ,  Ryan Mcomber Cooper ,  Frank Vollmer ,  Karel Domansky ,  Daniel Christopher Leslie ,  Michael Super

    IPC分类号： C12Q1/04

    CPC分类号： C12Q1/04 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2400/043 ,  G01N33/54306 ,  G01N33/54333 ,  G01N33/54366 ,  G01N35/0098

    摘要： A microfluidic device of a diagnostic and detection system includes an inlet port connected by one or more microchannels to an outlet port and includes a capture and visualization chamber (CVC) connected to at least one microchannel. A fluid to be analyzed can be mixed with magnetic microbeads that have an affinity to become bound to target components, such as pathogens in the fluid. The fluid including the magnetically bound target components can be injected through the microfluidic device. Magnetic field gradient, such as provided by permanent or electro-magnets, can be applied to the fluid and the magnetically bound target components flowing through the microfluidic device to cause the magnetically bound target components to migrate into the (CVC) and become separated from the fluid. The magnetically bound target components can be analyzed and tested using various techniques to detect the presence of specific organic and inorganic materials, such as pathogens in bio-fluids and contamination in liquid food sources (e.g. water). The device and method provide a system for rapidly detecting pathogens and contamination in relatively small fluid samples.

    摘要翻译： 诊断和检测系统的微流体装置包括通过一个或多个微通道连接到出口的入口端口，并且包括连接到至少一个微通道的捕获和可视化室（CVC）。 要分析的流体可以与具有亲和性的磁性微珠混合，以结合到目标组分，例如流体中的病原体。 包括磁结合的靶组分的流体可以通过微流体装置注入。 磁场梯度，例如由永磁体或电磁铁提供的磁场梯度可以被施加到流过微流体装置的流体和磁结合的目标组分，以使磁结合的靶组分迁移到（CVC）中并与 流体。 可以使用各种技术来分析和测试磁结合的靶组分，以检测特定有机和无机材料（例如生物流体中的病原体和液体食物来源（例如水））中的污染物的存在。 该装置和方法提供用于在相对小的流体样品中快速检测病原体和污染物的系统。

    DIALYSIS LIKE THERAPEUTIC (DLT) DEVICE
    2.
    发明申请
    DIALYSIS LIKE THERAPEUTIC (DLT) DEVICE 审中-公开
    DIALYSIS LIKE THERAPEUTIC（DLT）DEVICE

    公开(公告)号：US20140220617A1

    公开(公告)日：2014-08-07

    申请号：US14007738

    申请日：2012-04-02

    申请人： Chong Wing Yung ,  Karel Domansky ,  Richard Terry ,  David Kalish ,  Alexa Schulte ,  Joo Hun Kang ,  Donald E. Ingber ,  Michael Super ,  Ryan M. Cooper

    发明人： Chong Wing Yung ,  Karel Domansky ,  Richard Terry ,  David Kalish ,  Alexa Schulte ,  Joo Hun Kang ,  Donald E. Ingber ,  Michael Super ,  Ryan M. Cooper

    IPC分类号： C12Q1/04 ,  B03C1/00 ,  B01L3/00

    CPC分类号： C12Q1/04 ,  A61M1/36 ,  A61M1/3618 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/56 ,  B01L2200/0652 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/043 ,  B01L2400/0487 ,  B03C1/002 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/0335 ,  B03C1/288 ,  B03C2201/26

    摘要： A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. The source channel and the collection channels of the microfluidic device are analogous to the splenic arterioles and venules, respectively; the transfer channels mimic the vascular sinusoids of the spleen where opsonized particles are retained. Thus, the device acts as a dialysis like therapeutic device by combining fluidics and magnetics.

    摘要翻译： 提供透析治疗（DLT）装置。 DLT设备包括通过一个或多个传输信道连接至少一个收集信道的至少一个源信道。 通道的流体接触表面可以是防污表面，例如滑动的液体注入的多孔表面（SLIPS）。 流体可以通过通道以高流速流动。 源流体的目标组分可以是磁性的或使用亲和分子结合到磁性颗粒。 含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。 磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。 收集通道可以包括收集流体以将目标组分冲洗出收集通道。 随后分析目标成分进行检测和诊断。 微流体装置的源通道和收集通道分别类似于脾小动脉和小静脉; 转移通道模拟脾脏的血管窦状，其中保留调理颗粒。 因此，通过组合流体学和磁性，该装置作为透析像治疗装置。

    AEROSOL DELIVERY TO A MICROFLUIDIC DEVICE
    3.
    发明申请
    AEROSOL DELIVERY TO A MICROFLUIDIC DEVICE 审中-公开
    AEROSOL交付给微流控装置

    公开(公告)号：US20140158233A1

    公开(公告)日：2014-06-12

    申请号：US14116477

    申请日：2012-05-09

    申请人： Daniel Christopher Leslie ,  Karel Domansky ,  Geraldine A. Hamilton ,  Anthony Bahinski ,  Donald E. Ingber

    发明人： Daniel Christopher Leslie ,  Karel Domansky ,  Geraldine A. Hamilton ,  Anthony Bahinski ,  Donald E. Ingber

    IPC分类号： B05B15/00

    摘要： The present invention is directed to systems and methods for delivering aerosolized micro-droplets into microfluidic devices. In some embodiments, the microfluidic devices are designed for the culture of living cells at an air interface. In some embodiments, the systems and methods described herein can be used to deliver aerosolized micro-droplet into detection systems and small animals, tissues, organs and organisms.

    摘要翻译： 本发明涉及用于将雾化的微滴输送到微流体装置中的系统和方法。 在一些实施例中，微流体装置被设计用于在空气界面处培养活细胞。 在一些实施方案中，本文所述的系统和方法可用于将雾化的微滴输送到检测系统和小动物，组织，器官和生物中。

    Device for Filtration of Fluids Therethrough and Accompanying Method
    4.
    发明申请
    Device for Filtration of Fluids Therethrough and Accompanying Method 有权
    流体过滤装置及其附带方法

    公开(公告)号：US20120149021A1

    公开(公告)日：2012-06-14

    申请号：US13144572

    申请日：2010-01-15

    申请人： Chong Wing Yung ,  Donald E. Ingber ,  Jason O. Fiering ,  Mathew Varghese

    发明人： Chong Wing Yung ,  Donald E. Ingber ,  Jason O. Fiering ,  Mathew Varghese

    IPC分类号： B03C1/02 ,  C12Q1/68 ,  H01J49/26 ,  C12Q1/18 ,  C12M1/42 ,  G01N33/53 ,  C12Q1/02

    CPC分类号： B03C1/01 ,  B03C1/288 ,  B03C2201/18 ,  G01N1/40 ,  G01N33/54326 ,  G01N33/54366

    摘要： A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.

    摘要翻译： 用于从源流体分离目标部件的微流体装置包括通过一个或多个传输通道连接到一个或多个收集通道的一个或多个源通道。 源流体的目标组分可以使用已知的结合剂磁性或与磁性颗粒结合。 含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。 磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。 收集通道可以包括滞留的收集流体，直到预定量的源流体被处理或者预定量的目标组分积聚在收集通道中，此时收集流体可被泵入收集通道以冲洗目标组分 离开收集渠道。 随后分析目标成分进行检测和诊断。

    MICROFLUIDIC MODULE AND USES THEREOF
    5.
    发明申请
    MICROFLUIDIC MODULE AND USES THEREOF 审中-公开
    微流控模块及其用途

    公开(公告)号：US20140199764A1

    公开(公告)日：2014-07-17

    申请号：US14116481

    申请日：2012-05-08

    申请人： Karel Domansky ,  Daniel C. Leslie ,  Geraldine A. Hamilton ,  Anthony Bahinski ,  Donald E. Ingber

    发明人： Karel Domansky ,  Daniel C. Leslie ,  Geraldine A. Hamilton ,  Anthony Bahinski ,  Donald E. Ingber

    IPC分类号： C12N5/071 ,  B32B37/18

    CPC分类号： C12N5/0602 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00833 ,  B01J2219/0084 ,  B01J2219/0086 ,  B01J2219/00907 ,  B01L3/502707 ,  B01L2300/161 ,  B32B37/18 ,  G01N33/54393

    摘要： Described herein are microfluidic modules and methods for making the same, wherein the microfluidic modules include a substrate comprising at least one ether-based, aliphatic polyurethane, and at least one fluidic element disposed therein. The ether-based aliphatic polyurethane can be either the substrate of the microfluidic modules or a coating of another substrate material, such that at least a portion of the ether-based, aliphatic polyurethane is in fluid communication. In one embodiment, the ether-based, aliphatic polyurethane includes dicyclohexylmethane-4,4′-diisocyanate. As the ether-based aliphatic polyurethane can decrease absorption of molecules, e.g., hydrophobic molecules, in such microfluidic modules, the microfluidic modules described herein can be used in various applications such as drug screening and fluorescent microscopy.

    摘要翻译： 本文描述的是微流体模块和用于制造其的方法，其中微流体模块包括包含至少一种醚基脂族聚氨酯和设置在其中的至少一个流体元件的基材。 醚基脂肪族聚氨酯可以是微流体模块的基材或另一种基材的涂层，使得至少一部分醚基的脂族聚氨酯与流体连通。 在一个实施方案中，醚基脂族聚氨酯包括二环己基甲烷-4,4'-二异氰酸酯。 由于醚类脂族聚氨酯可以在这种微流体模块中减少分子（例如疏水性分子）的吸收，因此本文所述的微流体模块可用于各种应用，例如药物筛选和荧光显微镜。

    Microfluidic device and uses thereof
    6.
    发明授权
    Microfluidic device and uses thereof 有权
    微流体装置及其用途

    公开(公告)号：US09156037B2

    公开(公告)日：2015-10-13

    申请号：US13144572

    申请日：2010-01-15

    申请人： Chong Wing Yung ,  Donald E. Ingber ,  Jason O. Fiering ,  Mathew Varghese

    发明人： Chong Wing Yung ,  Donald E. Ingber ,  Jason O. Fiering ,  Mathew Varghese

    IPC分类号： C12Q1/68 ,  B03C1/01 ,  B03C1/28 ,  G01N33/543 ,  G01N1/40

    CPC分类号： B03C1/01 ,  B03C1/288 ,  B03C2201/18 ,  G01N1/40 ,  G01N33/54326 ,  G01N33/54366

    摘要： A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.

    摘要翻译： 用于从源流体分离目标部件的微流体装置包括通过一个或多个传送通道连接到一个或多个收集通道的一个或多个源通道。 源流体的目标组分可以使用已知的结合剂磁性或与磁性颗粒结合。 含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。 磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。 收集通道可以包括滞留的收集流体，直到预处理的体积的源流体被处理或预定量的目标组分积聚在收集通道中，此时收集流体可被泵入收集通道以冲洗目标组分 离开收集渠道。 随后分析目标成分进行检测和诊断。

    ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF
    9.
    发明申请
    ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF 有权
    工程微生物靶向分子及其用途

    公开(公告)号：US20140227723A1

    公开(公告)日：2014-08-14

    申请号：US14233553

    申请日：2012-07-18

    申请人： Donald E. Ingber ,  Michael Super ,  Jeffrey Charles Way ,  Mark J. Cartwright ,  Julia B. Berthet ,  Dinah R. Super ,  Martin M. Rottman ,  Alexander Watters

    发明人： Donald E. Ingber ,  Michael Super ,  Jeffrey Charles Way ,  Mark J. Cartwright ,  Julia B. Berthet ,  Dinah R. Super ,  Martin M. Rottman ,  Alexander Watters

    IPC分类号： C07K16/12 ,  G01N33/569 ,  C07K14/42

    CPC分类号： C07K16/12 ,  A61K47/68 ,  A61K47/6815 ,  C07K14/42 ,  C07K2319/33 ,  G01N33/54353 ,  G01N33/56911 ,  G01N33/56916 ,  G01N33/56938 ,  G01N33/56961 ,  G01N2333/42 ,  G01N2333/4724 ,  Y02A50/53 ,  Y02A50/58

    摘要： Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.

    摘要翻译： 本文描述了工程化的微生物靶向或微生物结合分子，包含其的试剂盒及其用途。 微生物靶向或微生物结合分子的一些具体实施方案包含与Fc区的一部分连接的甘露糖结合凝集素或其片段的碳水化合物识别结构域。 在一些实施方案中，微生物靶向分子或微生物结合分子可以与基底（例如磁性微珠）缀合，形成微生物靶向底物（例如，微生物靶向磁性微珠）。 这样的微生物靶向分子和/或底物及其包含的试剂盒可以结合和/或捕获微生物和/或其微生物物质，因此可以用于各种应用中，例如诊断和/或治疗感染 由微生物引起，如受试者或任何环境表面的败血症。 微生物靶向分子和/或底物可以在使用后通过用不溶于钙的低pH缓冲液或缓冲液洗涤而再生。

    Engineered opsonin for pathogen detection and treatment
    10.
    发明授权
    Engineered opsonin for pathogen detection and treatment 有权
    工程调理蛋白用于病原体检测和治疗

    公开(公告)号：US09150631B2

    公开(公告)日：2015-10-06

    申请号：US13574191

    申请日：2011-01-19

    申请人： Michael Super ,  Jeffrey Charles Way ,  Donald E. Ingber

    发明人： Michael Super ,  Jeffrey Charles Way ,  Donald E. Ingber

    IPC分类号： C07K19/00 ,  C12Q1/04 ,  A61K38/02 ,  A61P31/00 ,  C07K14/47

    CPC分类号： C07K14/4726 ,  C07K16/44 ,  C07K17/00 ,  C07K2317/53 ,  C07K2317/66 ,  C07K2319/30 ,  G01N33/56961 ,  G01N2333/40

    摘要： The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.

    摘要翻译： 本发明提供可用于结合生物病原体或鉴定用于治疗和诊断感染性疾病，血源性感染或败血症患者的装置和系统的亚类或特定病原体物种的工程化分子调理素。 本发明的一个方面提供了甘露糖结合凝集素（MBL），其是作为先天免疫系统的一部分的丰富的天然血清蛋白。 这种蛋白凝集素在几乎所有类型的生物病原体（病毒，细菌，真菌，原生动物）上结合表面分子的能力使MBL的工程化形式在诊断和治疗感染性疾病和败血症方面非常有用。