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公开(公告)号：US09133246B2
公开(公告)日：2015-09-15
申请号：US14112929
申请日：2011-12-16
IPC分类号： A61K38/00 , C07K14/78 , C07K14/00 , A61L27/24 , A61L27/54 , A61L27/60 , C12N15/62 , C07K14/49 , C07K14/51 , C07K14/47 , C07K14/485
CPC分类号： C07K14/001 , A61K38/00 , A61L27/24 , A61L27/54 , A61L27/60 , A61L2300/252 , A61L2300/404 , A61L2300/80 , A61L2430/02 , C07K14/4723 , C07K14/485 , C07K14/49 , C07K14/51 , C07K14/78 , C07K2319/00 , C12N15/62
摘要： A collagen membrane having fusion protein bound thereto is described, in which the fusion protein includes collagen binding peptide and antibacterial peptide. The collagen membrane is usefully employed in vivo to promote cell migration, proliferation, and differentiation associated with bone tissue regeneration, for bone induction and regeneration. The fusion protein may also be applied to other collagenic graft materials, for use as a biomaterial for regenerating other tissues such as the skin.
摘要翻译： 描述了与其结合的融合蛋白的胶原膜，其中融合蛋白包括胶原结合肽和抗菌肽。 胶原膜在体内有用地用于促进与骨组织再生相关的细胞迁移，增殖和分化，用于骨诱导和再生。 融合蛋白也可以应用于其它胶原移植材料，用作再生其他组织如皮肤的生物材料。
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公开(公告)号：US20140187743A1
公开(公告)日：2014-07-03
申请号：US14112929
申请日：2011-12-16
CPC分类号： C07K14/001 , A61K38/00 , A61L27/24 , A61L27/54 , A61L27/60 , A61L2300/252 , A61L2300/404 , A61L2300/80 , A61L2430/02 , C07K14/4723 , C07K14/485 , C07K14/49 , C07K14/51 , C07K14/78 , C07K2319/00 , C12N15/62
摘要： The present invention relates to a membrane having bound thereto an antibacterial peptide that binds to collagen, and more particularly to a collagen membrane comprising a fusion peptide of a collagen-binding peptide and an antibacterial peptide, fixed to the collagen surface.The present invention provides a collagen membrane having surface activity by a fusion peptide bound to the surface thereof. When the collagen membrane is transplanted in vivo, the retention time of the fusion peptide in a local region can increase, and the fusion peptide can promote the cell migration, proliferation and differentiation associated with bone tissue regeneration, thereby maximizing the ability to regenerate bone tissue. Thus, the collagen membrane contributes to the development of therapeutic technology for bone induction and regeneration. Also, the fusion peptide may be applied to other types of graft materials made of collagen. In addition, the collagen-binding peptide of the fusion peptide can also be bound to peptides having the effect of regenerating other tissues, and thus can be applied as a biomaterial for regeneration of other tissues such as the skin.
摘要翻译： 本发明涉及一种与胶原结合的抗菌肽结合的膜，更具体地涉及一种固定在胶原表面上的胶原膜，其包含胶原结合肽和抗菌肽的融合肽。 本发明提供了具有与其表面结合的融合肽的表面活性的胶原膜。 当胶原膜在体内移植时，融合肽在局部区域的停留时间可以增加，并且融合肽可以促进与骨组织再生相关的细胞迁移，增殖和分化，从而最大化再生骨组织的能力 。 因此，胶原膜有助于骨诱导和再生的治疗技术的发展。 此外，融合肽可以应用于由胶原蛋白制成的其他类型的移植材料。 此外，融合肽的胶原结合肽也可以与具有再生其他组织的作用的肽结合，因此可以用作其它组织如皮肤的再生的生物材料。
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公开(公告)号：US20110213036A1
公开(公告)日：2011-09-01
申请号：US13123484
申请日：2009-10-08
IPC分类号： A61K31/194 , A61P19/08
摘要： The present invention relates to a composition for prevention of tooth hypersensitivity, and more particularly to a composition for prevention of tooth hypersensitivity, which comprises an adhesive polymer for coating teeth, an active ingredient for prevention of hypersensitivity, a substance for promoting the penetration of the active ingredient for prevention of hypersensitivity, a desensitizing active ingredient, and a pH-adjusting agent. The composition for prevention of tooth hypersensitivity according to the invention can rapidly show the effect of preventing tooth hypersensitivity while maintaining the sensory feel of conventional tooth desensitizers, and it can maintain the tooth hypersensitivity-preventing effect for a long time.
摘要翻译： 本发明涉及用于预防牙齿过敏的组合物，更具体地说，涉及用于预防牙齿过敏的组合物，其包含用于涂覆牙齿的粘合剂聚合物，用于预防超敏反应的活性成分，用于促进牙齿过敏的物质 用于预防超敏反应的活性成分，脱敏活性成分和pH调节剂。 根据本发明的用于预防牙齿超敏反应的组合物可以在保持常规牙齿脱敏剂的感觉的同时快速显示出防止牙齿过敏的效果，并且可以长时间保持牙齿超敏反应的效果。
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公开(公告)号：US20100104519A1
公开(公告)日：2010-04-29
申请号：US12517616
申请日：2007-12-07
CPC分类号： A61K8/22 , A61K8/0241 , A61K8/24 , A61K8/25 , A61K8/64 , A61K8/8147 , A61K8/86 , A61K8/88 , A61K2800/413 , A61Q11/00
摘要： The present invention relates to a tooth whitening agent delivery system, more particularly, to a tooth whitening composition comprising an adhesive polymer, a tooth whitening active material, a material for promoting penetration of the tooth whitening active material, a hydrophobic surfactant, a stabilizer, an antioxidant, an antihypersensitive agent, pyrophosphate and SiO2.
摘要翻译： 本发明涉及一种牙齿增白剂递送系统，更具体地，涉及一种牙齿增白组合物，其包含粘合剂聚合物，牙齿增白活性物质，促进牙齿增白活性物质渗透的材料，疏水性表面活性剂，稳定剂， 抗氧化剂，抗过敏剂，焦磷酸盐和SiO 2。
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5.发明授权公开(公告)号：US08546529B2
公开(公告)日：2013-10-01
申请号：US12663399
申请日：2008-06-05
CPC分类号： A61L27/52 , A61L27/227 , A61L27/50 , A61L27/54 , A61L2300/25 , A61L2400/06 , A61L2430/02
摘要： The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc., and can be mixed with bone graft particles to apply, so that it can increase a treatment effect of existing medical devices to maximize a tissue regeneration effect.
摘要翻译： 本发明涉及含有骨形成增强肽的可注射骨再生材料，更具体地，涉及可注射骨再生材料，其中，基本上含有SEQ ID NO：1至 SEQ ID NO：28被结合或混合到选自壳聚糖，藻酸，丝素蛋白，丙二醇，丙二醇藻酸，泊洛沙姆，硫酸软骨素及其组合中的凝胶形成基材。 根据本发明的可注射骨再生材料可以增加骨髓基质细胞和成骨细胞分化成骨组织，从而通过能够促进骨组织分化和牙周组织再生的肽最大化组织再生。 可注射骨再生材料为凝胶形式，因此可以应用于诸如植入物等各种医疗装置的表面，并且可以与骨移植物颗粒混合使用，从而可以增加治疗效果 的现有医疗装置以最大化组织再生效果。
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公开(公告)号：US20130224128A1
公开(公告)日：2013-08-29
申请号：US13581073
申请日：2011-02-28
IPC分类号： A61K6/00
CPC分类号： A61K6/0035 , A61K8/39 , A61K8/64 , A61K8/731 , A61Q11/00 , A61Q17/005
摘要： The present invention relates to a dental cleanser composition for improving adhesion to teeth, and more particularly to, a dental cleanser composition which functions to remove not only a smear layer from the dentin surface of an exposed tooth root, but also oral bacteria, and thus is effective in improving adhesion to teeth in periodontal surgery. The present invention provides a dental cleanser composition containing sodium ethylene diaminotetraacetate and octyl phenol ethoxylate which is a surfactant. Sodium ethylene diaminotetraacetate in the composition functions to remove a smear layer on the tooth root surface and has antibacterial activity, and octyl phenol ethoxylate in the composition functions to lipopolysaccharide. Thus, the composition improves adhesion to teeth in periodontal surgery.
摘要翻译： 本发明涉及一种牙齿清洁剂组合物，其用于改善与牙齿的粘附性，更具体地说，涉及一种牙科清洁剂组合物，其不仅能够从暴露的牙根的牙本质表面除去涂抹层，而且还可以口服细菌， 有效改善牙周牙周围牙根的粘连。 本发明提供一种含有乙二胺四乙酸钠和辛基酚乙氧基化物的牙科清洁剂组合物，其是表面活性剂。 组合物中的乙二胺四乙酸钠起到除去牙根表面上的涂抹层的作用，具有抗菌活性，并且组合物中的辛基酚乙氧基化物对脂多糖起作用。 因此，该组合物在牙周手术中改善对牙齿的粘附性。
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7.发明授权Bone graft and scaffolding materials immobilized with type I collagen binding peptides 有权用I型胶原结合肽固定的骨移植物和脚手架材料公开(公告)号：US08349804B2
公开(公告)日：2013-01-08
申请号：US12278009
申请日：2007-01-19
CPC分类号： A61L27/10 , A61L27/34 , A61L27/54 , A61L2430/02
摘要： The present invention relates to a pharmaceutical composition comprising a bone graft material, a scaffold for tissue engineering applications and type I collagen Binding Peptides which have bone calcification-promoting peptides immobilized on the surface, and more particularly, to a bone graft material and a scaffold for tissue engineering applications (hereinafter, referred to as scaffold), which have peptides specifically binding with type I collagen immobilized on the surface, and pharmaceutical composition for recovering tissue regeneration containing type I collagen binding-inducing peptide. In the inventive bone graft material and scaffold for tissue engineering applications, the cells related to regeneration by collagen binding-inducing peptide adhered to the surface, promote an adhesion of type I collagen binding-inducing peptide (main ingredients of extracellular matrix) to increase differentiation rate into bone tissues, and promote a calcification which is last step of bone regeneration to maximize a tissue regeneration finally.
摘要翻译： 本发明涉及一种药物组合物，其包含骨移植材料，用于组织工程应用的支架和具有固定在表面上的骨钙化促进肽的I型胶原结合肽，更具体地涉及骨移植材料和支架 用于组织工程应用（以下称为支架），其具有与固定在表面上的I型胶原特异性结合的肽，以及用于回收含有I型胶原结合诱导肽的组织再生的药物组合物。 在用于组织工程应用的本发明的骨移植物材料和支架中，与通过胶原结合诱导肽再生的细胞粘附到表面上，促进I型胶原结合诱导肽（细胞外基质的主要成分）的粘附以增加分化 进入骨组织，并促进钙化，这是骨再生的最后一步，最终最大限度地发挥组织再生。
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8.发明授权公开(公告)号：US09408920B2
公开(公告)日：2016-08-09
申请号：US14119160
申请日：2011-12-16
CPC分类号： A61K47/48246 , A61K47/64 , C07K14/4702 , C07K14/51 , C07K2319/10 , C07K2319/21 , C07K2319/35 , C07K2319/73 , C12N9/0036 , C12N9/0089
摘要： The present invention relates to a cell permeable fusion protein for strengthening regenerative potential of stem cells, and more particularly to a cell permeable fusion protein for strengthening regenerative potential of stem cells for stimulating the differentiation of stem cells, inhibiting apoptosis, maintaining the functionality of stem cells and restoring the stress-inhibited functionality of stem cells.
摘要翻译： 本发明涉及一种用于增强干细胞再生潜力的细胞可渗透融合蛋白，更具体地涉及一种用于增强干细胞再生潜能以促进干细胞分化，抑制细胞凋亡，维持干细胞功能的细胞渗透融合蛋白 细胞并恢复干细胞的应激抑制功能。
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9.发明授权Peptide having the ability to regenerate bone tissue and for binding to apatite 有权具有再生骨组织和结合磷灰石的能力的肽公开(公告)号：US08853165B2
公开(公告)日：2014-10-07
申请号：US13821811
申请日：2011-03-09
IPC分类号： A61P19/08 , A61K38/16 , A61K38/10 , C07K17/02 , C07K17/14 , C07K14/00 , C07K7/08 , A61L27/12 , A61L27/22 , C07K14/52 , A61L27/54
CPC分类号： C07K14/52 , A61L27/12 , A61L27/22 , A61L27/54 , A61L2300/25
摘要： The present invention relates to a peptide having bone tissue regeneration capacity and binding to a surface of apatite. More particularly, a peptide is provided having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral. A composition for bone tissue regeneration containing the peptide is further provided.
摘要翻译： 本发明涉及具有骨组织再生能力并与磷灰石表面结合的肽。 更具体地，提供具有骨组织再生能力并且特异性结合磷灰石矿物表面的肽，其能够稳定地固定在磷灰石矿物的表面以保持有效活性并长时间显示出骨再生效果，通过将 具有骨组织再生能力的氨基酸序列和具有彼此磷灰石结合能力的氨基酸序列，从而提供具有磷灰石矿物表面的成骨作用和结合能力的肽。 还提供了含有该肽的骨组织再生用组合物。
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公开(公告)号：US08974805B2
公开(公告)日：2015-03-10
申请号：US13581073
申请日：2011-02-28
IPC分类号： A61Q11/00 , A61K8/02 , A61K38/00 , A61K38/10 , A61K6/00 , A61K8/39 , A61K8/64 , A61K8/73 , A61Q17/00
CPC分类号： A61K6/0035 , A61K8/39 , A61K8/64 , A61K8/731 , A61Q11/00 , A61Q17/005
摘要： The present invention relates to a dental cleanser composition for improving adhesion to teeth, and more particularly to, a dental cleanser composition which functions to remove not only a smear layer from the dentin surface of an exposed tooth root, but also oral bacteria, and thus is effective in improving adhesion to teeth in periodontal surgery. The present invention provides a dental cleanser composition containing sodium ethylene diaminotetraacetate and octyl phenol ethoxylate which is a surfactant. Sodium ethylene diaminotetraacetate in the composition functions to remove a smear layer on the tooth root surface and has antibacterial activity, and octyl phenol ethoxylate in the composition functions to lipopolysaccharide. Thus, the composition improves adhesion to teeth in periodontal surgery.
摘要翻译： 本发明涉及一种牙齿清洁剂组合物，其用于改善与牙齿的粘附性，更具体地说，涉及一种牙科清洁剂组合物，其不仅能够从暴露的牙根的牙本质表面除去涂抹层，而且还可以口服细菌， 有效改善牙周牙周围牙根的粘连。 本发明提供一种含有乙二胺四乙酸钠和辛基酚乙氧基化物的牙科清洁剂组合物，其是表面活性剂。 组合物中的乙二胺四乙酸钠起到除去牙根表面上的涂抹层的作用，具有抗菌活性，并且组合物中的辛基酚乙氧基化物对脂多糖起作用。 因此，该组合物在牙周手术中改善对牙齿的粘附性。
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