利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

28 条记录 (耗时 0.021 秒)

    Injectable bone regeneration gel containing bone formation enhancing peptide
    1.
    发明授权
    Injectable bone regeneration gel containing bone formation enhancing peptide 有权
    含有骨形成增强肽的可注射骨再生凝胶

    公开(公告)号：US08546529B2

    公开(公告)日：2013-10-01

    申请号：US12663399

    申请日：2008-06-05

    申请人： Chong-Pyoung Chung ,  Yoon-Jeong Park ,  Jue-Yeon Lee

    发明人： Chong-Pyoung Chung ,  Yoon-Jeong Park ,  Jue-Yeon Lee

    IPC分类号： C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  A61K38/00

    CPC分类号： A61L27/52 ,  A61L27/227 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/25 ,  A61L2400/06 ,  A61L2430/02

    摘要： The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc., and can be mixed with bone graft particles to apply, so that it can increase a treatment effect of existing medical devices to maximize a tissue regeneration effect.

    摘要翻译： 本发明涉及含有骨形成增强肽的可注射骨再生材料，更具体地，涉及可注射骨再生材料，其中，基本上含有SEQ ID NO：1至 SEQ ID NO：28被结合或混合到选自壳聚糖，藻酸，丝素蛋白，丙二醇，丙二醇藻酸，泊洛沙姆，硫酸软骨素及其组合中的凝胶形成基材。 根据本发明的可注射骨再生材料可以增加骨髓基质细胞和成骨细胞分化成骨组织，从而通过能够促进骨组织分化和牙周组织再生的肽最大化组织再生。 可注射骨再生材料为凝胶形式，因此可以应用于诸如植入物等各种医疗装置的表面，并且可以与骨移植物颗粒混合使用，从而可以增加治疗效果 的现有医疗装置以最大化组织再生效果。

    DENTAL CLEANSER COMPOSITION FOR IMPROVING ADHESION TO TEETH
    2.
    发明申请
    DENTAL CLEANSER COMPOSITION FOR IMPROVING ADHESION TO TEETH 有权
    牙齿清洁剂组合物，用于改善粘合剂对牙齿的影响

    公开(公告)号：US20130224128A1

    公开(公告)日：2013-08-29

    申请号：US13581073

    申请日：2011-02-28

    申请人： Chong-Pyoung Chung ,  Yoon-Jeong Park ,  Jue-Yeon Lee

    发明人： Chong-Pyoung Chung ,  Yoon-Jeong Park ,  Jue-Yeon Lee

    IPC分类号： A61K6/00

    CPC分类号： A61K6/0035 ,  A61K8/39 ,  A61K8/64 ,  A61K8/731 ,  A61Q11/00 ,  A61Q17/005

    摘要： The present invention relates to a dental cleanser composition for improving adhesion to teeth, and more particularly to, a dental cleanser composition which functions to remove not only a smear layer from the dentin surface of an exposed tooth root, but also oral bacteria, and thus is effective in improving adhesion to teeth in periodontal surgery. The present invention provides a dental cleanser composition containing sodium ethylene diaminotetraacetate and octyl phenol ethoxylate which is a surfactant. Sodium ethylene diaminotetraacetate in the composition functions to remove a smear layer on the tooth root surface and has antibacterial activity, and octyl phenol ethoxylate in the composition functions to lipopolysaccharide. Thus, the composition improves adhesion to teeth in periodontal surgery.

    摘要翻译： 本发明涉及一种牙齿清洁剂组合物，其用于改善与牙齿的粘附性，更具体地说，涉及一种牙科清洁剂组合物，其不仅能够从暴露的牙根的牙本质表面除去涂抹层，而且还可以口服细菌， 有效改善牙周牙周围牙根的粘连。 本发明提供一种含有乙二胺四乙酸钠和辛基酚乙氧基化物的牙科清洁剂组合物，其是表面活性剂。 组合物中的乙二胺四乙酸钠起到除去牙根表面上的涂抹层的作用，具有抗菌活性，并且组合物中的辛基酚乙氧基化物对脂多糖起作用。 因此，该组合物在牙周手术中改善对牙齿的粘附性。

    Bone graft and scaffolding materials immobilized with type I collagen binding peptides
    3.
    发明授权
    Bone graft and scaffolding materials immobilized with type I collagen binding peptides 有权
    用I型胶原结合肽固定的骨移植物和脚手架材料

    公开(公告)号：US08349804B2

    公开(公告)日：2013-01-08

    申请号：US12278009

    申请日：2007-01-19

    申请人： Yoon-Jeong Park ,  Chong-Pyoung Chung ,  Seung-Jin Lee ,  Jue-Yeon Lee

    发明人： Yoon-Jeong Park ,  Chong-Pyoung Chung ,  Seung-Jin Lee ,  Jue-Yeon Lee

    IPC分类号： A61K38/10 ,  A61K38/16

    CPC分类号： A61L27/10 ,  A61L27/34 ,  A61L27/54 ,  A61L2430/02

    摘要： The present invention relates to a pharmaceutical composition comprising a bone graft material, a scaffold for tissue engineering applications and type I collagen Binding Peptides which have bone calcification-promoting peptides immobilized on the surface, and more particularly, to a bone graft material and a scaffold for tissue engineering applications (hereinafter, referred to as scaffold), which have peptides specifically binding with type I collagen immobilized on the surface, and pharmaceutical composition for recovering tissue regeneration containing type I collagen binding-inducing peptide. In the inventive bone graft material and scaffold for tissue engineering applications, the cells related to regeneration by collagen binding-inducing peptide adhered to the surface, promote an adhesion of type I collagen binding-inducing peptide (main ingredients of extracellular matrix) to increase differentiation rate into bone tissues, and promote a calcification which is last step of bone regeneration to maximize a tissue regeneration finally.

    摘要翻译： 本发明涉及一种药物组合物，其包含骨移植材料，用于组织工程应用的支架和具有固定在表面上的骨钙化促进肽的I型胶原结合肽，更具体地涉及骨移植材料和支架 用于组织工程应用（以下称为支架），其具有与固定在表面上的I型胶原特异性结合的肽，以及用于回收含有I型胶原结合诱导肽的组织再生的药物组合物。 在用于组织工程应用的本发明的骨移植物材料和支架中，与通过胶原结合诱导肽再生的细胞粘附到表面上，促进I型胶原结合诱导肽（细胞外基质的主要成分）的粘附以增加分化 进入骨组织，并促进钙化，这是骨再生的最后一步，最终最大限度地发挥组织再生。

    Peptide having the ability to regenerate bone tissue and for binding to apatite
    6.
    发明授权
    Peptide having the ability to regenerate bone tissue and for binding to apatite 有权
    具有再生骨组织和结合磷灰石的能力的肽

    公开(公告)号：US08853165B2

    公开(公告)日：2014-10-07

    申请号：US13821811

    申请日：2011-03-09

    申请人： Chong-Pyoung Chung ,  Yoon-Jeong Park ,  Sang Hoon Rhee ,  Jue-Yeon Lee

    发明人： Chong-Pyoung Chung ,  Yoon-Jeong Park ,  Sang Hoon Rhee ,  Jue-Yeon Lee

    IPC分类号： A61P19/08 ,  A61K38/16 ,  A61K38/10 ,  C07K17/02 ,  C07K17/14 ,  C07K14/00 ,  C07K7/08 ,  A61L27/12 ,  A61L27/22 ,  C07K14/52 ,  A61L27/54

    CPC分类号： C07K14/52 ,  A61L27/12 ,  A61L27/22 ,  A61L27/54 ,  A61L2300/25

    摘要： The present invention relates to a peptide having bone tissue regeneration capacity and binding to a surface of apatite. More particularly, a peptide is provided having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral. A composition for bone tissue regeneration containing the peptide is further provided.

    摘要翻译： 本发明涉及具有骨组织再生能力并与磷灰石表面结合的肽。 更具体地，提供具有骨组织再生能力并且特异性结合磷灰石矿物表面的肽，其能够稳定地固定在磷灰石矿物的表面以保持有效活性并长时间显示出骨再生效果，通过将 具有骨组织再生能力的氨基酸序列和具有彼此磷灰石结合能力的氨基酸序列，从而提供具有磷灰石矿物表面的成骨作用和结合能力的肽。 还提供了含有该肽的骨组织再生用组合物。

    PEPTIDE HAVING THE ABILITY TO REGENERATE BONE TISSUE AND FOR BINDING TO APATITE
    7.
    发明申请
    PEPTIDE HAVING THE ABILITY TO REGENERATE BONE TISSUE AND FOR BINDING TO APATITE 有权
    具有再生骨组织和绑定至APATITE的能力的肽

    公开(公告)号：US20130210736A1

    公开(公告)日：2013-08-15

    申请号：US13821811

    申请日：2011-03-09

    申请人： Chong-Pyoung Chung ,  Yoon-Jeong Park ,  Sang Hoon Rhee ,  Jue- Yeon Lee

    发明人： Chong-Pyoung Chung ,  Yoon-Jeong Park ,  Sang Hoon Rhee ,  Jue- Yeon Lee

    IPC分类号： C07K14/52 ,  A61L27/12 ,  A61L27/54

    CPC分类号： C07K14/52 ,  A61L27/12 ,  A61L27/22 ,  A61L27/54 ,  A61L2300/25

    摘要： The present invention relates to a peptide having bone tissue regeneration capacity and binding to surface of apatite, and more particularly, to a peptide having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral, and a composition for bone tissue regeneration, containing the peptide. The peptide having binding capacity to the apatite mineral and bone tissue regeneration capacity according to the present invention binds to the surface of apatite to thereby be present in a stable state, and thus can be used in a bone replacement material for dental or orthopedic application, and metal, natural polymers, or synthetic polymers, coated with apatite; promote transition, proliferation, and differentiation of cells associated with regeneration and eventually maximize bone tissue regeneration; and can be stably present while maintaining peptide activity when being grafted into the body and thus is useful in development of the bone tissue regeneration therapeutic technology using the peptide.

    摘要翻译： 本发明涉及具有骨组织再生能力和与磷灰石表面结合的肽，更具体地，涉及具有骨组织再生能力并且特异性结合磷灰石矿物质表面的肽，能够稳定地固定在磷酸钙表面上 磷灰石矿物质通过将具有骨组织再生能力的氨基酸序列和具有磷灰石结合能力的氨基酸序列彼此连接，从而保持有效活性并长时间展现骨再生作用，从而提供具有骨形成 对磷灰石矿物表面的作用和结合能力，以及含有该肽的骨组织再生组合物。 根据本发明的具有磷灰石矿物和骨组织再生能力的结合能力的肽结合磷灰石的表面，从而以稳定的状态存在，因此可用于牙科或矫形应用的骨替代材料中， 和用磷灰石涂覆的金属，天然聚合物或合成聚合物; 促进与再生相关的细胞的转移，增殖和分化，并最终最大化骨组织再生; 并且可以在接枝入体内时保持肽活性而稳定地存在，因此可用于开发使用该肽的骨组织再生治疗技术。

    Cell-permeable peptide
    8.
    发明授权
    Cell-permeable peptide 有权
    细胞可渗透肽

    公开(公告)号：US09023987B2

    公开(公告)日：2015-05-05

    申请号：US13821790

    申请日：2011-04-25

    申请人： Chong-Pyoung Chung ,  Yoon-Jeong Park ,  Jue-Yeon Lee ,  Jin Sook Suh

    发明人： Chong-Pyoung Chung ,  Yoon-Jeong Park ,  Jue-Yeon Lee ,  Jin Sook Suh

    IPC分类号： C07K9/00 ,  C07K14/435 ,  C07K14/51 ,  C07K7/06 ,  C07K7/08 ,  A61K38/00

    CPC分类号： C07K14/435 ,  A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/51

    摘要： The present invention relates to a novel human-derived cell permeable peptide-bioactive peptide conjugate and the use thereof. According to the present invention, cationic cell permeable peptides derived from human bone morphogenetic protein-4 have no toxicity and immunogenicity and thus exhibit high stability as compared to viral peptide delivery vehicles, and can transport cell impermeable material into cells and into an organism without any damage to cell or material, thereby significantly increasing target gene expression. In addition, the peptide may be applied to clinical use without having to undergo a large number of processes and mass-produced, such that the present invention may be useful in the development of a drug delivery system and treatment technologies using said peptide.

    摘要翻译： 本发明涉及新型人源细胞可渗透肽 - 生物活性肽缀合物及其用途。 根据本发明，衍生自人骨形态发生蛋白-4的阳离子细胞可渗透肽没有毒性和免疫原性，因此与病毒肽递送载体相比表现出高稳定性，并且可以将细胞不可渗透的材料输送到细胞中并进入生物体 破坏细胞或物质，从而显着增加靶基因表达。 此外，该肽可以应用于临床用途，而不必经历大量的方法和批量生产，使得本发明可用于开发药物递送系统和使用所述肽的治疗技术。