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    NOVEL METHOD FOR THE PRODUCTION OF A ANTIMICROBIAL PEPTIDE
    1.
    发明申请
    NOVEL METHOD FOR THE PRODUCTION OF A ANTIMICROBIAL PEPTIDE 审中-公开
    用于生产抗微生物肽的新方法

    公开(公告)号：US20120213764A1

    公开(公告)日：2012-08-23

    申请号：US13395638

    申请日：2010-09-22

    申请人： Christian Naumer ,  Michael Krohn ,  Yvonne Tiffert ,  Jürgen Eck

    发明人： Christian Naumer ,  Michael Krohn ,  Yvonne Tiffert ,  Jürgen Eck

    IPC分类号： A61K38/48 ,  C12P21/06 ,  A61Q19/00 ,  C07K19/00 ,  A61P31/00 ,  A61K8/66 ,  C12P21/02 ,  C07H21/04

    CPC分类号： C07K14/4703 ,  A61K38/4873 ,  C12P21/06 ,  Y02A50/401 ,  A61K2300/00

    摘要： The present invention relates to a method of producing a peptide consisting of the amino acids 63 to 110 of dermcidin (SEQ ID NO: 3) comprising (a) culturing a host cell carrying a nucleic acid molecule encoding the peptide in an expressible form, and (b) optionally isolating the peptide from the culture. Furthermore, the invention relates to a nucleic acid molecule encoding a fusion protein comprising or consisting of (a) a peptide heterologous with regard to dermcidin protein-tag; and, C-terminally thereof (b) a peptide having the antimicrobial activity of dermcidin wherein the fusion protein contains an arginine residue located immediately N-terminally of the peptide of (b).

    摘要翻译： 本发明涉及一种由皮霉素（SEQ ID NO：3）的氨基酸63至110组成的肽的方法，该方法包括：（a）培养携带编码可表达形式的肽的核酸分子的宿主细胞，以及 （b）任选地从培养物中分离肽。 此外，本发明涉及编码融合蛋白的核酸分子，其包含或由（a）针对皮肤素蛋白标签异源的肽组成或由其组成; 及其C-末端（b）具有抗皮肤杀菌活性的肽，其中所述融合蛋白含有位于（b）的肽的N-末端的精氨酸残基。

    Protease for wound conditioning and skin care
    2.
    发明授权
    Protease for wound conditioning and skin care 有权
    用于伤口调理和护肤的蛋白酶

    公开(公告)号：US08623810B2

    公开(公告)日：2014-01-07

    申请号：US13254157

    申请日：2010-03-03

    申请人： Frank Niehaus ,  Jürgen Eck ,  Renate Schulze ,  Michael Krohn

    发明人： Frank Niehaus ,  Jürgen Eck ,  Renate Schulze ,  Michael Krohn

    IPC分类号： C12N9/48 ,  C12N9/50 ,  C12N15/52 ,  C12N15/57 ,  C12P21/00 ,  A61K38/43 ,  A61K38/48 ,  A61K48/00 ,  A61P17/02

    CPC分类号： C12N9/6408

    摘要： We have identified by molecular cloning a protease which originates from the larvae of Lucilia sericata and which was termed debrilase due to its activities useful for debridement of wounds. Described is a nucleic acid molecule encoding a serine protease having the ability to cleave fibrin and casein which is (a) a nucleic acid molecule encoding the serine protease comprising or consisting of the amino acid sequence of SEQ ID NO: 4 as well as to nucleic acid molecules encoding precursors or fragments of said serine protease; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 3; (c) a nucleic acid molecule encoding a serine protease the amino acid sequence of which is at least 80% identical to the amino acid sequence of (a), preferably at least 85% identical, more preferably at least 90% identical, and most preferred 95% identical; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 80% identical to the nucleotide sequence of (b), preferably at least 85% identical, more preferably at least 90% identical, and most preferred 95% identical; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (b) or (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (d) wherein T is replaced by U.

    摘要翻译： 我们已经通过分子克隆鉴定了源自丝蚕幼虫的蛋白酶，由于其可用于清创伤口的活性，所以被称为脱氨酶。 描述了编码具有裂解纤维蛋白和酪蛋白的能力的丝氨酸蛋白酶的核酸分子，其是（a）编码包含或由SEQ ID NO：4的氨基酸序列组成的丝氨酸蛋白酶的核酸分子以及核酸 编码所述丝氨酸蛋白酶的前体或片段的酸分子; （b）包含SEQ ID NO：3的核苷酸序列或由其组成的核酸分子; （c）编码丝氨酸蛋白酶的核酸分子，其氨基酸序列与（a）的氨基酸序列至少80％相同，优选至少85％相同，更优选至少90％相同，最多 优选95％相同; （d）核酸分子，其包含与（b）的核苷酸序列至少80％同一性，优选至少85％相同，更优选至少90％相同，最优选95％的核苷酸序列或由其组成， 相同; （e）相对于（b）或（d）的核酸分子简并的核酸分子; 或（f）对应于（a）至（d）中任一项的核酸分子的核酸分子，其中T被U.替代

    PROTEASE FOR WOUND CONDITIONING AND SKIN CARE
    3.
    发明申请
    PROTEASE FOR WOUND CONDITIONING AND SKIN CARE 有权
    保护皮肤护理和皮肤护理

    公开(公告)号：US20120093788A1

    公开(公告)日：2012-04-19

    申请号：US13254157

    申请日：2010-03-03

    申请人： Frank Niehaus ,  Jürgen Eck ,  Renate Schulze ,  Michael Krohn

    发明人： Frank Niehaus ,  Jürgen Eck ,  Renate Schulze ,  Michael Krohn

    IPC分类号： A61K48/00 ,  C12N9/50 ,  A61K36/06 ,  A61K36/064 ,  A61P17/02 ,  C07H21/04 ,  A61P17/00 ,  C12N1/21 ,  C12N1/19 ,  C12N15/63 ,  A61K31/7088 ,  C07K16/40 ,  A61K38/48 ,  A61K35/74

    CPC分类号： C12N9/6408

    摘要： We have identified by molecular cloning a protease which originates from the larvae of Lucilia sericata and which was termed debrilase due to its activities useful for debridement of wounds. Described is a nucleic acid molecule encoding a serine protease having the ability to cleave fibrin and casein which is (a) a nucleic acid molecule encoding the serine protease comprising or consisting of the amino acid sequence of SEQ ID NO: 4 as well as to nucleic acid molecules encoding precursors or fragments of said serine protease; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 3; (c) a nucleic acid molecule encoding a serine protease the amino acid sequence of which is at least 80% identical to the amino acid sequence of (a), preferably at least 85% identical, more preferably at least 90% identical, and most preferred 95% identical; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 80% identical to the nucleotide sequence of (b), preferably at least 85% identical, more preferably at least 90% identical, and most preferred 95% identical; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (b) or (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (d) wherein T is replaced by U.

    摘要翻译： 我们已经通过分子克隆鉴定了源自丝蚕幼虫的蛋白酶，由于其可用于清创伤口的活性，所以被称为脱氨酶。 描述了编码具有裂解纤维蛋白和酪蛋白的能力的丝氨酸蛋白酶的核酸分子，其是（a）编码包含或由SEQ ID NO：4的氨基酸序列组成的丝氨酸蛋白酶的核酸分子以及核酸 编码所述丝氨酸蛋白酶的前体或片段的酸分子; （b）包含SEQ ID NO：3的核苷酸序列或由其组成的核酸分子; （c）编码丝氨酸蛋白酶的核酸分子，其氨基酸序列与（a）的氨基酸序列至少80％相同，优选至少85％相同，更优选至少90％相同，最多 优选95％相同; （d）核酸分子，其包含与（b）的核苷酸序列至少80％相同，优选至少85％相同，更优选至少90％相同，最优选95％的核苷酸序列或由其组成， 相同; （e）相对于（b）或（d）的核酸分子简并的核酸分子; 或（f）对应于（a）至（d）中任一项的核酸分子的核酸分子，其中T被U.替代

    Small molecule inhibitors of TRPA1
    4.
    发明授权
    Small molecule inhibitors of TRPA1 有权
    TRPA1的小分子抑制剂

    公开(公告)号：US09440993B2

    公开(公告)日：2016-09-13

    申请号：US14116832

    申请日：2012-05-11

    申请人： Michael Krohn ,  Dirk Sombroek

    发明人： Michael Krohn ,  Dirk Sombroek

    IPC分类号： C07D513/04 ,  C07D249/08 ,  C07C255/44 ,  C07C69/78 ,  C07C62/30 ,  A23L1/22 ,  A61K31/235 ,  A61Q19/00 ,  A61K8/36 ,  A61K8/37 ,  A61K8/49 ,  A61K8/69

    CPC分类号： C07C62/30 ,  A23L27/86 ,  A23L27/88 ,  A61K8/36 ,  A61K8/37 ,  A61K8/49 ,  A61K8/496 ,  A61K8/69 ,  A61K31/192 ,  A61K31/235 ,  A61K2800/782 ,  A61Q19/00 ,  C07C69/78 ,  C07C255/44 ,  C07D249/08 ,  C07D513/04

    摘要： The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be caused, inter alia, by ingredients of cosmetic or pharmaceutical compositions and/or environmental irritants. In particular, the present invention relates to compounds having the property of antagonizing the activation of the transient receptor potential (TRP) ankyrin 1 (TRPA1) ion channel and the use of said compounds as soothing agents. Such compounds can be used in many fields, particularly in personal-care products, cosmetics, textile and packaging products, pharmaceutical compositions, medical devices, and foodstuffs. The present invention further relates to products and/or pharmaceutical compositions containing said compounds. The present invention also relates to the use of the compounds described herein for the modulation of the taste of a food product.

    摘要翻译： 本发明涉及当它们施用于皮肤时能够减轻皮肤刺激性的化合物的用途。 特别是由化妆品或药物组合物和/或环境刺激物的成分引起皮肤刺激。 特别地，本发明涉及具有拮抗瞬时受体电位（TRP）锚蛋白1（TRPA1）离子通道的活化和使用所述化合物作为舒缓剂的性质的化合物。 这些化合物可用于许多领域，特别是在个人护理产品，化妆品，纺织和包装产品，药物组合物，医疗装置和食品中。 本发明还涉及含有所述化合物的产品和/或药物组合物。 本发明还涉及本文所述的化合物用于调节食品味道的用途。

    SMALL MOLECULE INHIBITORS OF TRPA1
    6.
    发明申请
    SMALL MOLECULE INHIBITORS OF TRPA1 有权
    TRPA1小分子抑制剂

    公开(公告)号：US20140080842A1

    公开(公告)日：2014-03-20

    申请号：US14116832

    申请日：2012-05-11

    申请人： Michael Krohn ,  Dirk Sombroek

    发明人： Michael Krohn ,  Dirk Sombroek

    IPC分类号： C07D513/04 ,  A23L1/22 ,  C07C255/44 ,  C07C62/30 ,  C07C69/78 ,  C07D249/08

    CPC分类号： C07C62/30 ,  A23L27/86 ,  A23L27/88 ,  A61K8/36 ,  A61K8/37 ,  A61K8/49 ,  A61K8/496 ,  A61K8/69 ,  A61K31/192 ,  A61K31/235 ,  A61K2800/782 ,  A61Q19/00 ,  C07C69/78 ,  C07C255/44 ,  C07D249/08 ,  C07D513/04

    摘要： The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be caused, inter alia, by ingredients of cosmetic or pharmaceutical compositions and/or environmental irritants. In particular, the present invention relates to compounds having the property of antagonizing the activation of the transient receptor potential (TRP) ankyrin 1 (TRPA1) ion channel and the use of said compounds as soothing agents. Such compounds can be used in many fields, particularly in personal-care products, cosmetics, textile and packaging products, pharmaceutical compositions, medical devices, and foodstuffs. The present invention further relates to products and/or pharmaceutical compositions containing said compounds. The present invention also relates to the use of the compounds described herein for the modulation of the taste of a food product.

    摘要翻译： 本发明涉及当它们施用于皮肤时能够减轻皮肤刺激性的化合物的用途。 特别是由化妆品或药物组合物和/或环境刺激物的成分引起皮肤刺激。 特别地，本发明涉及具有拮抗瞬时受体电位（TRP）锚蛋白1（TRPA1）离子通道的活化和使用所述化合物作为舒缓剂的性质的化合物。 这些化合物可用于许多领域，特别是在个人护理产品，化妆品，纺织和包装产品，药物组合物，医疗装置和食品中。 本发明还涉及含有所述化合物的产品和/或药物组合物。 本发明还涉及本文所述的化合物用于调节食品味道的用途。

    CYCLIC LIPOPEPTIDES FOR USE AS TASTE MODULATORS
    7.
    发明申请
    CYCLIC LIPOPEPTIDES FOR USE AS TASTE MODULATORS 审中-公开
    用作测定剂的循环脂质体

    公开(公告)号：US20110256291A1

    公开(公告)日：2011-10-20

    申请号：US13000587

    申请日：2009-06-23

    申请人： Michael Krohn ,  Holger Zinke

    发明人： Michael Krohn ,  Holger Zinke

    IPC分类号： A23L1/227

    CPC分类号： A23L27/31 ,  A23L27/88

    摘要： The invention relates to the use of one or more cyclic lipopeptides, such as surfactins A, B, and C and derivatives and mixtures thereof, as a taste modulator and/or sweetness enhancer for comestible compositions containing at least one natural or artificial sweetener. The comestible compositions include food, beverages, medicinal products and cosmetics and contain preferably mono-, di- or oligosaccharides as sweeteners. The invention further relates to said comestible compositions containing a cyclic lipopeptide as taste modulator.

    摘要翻译： 本发明涉及一种或多种环状脂肽，例如表面活性素A，B和C及其衍生物和混合物作为含有至少一种天然或人造甜味剂的可食用组合物的调味剂和/或甜味增强剂的用途。 可食用组合物包括食品，饮料，医药产品和化妆品，并且优选含有作为甜味剂的单糖，二糖或寡糖。 本发明还涉及含有环状脂肽作为调味剂的所述可食用组合物。